Innovative strategies in radiation therapy targeting tumor hypoxia by biological and physical approaches.
| Project/Area Number |
17016036
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Kyoto University |
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Principal Investigator |
HIRAOKA Mashiro Kyoto University, 医学研究科, 教授 (70173218)
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| Co-Investigator(Kenkyū-buntansha) |
KONDOH Shinae 京都大学, 医学研究科, 教授 (40314182)
MIZOWAKI Takashi 京都大学, 医学研究科, 講師 (90314210)
SHIBUYA Keiko 京都大学, 医学研究科, 助教 (50335262)
ITASAKA Satoshi 京都大学, 医学研究科, 助教 (90378654)
HARADA Hirohsi 京都大学, 医学研究科, 講師 (80362531)
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| Project Period (FY) |
2005 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥71,500,000 (Direct Cost: ¥71,500,000)
Fiscal Year 2009: ¥14,300,000 (Direct Cost: ¥14,300,000)
Fiscal Year 2008: ¥14,300,000 (Direct Cost: ¥14,300,000)
Fiscal Year 2007: ¥14,300,000 (Direct Cost: ¥14,300,000)
Fiscal Year 2006: ¥14,300,000 (Direct Cost: ¥14,300,000)
Fiscal Year 2005: ¥14,300,000 (Direct Cost: ¥14,300,000)
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| Keywords | 低酸素 / イメージング / 強度変調放射線治療 / 蛋白質製剤 / 同所性移植モデル / 放射線治療 / 低酸素がん細胞 / がん治療 / 標的特異性 / 標的治療 |
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| Research Abstract |
Hypoxic fraction in solid malignant tumor is strongly correlated with poor treatment effects of irradiation and prognosis. In order to develop an innovative radiation therapy strategy to overcome intra-tumor hypoxia, we have accomplished (1)evaluation of the presence and dynamic change of hypoxic region in the lung orthotopic tumor model, (2) development of the hypoxia targeted protein drug and the promotion of translational research, (3)optimization of the combination of the hypoxia targeted protein drug and irradiation, (4)establishment of Intensity Modulated Radiation Therapy(IMRT) method for simultaneous dose escalation in intra-tumor hypoxic region, (5)development of a treatment planning technique which can handle target motion and a moving phantom system for dose verification of moving target.
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Report
(6 results)
Research Products
(127 results)
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[Journal Article] Geometrical differences in target volumes between slow CT and 4D CT imaging in stereotactic body radiotherapy for lung tumors in the upper and middle lobe.2008
Author(s)
Nakamura M., Narita Y., Matsuo Y., Narabayashi M., Nakata M., Yano S., Miyabe Y, Matsugi K., Sawada A., Norihisa Y., Mizowaki T., Nagata Y., Hiraoka M.
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Journal Title
Med Phys. 35(9)
Pages: 4142-4148
Related Report
Peer Reviewed
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[Journal Article] Comparisons of the impact of systematic uncertainties on doses to the target among different plans of definitive external-beam radiotherapy for prostate cancer.2008
Author(s)
Zhu S., Mizowaki, T., Norihisa, Y., Takayama, K., Nagata, Y., and Hiraoka, M.
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Journal Title
Int J Clin Oncol 13(1)
Pages: 54-61
Related Report
Peer Reviewed
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[Journal Article] Significance of HIF-1-active cells in angiogenesis and radioresistance.2007
Author(s)
Harada, H., Kizaka-Kondoh, S., Li, G., Itasaka, S., Shibuya, K., Inoue, M., Hiraoka, M.
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Journal Title
Oncogene 26(54)
Pages: 7508-7516
Related Report
Peer Reviewed
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[Journal Article] An integrated Monte Carlo dosimetric verification system for radiotherapy treatment planning.2007
Author(s)
Yamamoto T, Mizowaki T, Miyabe Y, Takegawa, H., Narita, Y., Yano, S., Nagata, Y., Teshima, T. and Hiraoka, M.
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Journal Title
Phys Med Biol 52
Pages: 1991-2008
Related Report
Peer Reviewed
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