p53 family : function and cancer therapy

• Project/Area Number: 17013072
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Sapporo Medical University
• Principal Investigator: TOKINO Takashi Sapporo Medical University, 医学部, 教授 (40202197)
• Project Period (FY): 2005 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥47,000,000 (Direct Cost: ¥47,000,000); Fiscal Year 2009: ¥9,400,000 (Direct Cost: ¥9,400,000); Fiscal Year 2008: ¥9,400,000 (Direct Cost: ¥9,400,000); Fiscal Year 2007: ¥9,400,000 (Direct Cost: ¥9,400,000); Fiscal Year 2006: ¥9,400,000 (Direct Cost: ¥9,400,000); Fiscal Year 2005: ¥9,400,000 (Direct Cost: ¥9,400,000)
• Keywords: 癌 / 癌抑制遺伝子 / 遺伝子治療 / p53 / p63 / p73 / アポトーシス / ウイルスベクター / がん / がん抑制遺伝子 / がん治療

Research Abstract

Our in silico approach is powerful for identification of p53 target genes and for further understanding the function of p53 in tumorigenesis. We identified that PEDF, FLOT2, and APOD are direct transcriptional targets of the p53 family member genes. We found that significant antitumor effect of adenovirus-mediated p53 family gene transfer on osteosarcoma cell lines in a mouse model. Furthermore, the histone deacetylase inhibitor FK228 was found to enhance adenovirus-mediated p53 family gene therapy in cancer models.

Research Products

• [Journal Article] IGFBP7 is a p53 responsive gene specifically silenced in colorectal cancer with CpG island methylator phenotype. (2010)
  • Author(s): Suzuki H, Igarashi S, Nojima M, Maruyama R, Yamamoto E, Kai M, Akashi H, Watanabe Y, Yamamoto H, Sasaki Y, Itoh F, Imai K, Sugai T, Shen L, Issa J-P J, Shinomura Y, Tokino T, Toyota M
  • Journal Title: Carcinogenesis 31(3) Pages: 342-349
  • Peer Reviewed
• [Journal Article] Genomic screening for genes upregulated by demethylation revealed novel targets of epigenetic silencing in breast cencer. (2010)
  • Author(s): Fujikane, Tomoko, et al
  • Journal Title: Breast Cancer Res Treat (in press)
  • Peer Reviewed
• [Journal Article] IGFBP7 is a p53 responsive gene specifically silenced in colorectal cancer with CpG island methylator phenotype. (2010)
  • Author(s): Suzuki, Hiromu, et al
  • Journal Title: Carcinigenesis VOL.31 Pages: 342-349
  • Peer Reviewed
• [Journal Article] A single recombinant adenovirus expressing p53 and p21-targeting artificial microRNAs efficiently induces apoptosis in human cancer cells. (2009)
  • Author(s): Idogawa M, Sasaki Y, Suzuki H, Mita H, Imai K, Shinomura Y, Tokino T
  • Journal Title: Clinical Cancer Research 15(11) Pages: 3725-3732
  • Peer Reviewed
• [Journal Article] CHFR, a potential tumor suppressor, downregulates interleukin-8 via inhibition of NF-kB. (2009)
  • Author(s): Kashima L, Toyota M, Mita H, Suzuki H, Idogawa M, Ogi K, Sasaki Y, Tokino T
  • Journal Title: Oncogene 28(29) Pages: 2643-2653
  • Peer Reviewed
• [Journal Article] p53 family members regulate the expression of the apolipoprotein D gene. (2009)
  • Author(s): Sasaki Y, Negishi H, Koyama R, Anbo N, Ohori K, Idogawa M, Mita H, Toyota M, Imai K, Shinomura Y, Tokino T
  • Journal Title: J Biol Chem 284(2) Pages: 872-883
  • Peer Reviewed
• [Journal Article] A novel method, digital genome scanning detects KRAS gene amplification in gastric cancers: involvement of overexpressed wild-type KRAS in downstream signaling and cancer cell growth. (2009)
  • Author(s): Mita H, Toyota M, Aoki F, Akashi H, Maruyama R, Sasaki Y, Suzuki H, Idogawa M, Kashima L, Yanagihara K, Fujita M, Hosokawa M, Kusano M, Sabau SV, Tatsumi H, Imai K, Shinomura Y, Tokino T
  • Journal Title: BMC Cancer 9 Pages: 198-198
  • Peer Reviewed
• [Journal Article] A novel biomarker for cervical cancer. (2009)
  • Author(s): Tokino T
  • Journal Title: Cancer Biology Therapy 8(12) Pages: 1154-1155
  • Peer Reviewed
• [Journal Article] Genomic Screening for genes silenced by DNA methylation revealed an association between RASD1 inactivation and dexamethasone resistence in multiple myeloma. (2009)
  • Author(s): Nojima M, Maruyama R, Yasui H, Suzuki H, Maruyama Y, Tarasawa I, Sasaki Y, Asaoku H, Sakai H, Hayashi T, Mori M, Imai K, Tokino T, Ishida T, Toyota M, Shinomura Y
  • Journal Title: Clinical Cancer Research 15(13) Pages: 4356-4364
  • Peer Reviewed
• [Journal Article] Cancer epigenomics: Implications of DNA methylation in personalized cancer therapy. (2009)
  • Author(s): Toyota M, Suzuki H, Yamashita T, Hirata K, Imai K, Tokino T, Shinomura Y
  • Journal Title: Cancer Science 100(5) Pages: 787-791
  • NAID: 10025145027
  • Peer Reviewed
• [Journal Article] Overexpression of Aurora A by loss of CHFR gene expression increases the growth and survival of HTLV-1-infected T cells through enhanced NF-kappaB activity. (2009)
  • Author(s): Tomita M, Toyota M, Ishikawa C, Nakazato T, Okudaira T, Matsuda T, Uchihara JN, Taira N, Ohshiro K, Senba M, Tanaka Y, Ohshima K, Saya H, Tokino T, Mori N
  • Journal Title: Int J Cancer 124(11) Pages: 2607-2615
  • Peer Reviewed
• [Journal Article] p53 family members regulate the expression of the apolipoprotein D gene. (2009)
  • Author(s): Sasaki, Yasushi, et al
  • Journal Title: J Biological Chemistry VOL.284 Pages: 872-883
  • Peer Reviewed
• [Journal Article] A single recombinant adenovirus expressing p53 and p21-targeting artificial microRNAs efficiently induces apoptosis in human cancer cells. (2009)
  • Author(s): Idogawa, Masashi, et al
  • Journal Title: Clinical Cancer Res VOL.15 Pages: 3725-3732
  • Peer Reviewed
• [Journal Article] CHFR, a potential tumor suppressor, downregulates interleukin-8 via inhibition of NF-kB. (2009)
  • Author(s): Kashima, Lisa, et al
  • Journal Title: Oncogene VOL.28 Pages: 2643-2653
  • Peer Reviewed
• [Journal Article] A novel method, digital genome scanning detects KRAS gene amplification in gastric cancers : involvement of overexpressed wild-type KRAS in downstream signaling and cancer cell growth. (2009)
  • Author(s): Mita, Hiroaki, et al
  • Journal Title: BMC Cancer VOL.9(Online) Pages: 198-198
  • Peer Reviewed
• [Journal Article] A novel biomarker for cervical cancer. (2009)
  • Author(s): Tokino, Takashi
  • Journal Title: Cancer Biology Therapy VOL.8 Pages: 1154-1155
  • Peer Reviewed
• [Journal Article] Genomic Screening for genes silenced by DNA methylation revealed an association between RASD1 inactivation and dexamethasone resistence in multipel myeloma. (2009)
  • Author(s): Nojima, Masanori, et al
  • Journal Title: Clinical Cancer Res VOL.15 Pages: 4356-4364
  • Peer Reviewed
• [Journal Article] Cancer epigenomics : Implications of DNA methylation in personalized cancer therapy. (2009)
  • Author(s): Toyots, Minoru, et al
  • Journal Title: Cancer Science VOL.100 Pages: 787-791
  • Peer Reviewed
• [Journal Article] Overexpression of Aurora A by loss of CHFR gene expression increases the growth and survival of HTLV-1-infected Tcells through enhanced NF-kappaB activity. (2009)
  • Author(s): Tomita, Markiko, et al
  • Journal Title: Int J Cancer VOL.124 Pages: 2607-2615
  • Peer Reviewed
• [Journal Article] p53 family members regulate the expression of the apolipoprotein D gene (2009)
  • Author(s): Sasaki Y, et.al.
  • Journal Title: J Biol Chem 284 Pages: 872-883
  • Peer Reviewed
• [Journal Article] A single recombinant adenovirus expressing p53 and p21-targeting artificial microRNAs efficiently induces apoptosis in human cancer cells (2009)
  • Author(s): Idogawa M, et.al.
  • Journal Title: Clinical Cancer Research (印刷中)
  • Peer Reviewed
• [Journal Article] Cancer epigenomics : Implications of DNA methylation in personalized cancer therapy (2009)
  • Author(s): Toyota M, et.al.
  • Journal Title: Cancer Science (印刷中)
  • Peer Reviewed
• [Journal Article] The histone deacetylase inhibitor FK228 enhances adenovirusmediated p53 family gene therapy in cancer models. (2008)
  • Author(s): Sasaki Y, Negishi H, Idogawa M, Suzuki H, Mita H, Toyota M, Shinomura Y, Imai K, Tokino T
  • Journal Title: M o l e c u l a r C a n c e r T h e r a p e u t i c s 7(4) Pages: 779-787
  • Peer Reviewed
• [Journal Article] Identification of flotillin-2, a major protein on lipid rafts, as a novel target of the p53 family members. (2008)
  • Author(s): Sasaki Y, Oshima Y, Koyama R, Maruyama R, Akashi H, Mita H, Toyota M, Shinomura Y, Imai K, Tokino T
  • Journal Title: M o l e c u l a r C a n c e r R e s 6(3) Pages: 395-406
  • Peer Reviewed
• [Journal Article] DNA hypermethylation causes incomplete systhesis of carbohydrate determinants in gastrointestinal cancer. (2008)
  • Author(s): Kawamura YI, Toyota M, Kawashima R, Hagiwara T, Suzuki H, Imai K, Shinomura Y, Tokino T, Kannagi R, Dohi T
  • Journal Title: G a s t r o e n t e r o l o g y 135(1) Pages: 142-151
  • Peer Reviewed
• [Journal Article] A requirment for DICER to maintain full promoter CpG island hypermethylation in human cancer cells. (2008)
  • Author(s): Ting AH, Suzuki H, Cope L, Schuebel KE, Lee BH, Toyota M, Imai K, Shinomura Y, Tokino T, Baylin SB
  • Journal Title: C a n c e r R e s e a r h 68(8) Pages: 2570-2575
  • Peer Reviewed
• [Journal Article] Epigenetic silencing of microRNA-34b/c and BTG4 is associated with CpG island methylation in colorectal cancer. (2008)
  • Author(s): Toyota M, Suzuki H, Sasaki Y, Maruyama R, Imai K, Shinomura Y, Tokino T
  • Journal Title: C a n c e r R e s e a r c h 68(11) Pages: 4124-4132
  • Peer Reviewed
• [Journal Article] Cytoplasmic RASSF2A is a pro-appoptotic mediator whose expression is epigenetically silenced in gastric cancer. (2008)
  • Author(s): Maruyama R, Akino K, Toyota M, Suzuki H, Imai T, Ohe-Toyota M, Yamamoto E, Nojima M, Fujikane, Sasaki Y, Yamashita T, Watanabe Y, Hiratsuka H, Hirata K, Itoh F, Imai K, Shinomura Y, Tokino T
  • Journal Title: C a r c i n o g e n e s i s 29(7): 29(7) Pages: 1312-1318
  • Peer Reviewed
• [Journal Article] Frequent epigenetic inactivation of Wnt antagonist genes in breast cancer. (2008)
  • Author(s): Suzuki H, Toyota M, Caraway H, Gabrielson E, Ohmura T, Fujikane T, Nishikawa N, Sogabe Y, Nojima M, Sonoda T, Mori M, Hirata K, Imai K, Shinomura Y, Baylin SB, Tokino T
  • Journal Title: B r J C a n c e r 98(6) Pages: 1147-1156
  • Peer Reviewed
• [Journal Article] DNA methylation and cancer pathways in gastrointestinal tumors. (2008)
  • Author(s): Suzuki H, Tokino T, Shinomura Y, Imai K, Toyota M
  • Journal Title: P h a r m a c o g e n o m i c s 9(12) Pages: 1917-1928
  • Peer Reviewed
• [Journal Article] Epigenetic inactivation of RASSF2 in oral squamous cell carcinoma. (2008)
  • Author(s): Imai T, Toyota M, Suzuki H, Akino K, Ogi K, Sogabe Y, Kashima L, Maruyama R, Nojima M, Mita H, Sasaki Y, Itoh F, Imai K, Shinomura Y, Hiratsuka H, Tokino T
  • Journal Title: C a n c e r S c i e n c e 99(5) Pages: 958-966
  • NAID: 10024006089
  • Peer Reviewed
• [Journal Article] Epigenetic inactivation of SFRP genes in oral squamous cell carcinoma. (2008)
  • Author(s): Sogabe Y, Suzuki H, Toyata M, Ogi K, Imai T, Nojima M, Sasaki Y, Hiratsuka H, Tokino T
  • Journal Title: I n t J O n c o l o g y 32(6) Pages: 1253-1261
  • Peer Reviewed
• [Journal Article] LINE-1 hypomethylation is associated with increased CpG island methylation in Helicobactor pylori-related enlarged-fold gastritis. (2008)
  • Author(s): Yamamoto E, Toyota M, Suzuki H, Kondo Y, Sanomura T, Murayama Y, Ohe-Toyota M, Muruyama R, Nojima M, Ashisa M, Fujii K, Sasaki Y, Hayashi N, Mori M, Imai K, Tokino T, Shinomura Y
  • Journal Title: C a n c e r E p i d e m i o l B i o m a r k e r s P r e v 17(10) Pages: 2555-2564
  • Peer Reviewed
• [Journal Article] Frequent epigenetic inactivation of SFRP genes in hepatocellular carcinoma. (2008)
  • Author(s): Takagi H, Sasaki S, Suzuki H, Toyota M, Maruyama R, Nojima M, Yamamoto H, Omata M, Tokino T, Imai K, Shinomura Y
  • Journal Title: J G a s t r o e n t e r o l 43(5) Pages: 378-389
  • NAID: 10021268741
  • Peer Reviewed
• [Journal Article] In vitro transformation of adult rat hepatic progenitor cells into pancreatic endocrine hormone-producing cells. (2008)
  • Author(s): Kawasaki H, Mizuguchi T, Kikkawa Y, Oshima H, Sasaki Y, Tokino T, Kokai Y, Miyazaki J, Katsuramaki T, Mitaka T, Hirata K
  • Journal Title: J H e p a t o b i l i a r y P a n c r e a t S u r g 15(3) Pages: 310-317
  • NAID: 10024157037
  • Peer Reviewed
• [Journal Article] The histone deacetylase inhibitor FK228 enhances adenovirus-mediated p53 family gene therapy in cancer models (2008)
  • Author(s): Sasaki Y, et.al.
  • Journal Title: Molecular Cancer Therapeutics 7 Pages: 779-787
  • Peer Reviewed
• [Journal Article] Identification of flotillin-2, a major protein on lipid rafts, as a novel target of the p53 family members (2008)
  • Author(s): Sasaki Y, et.al.
  • Journal Title: Molecular Cancer Research 6 Pages: 395-406
  • Peer Reviewed
• [Journal Article] Epigenetic silencing of microRNA-34b/c and BTG4 is associated with CpG island methvlation in colorectal cancer (2008)
  • Author(s): Toyota M, et.al.
  • Journal Title: Cancer Resaech 68 Pages: 4124-4132
  • Peer Reviewed
• [Journal Article] A requirment for DICER to maintain full promoter CpG island hypermethylation in human cancer cells (2008)
  • Author(s): Ting AH, et.al.
  • Journal Title: Cancer Research 68 Pages: 2570-2575
  • Peer Reviewed
• [Journal Article] Cytoplasmic RASSF2A is a pro-appoptotic mediator whose expression is enieenetically silenced in gastric cancer (2008)
  • Author(s): Maruyama R, et.al.
  • Journal Title: Carcinogenesis 29 Pages: 1312-1318
  • Peer Reviewed
• [Journal Article] Frequent epigenetic inactivation of Wnt antagonist genes in breast cancer (2008)
  • Author(s): Suzuki H, et.al.
  • Journal Title: British J Cancer 98 Pages: 1147-1156
  • Peer Reviewed
• [Journal Article] DNA methlation and cancer pathways in gastrointestinal tumors (2008)
  • Author(s): Suzuki H, et.al.
  • Journal Title: Pharmacogenomics 9 Pages: 1917-1928
  • Peer Reviewed
• [Journal Article] Epigenetic inactivation of RASSF2 in oral squamous cell carcinoma (2008)
  • Author(s): Imai T, et.al.
  • Journal Title: Cancer Science 99 Pages: 958-966
  • Peer Reviewed
• [Journal Article] Epigenetic inactivation of SFRP genes in oral squamous cell carcinoma (2008)
  • Author(s): Sogabe Y, et.al.
  • Journal Title: Int J Oncology 32 Pages: 1253-1261
  • Peer Reviewed
• [Journal Article] DNA hypermethylation causes incomplete systhesis of carbohydrate determinants in gastrointestinal cancer (2008)
  • Author(s): Kawamura YI, et.al.
  • Journal Title: Gastroenterology 135 Pages: 142-151
  • Peer Reviewed
• [Journal Article] Frequent epigenetic inactivation of SFRP genes in hepatocellular carcinoma (2008)
  • Author(s): Takagi H, et.al.
  • Journal Title: J Gastroenterol 43 Pages: 378-389
  • Peer Reviewed
• [Journal Article] LINE-1 hypomethylation is associated with increased CpG island methylation in Helicobactor pylori-related enlarged-fold gastritis (2008)
  • Author(s): Yamamoto E, et.al.
  • Journal Title: Cancer Epidemiol Biomakers Prey 17 Pages: 2555-2564
  • Peer Reviewed
• [Journal Article] In vitro transformation of adult rat hepatic progenitor cells into pancreatic endocrine hormone-producing cells (2008)
  • Author(s): Kawasaki H, et.al.
  • Journal Title: J Hepatobiliary Pancreat Surg 15 Pages: 310-317
  • Peer Reviewed
• [Journal Article] Prediction of p53 target genes based on integrative analysis of chromatin-immunoprecipitated and sequenced tags, by using Galaxy, aweb-based interactive platform for large-scale genome analysis (2008)
  • Author(s): Mita H, et.al.
  • Journal Title: Tumor Research 43 Pages: 1-23
• [Journal Article] Gene Amplification and Overexpression of PRDM14 in Breast Cancers. (2007)
  • Author(s): Nishikawa N, Toyota M, Suzuki H, Honma T, Fujikane T, Ohmura T, Nishidate T, Ohe-Toyota M, Maruyama R, Sonoda T, Sasaki Y, Urano T, Imai K, Hirata K, Tokino T
  • Journal Title: C a n c e r R e s e a r c h 67(20) Pages: 9649-9657
  • Peer Reviewed
• [Journal Article] Antitumor effect of adenovirusmediated p53 family gene transfer on osteosarcoma cell lines. (2007)
  • Author(s): Oshima Y, Sasaki Y, Negishi H, Toyota M, Yamashita T, Wada T, Nagoya S, Kawaguchi S, Yamashita T, Tokino T
  • Journal Title: C a n c e r B i o l o g y T h e r a p y 6(7) Pages: 1058-1066
  • Peer Reviewed
• [Journal Article] Expression profiling of PRDM family genes identified PRDM5 as a target of epigenetic silencing in colorectal and gastric cancer. (2007)
  • Author(s): Watanabe Y, Toyota M, Kondo Y, Suzuki H, Imai T, Ohe-Toyota M, Maruyama R, Nojima M, Sasaki Y, Sekido Y, Hiratsuka H, Shinomura Y, Imai K, Tokino T
  • Journal Title: C l i n i c a l C a n c e r R e s 13(16) Pages: 4786-4794
  • Peer Reviewed
• [Journal Article] Ku70 and poly(ADP-ribose) polymerase-1 competitively regulate betacatenine and T-cell factor-4-mediated gene transactivation: possible linkage of DNA damage recognition and Wnt signaling. (2007)
  • Author(s): Idogawa M, Masutani M, Shitashige M, Honda K, Tokino T, Shinomura, Imai K, Hirohashi S, Yamada T
  • Journal Title: C a n c e r R e s e a r c h 67(3) Pages: 911-918
  • Peer Reviewed
• [Journal Article] Identification of DFNA5 as a target of epigenetic inactivation in gastric cancer. (2007)
  • Author(s): Akino K, Toyota M, Suzuki H, Imai T, Maruyama R, Kusano M, Nishikawa N, Watanabe Y, Sasaki Y, Abe T, Yamamoto E, Tarasawa I, Sonoda T, Mori M, Imai K, Shinomura Y, Tokino T
  • Journal Title: C a n c e r S c i e n c e 98(1) Pages: 88-95
  • Peer Reviewed
• [Journal Article] Frequent epigenetic inactivation of SFRP genes and constitutive activation of Wnt signaling in gastric cancer. (2007)
  • Author(s): Nojima M, Suzuki H, Toyota M, Watanabe Y, Maruyama R, Sasaki S, Sasaki Y, Mita H, Nishikawa N, Yamaguchi K, Hirata K, Itoh F, Tokino T, Mori M, Imai K, Shinomura Y
  • Journal Title: O n c o g e n e 26(32) Pages: 4699-4713
  • Peer Reviewed
• [Journal Article] Frequent epigenetic inactivation of DICKKOPF family genes in human gastrointestinal tumors. (2007)
  • Author(s): Sato H, Suzuki H, Toyota M, Nojima M, Maruyama R, Sasaki S, Takagi H, Sogabe Y, Sasaki Y, Idogawa M, Sonoda T, Mori M, Imai K, Tokino T, Shinomura Y
  • Journal Title: C a r c i n o - g e n e s i s 28(12) Pages: 2459-2466
  • Peer Reviewed
• [Journal Article] Identification of DFNA5 as a target of epigenetic inactivation in gastric cancer. (2007)
  • Author(s): K.Akino
  • Journal Title: Cancer Science 98・1 Pages: 88-95
• [Journal Article] Frequent epigenetic inactivation of SFRP genes and constitutive activation of Wnt signaling in gastric cancer. (2007)
  • Author(s): M.Nojima
  • Journal Title: Oncogene (印刷中)
• [Journal Article] Ku70 and poly(ADP-ribose) polymerase-1 competitively regulate beta-catenine and T -cell factor-4-mediated gene transactivation : possible linkage of DNA damage recognition and Wnt signaling. (2007)
  • Author(s): M.Idogawa
  • Journal Title: Cancer Research 67・3 Pages: 911-918
• [Journal Article] Comparative genome analysis identifies the vitamin D receptor gene as a direct target of p53-mediated transcriptional activation. (2006)
  • Author(s): Maruyama R, Aoki F, Toyota M, Sasaki Y, Akashi H, Mita H, Suzuki H, Akino K, Ohe-Toyota M, Maruyama Y, Tatsumi H, Imai K, Shinomura Y, Tokino T
  • Journal Title: C a n c e r R e s e a r c h 66(9) Pages: 4574-83
  • Peer Reviewed
• [Journal Article] Genetic, epigenetic and clinicopathological features of gastric cancers with CpG island methylator phenotype and association to Epstein-Barr virus. (2006)
  • Author(s): Kusano M, Toyota M, Suzuki H, Akino K, Aoki F, Fujita M, Hosokawa M, Shinomura Y, Imai K, Tokino T
  • Journal Title: C a n c e r 106(7) Pages: 1467-1479
  • Peer Reviewed
• [Journal Article] Implications for gene therapy treatment of human glioblastomas. (2006)
  • Author(s): Kang X, Xiao X, Harata M, Bai Y, Nakazaki Y, Soda Y, Kurita R, Tanaka T, Komine F, Izawa K, Kunisaki R, Setoyama M, Nishimori H, Natsume A, Sunamura M, Lozonshi L, Saitoh I, Tokino T, Asano S, Nakamura Y, Tani K: Antiangiogenic potency of BAI1 in vivo
  • Journal Title: C a n c e r G e n e T h e r a p y 13(4) Pages: 385-392
  • Peer Reviewed
• [Journal Article] Epigenetic inactivation of the candidate tumor suppressor gene HOXB13 in human renal cell carcinama. (2006)
  • Author(s): Okuda H, Toyota M, Ishida W, Furihata M, Tsuchiya M, Kamada M, Tokino T, Shuinn T
  • Journal Title: O n c o g e n e 25(12) Pages: 1733-1742
  • Peer Reviewed
• [Journal Article] Unique domain functions of p63 isotypes that differentially regulate distinct aspects of epidermal homeostasis (2006)
  • Author(s): King KE, Ponnamperuma RM, Gerdes MJ, Tokino T, Yamashita T, Baker CC, Weinberg WC
  • Journal Title: C a r c i n o g e n e s i s 27(1) Pages: 53-63
  • Peer Reviewed
• [Journal Article] Epigenetic inactivation of TCF2 in ovarian cancer and various cancer cell lines. (2006)
  • Author(s): Terasawa K, Toyota M, Sagae S, Ogi K, Suzuki H, Sonoda T, Akino K, Maruyama R, Nishikawa N, Imai K, Shinohara Y, Saito T, Tokino T
  • Journal Title: B r J C a n c e r 94(6) Pages: 914-921
  • Peer Reviewed
• [Journal Article] Activation of the ribosomal protein L13 gene in human gastrointestinal cancer. (2006)
  • Author(s): Kobayashi T, Sasaki Y, Oshima Y, Yamamoto H, Mita H, Suzuki H, Toyota Y, Tokino T, Itoh F, Imai K, Shinomura Y
  • Journal Title: I n t J M o l M e d 18(1) Pages: 161-170
  • Peer Reviewed
• [Journal Article] Comparative genome analysis identifies the vitamin D receptor gene as a direct target of p53-mediated transcriptional activation. (2006)
  • Author(s): R.Maruyama
  • Journal Title: Cancer Research 66・9 Pages: 4574-4583
• [Journal Article] Genetic, epigenetic and clinicopathological features of gastric cancers with CpG island methylator phenotype and association to Epstein-Barr virus. (2006)
  • Author(s): M.Kusano
  • Journal Title: Cancer 106・7 Pages: 1467-1479
• [Journal Article] Epigenetic inactivation of TCF2 in ovarian cancer and various cancer cell lines (2006)
  • Author(s): K.Terasawa
  • Journal Title: British J Cancer 94・6 Pages: 914-921
• [Journal Article] Epigenetic inactivation of the candidate tumor suppressor gene HOXB 13 in human renal cell carcinama. (2006)
  • Author(s): H.Okuda
  • Journal Title: Oncogene 25・12 Pages: 1733-1742
• [Journal Article] Activation of the ribosomal protein L13 gene in human gastrointestinal cancer. (2006)
  • Author(s): T.Kobayashi
  • Journal Title: Int J Molecular Medicine 18・1 Pages: 161-170
• [Journal Article] Antiangiogenic potency of BAI1 in vivo : Implications for gene therapy treatment of human glioblastomas. (2006)
  • Author(s): X.Kang
  • Journal Title: Cancer Gene Therapy 13・4 Pages: 385-392
• [Journal Article] Unique domain functions of p63 isotypes that differentially regulate distinct aspects of epidermal homeostasis. (2006)
  • Author(s): K.E.King
  • Journal Title: Carcinogenesis 27・1 Pages: 53-63
• [Journal Article] Comparative genome analysis identifies the vitamin D receptor gene as a direct target of p53-mediated transcriptional activation. (2006)
  • Author(s): Maruyama R et al.
  • Journal Title: Cancer Research (印刷中)
• [Journal Article] Epigenetic inactivation of the candidate tumor suppressor gene HOXB13 in human renal cell carcinoma. (2006)
  • Author(s): Okuda H et al.
  • Journal Title: Oncogene 25・12 Pages: 1733-1742
• [Journal Article] Genetic, epigenetic an clinicopathological features of gastric cancers with CpG island methylator phenotype and association to Epstein-Barr virus. (2006)
  • Author(s): Kusano M et al.
  • Journal Title: Cancer (印刷中)
• [Journal Article] Unique domain functions of p63 isotypes that differentially regulate distinct aspects of epidermal homeostasis. (2006)
  • Author(s): King KE et al.
  • Journal Title: Carcinogenesis (印刷中)
• [Journal Article] Epigenetic inactivation of TCF2in ovarian cancer and various cancer cell lines. (2006)
  • Author(s): Terasawa K et al.
  • Journal Title: British J Cancer (印刷中)
• [Journal Article] Antiangiogenic potency of BAI1 in vivo : Implications for gene therapy treatment of human glioblastomas. (2006)
  • Author(s): Kang X et al.
  • Journal Title: Cancer Gene Therapy (印刷中)
• [Journal Article] Identification of pigment epithelium derived factor as a direct target of the p53 family member genes. (2005)
  • Author(s): Sasaki Y, Naishiro Y, Oshima Y, Imai K, Nakamura Y, Tokino T
  • Journal Title: O n c o g e n e 24(32) Pages: 5131-5136
  • Peer Reviewed
• [Journal Article] The Ras effector RASSF2 is a novel tumor suppressor gene in human colorectal cancer. (2005)
  • Author(s): Akino K, Toyota M, Suzuki H, Mita H, Sasaki Y, Ohe-Toyota M, Issa J-P J, Hinoda Y, Imai K, Tokino T
  • Journal Title: G a s t r o e n t e r o l o g y 129(1) Pages: 156-169
  • Peer Reviewed
• [Journal Article] Identification of laminin b3 isoforms downstream of EWS-ETS fusion genes in Ewing family tumors. (2005)
  • Author(s): Irifune H, Nishimori H, Watanabe G, Yoshida K, Ikeda T, Matsui C, Morohashi M, Kawaguchi S, Nagoya S, Wada T, Yamashita T, Nakamura Y, Tokino T
  • Journal Title: C a n c e r B i o l o g y T h e r a p y 4(4) Pages: 449-455
  • Peer Reviewed
• [Journal Article] Small interfering RNA-induced CHFR silencing sensitizes oral squamous cell cancer cells to microtuble inhibitors. (2005)
  • Author(s): Ogi K, Toyota M, Mita H, Satoh A, Kashima L, Sasaki Y, Suzuki H, Akino K, Nishikawa N, Shinomura Y, Imai K, Hiratsuka H, Tokino T
  • Journal Title: C a n c e r B i o l o g y T h e r a p y 4(7) Pages: 773-780
  • Peer Reviewed
• [Journal Article] Id2 protein is selectively upregulated by UVB in primary, but not in immortalized human keratinocytes and inhibits differentiation. (2005)
  • Author(s): Simbulan-Rosethal CM, Trabosh V, Velarde A, Chou FP, Daher A, Tenzin F, Tokino T, Rosenthal DS
  • Journal Title: O n c o g e n e 24(35) Pages: 5443-5458
  • Peer Reviewed
• [Journal Article] Upregulation of BNIP3 by 5-aza-2 ' -deoxycytidine sensitizes pancreatic cancer cells to hypoxia-mediated cell death. (2005)
  • Author(s): Abe T, Toyota M, Suzuki H, Murai M, Akino K, Ueno M, Nojima M, Yawata A, Miyakawa H, Suga T, Ito H, Endo T, Tokino T, Hinoda Y, Imai K
  • Journal Title: J G a s t r o e n t e r o l 40(5) Pages: 504-510
  • NAID: 10015648191
  • Peer Reviewed
• [Journal Article] Aberrant DNA methylation associated with silencing BNIP3 gene expression in haematopoietic tumours. (2005)
  • Author(s): Murai M, Toyota M, Satoh A, Suzuki H, Akino K, Mita H, Sasaki Y, Ishida T, Shen L, Garcia-Manero G, Issa JP, Hinoda Y, Tokino T, Imai K
  • Journal Title: B r J C a n c e r 92(6) Pages: 1165-1172
  • Peer Reviewed
• [Journal Article] Abnormal beta-catenin expression in oral cancer with no gene mutation: correlation with expression of cyclin D1 and epidermal growth factor receptor, Ki-67 labeling index, and clinicopathological features. (2005)
  • Author(s): Odajima T, Sasaki Y, Tanaka N, Kato-Mori Y, Asanuma H, Ikeda T, Satoh M, Hiratsuka H, Tokino T, Sawada N
  • Journal Title: H u m P a t h o l 36(3) Pages: 234-241
  • Peer Reviewed
• [Journal Article] The role of T-fimbrin in the response to DNA damage: Silencing of T-fimbrin by small interfering RNA sensitizes human liver cancer cells to DNA-damaging agents. (2005)
  • Author(s): Ikeda H, Sasaki Y, Kobayashi T, Suzuki H, Mita H, Toyota M, Itoh F, Shinomura Y, Tokino T, Imai K
  • Journal Title: I n t J O n c o l 27(4) Pages: 933-40
  • Peer Reviewed
• [Journal Article] Aberrant methylation and silencing of the BNIP3 gene in colorectal and gastric cancer. (2005)
  • Author(s): Murai M, Toyota M, Suzuki H, Satoh A, Sasaki Y, Akino K, Ueno M, Takahashi F, Kusano M, Mita H, Yanagihara K, Endo T, Hinoda Y, Tokino T, Imai K
  • Journal Title: C l i n i c a l C a n c e r R e s 11(3) Pages: 1021-1027
  • Peer Reviewed
• [Journal Article] Enhanced Bax in oral SCC in relation to antitumor effects of chemotherapy. (2005)
  • Author(s): Takemura K, Noguchi M, Ogi K, Tokino T, Kubota H, Miyazaki A, Kohama G, Horatsuka H
  • Journal Title: J O r a l P a t h o l M e d 34(2) Pages: 93-99
  • Peer Reviewed
• [Journal Article] Tight junction proteinMAGi-1 is up-regulated by tranfection with connexin 32 in an immortalized mouse hepatic cell line: cDNA microarray analysis. (2005)
  • Author(s): Murata M, Kojima T, Yamamoto T, Go M, Takano K, Chiba H, Tokino T, Sawada N
  • Journal Title: C e l l T i s s u e R e s 319(2) Pages: 341-347
  • Peer Reviewed
• [Journal Article] A full genome scan for gastric cancer. (2005)
  • Author(s): AokiM,YamamuraY,NoshiroH,SakaiK,YokotaJ,KohnoT,TokinoT,IshidaS,OhyamaS,NinomiyaI,UesakaK,KitajimaM,ShimadaS,MatsunoS,YanoM,HiratsukaM,SugimuraH,ItohF,MinamotoT,MaeharaY,TakenoshitaS,AikouT,KataiH,Yoshimura K, TakahashiT,AkagiK,SairenjiM,YamamotoK,SasazukiT
  • Journal Title: J M e d i c a l G e n e t i c s 42(1) Pages: 83-87
  • Peer Reviewed
• [Journal Article] Identification of pigment epithelium derived actor as a direct target of the p53 family member genes. (2005)
  • Author(s): Sasaki Y et al.
  • Journal Title: Oncogene 24・32 Pages: 5131-5136
• [Journal Article] The Ras effector RASSF2 is a novel tumor suppressor gene in human colorectal cancer. (2005)
  • Author(s): Akino K et al.
  • Journal Title: Gastroenterology 129・1 Pages: 156-169
• [Journal Article] A full genome scan for gastric cancer. (2005)
  • Author(s): Aoki M et al.
  • Journal Title: J Medical Genetics 42・1 Pages: 83-87
• [Journal Article] Aberrant methylation and silencing of the BNIP3 gene in colorectal and gastric cancer. (2005)
  • Author(s): Murai M et al.
  • Journal Title: Clinical Cancer Research 11・3 Pages: 1021-1027
• [Journal Article] Id2 protein is selectively upregulated by UVB in primary, but not in immortalized human keratinocytes and inhibits differentiation. (2005)
  • Author(s): Simbulan-Rosenthal CM et al.
  • Journal Title: Oncogene 24・35 Pages: 5443-5458
• [Journal Article] Aberrant DNA methylation associated with silencing BNIP3 gene expression in haematopoietic tumours. (2005)
  • Author(s): Murai M et al.
  • Journal Title: British J Cancer 92・6 Pages: 1165-1172
• [Journal Article] Small interfering RNA-induced CHFR silencing sensitizes oral aquamous cell cancer cells to microtuble inhibitors. (2005)
  • Author(s): Ogi K et al.
  • Journal Title: Cancer Biology Therapy 4・7 Pages: 773-780
• [Journal Article] Aberrant laminin beta3 isoforms downstream of EWS-ETS fusion genes in Ewing family tumors. (2005)
  • Author(s): Irifune H et al.
  • Journal Title: Cancer Biology Therapy 4・4 Pages: 449-455
• [Journal Article] The role of T-fimbrin in the response to DNA damage : Silencing of T-fimbrin by small interfering RNA sensitizes human liver cancer cells to DNA-damaging agents. (2005)
  • Author(s): Ikeda H et al.
  • Journal Title: Int J Oncology 27・4 Pages: 933-940
• [Journal Article] Abnormal beta-catenin expression of cyclin D1 and epidermal growth factor receptor, Ki-67 labeling index, and clinicopathological features. (2005)
  • Author(s): Odajima T et al.
  • Journal Title: Human Pathology 36・3 Pages: 234-241
• [Journal Article] Tight junction protein MAGI-1 is up-regulated by transfection with connexin 32 in an immortalized mouse hepatic cell line : cDNA micrroarray analysis. (2005)
  • Author(s): Murata M et al.
  • Journal Title: Cell Tissue Research 319・2 Pages: 341-347
• [Journal Article] Upregulation of BNIP3 by 5-aza-2' -deoxycytidine sensitizes pancreatic cancer cells to hypoxia-mediated cell death. (2005)
  • Author(s): Abe T et al.
  • Journal Title: J Gastroenterology 40・5 Pages: 504-510
• [Journal Article] Genomic screening for genes upregulated by demethylation revealed novel targets of epigenetic silencing in breast cancer.
  • Author(s): Fujikane T, Nishikawa N, Toyota M, Suzuki H, Nojima M, Maruyama R, Ashida M, Ohe-Toyota M, Kai M, Nishidate T, Sasaki Y, Ohmura T, Hirata K, Tokino T
  • Journal Title: Breast Cancer Res Treat (in press)
  • Peer Reviewed
• [Presentation] CHFR, a potential tumor suppressor, downregulates interleukin-8 via inhibition of NF-kB. (2010)
  • Author(s): Tokino T, Kashima L, Toyota M, Sasaki Y.
  • Organizer: 101th American Association of Cancer Research (AACR) Annual Meeting
  • Place of Presentation: Washington DC, USA.
  • Year and Date: 2010-04-20
• [Presentation] A single adenovirus expressing p53 protein and p21-targeting artificial microRNAs improves therapeutic outcome in cancer. (2010)
  • Author(s): Tokino T, Idogawa M, Sasaki Y.
  • Organizer: 8th Joint Conference of the American Association for Cancer Research and the Japanese Cancer Association.
  • Place of Presentation: Hawaii, USA.
  • Year and Date: 2010-02-09
• [Presentation] A single adenovirus expressing p53 protein and p21-targeting artificial microRNAs improves therapeutic outcome in cancer. (2010)
  • Author(s): Tokino, Takashi
  • Organizer: 8th Joint Conference of AACR and JCA
  • Place of Presentation: Hilton Waikoloa Village(米国)
  • Year and Date: 2010-02-09
• [Presentation] CHFR, a potential tumor suppressor, downregulates interleukin-8 via inhibition of NF-kB. (2010)
  • Author(s): Kashima, Lisa, et al
  • Organizer: 8th Joint Conference of AACR and JCA
  • Place of Presentation: Hilton Waikoloa Village(米国)
  • Year and Date: 2010-02-08
• [Presentation] hCLCA2, a p53 inducible transmembrane protein,, regulates cancer cell migration and adhesion. (2010)
  • Author(s): Sasaki, Yasushi, et al
  • Organizer: 8th Joint Conference of AACR and JCA
  • Place of Presentation: Hilton Waikoloa Village(米国)
  • Year and Date: 2010-02-07
• [Presentation] Identification and characterization of carly growth response gene-2 as a p53-regulated proapoptotic gene. (2010)
  • Author(s): Yokota, Ikuko, et al
  • Organizer: 8th Joint Conference of AACR and JCA
  • Place of Presentation: Hilton Waikoloa Village(米国)
  • Year and Date: 2010-02-07
• [Presentation] p53 family members regulate the expression of the apolipoprotein D gene. (2009)
  • Author(s): Sasaki, Yasushi, et al
  • Organizer: 米国癌学会年会
  • Place of Presentation: Colorado Convention Center(米国)
  • Year and Date: 2009-04-21
• [Presentation] A single recombinant adenovirus expressing p53 and p21-targeting artificial microRNAs efficiently induces apoptosis in human cancer cells. (2009)
  • Author(s): Idogawa Masashi, et al
  • Organizer: 米国癌学会年会
  • Place of Presentation: Colorado Convention Center(米国)
  • Year and Date: 2009-04-21
• [Presentation] Antitumor effect of adenovirus-mediated p53 family gene transfer on osteosarcoma cell lines (2008)
  • Author(s): 時野隆至
  • Organizer: 米国癌学会年会
  • Place of Presentation: 米国ロサンゼルス
  • Year and Date: 2008-04-17
• [Presentation] Identification of flotillin-2, a major protein on lipid rafts, as a novel target of the p53 family members. (2008)
  • Author(s): Tokino T, Sasaki Y.
  • Organizer: 99th American Association of Cancer Research (AACR) Annual Meeting.
  • Place of Presentation: San Diego, USA.
  • Year and Date: 2008-04-14
• [Presentation] Antitumor effect of adenovirus-mediated p53 family gene transfer on osteosarcoma cell lines. (2007)
  • Author(s): Tokino T, Oshima Y, Yamashita T, Sasaki Y.
  • Organizer: 98th American Association of Cancer Research (AACR) Annual Meeting.
  • Place of Presentation: Los Angeles, USA.
  • Year and Date: 2007-04-17
• [Presentation] Pigment epithelium derived factor as a direct target of the p53 family member genes. (2006)
  • Author(s): Tokino T, Sasaki Y.
  • Organizer: 97th American Association of Cancer Research (AACR) Annual Meeting.
  • Place of Presentation: Washington DC, USA.
  • Year and Date: 2006-04-03
• [Presentation] Identification of laminin beta 3 isoforms downstream of EWS-ETS fusion genes in Ewing family tumor. (2005)
  • Author(s): Tokino T, Irifune H, Sasaki Y, Yoshida K, Kawaguchi S, Wada T, Yamashita T.
  • Organizer: 96th American Association of Cancer Research (AACR) Annual Meeting.
  • Place of Presentation: Anaheim, USA.
  • Year and Date: 2005-04-19
• [Remarks]
  • URL: http://web.sapmed.ac.jp/canmol/
• [Remarks]
  • URL: http://web.sapmed.ac.jp/canmol/index.html