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Molecular dissection of molecular pathogenesis of lung cancer towards realization of personalized medicine

Research Project

Project/Area Number 17015019
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionNagoya University

Principal Investigator

TAKAHASHI Takashi  Nagoya University, 大学院・医学系研究科, 教授 (50231395)

Co-Investigator(Kenkyū-buntansha) YANAGISAWA Kiyoshi  名古屋大学, 高等研究院, 特任講師 (20372112)
TOMIDA Shuta  名古屋大学, 大学院・医学系研究科, 助教 (10372111)
YAMAGUCHI Tomoya  名古屋大学, 大学院・医学系研究科, 助教 (70452191)
Co-Investigator(Renkei-kenkyūsha) YANAGISAWA Kiyoshi  名古屋大学, 高等研究院, 特任講師 (20372112)
YAMAGUCHI Tomoya  名古屋大学, 大学院・医学系研究科, 助教 (70452191)
Project Period (FY) 2005 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥159,800,000 (Direct Cost: ¥159,800,000)
Fiscal Year 2009: ¥31,700,000 (Direct Cost: ¥31,700,000)
Fiscal Year 2008: ¥31,700,000 (Direct Cost: ¥31,700,000)
Fiscal Year 2007: ¥31,700,000 (Direct Cost: ¥31,700,000)
Fiscal Year 2006: ¥31,700,000 (Direct Cost: ¥31,700,000)
Fiscal Year 2005: ¥33,000,000 (Direct Cost: ¥33,000,000)
Keywords肺がん / マイクロアレイ / プロテオミクス / マイクロRNA / バイオインフォマティクス / 分子腫瘍医学 / 網羅的遺伝子発現解析 / マイクロアレー / 分子種瘍医学 / マクロアレー
Research Abstract

Our multi-faceted approach towards a better understanding of lung cancer pathogenesis revealed that two major expression profile-defined subtypes exist in lung adenocarcinomas and that TTF-1 confers lineage-specific dependency in lung adenocarcinomas. In addition, we identified mRNA and protein expression signatures highly related to postoperative prognosis, while we also found relationship between deregulation of mTOR-converging signaling and poor prognosis. Finally, we reported for the first time that let-7 is reduced, while miR-17-92 is overexpressed in lung cancers, suggesting important roles of miRNA alterations in lung carcinogenesis.

Report

(6 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (122 results)

All 2010 2009 2008 2007 2006 2005 2004 Other

All Journal Article (97 results) (of which Peer Reviewed: 64 results) Presentation (13 results) Book (1 results) Remarks (1 results) Patent(Industrial Property Rights) (10 results)

  • [Journal Article] Proteasomal non-catalytic subunit PSMD2 as a potential therapeutic target in association with various clinicopathologic features in lung adenocarcinomas2010

    • Author(s)
      Matsuyama, Y., Suzuki, M., Arima, C., Huang, Q.M., Tomida, S., Takeuchi, T., Sugiyama, R., Itoh, Y., Yatabe, Y., Goto, H., Takahashi, T.
    • Journal Title

      Mol. Carcinogenesis (in press)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Functions of base selection step in human DNA polymerase alpha DNA Repair2010

    • Author(s)
      Tanaka, S., Cao, K., Niimi, A., Limsirichaikul, S., Huang, Q., Nakamura, N., Murate, T., Hasegawa, Y., Takahashi, T., Suzuki M.
    • Journal Title

      DNA Repair (in press)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Roles of POLD4, smallest subunit of DNA polymeraseδin nuclear structures and genomic stability of human cells2010

    • Author(s)
      Huang, Q.A., Akashi, T., Matsuda, Y., Kamiya, K., Takahashi, T., Suzuki, M.
    • Journal Title

      Biochem. Biophys. Res. Comm. 391

      Pages: 542-546

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Homozygous deletion of CDKN2A/2B is a hallmark of iron-induced high-grade rat mesothelioma2010

    • Author(s)
      Hu Q, Akatsuka S, Yamashita Y, Ohara H, Nagai H, Okazaki Y, Takahashi T,, Toyokuni S.
    • Journal Title

      Lab. Invest. (in press)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Proteasomal non-catalytic subunit PSMD2 as a potential therapeutic target in association with various clinicopathologic features in lung adenocarcinomas.2010

    • Author(s)
      Matsuyama Y, et al.
    • Journal Title

      Mol.Carcinogenesis (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functions of base selection step in human DNA polymerase alpha DNA Repair.2010

    • Author(s)
      Tanaka S, et al.
    • Journal Title

      DNA Repair (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Roles of POLD4, smallest subunit of DNA polymerase δ, in nuclear structures and genomic stability of human cells.2010

    • Author(s)
      Huang QA, et al.
    • Journal Title

      Biochem.Biophys.Res.Comm. 391

      Pages: 542-546

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Homozygous deletion of CDKN2A/2B is a hallmark of iron-induced high-grade rat mesothelioma.2010

    • Author(s)
      Hu Q, et al.
    • Journal Title

      Lab.Invest. (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endogenous angiogenesis inhibitor vasohibinl exhibits a broad-spectrumanti-lymphangiogenic activity and suppresses lymph node metastasis.2010

    • Author(s)
      Heishi T, et al.
    • Journal Title

      Am.J.Pathol. (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relapse-related molecular signature in lung adenocarcinomas identifies patients with dismal prognosis2009

    • Author(s)
      Tomida, S., Takeuchi, T., Shimada, Y., Arima, C., Matsuo, K., Mitsudomi, T., Yatabe, Y.,, Takahashi, T.
    • Journal Title

      J. Clin. Oncol. 27

      Pages: 2793-2799

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Relationship of deregulated signaling converging onto mTOR with prognosis and classification of lung adenocarcinoma shown by two independent in silico analyses2009

    • Author(s)
      Ebi, H. *, Tomida, S., * Takeuchi, T., Arima, C., Sato, T., Mitsudomi, T., Yatabe, Y., Osada, H.,, Takahashi, T.
    • Journal Title

      Cancer Res. 69

      Pages: 4027-2035

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Counterbalancing influence of miR-17-92 overexpression on adverse effects of RB inactivation in lung cancers2009

    • Author(s)
      Ebi, H. *, Sato, T. *, Sugito, N., Hosono, Y., Suzuki, M., Yamaguchi, T., Yatabe, Y., Osada, H.,, Takahashi, T.
    • Journal Title

      Oncogene 28

      Pages: 3371-3379

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] PCNA Mono-ubiquitination and Activation of Translesion DNA Polymerases by DNA Polymeraseα2009

    • Author(s)
      Suzuki M, Niimi A, Limsirichaikul S, Tomida S, Huang QM, Izuta S, Usukura J, Itoh Y, Hishida T, Akashi T, Nakagawa Y, Kikuchi A, Pavlov Y, Murate T,, Takahashi T.
    • Journal Title

      J. Biochem. 146

      Pages: 13-21

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neuroendocrine cancer-specific up-regulating mechanism of insulin-like growth factor binding protein-2 in small cell lung cancer2009

    • Author(s)
      Yazawa, T., Sato, H., Shimoyamada, H., Okudela, K., Woo, H., Tajiri, M., Ogura, T., Ogawa, N., Suzuki, T., Mitsui, H., Ishii, J., Miyata, C., Sakaeda, M., Goto, K., Kashiwagi, K., Masuda, M., Takahashi, T.,, Kitamura, H.
    • Journal Title

      Am. J. Pathol. 175

      Pages: 976-987

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Relapse-related molecular signature in lung adenocarcinomas identifies patients with dismal prognosis.2009

    • Author(s)
      Tomida S, et al.
    • Journal Title

      J.Clin.Oncol. 27

      Pages: 2793-2799

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship of deregulated signaling converging onto mTOR with prognosis and classification of lung adenocarcinoma shown by two independent in silico analyses.2009

    • Author(s)
      Ebi H, et al.
    • Journal Title

      Cancer Res. 69

      Pages: 4027-4035

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Counterbalancing influence of miR-17-92 overexpression on adverse effects of RB inactivation in lung cancers.2009

    • Author(s)
      Ebi H, et al.
    • Journal Title

      Oncogene 28

      Pages: 3371-3379

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PCNA mono-ubiquitination and activation of translesion DNA polymerases by DNA polymerasea α2009

    • Author(s)
      Suzuki M, et al.
    • Journal Title

      J.Biochem. 146

      Pages: 13-21

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neuroendocrine cancer-specific up-regulating mechanism of insulin-like growth factor binding protein-2 in small cell lung cancer.2009

    • Author(s)
      Yazawa T, et al.
    • Journal Title

      Am.J.Pathol. 175

      Pages: 976-987

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Down-regulation of DUSP6 expression in lung cancers : its mechanism and potential role in carcinogenesis.2009

    • Author(s)
      Okudera K, et al.
    • Journal Title

      Am.J.Pathol. 175

      Pages: 867-881

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A bone metastasis model with osteolytic and osteoblastic properties of human lung cancer ACC-LC-319/bone 2 in natural killer cell-depleted severe combined immunodeficient mice.2009

    • Author(s)
      Otsuka S, et al.
    • Journal Title

      Oncol.Res. 17

      Pages: 581-591

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relapse-related molecular signature in lung adenocarcinomas identifies patients with dismal prognosis2009

    • Author(s)
      Tomida S, et.al.
    • Journal Title

      Journal of Clinical Oncology (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship of deregulated signaling converging onto mTOR with prognosis and classification of lung adenocarcinoma shown by two independent in silico analyses2009

    • Author(s)
      Ebi H, et.al.
    • Journal Title

      Cancer Research (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of HIF-1α as a novel target for miR-17-92 microRNA cluster2008

    • Author(s)
      Taguchi, A., Yanagisawa, K., Tanaka, M., Cao, K., Matsuyama, Y., Goto, H.,, Takahashi, T.
    • Journal Title

      Cancer Res. 68

      Pages: 5540-5545

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Roles of ASH1 in DKK1 and E-cadherin repression and neuroendocrine differentiation in lung cancer2008

    • Author(s)
      Osada, H., Tomida, S., Yatabe, Y., Tatematsu, Y., Takeuchi, T., Murakami, H., Kondo, Y., Sekido, Y., Takahashi, T.
    • Journal Title

      Cancer Res. 68

      Pages: 1647-1655

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Detailed characterization of a homozygously deleted region corresponding to a candidate tumor suppressor locus at 21q11-21 in human lung cancer2008

    • Author(s)
      Yamada, H., Yanagisawa, K., Tokumaru, S., Taguchi, A., Nimura, Y., Osada, H., Nagino, M.,, Takahashi, T.
    • Journal Title

      Genes, Chromosomes, Cancer. 47

      Pages: 810-818

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Epidermal growth factor receptor gene amplification is acquired in association with tumor progression of EGFR-mutated lung cancer2008

    • Author(s)
      Yatabe, Y., Takahashi, T.,, Mitsudomi, T.
    • Journal Title

      Cancer Res. 68

      Pages: 2106-2111

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] let-7 regulates Dicer expression and constitutes a negative feedback loop2008

    • Author(s)
      Tokumaru, S., Suzuki, M., Yamada, H., Nagino, N., Takahashi, T.
    • Journal Title

      Carcinogenesis 29

      Pages: 2073-2077

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of H/F-1α as a novel target for miR-17-92 microRNA cluster2008

    • Author(s)
      Taguchi A, et.al.
    • Journal Title

      Cancer Research 68

      Pages: 1647-1655

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Roles of ASHI in DKK 1 and E-cadherin repression and neuroendocrine differentiation in lung cancer2008

    • Author(s)
      Osada H, et.al.
    • Journal Title

      Cancer Research 68

      Pages: 1647-1655

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epidermal growth factor receptor gene amplification is acquired in association with tumor progression of EGFR-mutated lung cancer2008

    • Author(s)
      Yatabe Y, et.al.
    • Journal Title

      Cancer Research 68

      Pages: 2106-2111

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] let-7 regulates Dicer expression and constitutes a negative feedback loop2008

    • Author(s)
      Tokumaru S, et.al.
    • Journal Title

      Carcinogenesis 29

      Pages: 2073-2077

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Detailed characterization of a homozygously deleted region corresponding to a candidate tumor suppressor locus at 21 q 11-21 in human lung cancer2008

    • Author(s)
      Yamada H, et.al.
    • Journal Title

      Genes, Chromosomes & Cancer 47

      Pages: 810-818

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] mRNA expression of RRM 1, ERCC 1 and ERCC 2 is not associated with chemosensitivity to cisplatin, carboplatin and gemcitabine in human lung cancer cell lines2008

    • Author(s)
      Shimizu J, et.al.
    • Journal Title

      Respirology 13

      Pages: 510-517

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Roles of ASHI in DKKI and E-cadherin repression and neuroendocrine differentiation in lung cancer.2008

    • Author(s)
      Osada H, et. al.
    • Journal Title

      Cancer Res. (in press)

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Identification of a metastasis signature and the DLX4 homeobox protein as a regulator of metastasis by combined transcriptome approach2007

    • Author(s)
      Tomida, S., * Yanagisawa, K., * Koshikawa, K., Yatabe, Y., Mitsudomi, T., Osada, H., Takahashi, T.
    • Journal Title

      Oncogene 26

      Pages: 4600-4608

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] CLCP1 interacts with semaphorin 4B and regulates motility of lung cancer cells2007

    • Author(s)
      Nagai, H., Sugito, N., Matsubara, H., Tatematsu, Y., Hida, T., Sekido, Y., Nagino, M., Nimura, Y., Takahashi, T.,, Osada, H.
    • Journal Title

      Oncogene 26

      Pages: 4025-4031

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Apoptosis induction by antisense oligonucleotides against miR-17-5p and miR-20a in lung cancers overexpressing miR-17-922007

    • Author(s)
      Matsubara, H. *, Takeuchi, T. *, Nishikawa, E. *, Yanagisawa, K., Hayashita, Y., Ebi, H., Yamada, H., Suzuki, M., Nagino, M., Nimura, Y., Osada, H., Takahashi, T.
    • Journal Title

      Oncogene 26

      Pages: 6099-6105

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] A 25-signal proteomic signature and outcome for patients with resected non-small-cell lung cancer2007

    • Author(s)
      Yanagisawa, K., * Tomida, S., * Shimada, Y., Yatabe, Y., Mitsudomi, T., Takahashi, T.
    • Journal Title

      J. Natl. Cancer Inst. 99

      Pages: 858-867

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lineage-specific dependency of lung adenocarcinomas on the lung development regulator TTF-12007

    • Author(s)
      Tanaka, H., * Yanagisawa, K., * Shinjo, K., Taguchi, A., Maeno, K., Tomida, S., Shimada, Y., Osada, H., Kosaka, T., Matsubara, H., Mitsudomi, T., Sekido, Y., Tanimoto, M., Yatabe, Y.,, Takahashi, T.
    • Journal Title

      Cancer Res. 67

      Pages: 6007-6011

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression profiling of genes regulated by TGF-beta: Differential regulation in normal and tumour cells2007

    • Author(s)
      Ranganathan, P., Agrawal, A., Bhushan, R., Chavalmane, A.K., Kalathur, R.K.R., Takahashi, T., Kondaiah P.
    • Journal Title

      BMC Genomics 8

      Pages: 98-98

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Non-genomic β estrogen receptors enhance β1 adrenergic signaling induced by the nicotine-derived carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in human small airway epithelial cells2007

    • Author(s)
      Majidi, M., Al-Wadei, H.A., Takahashi, T., Schuller H.M.
    • Journal Title

      Cancer Res. 67

      Pages: 6863-6871

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Novel NBS1 heterozygous germline mutation causing MRE11-binding domain loss predisposes to common types of cancer2007

    • Author(s)
      Ebi, H., Matsuo, K., Sugito, N., Suzuki, M., Osada, H., Tajima, K., Ueda, R.,, Takahashi, T.
    • Journal Title

      Cancer Res. 67

      Pages: 11158-11165

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] MicroRNAs in Biological Processes and Carcinogenesis2007

    • Author(s)
      Osada, H., Takahashi, T.
    • Journal Title

      Carcinogenesis 28

      Pages: 2-12

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of a metastasis signature and the DLX4 homeobox protein as a regulator of metastasis by combined transcriptome approach.2007

    • Author(s)
      Tomida S, et. al.
    • Journal Title

      Oncogene 26

      Pages: 466-4608

    • Related Report
      2007 Annual Research Report
  • [Journal Article] CLCPI interacts with semaphorin 4B and regulates motility of lung cancer cells2007

    • Author(s)
      Nagai H, et. al.
    • Journal Title

      Oncogene 26

      Pages: 4025-4031

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Apoptosis induction by antisense oligonucleotides against miR-17-5p and miR-20a in lung cancers overexpressing miR-17-92.2007

    • Author(s)
      Matsubara H, et. al.
    • Journal Title

      Oncogene 26

      Pages: 6099-6105

    • Related Report
      2007 Annual Research Report
  • [Journal Article] A25-signal proteomic signature and outcome for patients with resectednon-small-cell lung cancer.2007

    • Author(s)
      Yanagisawa K, et. al.
    • Journal Title

      J. Natl. Cancer Inst. 99

      Pages: 858-867

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Lineage-specific dependency of lung adenocarcinomas on the lung development regulator TTF-1.2007

    • Author(s)
      Tanaka H, et. al.
    • Journal Title

      Cancer Res. 67

      Pages: 6007-6011

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Novel NBS1 heterozygous germline mutation causing MRE 11-binding domain loss predisposes to common types of cancer.2007

    • Author(s)
      Ebi H, et. al.
    • Journal Title

      Cancer Res. 67

      Pages: 11158-11165

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Non-genomic β estrogen receptors enhance β1 adrenergic signaling induced by the nicotine-derived carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in human small airway epithelial cells2007

    • Author(s)
      Majidi M, et. al.
    • Journal Title

      Carcinogenesis 67

      Pages: 6863-6871

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Disproportionate representation of KRAS gene mutation in atypical adenomatous hyperplasia, but even distribution of EGFR genemutation from preinvasive to invasive adenocarcinomas.2007

    • Author(s)
      Sakamoto H, et. al.
    • Journal Title

      J. Pathol. 212

      Pages: 287-294

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Identification of a metastasis signature and the DLX4 homeobox protein as a regulator of metastasis by combined transcriptome approach.2007

    • Author(s)
      Onozato R, et. al.
    • Journal Title

      Cancer Sci. 98

      Pages: 1747-1751

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Aryl radical involvement in amiodarone-induced pulmonary toxicity: Investigation of cytoprotection by spin trapping nitorones.2007

    • Author(s)
      Nicolescu AC, et. al.
    • Journal Title

      Toxicol. Appl. Pharmacol. 220

      Pages: 60-71

    • Related Report
      2007 Annual Research Report
  • [Journal Article] hDREF regulates cell proliferation and expression of ribosomal protein genes.2007

    • Author(s)
      Yamashita D, et. al.
    • Journal Title

      Mol. Cell. Biol. 27

      Pages: 2003-2013

    • Related Report
      2007 Annual Research Report
  • [Journal Article] hDREF regulates cell proliferation and expression of ribosomal protein genes.2007

    • Author(s)
      Yamashita D et al.
    • Journal Title

      Molecular and Cellular Biology 27

      Pages: 2003-2013

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Identification of a metastasis signature and the DLX4 homeobox protein as a regulator of metastasis by combined transcriptome approach.2007

    • Author(s)
      Tomida S et al.
    • Journal Title

      Oncogene (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Apoptosis induction by antisense oligonucleotides against miR-17-5p and miR-20a in lung cancers overexpressing miR-17-92.2007

    • Author(s)
      Matsubara H et al.
    • Journal Title

      Oncogene (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] CLCP1 interacts with semaphorin 4B and regulates motility of lung cancer cells.2007

    • Author(s)
      Nagai H et al.
    • Journal Title

      Oncogene (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] MicroRNAs in biological processes and carcinogenesis.2007

    • Author(s)
      Osada H et al.
    • Journal Title

      Carcinogenesis 28

      Pages: 2-12

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Expression profile-defined classification of lung adenocarcinoma shows close relationship with underlying major genetic changes and clinicopathologic behaviors2006

    • Author(s)
      Takeuchi, T., * Tomida, S., * Yatabe, Y., Kosaka, T., Osada, H., Yanagisawa, K., Mitsudomi, T.,, Takahashi, T.
    • Journal Title

      J. Clin. Oncol. 24

      Pages: 1679-1688

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Altered regulation of c-jun and its involvement in anchorage-independent growth of human lung cancers2006

    • Author(s)
      Maeno, K., Masuda, A., Yanagisawa, K., Konishi, H., Osada, H., Saito, T., Ueda, R.,, Takahashi, T.
    • Journal Title

      Oncogene 25

      Pages: 271-277

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fundamental study of small interfering RNAs for ganglioside GD3 synthase gene as a therapeutic target of lung cancers2006

    • Author(s)
      Ko, K., Furukawa, K., Takahashi, T., Urano, T., Sanai, Y., Nagino, M., Nimura, Y.,, Furukawa, K.
    • Journal Title

      Oncogene 25

      Pages: 6924-6935

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Growth regulation via insulin-like growth factor binding protein-4 and -2 in association with mutant K-ras in lung epithelia2006

    • Author(s)
      Sato, H., Yazawa, T., Suzuki, T., Shimoyamada, H., Okudela, K., Ikeda, M., Hamada, K., Yamada-Okabe, H., Yao, M., Kubota, Y., Takahashi, T., Kamma, H., Kitamura H.
    • Journal Title

      Am J Pathol. 169

      Pages: 1550-1566

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression profile-defined classification of lung adenocarcinoma shows close relationship with underlying major genetic changes and clinicopathologic behaviors.2006

    • Author(s)
      Takeuchi T et al.
    • Journal Title

      Journal of Clinical Oncology 24

      Pages: 155-160

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Altered regulation of c-jun and its involvement in anchorage-independent growth of human lung cancers.2006

    • Author(s)
      Maeno K et al.
    • Journal Title

      Oncogene 25

      Pages: 271-277

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Growth regulation via insulin-like growth factor binding protein-4 and -2 in association with mutant K-ras in lung epithelia.2006

    • Author(s)
      Sato H et al.
    • Journal Title

      American Journal of Pathology 169

      Pages: 1550-1556

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Growth stimulation of human pulmonary adenocarcinoma cells and small airway epithelial cells by beta-carotene via activation of cAMP, PKA, CREB and ERK1/2.2006

    • Author(s)
      Al-Wadei HA et al.
    • Journal Title

      International Journal of Cancer 118

      Pages: 1370-1380

    • Related Report
      2006 Annual Research Report
  • [Journal Article] A rapid, sensitive assay to detect EGFR mutation in small biopsy specimens from lung cancer.2006

    • Author(s)
      Yatabe Y et al.
    • Journal Title

      Journal of Molecular Diagnosis 8

      Pages: 335-341

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Fundamental study of small interfering RNAs for gaglioside GD3 synthase gene as a therapeutic target of lung cancers.2006

    • Author(s)
      Ko K et al.
    • Journal Title

      Oncogene 25

      Pages: 6924-6935

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Altered regulation of c-jun and its involvement in anchorage-independent growth of human lung cancers.2006

    • Author(s)
      Maeno, K., et al.
    • Journal Title

      Oncogene 25

      Pages: 271-277

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Growth stimulation of human pulmonary adenocarcinoma cells and small airway epithelial cells by β-carotene via activation of cAMP, PKA, CREB and ERK1/2.2006

    • Author(s)
      Al-Wadei, H.A., et al.
    • Journal Title

      International Journal of Cancer (in press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] A polycistronic miRNA cluster, miR-17-92, is overexpressed in human lung cancers and enhances cell proliferation2005

    • Author(s)
      Hayashita, Y., * Osada, H., * Tatematsu, Y., Yamada, H., Yanagisawa, K., Tomida, S., Kawahara, K., Sekido, Y.,, Takahashi, T.
    • Journal Title

      Cancer Res. 65

      Pages: 9628-9632

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] The ASH1 gene is a specific therapeutic target for lung cancers with neuroendocrine features2005

    • Author(s)
      Osada, H., Tatematsu, Y., Yatabe, Y., Horio, Y.,, Takahashi, T.
    • Journal Title

      Cancer Res. 65

      Pages: 10680-10685

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Histone modification in the TGFβRII gene promoter and its significance for responsiveness to HDAC inhibitor in lung cancer cell lines2005

    • Author(s)
      Osada, H,. Tatematsu, Y., Sugito, N., Horio, Y.,, Takahashi T.
    • Journal Title

      Mol. Carcinog. 44

      Pages: 233-241

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reduced expression of Dicer associated with poor prognosis in lung cancer patients2005

    • Author(s)
      Karube, Y., Tanaka, H., Osada, H., Tomida, S., Tatematsu, Y., Yanagisawa, K., Yatabe, Y., Takamizawa, J., Miyoshi, S., Mitsudomi, T.,, Takahashi, T.
    • Journal Title

      Cancer Sci. 96

      Pages: 111-115

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mutations of the epidermal growth factor receptor gene predict prolonged survival after gefitinib treatment in patients with non-small cell lung cancer with postoperative recurrence2005

    • Author(s)
      Mitsudomi, T., Kosaka, T., Endoh, H., Horio, Y., Hida, T., Mori, S., Hatooka, S., Shinoda, M., Takahashi, T., Yatabe, Y.
    • Journal Title

      J. Clin. Oncol. 23

      Pages: 2513-2520

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] EGFR mutation is specific for terminal respiratory unit type adenocarcinoma2005

    • Author(s)
      Yatabe, Y., Kosaka, T., Takahashi, T., Mitsudomi, T.
    • Journal Title

      Am. J. Surg. Pathol. 29

      Pages: 633-639

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Vascular endothelial cell growth factor receptor 3-mediated activation of lymphatic endothelium is crucial for tumor cell entry and spread via lymphatic vessels2005

    • Author(s)
      He, Y., Rajantie, I., Pajusola, K., Jeltsch, M., Holopainen, T., Yla-Herttuala, S., Harding, T., Jooss, K., Takahashi, T.,, Alitalo, K.
    • Journal Title

      Cancer Res. 65

      Pages: 4739-4746

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Throwing new light on lung cancer pathogenesis: updates on three recent topics2005

    • Author(s)
      Tomida, S., Yatabe, Y., Yanagisawa, K., Mitsudomi, T.,, Takahashi, T.
    • Journal Title

      Cancer Sci. 96

      Pages: 63-68

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Polycistronic miRNA cluster, miR-17-92, is overexpressed in human lung cancers and enhances cell proliferation.2005

    • Author(s)
      Hayashita, Y., et al.
    • Journal Title

      Cancer Research 65

      Pages: 9628-9632

    • Related Report
      2005 Annual Research Report
  • [Journal Article] The ASH1 gene is a specific therapeutic target for lung cancers with neuroendocrine features.2005

    • Author(s)
      Osada, H., et al.
    • Journal Title

      Cancer Research 65

      Pages: 10680-10685

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Histone modification in the TGFβRII gene promoter and its significance for responsiveness to HDAC inhibitor in lung cancer cell lines.2005

    • Author(s)
      Osada, H., et al.
    • Journal Title

      Molecular Carcinogenesis 44

      Pages: 233-241

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Vascular endothelial cell growth factor receptor 3-mediated activation of lymphatic endothelium is crucial for tumor cell entry and spread via lymphatic vessels.2005

    • Author(s)
      He Y., et al.
    • Journal Title

      Cancer Research 65

      Pages: 10680-10685

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Polycistronic miRNA cluster, miR-17-92, is overexpressed in human lung cancers and enhances cell proliferation.2005

    • Author(s)
      Mitsudomi, T., et al.
    • Journal Title

      Journal of Clinical Oncology 23

      Pages: 2513-2520

    • Related Report
      2005 Annual Research Report
  • [Journal Article] EGFR mutation is specific for terminal respiratory unit type adenocarcinoma.2005

    • Author(s)
      Yatabe, Y., et al.
    • Journal Title

      American Journal of Surgical Pathology 29

      Pages: 633-639

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Restoration of TGF-b signaling reduces tumorigenecity in human lung cancer cells.2005

    • Author(s)
      Anumanthan, G., et al.
    • Journal Title

      British Journal of Cancer 93

      Pages: 1157-1167

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Prognostic model of pulmonary adenocarcinoma by expression profiling of eight genes as determined by quantitative real-time RT-PCR2004

    • Author(s)
      Endoh, H., Tomida, S., Yatabe, Y., Konishi, H., Osada, H., Tajima, K., Kuwano, H., Takahashi, T.,, Mitsudomi, T.
    • Journal Title

      J. Clin. Oncol. 22

      Pages: 811-819

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] K-ras gene mutation enhances motility of immortalized airway cells and lung adenocarcinoma cells via Akt activation (possible contribution to non-invasive expansion of lung adenocarcinoma)2004

    • Author(s)
      Okudela, K., Hayashi, H., Ito, T., Yazawa, T., Suzuki, T., Nakane, Y., Sato, H., Ishi, H., Keqin, X, Masuda, A., Takahashi, T.,, Kitamura, H.
    • Journal Title

      Am. J. Pathol. 164

      Pages: 91-100

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Maspin expression in normal lung and non-small-cell lung cancers: cellular property-associated expression under the control of promotoer DNA methylation2004

    • Author(s)
      Yatabe, Y., Mitsudomi, T.,, Takahashi T.
    • Journal Title

      Oncogene 23

      Pages: 4041-4049

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] CK20 expression, CDX2 expression, K-ras mutation, and globet cell morphology in a subset of lung adenocarcinomas2004

    • Author(s)
      Yatabe, Y., Koga, T., Mitsudomi, T.,, Takahashi, T.
    • Journal Title

      J. Pathol. 203

      Pages: 645-652

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reduced expression of class II HDAC genes are associated with poor prognosis in lung cancer patients2004

    • Author(s)
      Osada H., Tatematsu, Y., Saito, H., Yatabe, Y., Mitsudomi, T.,, Takahashi, T.
    • Journal Title

      Int. J. Cancer 112

      Pages: 26-32

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gene expression-based, individualized outcome prediction of surgically treated lung cancer patients2004

    • Author(s)
      Tomida, S., * Koshikawa, K., * Yatabe, Y., Harano, T., Ogura, N., Mitsudomi, T., Some, M., Yanagisawa, K., Takahashi, T., Osada, H.,, Takahashi, T.
    • Journal Title

      Oncogene 23

      Pages: 5360-5370

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival2004

    • Author(s)
      Takamizawa, J. *, Konishi, H. *, Yanagisawa, K., Tomida, S., Osada, T., Harano, T., Yatabe, Y., Nagino, M., Nimura, Y., Mitsudomi, T.,, Takahashi, T.
    • Journal Title

      Cancer Res. 64

      Pages: 3753-3756

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of decatenation G2 checkpoint impairment independently of DNA damage G2 checkpoint in human lung cancer cell lines2004

    • Author(s)
      Nakagawa, T., Hayashita, Y., Maeno, K., Masuda, A., Sugito, N., Osada, T., Hideki, E., Yanagisawa, K., Ebi, H., Shimokata, K.,, Takahashi, T.
    • Journal Title

      Cancer Res. 64

      Pages: 4826-4832

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mutations of the epidermal growth factor receptor gene in lung cancer: biological and clinical implications2004

    • Author(s)
      Kosaka, T., Yatabe, Y., Endoh, H., Kuwano, H., Takahashi, T.,, Mitsudomi, T.
    • Journal Title

      Cancer Res. 64

      Pages: 8919-8923

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression profile-defined classification of lung adenocarcinoma shows close relationship with underlyin major genetic changes and clinicopathologic behaviors.

    • Author(s)
      Takeuchi, T., et al.
    • Journal Title

      Journal of Clinical Oncology (in press)

    • Related Report
      2005 Annual Research Report
  • [Presentation] MicroRNA alterations in the pathogenesis of lung cancers.2010

    • Author(s)
      Takahashi T
    • Organizer
      8^<th> AACR-JCA Joint Conference.
    • Place of Presentation
      Waikoloa, USA
    • Year and Date
      2010-02-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] MicroRNA alterations in the pathogenesis of lung cancers.2010

    • Author(s)
      Takahashi T
    • Organizer
      1^<st> AACR-IASLC Joint Conference
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2010-01-13
    • Related Report
      2009 Annual Research Report
  • [Presentation] MicroRNA alterations in the pathogenesis of lung cancers2010

    • Author(s)
      Takahashi, T.
    • Organizer
      1st AACR-IASLC Joint Conference: Molecular Origins of Lung Cancer: Prospects for Personalized Prevention and Therapy
    • Place of Presentation
      San Diego, USA
    • Related Report
      2009 Final Research Report
  • [Presentation] Expression profiling-based approaches for a better understanding of human lung cancer biology.2009

    • Author(s)
      Takahashi T
    • Organizer
      13^<th> World Conference on Lung Cancer, IASLC.
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2009-08-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] Expression profiling-based approaches for a better understanding of human lung cancer biology2009

    • Author(s)
      Takahashi, T.
    • Organizer
      13th World Conference on Lung Cancer, IASLC
    • Place of Presentation
      San Francisco, USA
    • Related Report
      2009 Final Research Report
  • [Presentation] ヒト肺癌の多様性の理解を目指して(シンポジウム)2008

    • Author(s)
      高橋隆
    • Organizer
      第31回日本分子生物学会年会第81回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-11
    • Related Report
      2008 Annual Research Report
  • [Presentation] ゲノム情報の読出しに反映された肺腺癌の分子病態の多様性(シンポジウム)2008

    • Author(s)
      高橋隆
    • Organizer
      第49回日本肺癌学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-11-13
    • Related Report
      2008 Annual Research Report
  • [Presentation] ヒト肺癌の病態とマイクロRNAの異常(シンポジウム)2008

    • Author(s)
      高橋隆
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] ヒト癌の分子病態の多様性 : 網羅的発現解析による描出と応用(教育講演)2008

    • Author(s)
      高橋隆
    • Organizer
      第19回日本消化器癌発生学会総会
    • Place of Presentation
      別府
    • Year and Date
      2008-08-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] Omics views of lung cancers. (シンポジウム)2008

    • Author(s)
      Takahashi T
    • Organizer
      2^<nd> Asian Pacific conference on perspectives in lung cancer
    • Place of Presentation
      Sapporo, Japan
    • Year and Date
      2008-08-02
    • Related Report
      2008 Annual Research Report
  • [Presentation] Improved integrative "omics" view and an unresolved question in lung cancer pathoeenesis (ラークショップ)2008

    • Author(s)
      Takahashi T
    • Organizer
      1^<st> European Lung Cancer Conference
    • Place of Presentation
      Geneva, Switzerland
    • Year and Date
      2008-04-25
    • Related Report
      2008 Annual Research Report
  • [Presentation] Improved integrative "omics" view and an unresolved question in lung cancer pathogenesis2008

    • Author(s)
      Takahashi, T.
    • Organizer
      1st European Lung Cancer Conference
    • Place of Presentation
      Geneva, Switzerland
    • Related Report
      2009 Final Research Report
  • [Presentation] Multidirectional dissection of the molecular pathogenesis of lung cancers2005

    • Author(s)
      Takahashi, T.
    • Organizer
      The 11th World Conference on Lung Cancer - International Association for the Study of Lung Cancer
    • Place of Presentation
      Barcelona, Spain
    • Related Report
      2009 Final Research Report
  • [Book] Biology of lung cancer.(RJ Mason, VC Broaddus JF Murray, JA Nadel,(eds.), Textbook of Respiratory Medicine., 4th edition)2005

    • Author(s)
      Takahashi T., Sidransky, D.
    • Publisher
      Elsevier Science
    • Related Report
      2009 Final Research Report
  • [Remarks] 平成19年6月7付 読売新聞、日本経済新聞、中日新聞、日刊工業新聞「肺癌症例の術後予後の予測に有用な25 種類のタンパクで構成されるタンパク発現パターンの抽出に成功し、分子病態解明と個別化治療(オーダーメード医療)の実現に大きく寄与し得る結果を得た。」との内容で新聞報道された。

    • Related Report
      2009 Final Research Report
  • [Patent(Industrial Property Rights)] 細胞増殖阻害剤2008

    • Inventor(s)
      高橋隆、山口知也、冨田秀太
    • Industrial Property Rights Holder
      名古屋大学
    • Filing Date
      2008-07-18
    • Related Report
      2009 Final Research Report
  • [Patent(Industrial Property Rights)] 細胞増殖阻害剤2008

    • Inventor(s)
      高橋隆, 山口知也, 冨田秀太
    • Industrial Property Rights Holder
      国立大学法人名古屋大学
    • Industrial Property Number
      2008-187857
    • Filing Date
      2008-07-18
    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] 肺腺癌患者の術後再発を予測するための方法及び組成物2007

    • Inventor(s)
      高橋隆、冨田秀太、竹内俊幸, 他
    • Industrial Property Rights Holder
      名古屋大学、(株)オンコミクス、愛知県
    • Filing Date
      2007-12-28
    • Related Report
      2009 Final Research Report
  • [Patent(Industrial Property Rights)] 肺腺癌患者の術後再発を予測するための方法及び組成物2007

    • Inventor(s)
      高橋隆、冨田秀太、竹内俊幸、他
    • Industrial Property Rights Holder
      名古屋大学、(株)オンコミクス、愛知県
    • Industrial Property Number
      2007-339214
    • Filing Date
      2007-12-28
    • Related Report
      2007 Annual Research Report
  • [Patent(Industrial Property Rights)] がん転移抑制組成物2006

    • Inventor(s)
      高橋隆、柳澤聖、冨田秀太, 他
    • Industrial Property Rights Holder
      名古屋大学、愛知県
    • Filing Date
      2006-12-28
    • Related Report
      2009 Final Research Report
  • [Patent(Industrial Property Rights)] がん転移抑制組成物2006

    • Inventor(s)
      高橋隆、柳澤聖、冨田秀太, 他
    • Industrial Property Rights Holder
      名古屋大学、愛知県
    • Filing Date
      2006
    • Related Report
      2009 Final Research Report
  • [Patent(Industrial Property Rights)] 癌の新規治療用組成物2006

    • Inventor(s)
      高橋隆, 柳澤聖, 他1名
    • Industrial Property Rights Holder
      名古屋大学, 愛知県
    • Filing Date
      2006-04-27
    • Related Report
      2006 Annual Research Report
  • [Patent(Industrial Property Rights)] がん転移抑制組成物2005

    • Inventor(s)
      高橋隆, 他
    • Industrial Property Rights Holder
      名古屋大学
    • Industrial Property Number
      2005-132926
    • Filing Date
      2005-04-28
    • Related Report
      2005 Annual Research Report
  • [Patent(Industrial Property Rights)] 肺線がん患者の術後予後を予想するための方法及び組成物2005

    • Inventor(s)
      高橋隆, 他
    • Industrial Property Rights Holder
      名古屋大学, 愛知県
    • Industrial Property Number
      2005-379867
    • Filing Date
      2005-10-04
    • Related Report
      2005 Annual Research Report
  • [Patent(Industrial Property Rights)] がん患者の術後の予後又は転移可能性を予測するための組成物及び方法2005

    • Inventor(s)
      高橋隆, 他
    • Industrial Property Rights Holder
      名古屋大学
    • Industrial Property Number
      2005-379867
    • Filing Date
      2005-12-28
    • Related Report
      2005 Annual Research Report

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Published: 2005-04-01   Modified: 2018-03-28  

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