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The study of multistep carcinogenesis using unique animal models

Research Project

Project/Area Number 17013076
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionJuntendo University

Principal Investigator

HINO Okio  Juntendo University, 医学部, 教授 (90127910)

Co-Investigator(Kenkyū-buntansha) KOBAYASHI Toshiyuki  順天堂大学, 医学部, 准教授 (40260070)
KAJINO Kazunori  順天堂大学, 医学部, 助教 (80260066)
MOMOSE Shuji  順天堂大学, 医学部, 准教授 (70360344)
Project Period (FY) 2005 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥48,500,000 (Direct Cost: ¥48,500,000)
Fiscal Year 2009: ¥9,700,000 (Direct Cost: ¥9,700,000)
Fiscal Year 2008: ¥9,700,000 (Direct Cost: ¥9,700,000)
Fiscal Year 2007: ¥9,700,000 (Direct Cost: ¥9,700,000)
Fiscal Year 2006: ¥9,700,000 (Direct Cost: ¥9,700,000)
Fiscal Year 2005: ¥9,700,000 (Direct Cost: ¥9,700,000)
Keywords遺伝性がん / 癌化遺伝子 / 多段階発がん / 分子標的治療 / Niban遺伝子 / TSC遺伝子 / Bhd遺伝子 / ERC遺伝子 / 遺伝子発現
Research Abstract

We investigated the unique animal models for the study of problems in carcinogenesis; eg., multistep carcinogenesis, cancer prevention and the development of the therapeutic treatments which can be translated into human patients. We discovered the ERC gene in Eker rat model (Tsc2 gene mutant). We developed a novel ELISA system for human asbestos-related mesothelioma. We have started a large-scale prospective study on building construction workers using our ELISA system.

Report

(6 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (76 results)

All 2010 2009 2008 2007 2006 2005 Other

All Journal Article (72 results) (of which Peer Reviewed: 22 results) Book (3 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Serine 62 is phosphorylation site in folliculin, the Birt-Hogg-Dube gene product.2010

    • Author(s)
      Wang L., Kobayashi T., Piao X., Shiono M., Takagi Y., Mineki R., Taka H., Zhang D., Abe M., Son G., Hagiwara Y., Okimoto K., Matsumoto I., Kouchi M., Hino O.
    • Journal Title

      FEBS Letters 584

      Pages: 39-43

    • Related Report
      2009 Final Research Report
  • [Journal Article] Frequent expression of Niban in head and neck squamous cell carcinoma and squamous dysplasia.2010

    • Author(s)
      Ito S., Fujii H., Matsumoto T., Abe M., Ikeda K., Hino O.
    • Journal Title

      Head Neck 32

      Pages: 96-103

    • Related Report
      2009 Final Research Report
  • [Journal Article] Phosphorylated hamartin-Hsp70 complex regulates apoptosis via mitochondrial localization.2010

    • Author(s)
      Inoue H., Uyama T., Suzuki T., Kazami M., Hino O., Kobayashi T., Kobayashi K., Tadokoro T.
    • Journal Title

      Biochem. Biophys. Res. Commun. 391

      Pages: 1148-1153

    • Related Report
      2009 Final Research Report
  • [Journal Article] Age dependence of radiation-induced renal cell carcinomas in an Eker rat model.2010

    • Author(s)
      Kokubo T., Kakinuma S., Kobayashi T., Watanabe F., Iritani R., Tateno K., Nishimura M., Nishikawa T., Hino O., Shimada Y.
    • Journal Title

      Cancer Sci. 101

      Pages: 616-623

    • NAID

      10026589138

    • Related Report
      2009 Final Research Report
  • [Journal Article] Antitumor activity of anti-C-ERC/mesothelin monoclonal antibody in vivo.2010

    • Author(s)
      Inami K., Abe M., Takeda K., Hagiwara Y., Maeda M., Segawa T., Suyama M., Watanabe S., Hino O.
    • Journal Title

      Cancer Sci. 101

      Pages: 969-974

    • NAID

      10026591120

    • Related Report
      2009 Final Research Report
  • [Journal Article] Serine 62 is phosphorylation site in folliculin, the Birt-Hogg-Dube gene product.2010

    • Author(s)
      Wang L., et al.
    • Journal Title

      FEBS Letters 584

      Pages: 39-43

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phosphorylated hamartin-Hsp70 complex regulates apoptosis via mitochondrial localization.2010

    • Author(s)
      Inoue H., et al.
    • Journal Title

      Biochem.Biophys.Res.Commun. 391

      Pages: 1148-1153

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Age dependence of radiation-induced renal cell carcinomas in an Eker rat model.2010

    • Author(s)
      Kokubo T., et al.
    • Journal Title

      Cancer Science 101

      Pages: 616-623

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical and genetic spectrum of Birt-Hogg-Dube syndrome patients in whom pneumothorax and/or multiple lung cysts are the presenting feature.2010

    • Author(s)
      Kunogi M., et al.
    • Journal Title

      J.Med.Genetics (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Establishment of novel monoclonal antibody to human ERC/mesothelin useful for study and diagnosis of ERC/mesothelin-expressing cancers.2009

    • Author(s)
      Ishikawa K., Segawa T., Hagiwara Y., Maeda M., Abe M., Hino O.
    • Journal Title

      Pathol. Int. 59

      Pages: 161-166

    • Related Report
      2009 Final Research Report
  • [Journal Article] Regulation of folliculin (the BHD gene product) phosphorylation by Tsc2-mTOR pathway.2009

    • Author(s)
      Piao X., Kobayashi T., Wang L., Shiono M., Takagi Y., Sun G., Abe M., Hagiwara Y., Zhang D., Okimoto K., Kouchi M., Matsumoto I., Hino O.
    • Journal Title

      Biochem. Biophys. Res. Commun. 389

      Pages: 16-21

    • Related Report
      2009 Final Research Report
  • [Journal Article] Establishment and chracterization of renal carcinoma cell lines from a Bhd gene mutant (Nihon) rat.2009

    • Author(s)
      Matsumoto I., Kouchi M., Okimoto K., Kijima K., Ueda T., Hirayama Y., Inoue T., Hino O.
    • Journal Title

      Tumor Biology 30

      Pages: 249-256

    • Related Report
      2009 Final Research Report
  • [Journal Article] An animal model of precilinical diagnosis of pancreatic ductal carcinomas.2009

    • Author(s)
      Fukamachi K., Tanaka H., Hagiwara Y., Ohara H., Joh T., Iigo M., Alexander D.B., Xu J., Long N., Takigahira M., Yonagihara K., Hino O., Saito I.
    • Journal Title

      Biochem. Biophys. Res. Commun. 390

      Pages: 636-641

    • Related Report
      2009 Final Research Report
  • [Journal Article] Regulation of folliculin (the BHD gene product) phosphorylation by Tsc2-mTOR pathway.2009

    • Author(s)
      Piao X., et al.
    • Journal Title

      Biochem.Biophys.Res.Commun. 389

      Pages: 16-21

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Establishment and chracterization of renal carcinoma cell lines from a Bhd gene mutant (Nihon) rat.2009

    • Author(s)
      Matsumoto I., et al.
    • Journal Title

      Tumor Biology 30

      Pages: 249-256

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tuberous sclerosis complex 2 loss-of-function mutation regulates reactive oxygen species production through Racl activation.2008

    • Author(s)
      Suzuki T., Das S.K., Inoue H., Kazami M., Hino O., Kobayashi T., Yeung R.S., Kobayashi K., Tadokoro T., Yamamoto Y.
    • Journal Title

      Biochem. Biophys. Res. Commun 368

      Pages: 132-137

    • Related Report
      2009 Final Research Report
  • [Journal Article] Sensitive and specific new enzyme-linked immunosorbent assay for N-ERC/mesothelin increases its potential as a useful serum tumor marker for mesothelioma.2008

    • Author(s)
      Shiomi K., Hagiwara Y., Sonoue K., Segawa T., Miyashita K., Maeda M., Izumi H., Masuda K., Hirabayashi M., Moroboshi T., Yoshiyama T., Ishida A., Natori Y., Inoue A., Kobayashi M., Sakao Y., Miyamoto H., Takahashi K., Hino O.
    • Journal Title

      Clinical Cancer Res. 14

      Pages: 1431-1437

    • Related Report
      2009 Final Research Report
  • [Journal Article] Mesomark kit detects C-ERC/mesothelin, but not SMRP with C-terminus.2008

    • Author(s)
      Segawa T., Hagiwara Y., Ishikawa K., Aoki N., Maeda M., Shiomi K., Hino O.
    • Journal Title

      BBRC 369

      Pages: 915-918

    • Related Report
      2009 Final Research Report
  • [Journal Article] Diagnostic tumor marker of asbestos-related messoth.2008

    • Author(s)
      Hino O., Maeda, M.
    • Journal Title

      Environmental Health and Preventive Medicine 13

      Pages: 71-74

    • Related Report
      2009 Final Research Report
  • [Journal Article] siRNA-mediated Erc gene silencing suppresses tumor growth in Tsc2 mutant renal carcinoma model.2008

    • Author(s)
      Imamura O., Okada H., Takashima Y., Zhang D., Kobayashi T., Hino O.
    • Journal Title

      Cancer Letters 268

      Pages: 278-285

    • Related Report
      2009 Final Research Report
  • [Journal Article] Interaction of folliculin (Birt-Hogg-Dube gene product) with a novel Fnipl-like (FnipL/Fnip2) protein.2008

    • Author(s)
      Takagi Y., Kobayashi, T., Shiono M., Wang L., Piao X., Sun G., Zhang D., Abe M., Hagiwara Y., Takahashi K., Hino O.
    • Journal Title

      Oncogene 27

      Pages: 5339-5347

    • Related Report
      2009 Final Research Report
  • [Journal Article] Secretion of N-ERC/mesothelin and expression of C-ERC/mesothelin in human pancreatic ductal carcinoma.2008

    • Author(s)
      Inami K., Kajino K., Abe M., Hgiwara Y., Maeda M., Suyama M., Watanabe S., Hino O.
    • Journal Title

      Oncology Reports 20

      Pages: 1375-1380

    • Related Report
      2009 Final Research Report
  • [Journal Article] Establishment of a Novel Specific ELISA system for rat N- and C-ERC/Mesothelin. -Rat ERC/Mesothelin in the body fluids of mice bearing mesothelioma-.2008

    • Author(s)
      Hagiwara Y., Hamada Y., Kuwahara M., Maeda M., Segawa T., Ishikawa K., Hino O.
    • Journal Title

      Cancer Sci. 99

      Pages: 666-670

    • NAID

      10024004555

    • Related Report
      2009 Final Research Report
  • [Journal Article] Biphasic response of pancreatic β cell mass to ablation of TSC2 mice.2008

    • Author(s)
      Shigeyama Y., Kobayashi T., Kido Y., Hashimoto N., Asahara S., Matsuda T., Takeda A., Inoue T., Shibutani Y., Koyanagi M., Uchida T., Inoue M., Hino O., Kasuga M., Noda T.
    • Journal Title

      Mol. Cell. Biology 28

      Pages: 2971-2979

    • Related Report
      2009 Final Research Report
  • [Journal Article] The G1556S-type tuberin variant suppresses tumor formation in tuberous sclerosis 2 mutant (Eker) rats despite its deficiency in mTOR inhibition.2008

    • Author(s)
      Shiono M., Kobayashi T., Takahashi R., Sun G., Abe M., Zhang D., Wang L., Piao X., Takagi Y., Mineki R., Taka H., Tada N., Sonobe S., Momose S., Ueda M., Hino O.
    • Journal Title

      Oncogene 27

      Pages: 6690-6697

    • Related Report
      2009 Final Research Report
  • [Journal Article] ERC/mesothelin as a marker for chemotherapeutic response in patients with mesothelioma.2008

    • Author(s)
      Tajima K., Hirama M., Shiomi K, Ishiwata T., Yoshioka M., Iwase A., Iwakami S., Yamazaki M., Toba M., Tobino K., Sugano K., Ichikawa M., Hagiwara Y., Takahashi K., Hino O.
    • Journal Title

      Anticancer Research 28

      Pages: 3933-3936

    • Related Report
      2009 Final Research Report
  • [Journal Article] Sensitive and specific new enzyme-linked immunosorbent assay for N-ERC/mesothelin increases its potential ans a useful serum tumor marker for mesothelioma2008

    • Author(s)
      Shiomi K., et.al.
    • Journal Title

      Clinical Cancer Res 14

      Pages: 1431-1437

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interaction of folliculin (Birt-Hogg-Dube gene product) with a novel Fnipl-like (FnipL/Fnip2) protein2008

    • Author(s)
      Takagi Y., et.al.
    • Journal Title

      Oncogene 27

      Pages: 5339-5347

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The G1556S-type tuberin variant suppresses tumor formation in tuberous sclerosis 2 mutant (Eker) rats despite its deficiency in mTOR inhibition2008

    • Author(s)
      Shiono M., et.al.
    • Journal Title

      Oncogene 27

      Pages: 6690-6697

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tuberous sclerosis complex 2 loss-of-function mutation regulates reactive oxygen species production through Racl actlvatlon.2008

    • Author(s)
      Suzuki, T., et. al.
    • Journal Title

      BBRC 368

      Pages: 132-137

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sensitive and specific new enzyme-linked immunosorbent assay for N-ERC/mesothelin increases its potential as a useful serum tumor marker for mesothelioma.2008

    • Author(s)
      Shiomi, K., et. al.
    • Journal Title

      Chnical Cancer Res 14

      Pages: 1431-1437

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Postoperative fibromatosis-type fibromas in the Bhdgene mutant (Nihon) rat.2008

    • Author(s)
      Kouchi, M., et. al.
    • Journal Title

      Exp Toxicol Pathology (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Establishment of a Novel Specific ELISA system for rat N-and C-ERC/Mesothelin.-Rat ERC/Mesothelin in the Body Fluids of mice bearing Mesothelioma-2008

    • Author(s)
      Hagiwara, Y., et. al.
    • Journal Title

      Cancer Science (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biphasic response of pancreatic β cell mass to ablation of TSC2 mice.2008

    • Author(s)
      Shigeyama, Y., et. al.
    • Journal Title

      Mol. Cell. Biology (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mesomark kit detects C-ERC/mesothelin, but not SMRP with C-terminus.2008

    • Author(s)
      Segawa, T., et. al.
    • Journal Title

      BBRC (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] GADD34 inhibits mammalian target of repamycin signaling via tuberous sclerosis complex and controls cell surbival under bioenergetic stress.2007

    • Author(s)
      Watanabe R., Tambe Y., Inoue H., Isono T., Haneda M., Isobe K., Kobayashi T., Hino O., Okabe H., Chano T.
    • Journal Title

      Int. J. Molecular Medicine 19

      Pages: 475-483

    • Related Report
      2009 Final Research Report
  • [Journal Article] N-terminal hamartin-binding and C-terminal GAP domain of tuberin can separate in vivo N-terminal hamartin-binding and C-termin.2007

    • Author(s)
      Momose S., Kobayashi T., Tada N., Itoyama S., Hino O.
    • Journal Title

      Biochem. Biophys. Res. Commun 356

      Pages: 693-698

    • Related Report
      2009 Final Research Report
  • [Journal Article] The endoplasmic reticulum stress-inducible protein Niban regulates eIF2 α and S6K1/4E-BP1 phosphorylation.2007

    • Author(s)
      Sun G.D., Kobayashi T., Abe M., Tada N., Adachi H., Shiota A., Totsuka Y., Hino O.
    • Journal Title

      Biochem. Biophys. Res. Commun 360

      Pages: 181-187

    • Related Report
      2009 Final Research Report
  • [Journal Article] Birt-Hogg-Dube (BHD) gene mutations in human gastric cancer with high hrequency microsatellite instability.2007

    • Author(s)
      Jiang W., Fujii H., Matsumoto T., Ohtsuji N., Tsurumaru M., Hino O.
    • Journal Title

      Cancer Letter 248

      Pages: 103-111

    • Related Report
      2009 Final Research Report
  • [Journal Article] Establishment of the ELISA system to detect the amino terminal secretory form of rat Erc/ Mesothelin.2007

    • Author(s)
      Nakaishi M., Kajino K., Ikesue M., Hagiwara Y., Kuwahara M., Mitani H., Horikoshi Y., Segawa T., Kon S., Maeda M., Baiyin T., Abe M., Yokoyama M., Hino O.
    • Journal Title

      Cancer Sci. 98

      Pages: 659-664

    • Related Report
      2009 Final Research Report
  • [Journal Article] A diagnostic biomarker of Asbestos-related mesothelioma-Example of translational research-.2007

    • Author(s)
      Hino O., Shiomi K., Maeda M.
    • Journal Title

      Cancer Sci. 98

      Pages: 1147-1157

    • Related Report
      2009 Final Research Report
  • [Journal Article] Suppression of viral replication by stress-inducible GADD34 protein via the mammalian serine/threonine protein kinase mTOR pathway.2007

    • Author(s)
      Minami K., Tambe Y., Watanabe R., Isono T., Haneda M., Isobe K., Kobayashi T., Hino O., Okabe H., Chano T., Inoue H.
    • Journal Title

      J. Virology 81

      Pages: 11106-11115

    • Related Report
      2009 Final Research Report
  • [Journal Article] GADD34 inhibits mammalian target of repamycin signaling via tuberous sclerosis complex and controls cell surbival under bioenergetic stress.2007

    • Author(s)
      Watanabe, R., et. al.
    • Journal Title

      Int. J. Molecular Medicine 19

      Pages: 475-483

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] N-terminal hamartin-binding and C-terminal GAP domain of tuberin can separate in vivo N-terminal hamartin-binding and C-termin.2007

    • Author(s)
      Momose, S., et. al.
    • Journal Title

      Biochemical and Biophysical Research Communications 356

      Pages: 693-698

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The endoplasmic reticulum stress-inducible protein Niban regulates eIF2α and S6K1/4E-BP1 phosphorylation.2007

    • Author(s)
      Sun, G.D., et. al.
    • Journal Title

      BBRC 360

      Pages: 181-187

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Birt-Hogg-Dube (BHD) gene mutations in human gastic cancer with high hrequency microsatellite instability.2007

    • Author(s)
      Jiang, W., et. al.
    • Journal Title

      Cancer Letter 248

      Pages: 103-111

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Establishment of the ELISA system to detect the amino terminal secretory form of rat Erc/Mesothelin.2007

    • Author(s)
      Nakanishi, M., et. al.
    • Journal Title

      Cancer Science 98

      Pages: 659-664

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A diagnostic biomarker of Asbestos-related mesothelioma-Example of translational research-2007

    • Author(s)
      Hino, O., et. al.
    • Journal Title

      Cancer Science 98

      Pages: 1147-1157

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Suppression of viral replication by stress-inducible GADD34 protein via the mammalian serine/threonine protein kinase mTOR pathway.2007

    • Author(s)
      Minami, K., et. al.
    • Journal Title

      J. Virology 81

      Pages: 11106-11115

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transgenic rescue from embryonic lethality and renal carcinogenesis in the Nihon rat model by introduction of a wild-type Bhd gene.2006

    • Author(s)
      Togashi Y, Kobayashi T, Momose S, Ueda M, Okimoto K, Hino O
    • Journal Title

      Oncogene 25

      Pages: 2885-2889

    • Related Report
      2009 Final Research Report
  • [Journal Article] Natural history of the Nihon (Bhd gene mutant) rat, a novel model for human Birt-Hogg-Dube syndrome.2006

    • Author(s)
      Kouchi M., Okimoto K., Matsumoto I., Tanaka K., Yasuba M., Hino O.
    • Journal Title

      Virchow Archives 448

      Pages: 463-471

    • Related Report
      2009 Final Research Report
  • [Journal Article] Novel ELISA system for detection of "N-ERC/mesothelin" in the sera of mesothelioma patients.2006

    • Author(s)
      Shiomi K., Miyamoto H., Segawa T., Hagiwara Y., Ota A., Maeda M., Takahashi K., Masuda K., Sakao Y., Hino O.
    • Journal Title

      Cancer Sci 97

      Pages: 928-932

    • NAID

      10018767738

    • Related Report
      2009 Final Research Report
  • [Journal Article] A novel tumor marker, Niban, is expressed in subsets of thyroid tumors and Hashimoto's thyroiditis.2006

    • Author(s)
      Matsumoto F., Fujii H., Abe M., Kajino K., Kobayashi T., Matsumoto T., Ikeda K., Hino O.
    • Journal Title

      Human Pathology 37

      Pages: 1592-1600

    • Related Report
      2009 Final Research Report
  • [Journal Article] Neuromuscular abundance of RB1CC1 contributes to the non-proliferating enlarged cell phenotype through both RB1 maintenance and TSC1 degradation.2006

    • Author(s)
      Chano T., Saji M., Inoue H., Minami K., Kobayashi T., Hino O., Okabe H.
    • Journal Title

      Int. J. Molecular Medicine 18

      Pages: 425-432

    • Related Report
      2009 Final Research Report
  • [Journal Article] Intraction of Fox01 and TSC2 induces insulin resistance through activation of the mammalian target of rapamycin/p70 S6K pathway.2006

    • Author(s)
      Cao Y., Kamioka Y., Yokoi N., Kobayashi T., Hino O., Onodera M., Mochizuki N., Nakae J.
    • Journal Title

      J. Biological Chemistry 281

      Pages: 40242-40251

    • Related Report
      2009 Final Research Report
  • [Journal Article] Blood tests for Asbestos-related mesothelioma.2006

    • Author(s)
      Maeda M., Hino O.
    • Journal Title

      Oncology 71

      Pages: 26-31

    • Related Report
      2009 Final Research Report
  • [Journal Article] Transgenic rescue from embryonic lethality and renal carcinogenesis in the Nihon rat model by introduction of a wild-type Bhd gene.2006

    • Author(s)
      Togashi Y, Kobayashi T, Momose S, et al.
    • Journal Title

      Oncogene 25

      Pages: 2885-2889

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Natural history of the Nihon (Bhd gene mutant) rat, a novel model for human Birt-Hogg-Dube syndrome.2006

    • Author(s)
      Kouchi M., Okimoto K., Matsumoto I., et al.
    • Journal Title

      Virchow Archives 448

      Pages: 463-471

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Novel ELISA system for detection of "N-ERC/mesothelin" in the sera of mesothelioma patients.2006

    • Author(s)
      Shiomi K., Miyamoto H., Segawa T., et al.
    • Journal Title

      Cancer Science 97

      Pages: 928-932

    • Related Report
      2006 Annual Research Report
  • [Journal Article] A novel tumor marker, Niban, is expressed in subsets of thyroid tumors and Hashimoto's thyroiditis.2006

    • Author(s)
      Matsumoto F., Fujii H., Abe M., et al.
    • Journal Title

      Human Pathology 37

      Pages: 1592-1600

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Intraction of FoxO1 and TSC2 induces insulin resistance through activation of the mammalian target of rapamycin/p70 S6K pathway.2006

    • Author(s)
      Cao Y., Kamioka Y., Yokoi N., et al.
    • Journal Title

      J. Biological Chemistry 281

      Pages: 40242-40251

    • Related Report
      2006 Annual Research Report
  • [Journal Article] A mutation in the SDHC gene of complex II increases oxidative stress, resulting in apoptosis and tumorigenesis.2005

    • Author(s)
      Ishii T., Yasuda K., Akatsuka A., Hino O., Hartman P.S., Ishii N.
    • Journal Title

      Cancer Res 65

      Pages: 203-209

    • Related Report
      2009 Final Research Report
  • [Journal Article] Genetic analysis of Pten and Tsc2 functional interactions in the mouse reveals asymmetrical haploinsufficiency in tumor.2005

    • Author(s)
      Ma L., Teruya-Feldstein J., Behrendt N., Chen Z., Noda T., Hino O., Cordon-Cardo C., Pandolfi P.P.
    • Journal Title

      Genes & Development 19

      Pages: 1779-1986

    • Related Report
      2009 Final Research Report
  • [Journal Article] A mutation in the SDHC gene of complex II increases oxidative stress, resulting in apoptosis and tumorigenesis.2005

    • Author(s)
      Ishii T., Yasuda K., Akatsuka A., Hino O., Hartman P.S., Ishii N.
    • Journal Title

      Cancer Research 65

      Pages: 203-209

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Genetic analysis of Pten and Tsc2 functional interactions in the mouse reveals asymmetrical haploinsufficiency in tumor.2005

    • Author(s)
      Ma L., Teruya-Feldstein J., Behrendt N., Chen Z., Noda T., Hino O.et al.
    • Journal Title

      Genes & Development 19

      Pages: 1779-1986

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Intentional delay of human hepatocarcinogenesis due to suppression of chronic hepatitis.2005

    • Author(s)
      Hino O.
    • Journal Title

      Intervirology 48

      Pages: 6-9

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Clinical and genetic spectrum of Birt-Hogg-Dube syndrome patients in whom pneumothorax and/or multiple lung cysts are the presenting feature.

    • Author(s)
      Kunogi M., Kurihara M., Shigihara-Ikegami T., Kobayashi T., Shindo N., Kumasaka T., Gunji Y., Kikkawa M., Iwakami S., Hino O., Takahashi K., Seyama K.
    • Journal Title

      J. Med. Genetics (in press)

    • Related Report
      2009 Final Research Report
  • [Journal Article] Development of positron emission tomography imaging by 64Cu-labeled Fab for detecting ERC/mesothelin in mesothelioma mouse model.

    • Author(s)
      Yoshida C., Sogawa C., Tsuji A., Sudo H., Sugyo A., Uehara T., Hino O., Yoshii Y., Fujibayashi Y., Fukumura T., Koizumi M., Arano Y., Saga T.
    • Journal Title

      Nuclear Medicine Communications (in press)

    • Related Report
      2009 Final Research Report
  • [Journal Article] Establishment of the ELISA system to detect the amino terminal secretorv form of rat Erc/Mesothelin

    • Author(s)
      Nakanishi M., Kajino K., Ikesue M., et al.
    • Journal Title

      Cancer Science (In press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Transgenic rescue from embryonic lethality and renal carcinogenesis in the Nihon rat model by introduction of a wild-type Bhd gene.

    • Author(s)
      Togashi Y, Kobayashi T, Momose S, Ueda M, Okimoto K, Hino O
    • Journal Title

      Oncogene (in press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Gene Expression Profile of dbpA (DNA Binding Protein A) transgenic mice.

    • Author(s)
      Tobita H, Kajino K, Inami K, Kano S, Yasen M, Imamura O, Kinoshita Y, Hino O.
    • Journal Title

      Int.J.Oncology (in press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Natural history of the Nihon (Bhd gene mutant) rat, a novel model for human Birt-Hogg-Dube syndrome.

    • Author(s)
      Kouchi M., Okimoto K., Matsumoto I., Tanaka K., Yasuba M., Hino O.
    • Journal Title

      Virchow Archives (in press)

    • Related Report
      2005 Annual Research Report
  • [Book] Models for genitourinary cancer-Hereditary renal carcinogenesis. The CANCER handbook. Second edition.2007

    • Author(s)
      Hino, O.
    • Publisher
      WILEY
    • Related Report
      2007 Annual Research Report
  • [Book] Cancer : Cell Structures, Carcinogens and Genomic Instability.2006

    • Author(s)
      Hino O., Kobayashi T., Okimoto K.
    • Total Pages
      24
    • Publisher
      Birkhauser Verlag
    • Related Report
      2006 Annual Research Report
  • [Book] Cancer : Cell Structures, Carinogenes and Genomic Instability.2005

    • Author(s)
      Hino O., Kobayashi T., Okimoto K.
    • Publisher
      Birkhauser Verlag
    • Related Report
      2005 Annual Research Report
  • [Patent(Industrial Property Rights)] 中皮種診断剤、中皮種診断キットおよび中皮種診断方法

    • Inventor(s)
      樋野興夫、清藤勉
    • Industrial Property Rights Holder
      株式会社免疫生物研究所
    • Industrial Property Number
      2006-331409
    • Related Report
      2009 Final Research Report

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Published: 2005-04-01   Modified: 2018-03-28  

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