| Project/Area Number |
17014055
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
|
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| Research Institution | Kobe University (2008-2009)
Osaka University (2005-2007) |
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Principal Investigator |
TAKAI Yoshimi Kobe University, 大学院・医学研究科, 教授 (60093514)
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| Co-Investigator(Kenkyū-buntansha) |
OGITA Hisakazu 神戸大学, 医学研究科, 准教授 (50379236)
RIKITAKE Yoshiyuki 神戸大学, 医学研究科, 准教授 (50419488)
TOGASHI Hideru 神戸大学, 医学研究科, 助教 (90415240)
SAKISAKA Toshiaki 神戸大学, 医学研究科, 教授 (80359843)
OKAMOTO Miki 大阪府立成人病センター, 分子生物学部門, 研究員 (20332455)
藤田 直之 熊本大学, 医学薬学研究部, 准教授 (50403192)
池田 わたる 大阪大学, 医学系研究科, 助教 (90362699)
|
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| Project Period (FY) |
2005 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥411,600,000 (Direct Cost: ¥411,600,000)
Fiscal Year 2009: ¥83,800,000 (Direct Cost: ¥83,800,000)
Fiscal Year 2008: ¥83,800,000 (Direct Cost: ¥83,800,000)
Fiscal Year 2007: ¥84,000,000 (Direct Cost: ¥84,000,000)
Fiscal Year 2006: ¥84,000,000 (Direct Cost: ¥84,000,000)
Fiscal Year 2005: ¥76,000,000 (Direct Cost: ¥76,000,000)
|
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| Keywords | 細胞増殖 / 細胞運動 / 細胞接着 / 細胞極性 / ネクチン / Necl / インテグリン / アファディン / 増殖因子受容体 / Nec1-5 / がん / Necl - 5 / Necl-5 |
|---|
| Research Abstract |
Cell adhesion molecules nectins and Necls were found to crucially regulate various cellular functions, including cell adhesion, polarization, morphology, movement, proliferation, differentiation, and survival, in cooperation with growth factor receptors and integrins. The molecular mechanisms underlying these functions were clearly elucidated. The dysfunctions of nectins and Necls were shown to be involved in the abnormal proliferation of cancer cells, leading to tumor invasion and metastasis. It was proposed that the normalization of the dysfunctions is the key to develop a new type of anti-cancer therapy.
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