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Anticancer drug discovery based on regulation of chromatin structure and function

Research Project

Project/Area Number 17016080
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionThe Institute of Physical and Chemical Research

Principal Investigator

YOSHIDA Minoru  The Institute of Physical and Chemical Research, 吉田化学遺伝学研究室, 主任研究員 (80191617)

Co-Investigator(Kenkyū-buntansha) YASHIRODA Yoko  独立行政法人理化学研究所, 吉田化学遺伝学研究室, 専任研究員 (60360658)
NISHINO Norikazu  九州工業大学, 大学院・生命体工学研究科, 教授 (40145165)
Co-Investigator(Renkei-kenkyūsha) YANORI Takao  財団法人癌研究会, 癌化学療法センター分子薬理部, 部長 (60200854)
Project Period (FY) 2005 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥76,500,000 (Direct Cost: ¥76,500,000)
Fiscal Year 2009: ¥15,400,000 (Direct Cost: ¥15,400,000)
Fiscal Year 2008: ¥15,400,000 (Direct Cost: ¥15,400,000)
Fiscal Year 2007: ¥15,400,000 (Direct Cost: ¥15,400,000)
Fiscal Year 2006: ¥15,400,000 (Direct Cost: ¥15,400,000)
Fiscal Year 2005: ¥14,900,000 (Direct Cost: ¥14,900,000)
Keywordsヒストン / アセチル化 / メチル化 / SUMO化 / ケミカルゲノミクス / ドラックデザイン / スプライシング / エピジェネティクス / ピストン脱アセチル化酵素 / ヒストンメチル化酵素 / SUMO化酵素 / HDAC阻害剤 / SF3b / ヒストン脱アセチル化酵素 / HDAC6 / CHAP
Research Abstract

It has been shown that regulation of chromatin structure and function including histone acetylation is involved in tumorigenesis. In this study, we aimed to identify factors responsible for chromatin regulation and develop their inhibitors. We succeeded in developing Ky-2, a new HDAC inhibitor exhibiting strong antitumor activity, the first splicing inhibitor spliceostatin A that affects chromatin structure, and a novel fluorescent imaging probe that allows detection of histone acetylation in living cells.

Report

(6 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (115 results)

All 2010 2009 2008 2007 2006 2005

All Journal Article (84 results) (of which Peer Reviewed: 67 results) Presentation (16 results) Book (6 results) Patent(Industrial Property Rights) (9 results) (of which Overseas: 2 results)

  • [Journal Article] Bicyclic peptides as potent inhibitors of histone deacetylases: Optimization of alkyl loop length.2010

    • Author(s)
      Islam, N.M., Kato, T., Nishino, N., Kim, H. -J., Ito, A., Yoshida, M.
    • Journal Title

      Bioorg. Med. Chem. Lett. 20

      Pages: 997-999

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Garbled messages and corrupted translations.2010

    • Author(s)
      Schneider-Poetsch, T., Usui, T., Kaida, D., Yoshida, M.
    • Journal Title

      Nature Chem. Biol. 6

      Pages: 189-198

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Garbled messages and corrupted translations2010

    • Author(s)
      Schneider-Poetsch, T.et al.
    • Journal Title

      Nature Chem.Biol 6

      Pages: 189-198

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Total synthesis of the bicyclic depsipeptide HDAC inhibitors spiruchostatins A and B, 5''-epi-spiruchostatin B, FK228 (FR901228) and preliminary evaluation of their biological activity.2009

    • Author(s)
      Narita, K., Kikuchi, T., Watanabe, K., Takizawa, T., Oguchi, T., Kudo, K., Matsuhara, K., Abe, H., Yamori, T., Yoshida, M., Katoh, T.
    • Journal Title

      Chemistry 15

      Pages: 11174-11186

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Real-time imaging of histone H4 hyperacetylation in living cells.2009

    • Author(s)
      Sasaki, K., Ito, T., Nishino, N., Khochbin, S., Yoshida, M.
    • Journal Title

      Proc. Natl. Acad. Sci. U.S.A. 106

      Pages: 16257-16262

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] JBIR-17, a novel trichostatin analogue from Streptomyces sp. 26634.2009

    • Author(s)
      Ueda, J. -y., Hwang, J. -H., Kato, T., Ochiai, A., Isshiki, K., Yoshida, M., Takagi, M., Shin-ya, K.
    • Journal Title

      J. Antibiotics 62

      Pages: 283-285

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] The protein farnesyltransferase regulates HDAC6 activity in a microtubule-dependent manner.2009

    • Author(s)
      Zhou, J., Vos, C.C., Gjyrezi, A., Yoshida, M., Khuri, F.R., Tamanoi, F., Giannakakou, P.
    • Journal Title

      J. Biol. Chem. 284

      Pages: 9648-9655

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] New Rev-export inhibitor from Alpinia galanga and structure-activity relationship.2009

    • Author(s)
      Tamura, S., Shiomi, A., Kaneko, M., Ye, Y., Yoshida, M., Yoshikawa, M., Kimura, T., Kobayashi, M., Murakami, N.
    • Journal Title

      Bioorg. Med. Chem. Lett. 19

      Pages: 2555-2557

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] A molecular barcoded yeast ORF library enables mode-of-action analysis of bioactive compounds.2009

    • Author(s)
      Ho, C.H., Magtanong, L., Barker, S.L., Gresham, D., Nishimura, S., Natarajan, P., Koh, J.L.Y., Proter, J., Gray, C.A., Andersen, R.J., Giaever, G., Nislow, C., Andrews, B., Botstein, D., Graham, T.R., Yoshida, M., Boone, C.
    • Journal Title

      Nature Biotechnol. 27

      Pages: 369-377

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ginkgolic acid inhibits protein SUMOylation by blocking formation of the E1-SUMO intermediate.2009

    • Author(s)
      Fukuda, I., Ito, A., Hirai, G., Nishimura, S., Kawasaki, H., Saitoh, H., Kimura, K. -i., Sodeoka, M., Yoshida, M.
    • Journal Title

      Chem. Biol. 16

      Pages: 133-140

    • NAID

      120006385875

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Kerriamycin B inhibits protein SUMOylation.2009

    • Author(s)
      Fukuda, I., Ito, A., Uramoto, M., Saitoh, H., Kawasaki, H., Osada, H., Yoshida, M.
    • Journal Title

      J. Antibiotics 62

      Pages: 221-224

    • NAID

      10030635072

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Real-time imaging of histone H4 hyperacetylation in living cells2009

    • Author(s)
      Sasaki, K.et al.
    • Journal Title

      Proc.Natl.Acad.Sci.U.S.A. 106

      Pages: 16257-16262

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bicyclic peptides as potent inhibitors of histone deacetylases : Optimization of alkyl loop length2009

    • Author(s)
      Islam, N.M.et al.
    • Journal Title

      Bioorg.Med.Chem.Lett. 20

      Pages: 997-999

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] JBIR-17, a novel trichostatin analogue from Streptomyces sp.266342009

    • Author(s)
      Ueda, J.-y.et al.
    • Journal Title

      J.Antibiotics 62

      Pages: 283-285

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A molecular barcoded yeast ORF library enables mode-of-action analysis of bioactive compounds2009

    • Author(s)
      Ho, C.H.et al.
    • Journal Title

      Nature Biotechnol. 27

      Pages: 369-377

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] New Rev-export inhibitor from Alpinia galanga and structure-activity relationship2009

    • Author(s)
      Tamura, S.et al.
    • Journal Title

      Bioorg.Med.Chem.Lett. 19

      Pages: 2555-2557

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The protein farnesyltransferase regulates HDAC6 activity in a microtubule-dependent manner2009

    • Author(s)
      Zhou, J.et al.
    • Journal Title

      J.Biol.Chem. 284

      Pages: 9341-9353

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Total synthesis of the bicyclic depsipeptide HDAC inhibitors spiruchostatins A and B, 5"-epi-spiruchostatin B, FK228(FR901228)and preliminary evaluation of their biological activity2009

    • Author(s)
      Narita, K.et al.
    • Journal Title

      Chemistry 15

      Pages: 11174-11186

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ginkgolic acid inhibits protein SUMOylation by blocking formation of the El-SUMO intermediate2009

    • Author(s)
      Fukuda, I., et al.
    • Journal Title

      Chem. Biol. (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Kerriamycin B inhibits protein SUMOylation2009

    • Author(s)
      Fukuda, I., et al.
    • Journal Title

      J. Antibiotics (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interaction of aliphatic cap group in inhibition of histone deacetylases by cyclic tetrapeptides.2008

    • Author(s)
      Nishino, N., Shivashimpi, G.M., Soni, P.B., Bhuiyan, M.P.I., Kato, T., Maeda, S., Nishino, T.G., Yoshida, M.
    • Journal Title

      Bioorg. Med. Chem. 16

      Pages: 437-445

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] HDAC6 a new cellular stress surveillance factor.2008

    • Author(s)
      Matthias, P., Yoshida, M., Khochbin, S.
    • Journal Title

      Cell Cycle 7

      Pages: 7-10

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of antiangiogenic activity of azumamides by the in vitro vascular organization model using mouse-induced pluripotent stem (iPS) cells.2008

    • Author(s)
      Nakao, Y., Narazaki, G., Hoshino, T., Maeda, S., Yoshida, M., Maejima, H., Yamashita, J.K.
    • Journal Title

      Bioorg. Med. Chem. Lett. 18

      Pages: 2982-2984

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bach1 inhibits oxidative stress-induced cellular senescence by impeding p53 function on chromatin. Nature Struct.2008

    • Author(s)
      Dohi, Y., Ikura, T., Hoshikawa, Y., Katoh, Y., Ota, K., Nakanome, A., Muto, A., Omura, S., Ohta, T., Ito, A., Yoshida, M., Noda, T., Igarashi, K.
    • Journal Title

      Mol. Biol. 15

      Pages: 1246-1254

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characterisation of the in vitro activity of the depsipeptide histone deacetylase inhibitor spiruchostatin A.2008

    • Author(s)
      Crabb, S.J., Howell, M., Rogers, H., Ishfaq, M., Yurek-George, A., Carey, K., Pickering, B.M., East, P., Mitter, R., Maeda, S., Johnson, P.W., Townsend, P., Shin-ya, K., Yoshida, M., Ganesan, A., Packham, G.
    • Journal Title

      Biochem. Pharmacol. 76

      Pages: 463-475

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Combined effects of p53 gene therapy and leptomycin B in human esophageal squamous cell carcinoma.2008

    • Author(s)
      Hoshino, I., Matsubara, H., Komatsu, A., Akutsu, Y., Nishimori, T., Yoneyama, Y., Murakami, K., Sakata, H., Matsushita, K., Miyazawa, Y., Brooks, R., Yoshida, M., Ochiai, T.
    • Journal Title

      Oncology 75

      Pages: 113-119

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of downregulated HDAC6 expression on the proliferation of lung cancer cells. Biochem.2008

    • Author(s)
      Kamemura, K., Ito, A., Shimazu, T., Matsuyama, A., Maeda, S., Yao, T. -P., Horinouchi, S., Khochbin, S., Yoshida, M.
    • Journal Title

      Biophys. Res. Commun. 374

      Pages: 84-89

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 14-3-3 regulates the nuclear import of class IIa histone deacetylases.2008

    • Author(s)
      Nishino, T.G., Miyazaki, M., Hoshino, H., Miwa, Y., Horinouchi, S., Yoshida, M.
    • Journal Title

      Biochem. Biophys. Res. Commun. 377

      Pages: 852-856

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 14-3-3 regulates the nuclear import of class Iia histone deacetylases2008

    • Author(s)
      Nishino, T. G., et al.
    • Journal Title

      Biochem. Biophys. Res. Commun. 377

      Pages: 852-856

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interaction of aliphatic cap group in inhibition of histone deacetylases by cyclic tetrapeptides2008

    • Author(s)
      Nishino, N., et al.
    • Journal Title

      Bioorg. Med. Chem. 16

      Pages: 437-445

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of downregulated HDAC6 expression on the proliferation of lung cancer cells2008

    • Author(s)
      Kamemura, K., et al.
    • Journal Title

      Biochem. Biophys. Res. Commun. 374

      Pages: 84-89

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of antiangiogenic activity of azumamides by the in vitro vascular organization model using mouse-induced pluripotent stem (iPS) cells2008

    • Author(s)
      Nakao, Y., et al.
    • Journal Title

      Bioorg. Med. Chem. Lett. 18

      Pages: 2982-2984

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] HDAC6 a new cellular stress surveillance factor2008

    • Author(s)
      Matthias, P., et al.
    • Journal Title

      Cell Cycle 7

      Pages: 7-10

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Combined effects of p53 gene therapy and leptomycin B in human esophageal squamous cell carcinoma2008

    • Author(s)
      Hoshino, I., et al.
    • Journal Title

      Oncology 75

      Pages: 113-119

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterisation of the in vitro activity of the depsipeptide histone deacetylase inhibitor spiruchostatin A2008

    • Author(s)
      Crabb, S. J., et al.
    • Journal Title

      Biochem. Pharmacol. 76

      Pages: 463-475

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bach1 inhibits oxidative stress-induced cellular senescence by impeding p53 function on chromatin2008

    • Author(s)
      Dohi, Y, et al.
    • Journal Title

      Nature Struct. Mol. Biol. 15

      Pages: 1246-1254

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of splicing and nuclear retention of pre-mRNA by spliceostatin A in fission yeast.2007

    • Author(s)
      Lo, C. -W., Kaida, D., Nishimura, S., Matsuyama, A., Yashiroda, Y., Taoka, H., Ishigami, K., Watanabe, H., Nakajima, H., Tani, T., Horinouchi, S., Yoshida, M.
    • Journal Title

      Biochem. Biophys. Res. Commun. 364

      Pages: 573-577

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Multiple histone deacetylases and the CREB-binding protein regulate pre-mRNA 3'-end processing.2007

    • Author(s)
      Shimazu, T., Horinouchi, S., Yoshida, M.
    • Journal Title

      J. Biol. Chem. 282

      Pages: 4470-4478

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of protein phosphatase 2A nuclear accumulation and subsequent inactivation of activator protein-1 in leptomycin B-inhibited cyclin D1 expression.2007

    • Author(s)
      Tsuchiya, A., Tashiro, E., Yoshida, M., Imoto, M.
    • Journal Title

      Oncogene 26

      Pages: 1522-1532

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular design of histone deacetylase inhibitors by aromatic ring shifting in chlamydocin framework.2007

    • Author(s)
      Shivashimpi, G.M., Amagai, S., Kato, T., Nishino, N., Maeda, S., Nishino, T.G., Yoshida, M.
    • Journal Title

      Bioorg. Med. Chem. 15

      Pages: 7830-7839

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Design, synthesis, and evaluation of isoindolinone-hydroxamic acid derivatives as histone deacetylase (HDAC) inhibitors.2007

    • Author(s)
      Lee, S., Shinji, C., Ogura, K., Shimizu, M., Maeda, S., Sato, M., Yoshida, M., Hashimoto, Y., Miyachi, H.
    • Journal Title

      Bioorg. Med. Chem. Lett. 17

      Pages: 4895-4900

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA.2007

    • Author(s)
      Kaida, D., Motoyoshi, H., Tashiro, E., Nojima, T., Hagiwara, M., Ishigami, K., Watanabe, H., Kitahara, T., Yoshida, T., Nakajima, H., Tani, T., Horinouchi, S., Yoshida, M.
    • Journal Title

      Nature Chem. Biol. 3

      Pages: 576-583

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] The first biologically active synthetic analogues of FK228, the depsipeptide histone deacetylase inhibitor.2007

    • Author(s)
      Yurek-George, A., Cecil, A.R.L., Mo, A.H.K., Wen, S., Rogers, H., Habens, F., Maeda, S., Yoshida, M., Packham, G., Ganesan, A.
    • Journal Title

      J. Med. Chem. 50

      Pages: 5720-5726

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Corepressor SMRT and class II histone deacetylases promote Bach2 nuclear retention and formation of nuclear foci that are responsible for local transcriptional repression.2007

    • Author(s)
      Hoshino, H., Nishino, T.G., Tashiro, S., Miyazaki, M., Ohmiya, Y., Igarashi, K., Horinouchi, S., Yoshida, M.
    • Journal Title

      J. Biochem. (Tokyo) 141

      Pages: 719-727

    • NAID

      10020099472

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA2007

    • Author(s)
      Kaida, D., et al.
    • Journal Title

      Nature Chem.Biol. 3

      Pages: 576-583

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of protein phosphatase 2A nuclear accumulation and subsequent inactivation of activator protein-1 in leptomycin B-inhibited cyclin D1 expression2007

    • Author(s)
      Tsuchiya, A., et al.
    • Journal Title

      Oncogene 26

      Pages: 1522-1532

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Compressor SMRT and class II histone deacetylases promote Bach2 nuclear retention and formation of nuclear foci that are responsible for local transcriptional repression2007

    • Author(s)
      Hoshino, H., et al.
    • Journal Title

      J.Biochem. (Tokyo) 141

      Pages: 719-727

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular design of histone deacetylase inhibitors by aromatic ring shifting in chlamydocin framework2007

    • Author(s)
      Shivashimpi, G.M., et al.
    • Journal Title

      Bioorg.Med.Chem. 15

      Pages: 7830-7839

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The first biologically active synthetic analogues of FK228, the depsipeptide histone deacetylase inhibitor2007

    • Author(s)
      Yurek-George, A., et al.
    • Journal Title

      J.Med.Chem. 50

      Pages: 5720-5726

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of splicing and nuclear retention of pre-mRNA by spliceostatin A in fission yeast2007

    • Author(s)
      Lo, C.-W., et al.
    • Journal Title

      Biochem.Biophys.Res.Commun. 364

      Pages: 573-577

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Design, synthesis, and evaluation of isoindolinone-hydroxamic acid derivatives as histone deacetylase (HDAC) inhibitors2007

    • Author(s)
      Lee, S.,
    • Journal Title

      Bioorg.Med.Chem.Lett. 17

      Pages: 4895-4900

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Multiple histone deacetylases and CBP regulates pre-mRNA 3'-end processing.2007

    • Author(s)
      Shimazu, T., et al.
    • Journal Title

      J. Biol. Chem. 282

      Pages: 4470-4478

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Bone morphogenetic protein-2 stimulates Runx2 acetylation.2006

    • Author(s)
      Jeon, E. -J., Lee, K. -Y., Choi, N. -S., Lee, M. -H., Kim, H. -N., Jin, Y. -H., Ryoo, H. -M., Choi, J. -Y., Yoshida, M., Nishino, N., Oh, B. -C., Lee, K. -S., Lee, Y.H., Bae, S. -C.
    • Journal Title

      J. Biol. Chem. 281

      Pages: 16502-16511

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nucleolin is involved in interferon Regulatory Factor-2 dependent transcriptional activation.2006

    • Author(s)
      Masumi, A., Fukazawa, H., Shimazu, T., Yoshida, M., Ozato, K., Komuro, K., Yamaguchi, K.
    • Journal Title

      Oncogene 25

      Pages: 5113-5124

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of SV40 large T antigen stability by reversible acetylation.2006

    • Author(s)
      Shimazu, T., Komatsu, Y., Nakayama, K.I., Fukazawa, H., Horinouchi, S., Yoshida, M.
    • Journal Title

      Oncogene 25

      Pages: 7391-7400

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.2006

    • Author(s)
      Matsuyama, A., Arai, R., Yashiroda, Y., Shirai, A., Kamata, A., Sekido, S., Kobayashi, Y., Hashimoto, A., Hamamoto, M., Hiraoka, Y., Horinouchi, S., Yoshida, M.
    • Journal Title

      Nature Biotechnol. 24

      Pages: 841-847

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nucleocytoplasmic transport of fluorescent mRNA in living mammalian cells: nuclear mRNA export is coupled to ongoing gene transcription.2006

    • Author(s)
      Tokunaga, K., Shibuya, T., Ishihama, Y., Tadakuma, H., Ide, M., Yoshida, M., Funatsu, T., Ohshima, Y., Tani, T.
    • Journal Title

      Genes Cells 11

      Pages: 305-317

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chlamydocin analogs bearing carbonyl group as possible ligand toward zinc atom in histone deacetylases.2006

    • Author(s)
      Bhuiyan, M.P., Kato, T., Okauchi, T., Nishino, N., Maeda, S., Nishino, T.G., Yoshida, M.
    • Journal Title

      Bioorg. Med. Chem. 14

      Pages: 3438-3446

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Induction of a ribotoxic stress response that stimulates stress-activated protein kinases by 13-deoxytedanolide, an antitumor marine macrolide. Biosci.2006

    • Author(s)
      Lee, K. -H., Nishimura, S., Matsunaga, S., Fusetani, N., Ichijo, H., Horinouchi, S., Yoshida, M.
    • Journal Title

      Biotechnol. Biochem. 69

      Pages: 161-171

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Design, synthesis, and evaluation of cyclic amide/imide-bearing hydroxamic acid derivatives as class-selective histone deacetylase (HDAC) inhibitors.2006

    • Author(s)
      Shinji, C., Maeda, S., Imai, K., Yoshida, M., Hashimoto, Y., Miyachi, H.
    • Journal Title

      Bioorg Med Chem. 14

      Pages: 7625-7651

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Highly potent and selective histone deacetylase 6 inhibitors designed based on a small-molecular substrate.2006

    • Author(s)
      Suzuki, T., Kouketsu, A., Itoh, Y., Hisakawa, S., Maeda, S., Yoshida, M., Nakagawa, H., Miyata, N.
    • Journal Title

      J Med. Chem. 49

      Pages: 4809-4812

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sichuan pepper extracts block the PAK1/Cyclin D1 pathway and the growth of NF1-deficient cancer xenograft in mice.2006

    • Author(s)
      Hirokawa, Y., Nheu, T., Grimm, K., Mautner, V., Maeda, S., Yoshida, M., Komiyama, K., Maruta, H.
    • Journal Title

      Cancer Biol Ther 5

      Pages: 305-309

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of SV40 large T antigen stability by reversible acetylation.2006

    • Author(s)
      Shimazu, T., et al.
    • Journal Title

      Oncogene 25

      Pages: 7391-7400

    • Related Report
      2006 Annual Research Report
  • [Journal Article] ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.2006

    • Author(s)
      Matsuyama, A., et al.
    • Journal Title

      Nature Biotechnol. 24

      Pages: 841-847

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Nucleolin is involved in interferon Regulatory Factor-2 dependent transcriptional activation.2006

    • Author(s)
      Masumi, A., et al.
    • Journal Title

      Oncogene 25

      Pages: 5113-5124

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Highly potent and selective histone deacetylase 6 inhibitors designed based on a small-molecular substrate.2006

    • Author(s)
      Suzuki, T., et al.
    • Journal Title

      J. Med. Chem. 49

      Pages: 4809-4812

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Design, synthesis, and evaluation of cyclic amide/imide-bearing hydroxamic acid derivatives as class-selective histone deacetylase (HDAC) inhibitors.2006

    • Author(s)
      Shinji, C., et al.
    • Journal Title

      Bioorg. Med. Chem. 14

      Pages: 7625-7651

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Nucleocytoplasmic transport of fluorescent mRNA in living mammalian cells : nuclear mRNA export is coupled to ongoing gene transcription.2006

    • Author(s)
      Tokunaga, K., et al.
    • Journal Title

      Genes Cells 11

      Pages: 305-317

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Sichuan pepper extracts block the PAK1/Cyclin D1 pathway and the growth of NF1 -deficient cancer xenograft in mice.2006

    • Author(s)
      Hirokawa, Y., et al.
    • Journal Title

      Cancer Biol. Ther. 5

      Pages: 3-3

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Bone morphogenetic protein-2 stimulates Runx2 acetylation.2006

    • Author(s)
      Jeon, E.-J., et al.
    • Journal Title

      J. Biol. Chem. 281

      Pages: 16502-16511

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Chlamydocin analogs bearing carbonyl group as possible ligand toward zinc atom in histone deacetylases.2006

    • Author(s)
      Bhuiyan, M.P., et al.
    • Journal Title

      Bioorg. Med. Chem. 14

      Pages: 3438-3446

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Induction of a ribotoxic stress response that stimulates stress-activated protein kinase by 13-deoxytedanolide, an antitumor marine macrolide.2006

    • Author(s)
      Lee, K.-H., et al.
    • Journal Title

      Biosci. Biotechnol. Biochem. 69

      Pages: 161-171

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Nuclear-cytoplasmic shuttling of a RING-IBR protein RBCK1 and its functional interaction with nuclear body proteins.2005

    • Author(s)
      Tatematsu, K., Yoshimoto, N., Koyanagi, T., Tokunaga, C., Tachibana, T., Yoneda, Y., Yoshida, M., Okajima, T., Tanizawa, K., Kuroda, S. i.
    • Journal Title

      . Biol. Chem. 280

      Pages: 22937-22944

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] HIV-Tat targets Tip60 to impair the apoptotic cell response to genotoxic stresses.2005

    • Author(s)
      Col, E., Caron, C., Chable-Bessia, C., Legube, G., Gazzeri, S., Komatsu, Y., Yoshida, M., Benkirane, M., Trouche, D., Khochbin, S.
    • Journal Title

      EMBO J. 24

      Pages: 2634-2645

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of protein synthesis and activation of stress-activated protein kinases by onnamide A and theopederin B, antitumor marine natural products.2005

    • Author(s)
      Lee, K. -H., Nishimura, S., Matsunaga, S., Fusetani, N., Horinouchi, S., Yoshida, M.
    • Journal Title

      Cancer Sci. 96

      Pages: 357-364

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] T. -P. HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor.2005

    • Author(s)
      Kovacs, J.J., Murphy, P.J.M., Gaillard, S., Zhao, X., Wu, J. -T., Nicchitta, C.V., Yoshida, M., Toft, D.O., Pratt, W.B., Yao
    • Journal Title

      Mol. Cell 18

      Pages: 601-607

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Design and synthesis of phthalimide-type histone deacetylase inhibitors.2005

    • Author(s)
      Shinji, C., Nakamura, T., Maeda, S., Yoshida, M., Hashimoto, Y., Miyachi, H.
    • Journal Title

      Bioorg Med Chem Lett. 15

      Pages: 4427-4431

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Significance of HDAC6 regulation via estrogen signaling for cell motility and prognosis in estrogen receptor-positive breast cancer.2005

    • Author(s)
      Saji, S., Kawakami, M., Hayashi, S.I., Yoshida, N., Hirose, M., Horiguchi, S.I., Itoh, A., Funata, N., Schreiber, S.L., Yoshida, M., Toi, M.
    • Journal Title

      Oncogene 24

      Pages: 4531-4539

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Design and synthesis of phthalimide-type histone deacetylase inhibitors2005

    • Author(s)
      Shinji et al.
    • Journal Title

      Bioorg.Med.Chem.Lett. 15・20

      Pages: 4427-4431

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Nuclear-cytoplasmic shuttling of a RING-IBR protein RBCK1 and its functional interaction with nuclear body proteins2005

    • Author(s)
      Tatematsu et al.
    • Journal Title

      J.Biol.Chem. 280・24

      Pages: 22937-22944

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Significance of HDAC6 regulation via estrogen signaling for cell motility and prognosis in estrogen receptor-positive breast cancer2005

    • Author(s)
      Saji et al.
    • Journal Title

      Oncogene 24・28

      Pages: 4531-4539

    • Related Report
      2005 Annual Research Report
  • [Journal Article] HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor2005

    • Author(s)
      Kovacs et al.
    • Journal Title

      Mol.Cell 18・5

      Pages: 601-607

    • Related Report
      2005 Annual Research Report
  • [Journal Article] HIV-Tat targets Tip60 to impair the apoptotic cell response to genotoxic stresses2005

    • Author(s)
      Col et al.
    • Journal Title

      EMBO J. 24・14

      Pages: 2634-2645

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Inhibition of protein synthesis and activation of stress-activated protein kinases by onnamide A and theopederin B, antitumor marine natural products2005

    • Author(s)
      Lee et al.
    • Journal Title

      Cancer Sci. 96・6

      Pages: 357-364

    • Related Report
      2005 Annual Research Report
  • [Presentation] 遺伝子発現とエピジェネティクスを制御する新たな分子標的の探索. 岩手医科大学2009

    • Author(s)
      吉田稔
    • Organizer
      化学療法基盤情報支援班共催シンポジウム「抗がん剤創薬の新たな展開」
    • Place of Presentation
      矢巾町
    • Year and Date
      2009-01-16
    • Related Report
      2009 Final Research Report
  • [Presentation] 遺伝子発現とエピジェネティクスを制御する新たな分子標的の探索2009

    • Author(s)
      吉田 稔
    • Organizer
      岩手医科大学・化学療法基盤情報支援班共催シンポジウム
    • Place of Presentation
      紫波郡 矢巾町
    • Year and Date
      2009-01-16
    • Related Report
      2008 Annual Research Report
  • [Presentation] Forward and reverse proteomic approaches for functional analysis of non-nuclear sirtuins. FASEB (Federation of American Societies for Experimental Biology) Summer Research Conferences2009

    • Author(s)
      Minoru Yoshida.
    • Organizer
      Histone Deacetylases and Reversible Acetylation in Signaling and Disease
    • Place of Presentation
      Lucca, Italy.
    • Related Report
      2009 Final Research Report
  • [Presentation] Forward and reverse proteomic approaches for functional analysis of non-nuclear sirtuins2009

    • Author(s)
      Yoshida, M.
    • Organizer
      Federation of American Societies for Experimental Biology Summer Research Conferences
    • Place of Presentation
      Lucca, Italy
    • Related Report
      2009 Annual Research Report
  • [Presentation] Splicing factor SF3b as a novel target for cancer therapy.2008

    • Author(s)
      Minoru Yoshida.
    • Organizer
      The 13th Japanese Foundation for Cancer Research International Symposium on Cancer Chemotherapy
    • Place of Presentation
      Tokyo, Japan.
    • Related Report
      2009 Final Research Report
  • [Presentation] ケミカルジェネティクスによる抗がん剤分子標的の探索2008

    • Author(s)
      吉田稔
    • Organizer
      第55回日本臨床検査医学会学術集会
    • Place of Presentation
      名古屋
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] クロマチン機能を標的としたケミカルバイオロジー2008

    • Author(s)
      吉田稔
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] Chemical genetics for novel anticancer microbial products.2008

    • Author(s)
      Minoru Yoshida.
    • Organizer
      The 4th Finland-Japan Meeting on Biotechnology
    • Place of Presentation
      Sapporo, Japan.
    • Related Report
      2009 Final Research Report
  • [Presentation] Chemical genetics for novel anticancer microbial products2008

    • Author(s)
      吉田 稔
    • Organizer
      The 4th Finland-Japan Meeting on Biotechnology
    • Place of Presentation
      札幌
    • Related Report
      2008 Annual Research Report
  • [Presentation] Splicing Factor SF3b as a novel target for cancer therapy2008

    • Author(s)
      吉田 稔
    • Organizer
      The 13th Japanese Foundation for Cancer Research International Symposium on Cancer Chemotherapy
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] Chemical genetics of a small molecule cell cycle inhibitor that inhibits pre-mRNA splicing.2007

    • Author(s)
      Minoru Yoshida.
    • Organizer
      The 4th Takeda Science Foundation Symposium on Pharma Sciences on the Frontiers of Chemical Biology
    • Place of Presentation
      Tokyo, Japan
    • Related Report
      2009 Final Research Report
  • [Presentation] Identification of a spliceosome sub-complex SF3b as a novel target for cancer therapy.2007

    • Author(s)
      吉田稔
    • Organizer
      第66回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2009 Final Research Report
  • [Presentation] Extracellular signal- dependent protein lysine acetylation as a molecular modulator for cellular functions. FASEB (Federation of American Societies for Experimental Biology)2007

    • Author(s)
      Minoru Yoshida.
    • Organizer
      Summer Research Conferences
    • Place of Presentation
      Snowmass Village, USA.
    • Related Report
      2009 Final Research Report
  • [Presentation] Extracellular signal-dependent protein lysine acetylation as a molecular modulator for cellular functions2007

    • Author(s)
      吉田稔
    • Organizer
      FASEB (Federation of American Societies for Experimental Biology) Summer Research Conferences
    • Place of Presentation
      Snowmass Village, USA
    • Related Report
      2007 Annual Research Report
  • [Presentation] Identification of a spliceosome sub-complex SF3b as a nobel target for cancer therapy2007

    • Author(s)
      吉田稔
    • Organizer
      第66回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] Chemical genetics of a small molecule cell cycle inhibitor that inhibits pre-mRNA splicing2007

    • Author(s)
      吉田稔
    • Organizer
      The 4th Takeda Science Foundation Symposium on Pharma Sciences On the Frontiers of Chemical Biology
    • Place of Presentation
      Tokyo
    • Related Report
      2007 Annual Research Report
  • [Book] Methods in Molecular Biology (Methods Mol. Biol. ) Vol. 577: Reverse chemical genetics methods and protocols.2009

    • Author(s)
      Akihisa Matsuyama, Minoru Yoshida.
    • Publisher
      Humana Press
    • Related Report
      2009 Final Research Report
  • [Book] Methods in Molecular Biology2009

    • Author(s)
      Matsuyama, A.
    • Publisher
      Humana Press
    • Related Report
      2009 Annual Research Report
  • [Book] Totowa New Jersey. Histone Deacetylases: Transcriptional Regulation and Other Cellular Functions.2006

    • Author(s)
      Akihiro Ito, Norikazu Nishino, Minoru Yoshida.
    • Publisher
      Humana Press
    • Related Report
      2009 Final Research Report
  • [Book] HDAC inhibitors : discovery, development, and clinical impacts. In Histone Deacetylases2006

    • Author(s)
      Ito, A., Nishino, N., Yoshida, M
    • Total Pages
      340
    • Publisher
      Humana Press, Totowa New Jersey
    • Related Report
      2006 Annual Research Report
  • [Book] ケミカルバイオロジー・ケミカルゲノミクス2005

    • Author(s)
      吉田稔
    • Publisher
      シュプリンガー・フェアラーク
    • Related Report
      2009 Final Research Report
  • [Book] ケミカルバイオロジー・ケミカルゲノミクス2005

    • Author(s)
      半田宏編
    • Total Pages
      278
    • Publisher
      シュプリンガー・フェアラーク東京
    • Related Report
      2005 Annual Research Report
  • [Patent(Industrial Property Rights)] ヒストン脱アセチル化酵素阻害剤およびその製造方法2010

    • Inventor(s)
      吉田稔、西野憲和
    • Industrial Property Rights Holder
      理化学研究所
    • Acquisition Date
      2010-03-10
    • Related Report
      2009 Final Research Report
  • [Patent(Industrial Property Rights)] ヒストン脱アセチル化酵素阻害剤およびその製造方法2010

    • Inventor(s)
      吉田稔、西野憲和
    • Industrial Property Rights Holder
      理化学研究所
    • Acquisition Date
      2010-03-10
    • Related Report
      2009 Final Research Report
  • [Patent(Industrial Property Rights)] ヒストン脱アセチル化酵素阻害剤およびその製造方法2010

    • Inventor(s)
      吉田稔、西野憲和
    • Industrial Property Rights Holder
      独立行政法人理化学研究所
    • Acquisition Date
      2010-03-10
    • Related Report
      2009 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] ヒストン脱アセチル化酵素阻害活性を有する化合物とそれを有効成分とする医薬(ヒストン脱アセチル化酵素の阻害剤およびその製造方法)2007

    • Inventor(s)
      西野憲和、吉田稔、中川純一
    • Industrial Property Rights Holder
      九州工業大学、理化学研究所、大正製薬株式会社
    • Filing Date
      2007-07-31
    • Related Report
      2009 Final Research Report
  • [Patent(Industrial Property Rights)] ヒストン脱アセチル化酵素阻害活性を有する化合物とそれを有効成分とする医薬(ピストン脱アセチル化酵素の阻害剤およびその製造方法)2007

    • Inventor(s)
      九州工業大学理化学研究所大正製薬株式会社
    • Industrial Property Rights Holder
      西野憲和, 吉田稔, 中川純一
    • Filing Date
      2007-07-31
    • Related Report
      2007 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] ヒストン脱アセチル化酵素阻害活性を有する化合物とそれを有効成分とする医薬2006

    • Inventor(s)
      西野憲和、吉田稔、中川純一
    • Industrial Property Rights Holder
      九州工業大学、理化学研究所、大正製薬株式会社
    • Industrial Property Number
      2006-239901
    • Filing Date
      2006-09-05
    • Related Report
      2009 Final Research Report
  • [Patent(Industrial Property Rights)] ヒストン脱アセチル化酵素阻害活性を有する化合物とそれを有効成分とする医薬2006

    • Inventor(s)
      西野憲和, 吉田稔, 中川純一
    • Industrial Property Rights Holder
      九工大, 理研, 大正製薬
    • Industrial Property Number
      2006-239901
    • Filing Date
      2006-09-05
    • Related Report
      2006 Annual Research Report
  • [Patent(Industrial Property Rights)] HDAC阻害活性を有する新規置換ヒドロキサム酸誘導体2005

    • Inventor(s)
      宮地弘幸、橋本祐一、進士千尋、吉田稔
    • Industrial Property Rights Holder
      東京大学、理化学研究所
    • Industrial Property Number
      2005-267767
    • Filing Date
      2005-09-15
    • Related Report
      2009 Final Research Report
  • [Patent(Industrial Property Rights)] HDAC阻害活性を有する新規置換ヒドロキサム酸誘導体2005

    • Inventor(s)
      宮地 弘幸 他3名
    • Industrial Property Rights Holder
      東京大学, 理化学研究所
    • Industrial Property Number
      2005-267767
    • Filing Date
      2005-09-15
    • Related Report
      2005 Annual Research Report

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Published: 2005-04-01   Modified: 2018-03-28  

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