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Polyvalent cancer vaccine

Research Project

Project/Area Number 17016031
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionMie University

Principal Investigator

SHIKU Hiroshi  Mie University, 大学院・医学系研究科, 寄付講座教員・産学官連携講座教員 (80154194)

Co-Investigator(Kenkyū-buntansha) KAGEYAMA Shinichi  三重大学, 大学院・医学系研究科, 准教授 (80194695)
Project Period (FY) 2005 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥104,800,000 (Direct Cost: ¥104,800,000)
Fiscal Year 2009: ¥21,100,000 (Direct Cost: ¥21,100,000)
Fiscal Year 2008: ¥21,100,000 (Direct Cost: ¥21,100,000)
Fiscal Year 2007: ¥21,100,000 (Direct Cost: ¥21,100,000)
Fiscal Year 2006: ¥21,100,000 (Direct Cost: ¥21,100,000)
Fiscal Year 2005: ¥20,400,000 (Direct Cost: ¥20,400,000)
Keywords癌・精巣抗原 / キラーT細胞 / ヘルパーT細胞 / マルチファンクション性T細胞 / ペプチド抗原 / GITR / TCR遺伝子改変T細胞 / ペプチドワクチン / アジュバント / 癌 / 精巣抗原 / TCR / T細胞療法 / レトロウイルスベクター / 遺伝子治療 / 制御性T細胞 / 抗原ペプチド / 癌精巣抗原 / HLA-A24
Research Abstract

1) Analyses on in vivo kinetics and functions of tumor specific T cells : We found the mechanism of antitumor effect of GITR stimulation and the importance of T cell multifunctionality in antitumor immune response. 2) The verification of polyvalent cancer vaccine in animal models : We verified the enhanced antitumor effect of cancer vaccine by GITR stimulation. We developed TCR gene-modified T cells and verified the effectiveness of adoptive T cell therapy using TCR gene-modified T cells. 3) Identification of antigen peptides for clinical use: We identified the MAGE-A4-, NY-ESO-1-, and SAGE-derived antigen peptides recognized by CD8^+ and CD4^+ T cells.

Report

(6 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (63 results)

All 2009 2008 2007 2006 2005 2004 Other

All Journal Article (46 results) (of which Peer Reviewed: 34 results) Presentation (12 results) Book (1 results) Remarks (1 results) Patent(Industrial Property Rights) (3 results)

  • [Journal Article] Tumor progression inhibits the induction of multifunctionality in adoptively transferred tumor-specific CD8+ T cells2009

    • Author(s)
      Imai N., Ikeda H., Tawara I., Shiku H
    • Journal Title

      Eur. J. Immunol 39

      Pages: 241-53

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Rapid alphabeta TCR-mediated responses in gammadelta T cells transduced with cancer-specific TCR genes2009

    • Author(s)
      Hiasa A., Nishikawa H., Hirayama M., Kitano S., Okamoto S., Chono H., Yu SS., Mineno J., Tanaka Y., Minato N., Kato I., Shiku H
    • Journal Title

      Gene Ther 16

      Pages: 620-8

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Glucocorticoid-induced tumor necrosis factor receptor stimulation enhances the multifunctionality of adoptively transferred tumor antigen-specific CD8 T cells with tumor regression2009

    • Author(s)
      Imai N., Ikeda H., Tawara I., Wang L., Wang L., Nishikawa H., Kato T., Shiku H
    • Journal Title

      Cancer Sci 100

      Pages: 1317-25

    • NAID

      10027192470

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Antibody responses against NY-ESO-1 and HER2 antigens in patients vaccinated with combinations of cholesteryl pullulan (CHP)-NY-ESO-1 and CHP-HER2 with OK-4322009

    • Author(s)
      Aoki M., Ueda S., Nishikawa H., Kitano S., Hirayama M., Ikeda H., Toyoda H., Tanaka K., Kanai M., Takabayashi A., Imai H., Shiraishi T., Sato E., Wada H., Nakayama E., Takei Y., Katayama N., Shiku H., Kageyama S
    • Journal Title

      Vaccine 27

      Pages: 6854-61

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Improved Expression and Reactivity of Transduced Tumor-Specific TCRs in Human Lymphocytes by Specific Silencing of Endogenous TCR2009

    • Author(s)
      Okamoto S., Mineno J., Ikeda H., Fujiwara H., Yasukawa M., Shiku H., Kato I
    • Journal Title

      Cancer Res 69

      Pages: 9003-11

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Rapid alphabeta TCR-mediated responses in gammadelta T cells transduced with cancer-specific TCR genes.2009

    • Author(s)
      Hiasa A, Nishikawa H, Hirayama M, Kitano S, Okamo to S, Chono H, Yu SS, Mineno J, Tanaka Y, Minato N, Kato I, Shiku H
    • Journal Title

      Gene Therapy 16(5)

      Pages: 620-628

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tumor progression inhibits the induction of multifunctionality in adoptively transferred tumor-specific CD8^+T cells.2009

    • Author(s)
      Imai N, Ikeda H, Tawara I.Shiku H
    • Journal Title

      Eur J Immunol. 39(1)

      Pages: 241-253

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Improved Expression and Reactivity of Transduced Tumor-Specific TCRs in Human Lymphocytes by Specific Silencing of Endogen ous TCR.2009

    • Author(s)
      Okamoto S, Mineno J, Ikeda H, Fujiwara H, Yasukawa M, Shiku H, Kato I
    • Journal Title

      Cancer Research 69(23)

      Pages: 9003-9011

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antibody responses against NY-ESO-1 and HER2 antigens in patients vaccinated with combinations of cholesteryl pullulan (CHP)-NY-ESO-1 and CHP-HER2 with OK-432.2009

    • Author(s)
      Aoki M, Ueda S, Nishikawa H, Kitano S, Hirayama M, Ikeda H, Toyoda H, Tanaka K, Kanai M, Takabayashi A, Imai H, Shiraishi T, Sato E, Wada H, Nakayama E, Takei Y, Katayama N, Shiku H, Kageyama S
    • Journal Title

      Vaccine 27(49)

      Pages: 6854-6861

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Glucocorticoid-induced tumor necrosis factor receptor stimulate on enhances the multifunctionality of adoptively transferred tumor antigen- specific CD8^+ T cells with tumor regression.2009

    • Author(s)
      Imai N, Ikeda H, Tawara I, Wang L, Wang L, Nishikawa H, Kato T, Shiku H
    • Journal Title

      Cancer Science 100(7)

      Pages: 1317-1325

    • NAID

      10027192470

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gene expression profiling of peripheral T-cell lymphoma including gammadelta T-cell lymphoma.2009

    • Author(s)
      Miyazaki K, Yamaguchi M, Imai H, Kobayashi T, Tamaru S, Nishii K, Yuda M, Shiku H, Katayama N
    • Journal Title

      Blood 113(5)

      Pages: 1071-1074

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Emerging concepts in biomarker discovery ; the US-Japan Workshop on Immunological Molecular Markers in Oncology.2009

    • Author(s)
      Tahara H, Sato M, Thurin M, Wang E, Butterfield LH, Disis ML, Fox BA, Lee PP, Khleif SN, Wigginton JM, Ambs S, Akutsu Y, Chaussabel D, Doki Y, Eremin O, Fridman WH, Hirohashi Y, Imai K, Jacobson J, Jinushi M, Kanamoto A, Kashani-Sabet M, Kato K, Kawakami Y, Kirkwood JM, Kleen TO, Lehmann PV, Liotta L, Lotze MT, Maio M, Malyguine A, Masucci G, Matsubara H, Mayrand-Chung S, Nakamura K, Nishikawa H, Palucka AK, Petricoin EF, Pos Z, Ribas A, Rivoltini L, Sato N, Shiku H, Slingluff CL, Stretcher H, Stroncek DF, Takeuchi H, Toyota M, Wada H, Wu X, Wulfkuhle J, Yaguchi T, Zeskind B , Zhao Y, Zocca MB, Marincola FM
    • Journal Title

      J Transl Med. 7

      Pages: 45-45

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential Regulatory function of resting and preactivated allergen-specific CD4+CD25+ regulatory T cells in Th2-type airway inflammation2008

    • Author(s)
      Saito K., Torii M., Ma N., Tsuchiya T., Wang L., Hori T., Nagakubo D., Nitta N., Kanegasaki S., Hieshima K., Yoshie O., Gabazza EC., Katayama N., Shiku H., Kuribayashi K., Kato T
    • Journal Title

      J. Immunol. 181

      Pages: 6889-97

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regulatory T cell-resistant CD8+ T cells induced by glucocorticoid-induced tumor necrosis factor receptor signaling2008

    • Author(s)
      Nishiakwa H., Kato T., Hirayama M., Orito Y., Sato E., Harada N., Gnjastic S., Old LJ., Shiku H
    • Journal Title

      Cancer Res 68

      Pages: 5948-54

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Induction of immune response against NY-ESO-1 by CHP-NY-ESO-1 vaccination and immune regulation in a melanoma patient2008

    • Author(s)
      Tsuji K., Hamada T., Uenaka A., Wada H., Sato E., Isobe M., Asagoe K., Yamasaki O., Shiku H., Ritter G., Murphy R., Hoffman EW., Old LJ., Nakayama E., Iwatsuki K
    • Journal Title

      Cancer Immunol. Immunother 57

      Pages: 1429-37

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Humoral immune responses in patients vaccinated with 1-146 HER2 Protein complexed with cholesteryl pullulan nanogel(CHP-HER2)2008

    • Author(s)
      Kageyama S., Kitano S., Hirayama M., Nagata Y., Imai H., Shiraishi T., Akiyoshi K., Scott A., Murphy R., Hoffman E., Old L., Katayama N., Shiku H
    • Journal Title

      Cancer Science 99

      Pages: 601-7

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Long-term phenotypic, functional and genetic stability of cancer-specific T cell receptor(TCR)αβgenes transduced to CD8^+T cells.2008

    • Author(s)
      Hiasa A., Hirayama M., Nishikawa H., Kitano S., Nukaya I., Yu SS., Mineno J., Kato I., Shiku H.
    • Journal Title

      Gene Ther 15

      Pages: 695-9

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Induction of regulatory T cell-resistant helper CD4^+T cells by bacterial vector.2008

    • Author(s)
      Nishikawa H., Tsuji T., Jager E., Briones G., Ritter G., Old LJ., Galan JE., Shiku H., Gnjatic S
    • Journal Title

      Blood 111

      Pages: 1404-12

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Post immune UV-irradiation induces Tr1-like regulatory T cells that suppress humoral immune responses2008

    • Author(s)
      Wang L., Toda M., Saito K., Hori T., Horii T., Shiku H., Kuribayashi K., Kato T
    • Journal Title

      Int. Immunology 20

      Pages: 57-70

    • NAID

      10020106223

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Induction of regulatory T cell-resistant helper CD4^+ T cells by bacterial vector2008

    • Author(s)
      Nishikawa H, Tsuji T, Jager E, Briones G, Ritter G, Old LJ, Galan JE, Shiku H, Gniatic S
    • Journal Title

      Blood 111(3)

      Pages: 1404-12

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Long-term phenotypic, functional and genetic stability of cancer-specific T cell receptor (TCR) genes transduced to CD 8+T cells2008

    • Author(s)
      Hiasa A, Hirayama M, Nishikawa H, Kitano S, Nukaya I, Yu SS, Mineno J, Kato I, Shiku H
    • Journal Title

      Gene Therapy 15(9)

      Pages: 695-9

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Humoral immune responses in patients vaccinated with 1-146 HER2 protein complexed with cholesteryl pullulan nanogel (CHP-HER2)2008

    • Author(s)
      Kageyama S, Kitano S, Hirayama M, Nagata Y, Imai H, Shiraishi T, Akiyoshi K, Scott A, Murphy R, Hoffman E, Old, L, Katayama N, Shiku H
    • Journal Title

      Cancer Science 99(3)

      Pages: 601-7

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulatory T cell-resistant CD8+ T cells induced by glucocorticoid-induced tumor necrosis factor receptor signaling2008

    • Author(s)
      Nishikawa H, Kato T, Hirayama M, Orito Y, Sato E, Harada N, Gnjastic S, Old LJ, Shiku H
    • Journal Title

      Cancer Research 68(14)

      Pages: 5948-54

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of peripheral and local anti-tumor immune response in esophageal cancer patients after NY-ES0-1 protein vaccinetion2008

    • Author(s)
      Wada H, Sato E, Uenaka A, Isobe M, Kawabata R, Nakamura Y, Iwae S, Yonezawa K, Yamasaki M, Miyata H, Doki Y, Shiku H, Jungbluth AA, Ritter G, Murphy R, Hoffman EW, Old LJ, Monden M, Nakayama E
    • Journal Title

      Int. J Cancer 123(10)

      Pages: 2362-9

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tumor progression inhibits the induction of multifunctionality in adoptively transferred tumor-specific CD8(+) T cells2008

    • Author(s)
      Imai N, Ikeda H, Tawara I, Shiku H
    • Journal Title

      Eur J Immunol 39(1)

      Pages: 241-253

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Induction of regulatory T cell-resistant helper CD4^+ T cells by bacterial vector.2008

    • Author(s)
      Nishikawa, H.
    • Journal Title

      Blood. 113(3)

      Pages: 1404-1412

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Long-term phenotypic, functional and genetic stability of cancer-specific T cell receptor (TCR) αβ genes transduced to CD8^+ T cells.2008

    • Author(s)
      Hiasa, A.
    • Journal Title

      Gene Ther. (Epub ahead of print)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antibody response against NY-ESO-1 in CHP-NY-ESO-1 vaccinated patients.2007

    • Author(s)
      Kawabata, R.
    • Journal Title

      Int J Cancer. 120(10)

      Pages: 2178-2184

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vivo antigen delivery by a Salmonella typhimurium type III secretion system for therapeutic cancer vaccines2006

    • Author(s)
      Nishikawa H., Sato E., Briones G., Chen LM., Matsuo M., Nagata Y., Ritter G., Jager E., Nomura H., Kondo S., Tawara I., Kato T., Shiku H., Old LJ., Galan JE., Gnjatic S
    • Journal Title

      J. Clin. Invest 116

      Pages: 1946-54

    • NAID

      120000949466

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Generation of peptide-specific CD8(+) T cells by phytohemagglutinin-stimulated antigen-mRNA-transduced CD4(+) T cells2006

    • Author(s)
      Naota H., Miyahara Y., Okumura S., Kuzushima K., Akatsuka Y., Hiasa A., Kitano S., Takahashi T., Yuta A., Majima Y., Shiku H
    • Journal Title

      J. Immunol. Methods 314

      Pages: 54-66

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] HER2-specific T-cell immune responses in patients vaccinated with truncated HER2 protein complexed with nanogels of cholesteryl pullulan2006

    • Author(s)
      Kitano S., Kageyama S., Nagata Y., Miyahara Y., Hiasa A., Naota H., Okumura S., Imai H., Shiraishi T., Masuya M., Nishikawa M., Sunamoto J., Akiyoshi K., Kanematsu T., Scott AM., Murphy R., Hoffman EW., Old LJ., Shiku H
    • Journal Title

      Clin. Cancer Res 12

      Pages: 7397-405

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] HER2-specitic T-cell immune responses in patients vaccinated with truncated HER2 protein complexed with nanogels of cholesteryl pullulan.2006

    • Author(s)
      Kitano, S.
    • Journal Title

      Clin Cancer Res. 12(24)

      Pages: 7397-7405

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Differential cell division history between neutrophils and macrophages in their development from granulocyte-macrophage progenitors.2006

    • Author(s)
      Sugimoto, Y.
    • Journal Title

      Br J Haematol. 135(5)

      Pages: 725-731

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Molecular and phenotypic analysis of Philadelphia chromosome-positive bilineage leukemia : possibility of a lineage switch from T-lymphoid leukemic progenitor to myeloid cells2006

    • Author(s)
      Monma, F.
    • Journal Title

      Cancer Genet Cytogenet. 164(2)

      Pages: 118-121

    • Related Report
      2006 Annual Research Report
  • [Journal Article] In vitro stimulation of CD8 and CD4 cells by dendritic cells loaded with a complex of cholesterol-bearing hydrophobized pullulan and NY- ESO-1 protein : Identification of a new HLA-DR15-binding CD4 T-cell epitope.2006

    • Author(s)
      Hasegawa, K.
    • Journal Title

      Clin Cancer Res. 12(6)

      Pages: 1921-1927

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Generation of peptide-specific CD8(+) T cells by phytohemagglutinin-stimulated antigen-mRNA-transduced CD4(+) T cells2006

    • Author(s)
      Naota, H.
    • Journal Title

      J Immunol Methods. 314(1-2)

      Pages: 54-66

    • Related Report
      2006 Annual Research Report
  • [Journal Article] In vivo antigen delivery by a Salmonella typhimurium type III secretion system for therapeutic cancer vaccines.2006

    • Author(s)
      Nishikawa, H.
    • Journal Title

      J Clin Invest. 116(7)

      Pages: 1946-1954

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Interferon-γcontrols the generation/activation of CD4^+ CD25^+ regulatory T cells in anti-tumor immune response2005

    • Author(s)
      Nishikawa H., Kato T., Tawara I., Ikeda H., Kuribayashi K., Allen PM., Schreiber RD., Old LJ., Shiku H
    • Journal Title

      J. Immunol 175

      Pages: 4433-40

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Determination of Cellularly Processed HLA-A2402-Restricted Novel CTL Epitopes Derived from Two Cancer Germ line genes, MAGE-A4 and SAGE. Clin2005

    • Author(s)
      Miyahara Y., Naota H., Wang L., Hiasa A., Goto M., Watanabe M., Kitano S., Okumura S., Takemitsu T., Yuta A., Majima Y., Lemonnier FA., Boon T., Shiku H
    • Journal Title

      Cancer Res 11

      Pages: 5581-9

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Accelerated chemically induced tumor development mediated by CD4^+CD25^+ regulatory T cells in wild-type hosts2005

    • Author(s)
      Nishikawa H., Kato T., Tawara I., Takemitsu T., Saito K., Wang L., Ikarashi Y., Wakasugi H., Nakayama T., Taniguchi M., Kuribayashi K., Old LJ., Shiku H
    • Journal Title

      Proc. Natl. Acad. Sci. USA 102

      Pages: 9253-7

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Definition of target antigens for naturally occurring CD4^+CD25^+ regulatory T cells.2005

    • Author(s)
      Nishikawa, H.
    • Journal Title

      J.Exp Med. 201

      Pages: 681-686

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Accelerated chemically induced tumor development mediated by CD4^+CD25^+ regulatory T cells in wild-type hosts.2005

    • Author(s)
      Nishikawa, H.
    • Journal Title

      Proc Natl Acad Sci USA. 102

      Pages: 9253-9257

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Determination of Cellularly Processed HLA-A2402-Restricted Novel CTL Epitopes Derived from Two Cancer Germ Line Genes, MAGE-A4 and SAGE.2005

    • Author(s)
      Miyahara, Y.
    • Journal Title

      Clin Cancer Res. 11

      Pages: 5581-5589

    • Related Report
      2005 Annual Research Report
  • [Journal Article] A novel role for Notch ligand Delta-1 as a regulator of human Langerhans cell development from blood monocytes.2005

    • Author(s)
      Hoshino, N.
    • Journal Title

      J Leukoc Biol. 78(4)

      Pages: 921-929

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Interferon-γ controls the generation/activation of CD4^+CD25^+ regulatory T cells in anti-tumor immune response.2005

    • Author(s)
      Nishikawa, H.
    • Journal Title

      J Immunol. 175(7)

      Pages: 4433-4440

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Eexpression of CD29 on lymphoma cells ana/or CD36 on microvascular endothels correlates with high serum LDH level in diffuse large B-cell lymphomas (DLBCLs) and is frequent in de novo CD5-positive DLBCLs.2005

    • Author(s)
      Ueno, S.
    • Journal Title

      Int J Oncol. 27(5)

      Pages: 1241-1246

    • Related Report
      2005 Annual Research Report
  • [Presentation] Specific silencing of endogenous TCR with siRNAs in human lymphocytes improved expression and anti-tumor reactivity of transduced tumor-specific TCRs2009

    • Author(s)
      Okamoto S, MinenoJ, Ikeda H, Fujiwara H, Yasukawa M, Shiku H, Kato I
    • Organizer
      24th Annual Meeting of International Society for Biological Therapy of Cancer
    • Place of Presentation
      Washington DC, USA
    • Related Report
      2009 Final Research Report
  • [Presentation] Cancer regression in immunodeficient NOG mice by transfer of human T cellstransduced with MAGE-A4-specificαβtype TCR genes2008

    • Author(s)
      Ikeda H, Shirakura Y, Hiasa A, Hirayama M, Nishikawa H, Sato E, Nukaya I, Yu SS, Mineno J, Ito M, Kato I, Shiku H
    • Organizer
      16th Meeting in the Cancer Research Institute International Cancer Immunotherapy Symposium Siries and the 2008 Meeting of the Cancer Vaccine Consortium
    • Place of Presentation
      NY, USA
    • Related Report
      2009 Final Research Report
  • [Presentation] Appearance of multifunctional CD8+ effector T cell in vivo is a critical determinant of successful tumor eradication2008

    • Author(s)
      Imai N, Ikeda H, Tawara S, Mineno J, Kato I, Shiku H
    • Organizer
      16th Meeting in the Cancer Research Institute International Cancer Immunotherapy Symposium Siries and the 2008 Meeting of the Cancer Vaccine Consortium
    • Place of Presentation
      NY, USA
    • Related Report
      2009 Final Research Report
  • [Presentation] Regulatory T cell-resistant CD8+ T cells induced by GITR signaling2008

    • Author(s)
      Nishikawa H, Kato T, Harada N, Gnjatic S, Ritter G, Old LJ, Shiku H
    • Organizer
      16th Meeting in the Cancer Research Institute International Cancer Immunotherapy Symposium Siries and the 2008 Meeting of the Cancer Vaccine Consortium
    • Place of Presentation
      NY, USA
    • Related Report
      2009 Final Research Report
  • [Presentation] Vaccination with CHP-NY-ESO-1 to esophageal cancer patients elicits high-affinity NY-ESO-1-specific CD8+ CTLs recognizing tumor cells2008

    • Author(s)
      Hirayama M, Nishikawa H, Aoki M, Ueda S, Kanai M, Takabayashi A, Sato E, Kageyam S, Shiku H
    • Organizer
      16th Meeting in the Cancer Research Institute International Cancer Immunotherapy Symposium Siries and the 2008 Meeting of the Canser Vaccine Consortium
    • Place of Presentation
      NY, USA
    • Related Report
      2009 Final Research Report
  • [Presentation] Functional analyses of T cells transduced withMAGE-A4-specificαβtype TCR genes2008

    • Author(s)
      Hirayama M, Hiasa A, Nishikawa H, Shirakura Y, Ikeda H, Kitano S, Tajima K, Nukaya I, Yu SS, Mineno J, Ito M, Kato I, Shiku H
    • Organizer
      American Association for Cancer Research 99th Annual Meeting
    • Place of Presentation
      San Diego, USA
    • Related Report
      2009 Final Research Report
  • [Presentation] Rapid ab TCR-mediated responses in gd T cells transduced with cancer-specific TCR genes2008

    • Author(s)
      Hiasa A, Nishikawa H, Hirayama M, Kitano S, Okamoto S, Chono H, Yu SS, Mineno J, Tanaka Y, Minato N, Kato I, Shiku H
    • Organizer
      American Association for Cancer Research 99th Annual Meeting
    • Place of Presentation
      San Diego, USA
    • Related Report
      2009 Final Research Report
  • [Presentation] Combination cancer vaccine of CHP-NY-ESO-1 and CHP-HER2 with immuno-adjuvant, OK-432, for chemorefractory metastatic or recurrent esophageal cancer patients2008

    • Author(s)
      Ueda S, Aoki M, Nishikawa H, Hirayama M, Kitano S, Hayashi E, Kanai M, Takabayashi A, Shiku H, Kageyama S
    • Organizer
      American Association for Cancer Research 99th Annual Meeting
    • Place of Presentation
      San Diego, USA
    • Related Report
      2009 Final Research Report
  • [Presentation] GITR stimmulation enhances anti-tumor effect of adoptive cell therapy restoring activation of antigen-specific CD8+ T Cells2007

    • Author(s)
      Imai N, Ikeda H, Nishikawa H, Yamashita Y, Tawara I, Kato T, Shiku H
    • Organizer
      15th Cancer Research Institute Annual symposium
    • Place of Presentation
      NY, USA
    • Related Report
      2009 Final Research Report
  • [Presentation] A clinical trial of CHP-HER2 vaccine with adjuvant GM-CSF:A case representing antigen spreading2007

    • Author(s)
      Kitano S, Kageyama S, Nishikawa H, Hirayama M, Hiasa A, Ikeda H, Old LJ, Shiku H
    • Organizer
      15th Cancer Research Institute Annual symposium
    • Place of Presentation
      NY, USA
    • Related Report
      2009 Final Research Report
  • [Presentation] Ex vivo generation of human peripheral blood monocyte-derived antigen presenting cells2006

    • Author(s)
      Katayama N, Shiku H
    • Organizer
      International Symposium on Molecular Cell Biology of Macrophages and Dendritic Cells 2006
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2006-06-10
    • Related Report
      2009 Final Research Report
  • [Presentation] Humoral immune responses in patients vaccinated with HER2 protein complexed with a novel antigen delivery system of cholesteryl pullulan(CHP-HER2)2006

    • Author(s)
      Kitano S, Hirayama M, Kageyama S, Nagata Y, Nishikawa H, Scott AM, Murphy R, Hoffman EW, Old LJ, Shiku H
    • Organizer
      97TH Annual Meeting of American Association for Cancer Reseach
    • Place of Presentation
      Washington DC, USA
    • Related Report
      2009 Final Research Report
  • [Book] 内科学書内科学総論2009

    • Author(s)
      珠玖洋、池田裕明, 他
    • Publisher
      中山書店
    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://www.shikuken.jp/

    • Related Report
      2009 Final Research Report
  • [Patent(Industrial Property Rights)] 特異的遺伝子の発現方法2008

    • Inventor(s)
      峰野純一、岡本幸子、住岡理早、北川正成、珠玖洋、加藤郁之進
    • Industrial Property Rights Holder
      国立大学法人三重大学、タカラバイオ株式会社
    • Filing Date
      2008-06-10
    • Related Report
      2009 Final Research Report
  • [Patent(Industrial Property Rights)] 外来性GITRリガント発現細胞2008

    • Inventor(s)
      珠玖洋, 他
    • Industrial Property Rights Holder
      三重大学
    • Industrial Property Number
      2008-234812
    • Filing Date
      2008-09-12
    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] 細胞傷害性Tリンパ球2004

    • Inventor(s)
      珠玖洋、日浅厚則、奥村悟司、直田浩明、宮原慶裕
    • Industrial Property Rights Holder
      国立大学法人三重大学、タカラバイオ株式会社
    • Industrial Property Number
      2004-290785
    • Filing Date
      2004-10-01
    • Related Report
      2009 Final Research Report

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Published: 2005-04-01   Modified: 2018-03-28  

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