| Project/Area Number |
17016059
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
HAMADA Hirohumi Sapporo Medical University, 医学部, 教授 (00189614)
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| Co-Investigator(Kenkyū-buntansha) |
KATO Kazunori 札幌医科大学, 医学部, 准教授 (60233780)
NAKAMURA Kiminori 札幌医科大学, 医学部, 講師 (80381276)
HAMA Susumu 札幌医科大学, 医学部, 助教 (60438041)
YAMAGUCHI Miki 札幌医科大学, 医学部, 助教 (10530454)
濱田 洋文 札幌医科大学, 医学部, 准教授 (00189614)
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| Project Period (FY) |
2005 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥76,900,000 (Direct Cost: ¥76,900,000)
Fiscal Year 2009: ¥15,500,000 (Direct Cost: ¥15,500,000)
Fiscal Year 2008: ¥15,500,000 (Direct Cost: ¥15,500,000)
Fiscal Year 2007: ¥15,500,000 (Direct Cost: ¥15,500,000)
Fiscal Year 2006: ¥15,500,000 (Direct Cost: ¥15,500,000)
Fiscal Year 2005: ¥14,900,000 (Direct Cost: ¥14,900,000)
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| Keywords | 遺伝子治療 / アデノウィルスベクター / モノクローナル抗体 / 標的化抗体 / 標的化遺伝子導入 / 膵癌 / 悪性黒色腫 / 前立腺癌 / 遺伝子冶療 / アテノイルスベクター / アデノウイルスベクター / 悪性神経膠腫 / B細胞系の腫瘍 |
|---|
| Research Abstract |
In order to systematically search for the target molecules for cancer gene therapy, we generated a fiber-modified recombinant adenovirus, Adv-FZ33, which contains a Z33 domain with a high affinity for immunoglobulin Fc. By screening with Adv-FZ33, we established a large number of high affinity targeting antibodies (Ab), and identified their target antigen (Ag) molecules, e.g., a panel of 60 Ag species. During these efforts, we also established a unique method (EZiTox) to generate immunotoxins (iTox), which consists of the targeting Ab conjugated with ribosome-inactivating enzyme toxins. EZiTox method will be a strong screening method to find a powerful combination of Ag/Ab for cancer iTox-chemotherapy.
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