| Project/Area Number |
17014034
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Kanazawa University |
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Principal Investigator |
TAKUWA Yoh Kanazawa University, 医学系, 教授 (60171592)
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| Co-Investigator(Kenkyū-buntansha) |
OKAMOTO Yasuo 金沢大学, 医学系, 准教授 (80293877)
YOSHIOKA Kazuaki 金沢大学, 医学系, 助手 (80333368)
杉本 直俊 金沢大学, 医学系研究科, 准教授 (80272954)
多久和 典子 石川県立看護大学, 看護学部, 教授 (70150290)
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| Co-Investigator(Renkei-kenkyūsha) |
SUGIMOTO Naotoshi 金沢大学, 医学系, 准教授 (80272954)
TAKUWA Noriko 石川県立看護大学, 看護学部, 教授 (70150290)
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| Project Period (FY) |
2005 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥46,800,000 (Direct Cost: ¥46,800,000)
Fiscal Year 2009: ¥9,100,000 (Direct Cost: ¥9,100,000)
Fiscal Year 2008: ¥9,100,000 (Direct Cost: ¥9,100,000)
Fiscal Year 2007: ¥10,100,000 (Direct Cost: ¥10,100,000)
Fiscal Year 2006: ¥10,100,000 (Direct Cost: ¥10,100,000)
Fiscal Year 2005: ¥8,400,000 (Direct Cost: ¥8,400,000)
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| Keywords | がん / 血管新生 / スフィンゴシン-1-リン酸 / S1P_2 / 血管成熟 / ノックアウトマウス / SIP_2 / S1P / Edg受容体 / 浸潤 / 転移 / 遊走 / Rac / Rho / SIP |
|---|
| Research Abstract |
The lysophospholipid mediator sphingosine-1-phosphate (S1P) exerts positive or negative effects on cell migration and invasion via a receptor family. Among these, the S1P receptor type 2, S1P_2, was found to be expressed in vascular endothelial cells, smooth muscle cells, and bone marrow-derived cells. S1P_2 in the host cells suppresses tumor angiogenesis and tumor growth. On the contrary to previous reports, overexpression of the S1P synthesizing enzyme sphingosine kinase-1 in tumor cells or host tissues does not aggravate tumor progression. S1P_2 in tumor cells and host cells are a potential novel therapeutic target for tumors.
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