Protein tyrosine phosphatases and regulation of cancer cell adhesion/migration

• Project/Area Number: 17014010
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Gunma University
• Principal Investigator: MATOZAKI Takashi Gunma University, 生体調節研究所, 教授 (80252782)
• Co-Investigator(Kenkyū-buntansha): OHNISHI Hiroshi 群馬大学, 生体調節研究所, 准教授 (70334125) ; OKAZAWA Hideki 群馬大学, 生体調節研究所, 助教 (80334126) ; MURATA Yoji 群馬大学, 生体調節研究所, 助教 (60400735)
• Project Period (FY): 2005 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥67,900,000 (Direct Cost: ¥67,900,000); Fiscal Year 2009: ¥12,900,000 (Direct Cost: ¥12,900,000); Fiscal Year 2008: ¥12,900,000 (Direct Cost: ¥12,900,000); Fiscal Year 2007: ¥13,900,000 (Direct Cost: ¥13,900,000); Fiscal Year 2006: ¥13,900,000 (Direct Cost: ¥13,900,000); Fiscal Year 2005: ¥14,300,000 (Direct Cost: ¥14,300,000)
• Keywords: 癌 / 酵素 / シグナル伝達 / 生体分子 / 細胞増殖 / 細胞接着 / CD47 / SHPS-1 / NKT細胞 / 樹状細胞 / がん / SAP-1 / Rac / Cdc42

Research Abstract

In this grant project, we have investigated the physiological role of protein tyrosine phosphorylation as well as its relation to oncogenesis and metastasis. We have clarified that a novel cell-cell communication system “CD47-SHPS-1 system" or SAP-1, a receptor-type protein tyrosine phosphatase, is important for regulation of cancer metastasis and of inflammation that is directly related to development of cancers.

Research Products

• [Journal Article] Promotion of cell spreading and migration by vascular endothelial-protein tyrosine phosphatase (VE-PTP) in cooperation with integrins. (2010)
  • Author(s): Mori, M., Murata, Y., Kotani, T., Kusakari, S., Ohnishi, H., Saito, Y., Okazawa, H., Ishizuka, T., Mori, M., Matozaki, T.
  • Journal Title: J. Cell. Physiol. 224 Pages: 195-204
  • Peer Reviewed
• [Journal Article] Tyrosine phosphorylation of R3 subtype receptor-type protein tyrosine phosphatases and their complex formations with Grb2 or Fyn. (2010)
  • Author(s): Murata, Y., Mori, M., Kotani, T., Supriatna, Y., Okazawa, H., Kusakari, S., Saito, Y., Ohnishi, H., Matozaki, T.
  • Journal Title: Genes Cells 15 Pages: 513-524
  • Peer Reviewed
• [Journal Article] Expression of PTPRO in the interneurons of adult mouse olfactory bulb (2010)
  • Author(s): Kotani, T., 他
  • Journal Title: J.Comp.Neurol. 518 Pages: 119-136
  • Peer Reviewed
• [Journal Article] Functions and molecular mechanisms of the CD47-SIRPα signalling pathway. (2009)
  • Author(s): Matozaki, T., Murata, Y., Okazawa, H., Ohnishi, H.
  • Journal Title: Trends Cell Biol. 19 Pages: 72-80
  • Peer Reviewed
• [Journal Article] SAP-1 is a microvillus-specific protein tyrosine phosphatase that modulates intestinal tumorigenesis. (2009)
  • Author(s): Sadakata, H., Okazawa, H., Sato, T., Supriatna, Y., Ohnishi, H., Kusakari, S., Murata, Y., Ito, T., Nishiyama, U., Minegishi, T., Harada, A., Matozaki, T.
  • Journal Title: Genes Cells 14 Pages: 295-308
  • Peer Reviewed
• [Journal Article] Protein tyrosine phosphatase SHP-2: A proto-oncogene product that promotes Ras activation. (2009)
  • Author(s): Matozaki, T., Murata, Y., Saito, Y., Okazawa, H., Ohnishi, H.
  • Journal Title: Cancer Sci. 100 Pages: 1786-1793
  • NAID: 10027195202
  • Peer Reviewed
• [Journal Article] Inhibitory regulation of osteoclast bone resorption by signal regulatory protein (2009)
  • Author(s): van Beek, E.M., de Vries, T.J., Mulder, L., Schoenmaker, T., Hoeben, K.A., Matozaki, T., Langenbach, G.E.J., Kraal, G., Everts, V., van den Berg, T.K.
  • Journal Title: FASEB J. 23 Pages: 4081-4090
  • Peer Reviewed
• [Journal Article] Signal regulatory protein-β1: a microglial modulator of phagocytosis in Alzheimer's disease. (2009)
  • Author(s): Gaikwad, S., Larionov, Wang, Y., Dannenberg, H., Matozaki, T., Monsonego, A., Thal, D.R., Neumann, H.
  • Journal Title: Am. J. Pathol. 175 Pages: 2528-2539
  • Peer Reviewed
• [Journal Article] Inhibitory regulation of osteoclast bone resorption by SIRPα (2009)
  • Author(s): van Beek, E.M., 他
  • Journal Title: FASEB J. 23 Pages: 4081-4190
  • Peer Reviewed
• [Journal Article] Signal regulatory protein-b1 : a microglial modulator of phagocytosis in Alzheimer's disease (2009)
  • Author(s): Gaikwad, S., 他
  • Journal Title: AM.J., Pathol 175 Pages: 2528-2539
  • Peer Reviewed
• [Journal Article] Functions and molecular mechanisms of the CD47-SIRPα signalling pathway (2009)
  • Author(s): Matozaki, T., 他
  • Journal Title: Trends Cell Biol. 19 Pages: 72-80
  • Peer Reviewed
• [Journal Article] Protein tyrosine phosphatase SHP-2 : A proto-oncogene product that promotes Ras activation (2009)
  • Author(s): Matozaki, T., 他
  • Journal Title: Cancer Sci. 100 Pages: 1786-1793
  • NAID: 10027195202
  • Peer Reviewed
• [Journal Article] SAP-1 is a microvillus-specific protein tyrosine phosphatase that modulates intestinal tumorigenesis (2009)
  • Author(s): Sadakata, H., 他
  • Journal Title: Genes Cells 14 Pages: 295-308
  • Peer Reviewed
• [Journal Article] Trans-endocytosis of CD47 and SHPS-1 and its role in regulation of the CD47-SHPS-1 system. (2008)
  • Author(s): Kusakari, S., Ohnishi, H., Jin, F. -J., Kaneko, Y., Murata, T., Murata, Y., Okazawa, H., Matozaki, T.
  • Journal Title: J. Cell Sci. 121 Pages: 1213-1223
  • Peer Reviewed
• [Journal Article] Negative regulation by SHPS-1 of Toll-like receptor-dependent proinflammatory cytokine production in macrophages. (2008)
  • Author(s): Miyake, A., Murata, Y., Okazawa, H., Ikeda, H., Niwayama, Y., Ohnishi, H., Hirata, Y., Matozaki, T.
  • Journal Title: Genes Cells 3 Pages: 209-219
  • Peer Reviewed
• [Journal Article] Essential roles of SHPS-1 in induction of contact hypersensitivity of skin. (2008)
  • Author(s): Motegi, S., Okazawa, H., Murata, Y., Kanazawa, Y., Saito, Y., Kobayashi, H., Ohnishi, H., Oldenborg, P. -A., Ishikawa, O., Matozaki, T.
  • Journal Title: Immunol. Lett. 121 Pages: 52-60
  • Peer Reviewed
• [Journal Article] Structural insight into the specific interaction between murine SHPS-1/SIRPα and its ligand CD47. (2008)
  • Author(s): Nakaishi, A., Hirose, M., Yoshimura, M., Oneyama, C., Saito, K., Kuki, N., Matsuda, M., Honma, N., Ohnishi, H., Matozaki, T., Okada, M., Nakagawa, A.
  • Journal Title: J. Mol. Biol. 375 Pages: 650-660
  • Peer Reviewed
• [Journal Article] Effective clearance of intracellular Leishmania major in vivo requires Pten in macrophages. (2008)
  • Author(s): Kuroda, S., Nishio, M., Sasaki, T., Horie, Y., Kawahara, K., Sasaki, M., Natsui, M., Matozaki, T., Tezuka, H., Ohteki, T., Forster, I., Mak, T.W., Nakano, T., Suzuki A.
  • Journal Title: Eur. J. Immunol. 38 Pages: 1331-1340
  • Peer Reviewed
• [Journal Article] Trans-endocytosis of CD47 and SHPS-1 and its role in regulation of the CD47-SHPS-1 system. (2008)
  • Author(s): Kusakari, S., 他
  • Journal Title: J. Cell Sci. 121 Pages: 1213-1223
  • Peer Reviewed
• [Journal Article] Negative regulation by SHPS-1 of Toll-like receptor-dependent proinflammatory cytokine production in macrophages. (2008)
  • Author(s): Miyake, A., 他
  • Journal Title: Genes Cells 13 Pages: 209-219
  • Peer Reviewed
• [Journal Article] Resistance to collagen-induced arthritis in SHPS-1 mutant mice (2008)
  • Author(s): Okuzawa, C., 他
  • Journal Title: Biochem. Biophys. Res. Commun 371 Pages: 561-566
  • Peer Reviewed
• [Journal Article] Essential roles of SHPS-1 in induction of contact hypersensitivity of skin (2008)
  • Author(s): Motegi, S.,他
  • Journal Title: Immunol. Lett. 121 Pages: 52-60
  • Peer Reviewed
• [Journal Article] Impaired proliferation and Thl differentiation of CD4' T cells in SHPS-1 mutant mice (2008)
  • Author(s): Kaneko, Y., MI
  • Journal Title: Kitakanto Med. J. 58 Pages: 133-139
  • Peer Reviewed
• [Journal Article] Structural insight into the specific interaction between murine SHPS-1/SIRPa and its ligand CD47 (2008)
  • Author(s): Nakaishi, A., 他
  • Journal Title: J. Mol. Biol. 375 Pages: 650-660
  • Peer Reviewed
• [Journal Article] Effective clearance of intracellular Leishmania major in vivo requires Pten in macrophages (2008)
  • Author(s): Kuroda, S., 他
  • Journal Title: Eur. J. Immunol 38 Pages: 1331-1340
  • Peer Reviewed
• [Journal Article] Functions and molecular mechanisms of the CD47-SIRPa signalling pathway (2008)
  • Author(s): Matozaki,T., 他
  • Journal Title: Trends Cell Biol 19 Pages: 72-80
  • Peer Reviewed
• [Journal Article] Negative regulation by SHPS-1 of Toll-like receptor-dependent proinflammatory cytokine production in macrophages. (2008)
  • Author(s): Miyake, A., et. al.
  • Journal Title: Genes Cells 13 Pages: 209-219
  • Peer Reviewed
• [Journal Article] Structural insight into the specific interaction between murine SHPS-1/SIRPα and its ligand CD47. (2008)
  • Author(s): Nakaishi, A., et. al.
  • Journal Title: J. Mol. Biol. 375 Pages: 650-660
  • Peer Reviewed
• [Journal Article] Trans-endocytosis of CD47 and SHPS-1 and its role in regulation of the CD47-SHPS-1 system. (2008)
  • Author(s): Kusakari, S., et. al.
  • Journal Title: J. Cell Sci. 121 Pages: 1213-1223
  • Peer Reviewed
• [Journal Article] Resistance to experimental autoimmune encephalomyelitis and impaired T cell priming by dendritic cells in SHPS-1 mutant mice. (2007)
  • Author(s): Tomizawa, T., Kaneko, Y., Kaneko, Y., Saito, Y., Ohnishi, H., Okajo, J., Okuzawa, C., Ishikawa-Sekigami, T., Murata, Y., Okazawa, H., Okamoto, K., Nojima, Y. Matozaki, T.
  • Journal Title: J. Immunol. 179 Pages: 869-877
  • Peer Reviewed
• [Journal Article] Regulation by Src homology 2 domain-containing protein tyrosine phosphatase substrate-1 of α-galactosylceramide-induced antimetastatic activity and Th1 and Th2 responses of NKT cells. (2007)
  • Author(s): Okajo, J., Kaneko, Y., Murata, Y., Tomizawa, T., Okuzawa, C., Saito, Y., Kaneko, Y., Ishikawa-Sekigami, T., Okazawa, H., Ohnishi, H., Matozaki, T. Nojima, Y.
  • Journal Title: J. Immunol. 178 Pages: 6164-6172
  • Peer Reviewed
• [Journal Article] Resistance to experimental autoimmune encephalomyelitis and impaired T cellpriming by dendritic cells in SHPS-1 mutant mice. (2007)
  • Author(s): Tomizawa, T., et. al.
  • Journal Title: J. Immunol. 179 Pages: 869-877
  • Peer Reviewed
• [Journal Article] Regulation by SHPS-1 of α-GalCer-induced antimetastatic activity and Th1 and Th2 responses of natural killer T cells. (2007)
  • Author(s): Okajo, J., et. al.
  • Journal Title: J. Immunol. 178 Pages: 6164-6172
  • Peer Reviewed
• [Journal Article] Regulation by SHPS-1 of α-GalCer-induced antimetastatic activity and Th1 and Th2 responses of natural killer T cells. (2007)
  • Author(s): Okajo, J., et al.
  • Journal Title: J.Immunol. (In press)
• [Journal Article] SHPS-1 promotes the survival of circulating erythrocytes through inhibition of phagocytosis by splenic macrophages. (2006)
  • Author(s): Ishikawa-Sekigami, T., Kaneko, Y., Okazawa, H., Tomizawa, T., Okajo, J., Saito, Y., Okuzawa, C., Sugawara-Yokoo, M., Nishiyama, U., Ohnishi, H., Matozaki, T. Nojima, Y.
  • Journal Title: Blood 107 Pages: 341-348
  • Peer Reviewed
• [Journal Article] Mutational analysis of the mechanism of negative regulation by SHPS-1 of phagocytosis in macrophages. (2006)
  • Author(s): Ikeda, H., Okazawa, H., Ohnishi, H., Murata, Y., Oldenborg, P. -A. Matozaki, T.
  • Journal Title: J. Immunol. 177 Pages: 3123-3132
  • Peer Reviewed
• [Journal Article] CD47 regulation of epithelial cell spreading and migration, and its signal transduction. (2006)
  • Author(s): Shinohara, M., Ohyama, N., Murata, Y., Okazawa, H., Ohnishi, H., Ishikawa, O., Matozaki, T.
  • Journal Title: Cancer Sci. 97 Pages: 889-895
  • NAID: 10018767488
  • Peer Reviewed
• [Journal Article] SHPS-1 promotes the survival of circulating erythrocytes through inhibition of phagocytosis by splenic macrophages. (2006)
  • Author(s): Ishikawa-Sekigami, T., et al.
  • Journal Title: Blood 107巻・1号 Pages: 341-348
• [Journal Article] Mutational analysis of the mechanism of negative regulation by SHPS-1 of phagocytosis in macrophages. (2006)
  • Author(s): Ikeda, H., et al.
  • Journal Title: J.Immunol. 177巻・5号 Pages: 3123-3132
• [Journal Article] CD47 promotes neuronal development through Src-and FRG/Vav2-mediated activation of Rac and Cdc42. (2006)
  • Author(s): Murata, T., et al.
  • Journal Title: J.Neurosci. 26巻・48号 Pages: 12397-12407
• [Journal Article] CD47 regulation of epithelial cell spreading and migration, and its signal transduction. (2006)
  • Author(s): Shinohara, M., et al.
  • Journal Title: Cancer Sci. 97巻・9号 Pages: 889-895
• [Journal Article] Src homology 2 domain-containing protein tyrosine phosphatase substrate 1 regulates the induction of Langerhans cell maturation. (2006)
  • Author(s): Fukunaga, A., et al.
  • Journal Title: Eur.J.Immunol. 36巻・12号 Pages: 3216-3226
• [Journal Article] Engagement of CD47 inhibits the contact hypersensitivity response via the suppression of motility and B7 expression by Langerhans cells. (2006)
  • Author(s): Yu, X., et al.
  • Journal Title: J.Invest.Dermatol. (In press)
• [Journal Article] Negative regulation of phagocytosis in macrophages by the CD47-SHPS-1 system. (2005)
  • Author(s): Okazawa, H., Motegi, S., Ohyama, N., Ohnishi, H., Tomizawa, T., Kaneko, Y., Oldenborg, P. -A., Ishikawa, O., Matozaki, T.
  • Journal Title: J. Immunol. 174 Pages: 2004-2011
  • Peer Reviewed
• [Journal Article] A nomenclature for signal regulatory protein family members. (2005)
  • Author(s): van den Berg, T.K., et al.
  • Journal Title: J.Immunol. 175巻・12号 Pages: 7788-7789
• [Journal Article] Negative regulation of phagocytosis in macrophages by the CD47-SHPS-1 system. (2005)
  • Author(s): Okazawa, H., et al.
  • Journal Title: J.Immunol. 174巻・4号 Pages: 2004-2011
• [Journal Article] Differential localization of SHPS-1 and CD47 and its molecular mechanisms in cultured hippocampal neurons. (2005)
  • Author(s): Ohnishi, H., et al.
  • Journal Title: J.Neurosci. 25巻・10号 Pages: 2702-2711
• [Journal Article] Promotion of cell spreading and migration by vascular endothelial-protein tyrosine phosphatase(VE-PTP)in cooperation with integrins
  • Author(s): Mori, M., 他
  • Journal Title: J.Cell.Physiol. (in press)
  • Peer Reviewed
• [Journal Article] Tyrosine phosphorylation of R3 subtype receptor-type protein tyrosine phosphatases and their complex formations with Grb2 or Fyn
  • Author(s): Murata, Y., 他
  • Journal Title: Genes Cells (in press)
  • Peer Reviewed
• [Presentation] Tyrosine phosphorylation of SAP-1, a receptor-type protein tyrosine phosphatase, and its association with Grb2. (2009)
  • Author(s): Murata, Y., Kotani, Supriatna, Y., Mori, M., Okazawa, H., Ohnishi, H., Saito, Y., Matozaki, T.
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2009-10-01
• [Presentation] Promotion by VE-PTP of lamellipodium formation in cooperation with Ras and integrin. (2009)
  • Author(s): M ori, M., Murata, Y., Ohnishi, H., Okazawa, H., Kotani, T., Saito, Y., Mori, M. Matozaki, T.
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2009-10-01
• [Presentation] Essenntial roles of the CD47-SIRPα signaling for homeostasis of lymphoid tissue dendritic cells (2009)
  • Author(s): 齊藤泰之, et al.
  • Organizer: Immune Regulation : Present and Future
  • Place of Presentation: 大阪国際会議場
• [Presentation] Promotion by VE-PTP of lamellipodium formation in cooperation with Ras and integrin (2009)
  • Author(s): 森宗昌、的崎尚, 他
  • Organizer: 第61回日本細胞生物学会大会
  • Place of Presentation: 名古屋国際会議場
• [Presentation] SAP-1 is an intestinal microvillus-specific protein tyrosine phosphatase that protects against colitis in cooperation with IL-10 (2009)
  • Author(s): 村田陽二、的崎尚, 他
  • Organizer: 第61回日本細胞生物学会大会
  • Place of Presentation: 名古屋国際会議場
• [Presentation] Roles of the CD47-SIRPα signaling in homeostasis of lymphoid tissue dendritic cells and development of autoimmune diseases (2009)
  • Author(s): 的崎尚, et al.
  • Organizer: G-COE Program International Symposium
  • Place of Presentation: 秋田大学
• [Presentation] SAP-1 is an intestinal microvillus-specific protein tyrosine phosphatase that protects against colitis (2009)
  • Author(s): 小谷武徳、的崎尚, 他
  • Organizer: 第9回 文部科学省特定領域研究「がん」5領域 若手研究者ワークショップ
  • Place of Presentation: アートランドホテル蓼科
• [Presentation] Tyrosine phosphorylation of SAP-1, a receptor-type protein tyrosine phosphatase, and its association with Grb2 (2009)
  • Author(s): 村田陽二、的崎尚, 他
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜
• [Presentation] Promotion by VE-PTP of lamellipodium formation in cooperation with Ras and integrin (2009)
  • Author(s): 森宗昌、的崎尚, 他
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜
• [Presentation] 腸微絨毛特異的な発現を示す受容体型チロシンホスファターゼSAP-1とIL-10による炎症性腸疾患の制御 (2009)
  • Author(s): 小谷武徳、的崎尚, 他
  • Organizer: 第82回日本生化学会
  • Place of Presentation: 神戸国際会議場
• [Presentation] VE-PTPによる Ras, インテグリン依存的なラメリポディア形成の促進 (2009)
  • Author(s): 森宗昌、的崎尚, 他
  • Organizer: 第82回日本生化学会
  • Place of Presentation: 神戸国際会議場
• [Presentation] CD47-SIRPαシグナル系によるリンパ組織内樹状細胞の恒常性の制御 (2009)
  • Author(s): 齊藤泰之、的崎尚, 他
  • Organizer: 第71回日本血液学会
  • Place of Presentation: 京都国際会議場
• [Presentation] クラス3受容体型チロシンホスファターゼの機能と病態への関与 (2008)
  • Author(s): Y ana Supriatna、岡澤秀樹、村田陽二、大西浩史、的崎尚
  • Organizer: 第31回日本分子生物学会年会第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸国際会議場(兵庫県)
  • Year and Date: 2008-12-09
• [Presentation] チロシンホスファターゼによるがん、炎症性腸炎の制御 (2008)
  • Author(s): 的崎尚、岡澤秀樹、村田陽二、大西浩史
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場(愛知県)
  • Year and Date: 2008-10-28
• [Presentation] レセプター型チロシンボスファターゼの発現、機能と病態への関与 (2008)
  • Author(s): 的崎尚
  • Organizer: G-COE合同シンポジウム
  • Place of Presentation: 秋田市明徳館ビル
  • Year and Date: 2008-10-18
• [Presentation] 細胞間シグナル伝達システムCD47-SHPS-1系とがんの浸潤・転移の制御, シンポジウム<浸潤・転移・血管新生研究の進歩> (2008)
  • Author(s): 的崎尚
  • Organizer: 第64回日本癌学会学術総会
  • Place of Presentation: ロイトン札幌(北海道)
  • Year and Date: 2008-09-14
• [Presentation] SAP-1 is a microvillus-specific protein tyrosine phosphatase that regulates intestinal tumorigenesis. (2008)
  • Author(s): S adakata, H., Okazawa, H., Supriatna, Y., Ohnishi, H., Murata, Y., Matozaki, T.
  • Organizer: FASEB Summer Research Conferences
  • Place of Presentation: Snowmass, Colorado(USA)
  • Year and Date: 2008-07-13
• [Presentation] CD47とSHPS-1のトランスエンドサイトーシスとCD47-SHPS-1系の制御における役割 (2008)
  • Author(s): 大西浩史、的崎尚他
  • Organizer: 第60回日本細胞生物学会大会
  • Place of Presentation: パシフイコ横浜
• [Presentation] SAP-1 is a microyillus-specific protein tyrosine phosphatase that regulates intestinal tumorigenesis (2008)
  • Author(s): Sadakata, EL et. al.
  • Organizer: FASEB Summer Research Conferences
  • Place of Presentation: SnQwmass, Colorado、米国
• [Presentation] Regulation of CD47-SHPS-1 system by trans-endocytosis (2008)
  • Author(s): 草苅伸也、的崎尚他
  • Organizer: 第9回文部科学省特定領域研究「がん」5領域若手研究者ワークショップ
  • Place of Presentation: アートランドホテル蓼科
• [Presentation] Essential roles of SHPS-1 in homeostasis of dendritic cells (2008)
  • Author(s): Saito, Y. et. al.
  • Organizer: 第10回国際樹状細胞シンポジウム
  • Place of Presentation: 神戸国際会議場
• [Presentation] SAP-1 is a microvillus-specific protein tyrosine phosphatase that regulates intestinal tumorigenesis and inflammation (2008)
  • Author(s): Mtozaki, T.
  • Organizer: 第8回国際プロテインボスファターゼヵンファレンス
  • Place of Presentation: 前橋テルサ
• [Presentation] Trans-endocytosis of CD47 and SHPS-1 and its role in regulation of the CD47-SHPS-1 system (2008)
  • Author(s): Kusakari, S. et. al.
  • Organizer: 第8回国際プロテインボスファターゼカンファレンス
  • Place of Presentation: 前橋テルサ
• [Presentation] Defective development of dendritic cells in SHPS-1 mutant mice (2008)
  • Author(s): Saito, Y. et. al.
  • Organizer: 第8回国際プロテインボスファターゼカンファレンス
  • Place of Presentation: 前橋テルサ
• [Presentation] チロシンボスファターゼによるがん、炎症性腸炎の制御 (2008)
  • Author(s): 的崎尚
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場
• [Presentation] SHPS-1は樹状細胞の恒常性に重要である (2008)
  • Author(s): 齊藤泰之、的崎尚他
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都国際会議場
• [Presentation] 腸管におけるSHPS-1発現と腹管免疫制御 (2008)
  • Author(s): 金澤義丈、的崎尚他
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都国際会議場
• [Presentation] 腸微絨毛特異的発現を示すチロシシホスファターゼSAP-1による腸管腫瘍形成の制御 (2008)
  • Author(s): 定方久延、的崎尚他
  • Organizer: 第31回日本分子生物学会年会, 第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸国際会議場
• [Presentation] 受容体型チロシンボスファターゼSAP-1のチロシンリン酸化とその生理的意義 (2008)
  • Author(s): 村田陽二、的崎尚他
  • Organizer: 第31回日本分子生物学会年会, 第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸国際会議場
• [Presentation] クラス3受容体型チロシンボスファターゼの機能と病態への関与 (2008)
  • Author(s): Yana Supriatona、的崎尚他
  • Organizer: 第31回日本分子生物学会年会, 第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸国際会議場
• [Presentation] REGULATION BY SHPS-1 OF DENDRITIC CELLS IN AUTO-IMMUNITY AND PEVENTION OF CANCER METASTASIS (2007)
  • Author(s): 的崎 尚
  • Organizer: 第12回日韓癌ワークショップ
  • Place of Presentation: 京王プラザホテル札幌
  • Year and Date: 2007-12-21
• [Presentation] CD47-SHPS-1シグナルシステムの機能とその分子機構 (2007)
  • Author(s): 的崎 尚, 他
  • Organizer: BMB2007
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2007-12-11
• [Presentation] SHPS-1による皮膚免疫とToll-like receptorを介したサイトカイン分泌の制御 (2007)
  • Author(s): 茂木精一郎、的崎 尚, 他
  • Organizer: 第37回日本免疫学会総会・学術集会
  • Place of Presentation: グランドプリンスホテル新高輪
  • Year and Date: 2007-11-20
• [Presentation] Regulation by CD47-SHPS-1 system of neurite development. (2007)
  • Author(s): M urata, T., Ohnishi, H., Kusakari, S., Murata, Y., Okazawa, H., Furuya, N., Matozaki, T.
  • Organizer: Neurosciense 2007
  • Place of Presentation: San Diego Convention center(サンディエゴ)
  • Year and Date: 2007-11-03
• [Presentation] SHPS-1による皮膚免疫とToll様受容体を介したサイトカイン産生の制御 (2007)
  • Author(s): 茂木精一郎、岡澤秀樹、小林久江、村田陽二、大西浩史、石川治、的崎尚
  • Organizer: 第66回日本癌学会総会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2007-10-03
• [Presentation] Trans-endocytosis of CD47-SHPS-1 system and its molecular mechanism. (2007)
  • Author(s): K usakari, S., Ohnishi, H., Okazawa, H., Murata, T., Murata, Y., Matozaki, T.
  • Organizer: 第66回日本癌学会総会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2007-10-03
• [Presentation] SHPS-1による皮膚免疫とToll様受容体を介したサイトカイン産生の制御 (2007)
  • Author(s): 茂木精一郎、的崎 尚, 他
  • Organizer: 日本癌学会第66回総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2007-10-03
• [Presentation] Trans-endocytosis of CD47-SHPS-1 system and its molecular mechanism (2007)
  • Author(s): 草苅伸也、的崎 尚, 他
  • Organizer: 日本癌学会第66回総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2007-10-03
• [Presentation] Regulation by CD47-SHPS-1 system of neurite development and its molecular mechanism (2007)
  • Author(s): 大西浩史、的崎 尚, 他
  • Organizer: 第59回日本細胞生物学会大会
  • Place of Presentation: 福岡国際会議場
  • Year and Date: 2007-05-28
• [Presentation] NKT細胞の活性化と癌転移抑制におけるSHPS-1の役割 (2006)
  • Author(s): 岡上準、金子和光、村田陽二、岡澤秀樹、大西浩史、野島美久、的崎尚, 他
  • Organizer: 第65回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2006-09-28
• [Presentation] CD47 promotes neuronal development through Src-and FRG/Vav2-mediated activation of Rac and Cdc42. (2006)
  • Author(s): M urata, T., Ohnishi, H., Okazawa, H., Murata, Y., Kusakari, S., Hayashi, Y., Miyashita, M., Furuya, N., Matozaki, T.
  • Organizer: 20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress
  • Place of Presentation: 国立京都国際会館(京都府)
  • Year and Date: 2006-06-18
• [Presentation] A Novel Intercellular Communication System, The CD47-SHPS-1 System, in Neuronal Network. (2005)
  • Author(s): Ohnishi, H., Miyashita, M., Murata, T., Kaneko, Y., Okazawa, H., Matozaki, T.
  • Organizer: ISN-ESN:20th Biennial Meeting International Society for Neurochemistry jointly with the European Society for Neurochemistry
  • Place of Presentation: Congress Innsbruck(Innsbruck, Austria)
  • Year and Date: 2005-08-25
• [Book] シグナル伝達研究 (2009)
  • Author(s): 的崎尚、岡田雅人, 他
  • Publisher: 羊土社
• [Book] シグナル伝達研究(2008-09 Vol.26 No.15) (2008)
  • Author(s): 的崎尚、岡田雅人、他
  • Total Pages: 248
  • Publisher: 羊土社
• [Remarks]
  • URL: http://www.imcr.gunma-u.ac.jp/lab/biosig/
• [Remarks]
  • URL: http://imcr.showa.gunma-u.ac.jp/lab/brc/index.html
• [Remarks]
  • URL: http://www.imcr.gunma-u.ac.jp/lab/biosig/
• [Patent(Industrial Property Rights)] マクロファージ活性化剤並びにその製造方法及びスクリーニング方法 (2008)
  • Inventor(s): 的崎尚、大西浩史
  • Industrial Property Rights Holder: 国立大学法人群馬大学
  • Filing Date: 2008-12-05
  • Acquisition Date: 2008-12-05
• [Patent(Industrial Property Rights)] Pharmaceutical Composition and Method for Activating Macrophage Using the Same(医薬組成物及びそれを用いたマクロファージの活性化方法) (2008)
  • Inventor(s): 的崎尚、大西浩史
  • Industrial Property Rights Holder: 国立大学法人群馬大学
  • Filing Date: 2008-11-11
  • Acquisition Date: 2008-11-11
• [Patent(Industrial Property Rights)] マクロファージ活性化剤並びにその製造方法及びスクリーニング方法 (2008)
  • Inventor(s): 的崎尚、大西浩史
  • Industrial Property Rights Holder: 国立大学法人群馬大学
  • Acquisition Date: 2008-12-05
• [Patent(Industrial Property Rights)] Pharmaceutical Composition and Method for Activating Macrophage Using the Same(医薬組成物及びそれを用いたマクロファージの活性化方法) (2008)
  • Inventor(s): 的崎尚、大西浩史
  • Industrial Property Rights Holder: 国立大学法人群馬大学
  • Acquisition Date: 2008-11-11
  • Overseas