Molecular dissection of molecular pathogenesis of lung cancer towards realization of personalized medicine

• Project/Area Number: 17015019
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Nagoya University
• Principal Investigator: TAKAHASHI Takashi Nagoya University, 大学院・医学系研究科, 教授 (50231395)
• Co-Investigator(Kenkyū-buntansha): YANAGISAWA Kiyoshi 名古屋大学, 高等研究院, 特任講師 (20372112) ; TOMIDA Shuta 名古屋大学, 大学院・医学系研究科, 助教 (10372111) ; YAMAGUCHI Tomoya 名古屋大学, 大学院・医学系研究科, 助教 (70452191)
• Co-Investigator(Renkei-kenkyūsha): YANAGISAWA Kiyoshi 名古屋大学, 高等研究院, 特任講師 (20372112) ; YAMAGUCHI Tomoya 名古屋大学, 大学院・医学系研究科, 助教 (70452191)
• Project Period (FY): 2005 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥159,800,000 (Direct Cost: ¥159,800,000); Fiscal Year 2009: ¥31,700,000 (Direct Cost: ¥31,700,000); Fiscal Year 2008: ¥31,700,000 (Direct Cost: ¥31,700,000); Fiscal Year 2007: ¥31,700,000 (Direct Cost: ¥31,700,000); Fiscal Year 2006: ¥31,700,000 (Direct Cost: ¥31,700,000); Fiscal Year 2005: ¥33,000,000 (Direct Cost: ¥33,000,000)
• Keywords: 肺がん / マイクロアレイ / プロテオミクス / マイクロRNA / バイオインフォマティクス / 分子腫瘍医学 / 網羅的遺伝子発現解析 / マイクロアレー / 分子種瘍医学 / マクロアレー

Research Abstract

Our multi-faceted approach towards a better understanding of lung cancer pathogenesis revealed that two major expression profile-defined subtypes exist in lung adenocarcinomas and that TTF-1 confers lineage-specific dependency in lung adenocarcinomas. In addition, we identified mRNA and protein expression signatures highly related to postoperative prognosis, while we also found relationship between deregulation of mTOR-converging signaling and poor prognosis. Finally, we reported for the first time that let-7 is reduced, while miR-17-92 is overexpressed in lung cancers, suggesting important roles of miRNA alterations in lung carcinogenesis.

Research Products

• [Journal Article] Proteasomal non-catalytic subunit PSMD2 as a potential therapeutic target in association with various clinicopathologic features in lung adenocarcinomas (2010)
  • Author(s): Matsuyama, Y., Suzuki, M., Arima, C., Huang, Q.M., Tomida, S., Takeuchi, T., Sugiyama, R., Itoh, Y., Yatabe, Y., Goto, H., Takahashi, T.
  • Journal Title: Mol. Carcinogenesis (in press)
  • Peer Reviewed
• [Journal Article] Functions of base selection step in human DNA polymerase alpha DNA Repair (2010)
  • Author(s): Tanaka, S., Cao, K., Niimi, A., Limsirichaikul, S., Huang, Q., Nakamura, N., Murate, T., Hasegawa, Y., Takahashi, T., Suzuki M.
  • Journal Title: DNA Repair (in press)
  • Peer Reviewed
• [Journal Article] Roles of POLD4, smallest subunit of DNA polymeraseδin nuclear structures and genomic stability of human cells (2010)
  • Author(s): Huang, Q.A., Akashi, T., Matsuda, Y., Kamiya, K., Takahashi, T., Suzuki, M.
  • Journal Title: Biochem. Biophys. Res. Comm. 391 Pages: 542-546
  • Peer Reviewed
• [Journal Article] Homozygous deletion of CDKN2A/2B is a hallmark of iron-induced high-grade rat mesothelioma (2010)
  • Author(s): Hu Q, Akatsuka S, Yamashita Y, Ohara H, Nagai H, Okazaki Y, Takahashi T,, Toyokuni S.
  • Journal Title: Lab. Invest. (in press)
  • Peer Reviewed
• [Journal Article] Proteasomal non-catalytic subunit PSMD2 as a potential therapeutic target in association with various clinicopathologic features in lung adenocarcinomas. (2010)
  • Author(s): Matsuyama Y, et al.
  • Journal Title: Mol.Carcinogenesis (in press)
  • Peer Reviewed
• [Journal Article] Functions of base selection step in human DNA polymerase alpha DNA Repair. (2010)
  • Author(s): Tanaka S, et al.
  • Journal Title: DNA Repair (in press)
  • Peer Reviewed
• [Journal Article] Roles of POLD4, smallest subunit of DNA polymerase δ, in nuclear structures and genomic stability of human cells. (2010)
  • Author(s): Huang QA, et al.
  • Journal Title: Biochem.Biophys.Res.Comm. 391 Pages: 542-546
  • Peer Reviewed
• [Journal Article] Homozygous deletion of CDKN2A/2B is a hallmark of iron-induced high-grade rat mesothelioma. (2010)
  • Author(s): Hu Q, et al.
  • Journal Title: Lab.Invest. (in press)
  • Peer Reviewed
• [Journal Article] Endogenous angiogenesis inhibitor vasohibinl exhibits a broad-spectrumanti-lymphangiogenic activity and suppresses lymph node metastasis. (2010)
  • Author(s): Heishi T, et al.
  • Journal Title: Am.J.Pathol. (in press)
  • Peer Reviewed
• [Journal Article] Relapse-related molecular signature in lung adenocarcinomas identifies patients with dismal prognosis (2009)
  • Author(s): Tomida, S., Takeuchi, T., Shimada, Y., Arima, C., Matsuo, K., Mitsudomi, T., Yatabe, Y.,, Takahashi, T.
  • Journal Title: J. Clin. Oncol. 27 Pages: 2793-2799
  • Peer Reviewed
• [Journal Article] Relationship of deregulated signaling converging onto mTOR with prognosis and classification of lung adenocarcinoma shown by two independent in silico analyses (2009)
  • Author(s): Ebi, H. *, Tomida, S., * Takeuchi, T., Arima, C., Sato, T., Mitsudomi, T., Yatabe, Y., Osada, H.,, Takahashi, T.
  • Journal Title: Cancer Res. 69 Pages: 4027-2035
  • Peer Reviewed
• [Journal Article] Counterbalancing influence of miR-17-92 overexpression on adverse effects of RB inactivation in lung cancers (2009)
  • Author(s): Ebi, H. *, Sato, T. *, Sugito, N., Hosono, Y., Suzuki, M., Yamaguchi, T., Yatabe, Y., Osada, H.,, Takahashi, T.
  • Journal Title: Oncogene 28 Pages: 3371-3379
  • Peer Reviewed
• [Journal Article] PCNA Mono-ubiquitination and Activation of Translesion DNA Polymerases by DNA Polymeraseα (2009)
  • Author(s): Suzuki M, Niimi A, Limsirichaikul S, Tomida S, Huang QM, Izuta S, Usukura J, Itoh Y, Hishida T, Akashi T, Nakagawa Y, Kikuchi A, Pavlov Y, Murate T,, Takahashi T.
  • Journal Title: J. Biochem. 146 Pages: 13-21
  • Peer Reviewed
• [Journal Article] Neuroendocrine cancer-specific up-regulating mechanism of insulin-like growth factor binding protein-2 in small cell lung cancer (2009)
  • Author(s): Yazawa, T., Sato, H., Shimoyamada, H., Okudela, K., Woo, H., Tajiri, M., Ogura, T., Ogawa, N., Suzuki, T., Mitsui, H., Ishii, J., Miyata, C., Sakaeda, M., Goto, K., Kashiwagi, K., Masuda, M., Takahashi, T.,, Kitamura, H.
  • Journal Title: Am. J. Pathol. 175 Pages: 976-987
  • Peer Reviewed
• [Journal Article] Relapse-related molecular signature in lung adenocarcinomas identifies patients with dismal prognosis. (2009)
  • Author(s): Tomida S, et al.
  • Journal Title: J.Clin.Oncol. 27 Pages: 2793-2799
  • Peer Reviewed
• [Journal Article] Relationship of deregulated signaling converging onto mTOR with prognosis and classification of lung adenocarcinoma shown by two independent in silico analyses. (2009)
  • Author(s): Ebi H, et al.
  • Journal Title: Cancer Res. 69 Pages: 4027-4035
  • Peer Reviewed
• [Journal Article] Counterbalancing influence of miR-17-92 overexpression on adverse effects of RB inactivation in lung cancers. (2009)
  • Author(s): Ebi H, et al.
  • Journal Title: Oncogene 28 Pages: 3371-3379
  • Peer Reviewed
• [Journal Article] PCNA mono-ubiquitination and activation of translesion DNA polymerases by DNA polymerasea α (2009)
  • Author(s): Suzuki M, et al.
  • Journal Title: J.Biochem. 146 Pages: 13-21
  • Peer Reviewed
• [Journal Article] Neuroendocrine cancer-specific up-regulating mechanism of insulin-like growth factor binding protein-2 in small cell lung cancer. (2009)
  • Author(s): Yazawa T, et al.
  • Journal Title: Am.J.Pathol. 175 Pages: 976-987
  • Peer Reviewed
• [Journal Article] Down-regulation of DUSP6 expression in lung cancers : its mechanism and potential role in carcinogenesis. (2009)
  • Author(s): Okudera K, et al.
  • Journal Title: Am.J.Pathol. 175 Pages: 867-881
  • Peer Reviewed
• [Journal Article] A bone metastasis model with osteolytic and osteoblastic properties of human lung cancer ACC-LC-319/bone 2 in natural killer cell-depleted severe combined immunodeficient mice. (2009)
  • Author(s): Otsuka S, et al.
  • Journal Title: Oncol.Res. 17 Pages: 581-591
  • Peer Reviewed
• [Journal Article] Relapse-related molecular signature in lung adenocarcinomas identifies patients with dismal prognosis (2009)
  • Author(s): Tomida S, et.al.
  • Journal Title: Journal of Clinical Oncology (in press)
  • Peer Reviewed
• [Journal Article] Relationship of deregulated signaling converging onto mTOR with prognosis and classification of lung adenocarcinoma shown by two independent in silico analyses (2009)
  • Author(s): Ebi H, et.al.
  • Journal Title: Cancer Research (in press)
  • Peer Reviewed
• [Journal Article] Identification of HIF-1α as a novel target for miR-17-92 microRNA cluster (2008)
  • Author(s): Taguchi, A., Yanagisawa, K., Tanaka, M., Cao, K., Matsuyama, Y., Goto, H.,, Takahashi, T.
  • Journal Title: Cancer Res. 68 Pages: 5540-5545
  • Peer Reviewed
• [Journal Article] Roles of ASH1 in DKK1 and E-cadherin repression and neuroendocrine differentiation in lung cancer (2008)
  • Author(s): Osada, H., Tomida, S., Yatabe, Y., Tatematsu, Y., Takeuchi, T., Murakami, H., Kondo, Y., Sekido, Y., Takahashi, T.
  • Journal Title: Cancer Res. 68 Pages: 1647-1655
  • Peer Reviewed
• [Journal Article] Detailed characterization of a homozygously deleted region corresponding to a candidate tumor suppressor locus at 21q11-21 in human lung cancer (2008)
  • Author(s): Yamada, H., Yanagisawa, K., Tokumaru, S., Taguchi, A., Nimura, Y., Osada, H., Nagino, M.,, Takahashi, T.
  • Journal Title: Genes, Chromosomes, Cancer. 47 Pages: 810-818
  • Peer Reviewed
• [Journal Article] Epidermal growth factor receptor gene amplification is acquired in association with tumor progression of EGFR-mutated lung cancer (2008)
  • Author(s): Yatabe, Y., Takahashi, T.,, Mitsudomi, T.
  • Journal Title: Cancer Res. 68 Pages: 2106-2111
  • Peer Reviewed
• [Journal Article] let-7 regulates Dicer expression and constitutes a negative feedback loop (2008)
  • Author(s): Tokumaru, S., Suzuki, M., Yamada, H., Nagino, N., Takahashi, T.
  • Journal Title: Carcinogenesis 29 Pages: 2073-2077
  • Peer Reviewed
• [Journal Article] Identification of H/F-1α as a novel target for miR-17-92 microRNA cluster (2008)
  • Author(s): Taguchi A, et.al.
  • Journal Title: Cancer Research 68 Pages: 1647-1655
  • Peer Reviewed
• [Journal Article] Roles of ASHI in DKK 1 and E-cadherin repression and neuroendocrine differentiation in lung cancer (2008)
  • Author(s): Osada H, et.al.
  • Journal Title: Cancer Research 68 Pages: 1647-1655
  • Peer Reviewed
• [Journal Article] Epidermal growth factor receptor gene amplification is acquired in association with tumor progression of EGFR-mutated lung cancer (2008)
  • Author(s): Yatabe Y, et.al.
  • Journal Title: Cancer Research 68 Pages: 2106-2111
  • Peer Reviewed
• [Journal Article] let-7 regulates Dicer expression and constitutes a negative feedback loop (2008)
  • Author(s): Tokumaru S, et.al.
  • Journal Title: Carcinogenesis 29 Pages: 2073-2077
  • Peer Reviewed
• [Journal Article] Detailed characterization of a homozygously deleted region corresponding to a candidate tumor suppressor locus at 21 q 11-21 in human lung cancer (2008)
  • Author(s): Yamada H, et.al.
  • Journal Title: Genes, Chromosomes & Cancer 47 Pages: 810-818
  • Peer Reviewed
• [Journal Article] mRNA expression of RRM 1, ERCC 1 and ERCC 2 is not associated with chemosensitivity to cisplatin, carboplatin and gemcitabine in human lung cancer cell lines (2008)
  • Author(s): Shimizu J, et.al.
  • Journal Title: Respirology 13 Pages: 510-517
  • Peer Reviewed
• [Journal Article] Roles of ASHI in DKKI and E-cadherin repression and neuroendocrine differentiation in lung cancer. (2008)
  • Author(s): Osada H, et. al.
  • Journal Title: Cancer Res. (in press)
• [Journal Article] Identification of a metastasis signature and the DLX4 homeobox protein as a regulator of metastasis by combined transcriptome approach (2007)
  • Author(s): Tomida, S., * Yanagisawa, K., * Koshikawa, K., Yatabe, Y., Mitsudomi, T., Osada, H., Takahashi, T.
  • Journal Title: Oncogene 26 Pages: 4600-4608
  • Peer Reviewed
• [Journal Article] CLCP1 interacts with semaphorin 4B and regulates motility of lung cancer cells (2007)
  • Author(s): Nagai, H., Sugito, N., Matsubara, H., Tatematsu, Y., Hida, T., Sekido, Y., Nagino, M., Nimura, Y., Takahashi, T.,, Osada, H.
  • Journal Title: Oncogene 26 Pages: 4025-4031
  • Peer Reviewed
• [Journal Article] Apoptosis induction by antisense oligonucleotides against miR-17-5p and miR-20a in lung cancers overexpressing miR-17-92 (2007)
  • Author(s): Matsubara, H. *, Takeuchi, T. *, Nishikawa, E. *, Yanagisawa, K., Hayashita, Y., Ebi, H., Yamada, H., Suzuki, M., Nagino, M., Nimura, Y., Osada, H., Takahashi, T.
  • Journal Title: Oncogene 26 Pages: 6099-6105
  • Peer Reviewed
• [Journal Article] A 25-signal proteomic signature and outcome for patients with resected non-small-cell lung cancer (2007)
  • Author(s): Yanagisawa, K., * Tomida, S., * Shimada, Y., Yatabe, Y., Mitsudomi, T., Takahashi, T.
  • Journal Title: J. Natl. Cancer Inst. 99 Pages: 858-867
  • Peer Reviewed
• [Journal Article] Lineage-specific dependency of lung adenocarcinomas on the lung development regulator TTF-1 (2007)
  • Author(s): Tanaka, H., * Yanagisawa, K., * Shinjo, K., Taguchi, A., Maeno, K., Tomida, S., Shimada, Y., Osada, H., Kosaka, T., Matsubara, H., Mitsudomi, T., Sekido, Y., Tanimoto, M., Yatabe, Y.,, Takahashi, T.
  • Journal Title: Cancer Res. 67 Pages: 6007-6011
  • Peer Reviewed
• [Journal Article] Expression profiling of genes regulated by TGF-beta: Differential regulation in normal and tumour cells (2007)
  • Author(s): Ranganathan, P., Agrawal, A., Bhushan, R., Chavalmane, A.K., Kalathur, R.K.R., Takahashi, T., Kondaiah P.
  • Journal Title: BMC Genomics 8 Pages: 98-98
  • Peer Reviewed
• [Journal Article] Non-genomic β estrogen receptors enhance β1 adrenergic signaling induced by the nicotine-derived carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in human small airway epithelial cells (2007)
  • Author(s): Majidi, M., Al-Wadei, H.A., Takahashi, T., Schuller H.M.
  • Journal Title: Cancer Res. 67 Pages: 6863-6871
  • Peer Reviewed
• [Journal Article] Novel NBS1 heterozygous germline mutation causing MRE11-binding domain loss predisposes to common types of cancer (2007)
  • Author(s): Ebi, H., Matsuo, K., Sugito, N., Suzuki, M., Osada, H., Tajima, K., Ueda, R.,, Takahashi, T.
  • Journal Title: Cancer Res. 67 Pages: 11158-11165
  • Peer Reviewed
• [Journal Article] MicroRNAs in Biological Processes and Carcinogenesis (2007)
  • Author(s): Osada, H., Takahashi, T.
  • Journal Title: Carcinogenesis 28 Pages: 2-12
  • Peer Reviewed
• [Journal Article] Identification of a metastasis signature and the DLX4 homeobox protein as a regulator of metastasis by combined transcriptome approach. (2007)
  • Author(s): Tomida S, et. al.
  • Journal Title: Oncogene 26 Pages: 466-4608
• [Journal Article] CLCPI interacts with semaphorin 4B and regulates motility of lung cancer cells (2007)
  • Author(s): Nagai H, et. al.
  • Journal Title: Oncogene 26 Pages: 4025-4031
• [Journal Article] Apoptosis induction by antisense oligonucleotides against miR-17-5p and miR-20a in lung cancers overexpressing miR-17-92. (2007)
  • Author(s): Matsubara H, et. al.
  • Journal Title: Oncogene 26 Pages: 6099-6105
• [Journal Article] A25-signal proteomic signature and outcome for patients with resectednon-small-cell lung cancer. (2007)
  • Author(s): Yanagisawa K, et. al.
  • Journal Title: J. Natl. Cancer Inst. 99 Pages: 858-867
• [Journal Article] Lineage-specific dependency of lung adenocarcinomas on the lung development regulator TTF-1. (2007)
  • Author(s): Tanaka H, et. al.
  • Journal Title: Cancer Res. 67 Pages: 6007-6011
• [Journal Article] Novel NBS1 heterozygous germline mutation causing MRE 11-binding domain loss predisposes to common types of cancer. (2007)
  • Author(s): Ebi H, et. al.
  • Journal Title: Cancer Res. 67 Pages: 11158-11165
• [Journal Article] Non-genomic β estrogen receptors enhance β1 adrenergic signaling induced by the nicotine-derived carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in human small airway epithelial cells (2007)
  • Author(s): Majidi M, et. al.
  • Journal Title: Carcinogenesis 67 Pages: 6863-6871
• [Journal Article] Disproportionate representation of KRAS gene mutation in atypical adenomatous hyperplasia, but even distribution of EGFR genemutation from preinvasive to invasive adenocarcinomas. (2007)
  • Author(s): Sakamoto H, et. al.
  • Journal Title: J. Pathol. 212 Pages: 287-294
• [Journal Article] Identification of a metastasis signature and the DLX4 homeobox protein as a regulator of metastasis by combined transcriptome approach. (2007)
  • Author(s): Onozato R, et. al.
  • Journal Title: Cancer Sci. 98 Pages: 1747-1751
• [Journal Article] Aryl radical involvement in amiodarone-induced pulmonary toxicity: Investigation of cytoprotection by spin trapping nitorones. (2007)
  • Author(s): Nicolescu AC, et. al.
  • Journal Title: Toxicol. Appl. Pharmacol. 220 Pages: 60-71
• [Journal Article] hDREF regulates cell proliferation and expression of ribosomal protein genes. (2007)
  • Author(s): Yamashita D, et. al.
  • Journal Title: Mol. Cell. Biol. 27 Pages: 2003-2013
• [Journal Article] hDREF regulates cell proliferation and expression of ribosomal protein genes. (2007)
  • Author(s): Yamashita D et al.
  • Journal Title: Molecular and Cellular Biology 27 Pages: 2003-2013
• [Journal Article] Identification of a metastasis signature and the DLX4 homeobox protein as a regulator of metastasis by combined transcriptome approach. (2007)
  • Author(s): Tomida S et al.
  • Journal Title: Oncogene (in press)
• [Journal Article] Apoptosis induction by antisense oligonucleotides against miR-17-5p and miR-20a in lung cancers overexpressing miR-17-92. (2007)
  • Author(s): Matsubara H et al.
  • Journal Title: Oncogene (in press)
• [Journal Article] CLCP1 interacts with semaphorin 4B and regulates motility of lung cancer cells. (2007)
  • Author(s): Nagai H et al.
  • Journal Title: Oncogene (in press)
• [Journal Article] MicroRNAs in biological processes and carcinogenesis. (2007)
  • Author(s): Osada H et al.
  • Journal Title: Carcinogenesis 28 Pages: 2-12
• [Journal Article] Expression profile-defined classification of lung adenocarcinoma shows close relationship with underlying major genetic changes and clinicopathologic behaviors (2006)
  • Author(s): Takeuchi, T., * Tomida, S., * Yatabe, Y., Kosaka, T., Osada, H., Yanagisawa, K., Mitsudomi, T.,, Takahashi, T.
  • Journal Title: J. Clin. Oncol. 24 Pages: 1679-1688
  • Peer Reviewed
• [Journal Article] Altered regulation of c-jun and its involvement in anchorage-independent growth of human lung cancers (2006)
  • Author(s): Maeno, K., Masuda, A., Yanagisawa, K., Konishi, H., Osada, H., Saito, T., Ueda, R.,, Takahashi, T.
  • Journal Title: Oncogene 25 Pages: 271-277
  • Peer Reviewed
• [Journal Article] Fundamental study of small interfering RNAs for ganglioside GD3 synthase gene as a therapeutic target of lung cancers (2006)
  • Author(s): Ko, K., Furukawa, K., Takahashi, T., Urano, T., Sanai, Y., Nagino, M., Nimura, Y.,, Furukawa, K.
  • Journal Title: Oncogene 25 Pages: 6924-6935
  • Peer Reviewed
• [Journal Article] Growth regulation via insulin-like growth factor binding protein-4 and -2 in association with mutant K-ras in lung epithelia (2006)
  • Author(s): Sato, H., Yazawa, T., Suzuki, T., Shimoyamada, H., Okudela, K., Ikeda, M., Hamada, K., Yamada-Okabe, H., Yao, M., Kubota, Y., Takahashi, T., Kamma, H., Kitamura H.
  • Journal Title: Am J Pathol. 169 Pages: 1550-1566
  • Peer Reviewed
• [Journal Article] Expression profile-defined classification of lung adenocarcinoma shows close relationship with underlying major genetic changes and clinicopathologic behaviors. (2006)
  • Author(s): Takeuchi T et al.
  • Journal Title: Journal of Clinical Oncology 24 Pages: 155-160
• [Journal Article] Altered regulation of c-jun and its involvement in anchorage-independent growth of human lung cancers. (2006)
  • Author(s): Maeno K et al.
  • Journal Title: Oncogene 25 Pages: 271-277
• [Journal Article] Growth regulation via insulin-like growth factor binding protein-4 and -2 in association with mutant K-ras in lung epithelia. (2006)
  • Author(s): Sato H et al.
  • Journal Title: American Journal of Pathology 169 Pages: 1550-1556
• [Journal Article] Growth stimulation of human pulmonary adenocarcinoma cells and small airway epithelial cells by beta-carotene via activation of cAMP, PKA, CREB and ERK1/2. (2006)
  • Author(s): Al-Wadei HA et al.
  • Journal Title: International Journal of Cancer 118 Pages: 1370-1380
• [Journal Article] A rapid, sensitive assay to detect EGFR mutation in small biopsy specimens from lung cancer. (2006)
  • Author(s): Yatabe Y et al.
  • Journal Title: Journal of Molecular Diagnosis 8 Pages: 335-341
• [Journal Article] Fundamental study of small interfering RNAs for gaglioside GD3 synthase gene as a therapeutic target of lung cancers. (2006)
  • Author(s): Ko K et al.
  • Journal Title: Oncogene 25 Pages: 6924-6935
• [Journal Article] Altered regulation of c-jun and its involvement in anchorage-independent growth of human lung cancers. (2006)
  • Author(s): Maeno, K., et al.
  • Journal Title: Oncogene 25 Pages: 271-277
• [Journal Article] Growth stimulation of human pulmonary adenocarcinoma cells and small airway epithelial cells by β-carotene via activation of cAMP, PKA, CREB and ERK1/2. (2006)
  • Author(s): Al-Wadei, H.A., et al.
  • Journal Title: International Journal of Cancer (in press)
• [Journal Article] A polycistronic miRNA cluster, miR-17-92, is overexpressed in human lung cancers and enhances cell proliferation (2005)
  • Author(s): Hayashita, Y., * Osada, H., * Tatematsu, Y., Yamada, H., Yanagisawa, K., Tomida, S., Kawahara, K., Sekido, Y.,, Takahashi, T.
  • Journal Title: Cancer Res. 65 Pages: 9628-9632
  • Peer Reviewed
• [Journal Article] The ASH1 gene is a specific therapeutic target for lung cancers with neuroendocrine features (2005)
  • Author(s): Osada, H., Tatematsu, Y., Yatabe, Y., Horio, Y.,, Takahashi, T.
  • Journal Title: Cancer Res. 65 Pages: 10680-10685
  • Peer Reviewed
• [Journal Article] Histone modification in the TGFβRII gene promoter and its significance for responsiveness to HDAC inhibitor in lung cancer cell lines (2005)
  • Author(s): Osada, H,. Tatematsu, Y., Sugito, N., Horio, Y.,, Takahashi T.
  • Journal Title: Mol. Carcinog. 44 Pages: 233-241
  • Peer Reviewed
• [Journal Article] Reduced expression of Dicer associated with poor prognosis in lung cancer patients (2005)
  • Author(s): Karube, Y., Tanaka, H., Osada, H., Tomida, S., Tatematsu, Y., Yanagisawa, K., Yatabe, Y., Takamizawa, J., Miyoshi, S., Mitsudomi, T.,, Takahashi, T.
  • Journal Title: Cancer Sci. 96 Pages: 111-115
  • Peer Reviewed
• [Journal Article] Mutations of the epidermal growth factor receptor gene predict prolonged survival after gefitinib treatment in patients with non-small cell lung cancer with postoperative recurrence (2005)
  • Author(s): Mitsudomi, T., Kosaka, T., Endoh, H., Horio, Y., Hida, T., Mori, S., Hatooka, S., Shinoda, M., Takahashi, T., Yatabe, Y.
  • Journal Title: J. Clin. Oncol. 23 Pages: 2513-2520
  • Peer Reviewed
• [Journal Article] EGFR mutation is specific for terminal respiratory unit type adenocarcinoma (2005)
  • Author(s): Yatabe, Y., Kosaka, T., Takahashi, T., Mitsudomi, T.
  • Journal Title: Am. J. Surg. Pathol. 29 Pages: 633-639
  • Peer Reviewed
• [Journal Article] Vascular endothelial cell growth factor receptor 3-mediated activation of lymphatic endothelium is crucial for tumor cell entry and spread via lymphatic vessels (2005)
  • Author(s): He, Y., Rajantie, I., Pajusola, K., Jeltsch, M., Holopainen, T., Yla-Herttuala, S., Harding, T., Jooss, K., Takahashi, T.,, Alitalo, K.
  • Journal Title: Cancer Res. 65 Pages: 4739-4746
  • Peer Reviewed
• [Journal Article] Throwing new light on lung cancer pathogenesis: updates on three recent topics (2005)
  • Author(s): Tomida, S., Yatabe, Y., Yanagisawa, K., Mitsudomi, T.,, Takahashi, T.
  • Journal Title: Cancer Sci. 96 Pages: 63-68
  • Peer Reviewed
• [Journal Article] Polycistronic miRNA cluster, miR-17-92, is overexpressed in human lung cancers and enhances cell proliferation. (2005)
  • Author(s): Hayashita, Y., et al.
  • Journal Title: Cancer Research 65 Pages: 9628-9632
• [Journal Article] The ASH1 gene is a specific therapeutic target for lung cancers with neuroendocrine features. (2005)
  • Author(s): Osada, H., et al.
  • Journal Title: Cancer Research 65 Pages: 10680-10685
• [Journal Article] Histone modification in the TGFβRII gene promoter and its significance for responsiveness to HDAC inhibitor in lung cancer cell lines. (2005)
  • Author(s): Osada, H., et al.
  • Journal Title: Molecular Carcinogenesis 44 Pages: 233-241
• [Journal Article] Vascular endothelial cell growth factor receptor 3-mediated activation of lymphatic endothelium is crucial for tumor cell entry and spread via lymphatic vessels. (2005)
  • Author(s): He Y., et al.
  • Journal Title: Cancer Research 65 Pages: 10680-10685
• [Journal Article] Polycistronic miRNA cluster, miR-17-92, is overexpressed in human lung cancers and enhances cell proliferation. (2005)
  • Author(s): Mitsudomi, T., et al.
  • Journal Title: Journal of Clinical Oncology 23 Pages: 2513-2520
• [Journal Article] EGFR mutation is specific for terminal respiratory unit type adenocarcinoma. (2005)
  • Author(s): Yatabe, Y., et al.
  • Journal Title: American Journal of Surgical Pathology 29 Pages: 633-639
• [Journal Article] Restoration of TGF-b signaling reduces tumorigenecity in human lung cancer cells. (2005)
  • Author(s): Anumanthan, G., et al.
  • Journal Title: British Journal of Cancer 93 Pages: 1157-1167
• [Journal Article] Prognostic model of pulmonary adenocarcinoma by expression profiling of eight genes as determined by quantitative real-time RT-PCR (2004)
  • Author(s): Endoh, H., Tomida, S., Yatabe, Y., Konishi, H., Osada, H., Tajima, K., Kuwano, H., Takahashi, T.,, Mitsudomi, T.
  • Journal Title: J. Clin. Oncol. 22 Pages: 811-819
  • Peer Reviewed
• [Journal Article] K-ras gene mutation enhances motility of immortalized airway cells and lung adenocarcinoma cells via Akt activation (possible contribution to non-invasive expansion of lung adenocarcinoma) (2004)
  • Author(s): Okudela, K., Hayashi, H., Ito, T., Yazawa, T., Suzuki, T., Nakane, Y., Sato, H., Ishi, H., Keqin, X, Masuda, A., Takahashi, T.,, Kitamura, H.
  • Journal Title: Am. J. Pathol. 164 Pages: 91-100
  • Peer Reviewed
• [Journal Article] Maspin expression in normal lung and non-small-cell lung cancers: cellular property-associated expression under the control of promotoer DNA methylation (2004)
  • Author(s): Yatabe, Y., Mitsudomi, T.,, Takahashi T.
  • Journal Title: Oncogene 23 Pages: 4041-4049
  • Peer Reviewed
• [Journal Article] CK20 expression, CDX2 expression, K-ras mutation, and globet cell morphology in a subset of lung adenocarcinomas (2004)
  • Author(s): Yatabe, Y., Koga, T., Mitsudomi, T.,, Takahashi, T.
  • Journal Title: J. Pathol. 203 Pages: 645-652
  • Peer Reviewed
• [Journal Article] Reduced expression of class II HDAC genes are associated with poor prognosis in lung cancer patients (2004)
  • Author(s): Osada H., Tatematsu, Y., Saito, H., Yatabe, Y., Mitsudomi, T.,, Takahashi, T.
  • Journal Title: Int. J. Cancer 112 Pages: 26-32
  • Peer Reviewed
• [Journal Article] Gene expression-based, individualized outcome prediction of surgically treated lung cancer patients (2004)
  • Author(s): Tomida, S., * Koshikawa, K., * Yatabe, Y., Harano, T., Ogura, N., Mitsudomi, T., Some, M., Yanagisawa, K., Takahashi, T., Osada, H.,, Takahashi, T.
  • Journal Title: Oncogene 23 Pages: 5360-5370
  • Peer Reviewed
• [Journal Article] Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival (2004)
  • Author(s): Takamizawa, J. *, Konishi, H. *, Yanagisawa, K., Tomida, S., Osada, T., Harano, T., Yatabe, Y., Nagino, M., Nimura, Y., Mitsudomi, T.,, Takahashi, T.
  • Journal Title: Cancer Res. 64 Pages: 3753-3756
  • Peer Reviewed
• [Journal Article] Identification of decatenation G2 checkpoint impairment independently of DNA damage G2 checkpoint in human lung cancer cell lines (2004)
  • Author(s): Nakagawa, T., Hayashita, Y., Maeno, K., Masuda, A., Sugito, N., Osada, T., Hideki, E., Yanagisawa, K., Ebi, H., Shimokata, K.,, Takahashi, T.
  • Journal Title: Cancer Res. 64 Pages: 4826-4832
  • Peer Reviewed
• [Journal Article] Mutations of the epidermal growth factor receptor gene in lung cancer: biological and clinical implications (2004)
  • Author(s): Kosaka, T., Yatabe, Y., Endoh, H., Kuwano, H., Takahashi, T.,, Mitsudomi, T.
  • Journal Title: Cancer Res. 64 Pages: 8919-8923
  • Peer Reviewed
• [Journal Article] Expression profile-defined classification of lung adenocarcinoma shows close relationship with underlyin major genetic changes and clinicopathologic behaviors.
  • Author(s): Takeuchi, T., et al.
  • Journal Title: Journal of Clinical Oncology (in press)
• [Presentation] MicroRNA alterations in the pathogenesis of lung cancers. (2010)
  • Author(s): Takahashi T
  • Organizer: 8^<th> AACR-JCA Joint Conference.
  • Place of Presentation: Waikoloa, USA
  • Year and Date: 2010-02-08
• [Presentation] MicroRNA alterations in the pathogenesis of lung cancers. (2010)
  • Author(s): Takahashi T
  • Organizer: 1^<st> AACR-IASLC Joint Conference
  • Place of Presentation: San Diego, USA
  • Year and Date: 2010-01-13
• [Presentation] MicroRNA alterations in the pathogenesis of lung cancers (2010)
  • Author(s): Takahashi, T.
  • Organizer: 1st AACR-IASLC Joint Conference: Molecular Origins of Lung Cancer: Prospects for Personalized Prevention and Therapy
  • Place of Presentation: San Diego, USA
• [Presentation] Expression profiling-based approaches for a better understanding of human lung cancer biology. (2009)
  • Author(s): Takahashi T
  • Organizer: 13^<th> World Conference on Lung Cancer, IASLC.
  • Place of Presentation: San Francisco, USA
  • Year and Date: 2009-08-02
• [Presentation] Expression profiling-based approaches for a better understanding of human lung cancer biology (2009)
  • Author(s): Takahashi, T.
  • Organizer: 13th World Conference on Lung Cancer, IASLC
  • Place of Presentation: San Francisco, USA
• [Presentation] ヒト肺癌の多様性の理解を目指して(シンポジウム) (2008)
  • Author(s): 高橋隆
  • Organizer: 第31回日本分子生物学会年会第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-11
• [Presentation] ゲノム情報の読出しに反映された肺腺癌の分子病態の多様性(シンポジウム) (2008)
  • Author(s): 高橋隆
  • Organizer: 第49回日本肺癌学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-11-13
• [Presentation] ヒト肺癌の病態とマイクロRNAの異常(シンポジウム) (2008)
  • Author(s): 高橋隆
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-30
• [Presentation] ヒト癌の分子病態の多様性 : 網羅的発現解析による描出と応用(教育講演) (2008)
  • Author(s): 高橋隆
  • Organizer: 第19回日本消化器癌発生学会総会
  • Place of Presentation: 別府
  • Year and Date: 2008-08-28
• [Presentation] Omics views of lung cancers. (シンポジウム) (2008)
  • Author(s): Takahashi T
  • Organizer: 2^<nd> Asian Pacific conference on perspectives in lung cancer
  • Place of Presentation: Sapporo, Japan
  • Year and Date: 2008-08-02
• [Presentation] Improved integrative "omics" view and an unresolved question in lung cancer pathoeenesis (ラークショップ) (2008)
  • Author(s): Takahashi T
  • Organizer: 1^<st> European Lung Cancer Conference
  • Place of Presentation: Geneva, Switzerland
  • Year and Date: 2008-04-25
• [Presentation] Improved integrative "omics" view and an unresolved question in lung cancer pathogenesis (2008)
  • Author(s): Takahashi, T.
  • Organizer: 1st European Lung Cancer Conference
  • Place of Presentation: Geneva, Switzerland
• [Presentation] Multidirectional dissection of the molecular pathogenesis of lung cancers (2005)
  • Author(s): Takahashi, T.
  • Organizer: The 11th World Conference on Lung Cancer - International Association for the Study of Lung Cancer
  • Place of Presentation: Barcelona, Spain
• [Book] Biology of lung cancer.(RJ Mason, VC Broaddus JF Murray, JA Nadel,(eds.), Textbook of Respiratory Medicine., 4th edition) (2005)
  • Author(s): Takahashi T., Sidransky, D.
  • Publisher: Elsevier Science
• [Remarks] 平成19年6月7付 読売新聞、日本経済新聞、中日新聞、日刊工業新聞「肺癌症例の術後予後の予測に有用な25 種類のタンパクで構成されるタンパク発現パターンの抽出に成功し、分子病態解明と個別化治療(オーダーメード医療)の実現に大きく寄与し得る結果を得た。」との内容で新聞報道された。
• [Patent(Industrial Property Rights)] 細胞増殖阻害剤 (2008)
  • Inventor(s): 高橋隆、山口知也、冨田秀太
  • Industrial Property Rights Holder: 名古屋大学
  • Filing Date: 2008-07-18
• [Patent(Industrial Property Rights)] 細胞増殖阻害剤 (2008)
  • Inventor(s): 高橋隆, 山口知也, 冨田秀太
  • Industrial Property Rights Holder: 国立大学法人名古屋大学
  • Industrial Property Number: 2008-187857
  • Filing Date: 2008-07-18
• [Patent(Industrial Property Rights)] 肺腺癌患者の術後再発を予測するための方法及び組成物 (2007)
  • Inventor(s): 高橋隆、冨田秀太、竹内俊幸, 他
  • Industrial Property Rights Holder: 名古屋大学、(株)オンコミクス、愛知県
  • Filing Date: 2007-12-28
• [Patent(Industrial Property Rights)] 肺腺癌患者の術後再発を予測するための方法及び組成物 (2007)
  • Inventor(s): 高橋隆、冨田秀太、竹内俊幸、他
  • Industrial Property Rights Holder: 名古屋大学、(株)オンコミクス、愛知県
  • Industrial Property Number: 2007-339214
  • Filing Date: 2007-12-28
• [Patent(Industrial Property Rights)] がん転移抑制組成物 (2006)
  • Inventor(s): 高橋隆、柳澤聖、冨田秀太, 他
  • Industrial Property Rights Holder: 名古屋大学、愛知県
  • Filing Date: 2006-12-28
• [Patent(Industrial Property Rights)] がん転移抑制組成物 (2006)
  • Inventor(s): 高橋隆、柳澤聖、冨田秀太, 他
  • Industrial Property Rights Holder: 名古屋大学、愛知県
  • Filing Date: 2006
• [Patent(Industrial Property Rights)] 癌の新規治療用組成物 (2006)
  • Inventor(s): 高橋隆, 柳澤聖, 他1名
  • Industrial Property Rights Holder: 名古屋大学, 愛知県
  • Filing Date: 2006-04-27
• [Patent(Industrial Property Rights)] がん転移抑制組成物 (2005)
  • Inventor(s): 高橋隆, 他
  • Industrial Property Rights Holder: 名古屋大学
  • Industrial Property Number: 2005-132926
  • Filing Date: 2005-04-28
• [Patent(Industrial Property Rights)] 肺線がん患者の術後予後を予想するための方法及び組成物 (2005)
  • Inventor(s): 高橋隆, 他
  • Industrial Property Rights Holder: 名古屋大学, 愛知県
  • Industrial Property Number: 2005-379867
  • Filing Date: 2005-10-04
• [Patent(Industrial Property Rights)] がん患者の術後の予後又は転移可能性を予測するための組成物及び方法 (2005)
  • Inventor(s): 高橋隆, 他
  • Industrial Property Rights Holder: 名古屋大学
  • Industrial Property Number: 2005-379867
  • Filing Date: 2005-12-28