Analysis of developmental mechanisms based on functional genomic information of the nematode C. elegans
| Project/Area Number |
17017038
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
SUGIMOTO Asako The Institute of Physical and Chemical Research, 発生ゲノミクス研究チーム, チームリーダー (80281715)
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| Co-Investigator(Kenkyū-buntansha) |
ONAMI Shuichi 独立行政法人理化学研究所, 発生システムモデル化研究チーム, チームリーダー (50348843)
KIMURA Akatsuki 慶應義塾大学, 大学院・理工学研究科, 助手 (10365447)
KYODA Koji 独立行政法人理化学研究所, 合成ゲノミクス研究チーム, 研究員 (30415145)
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| Project Period (FY) |
2005 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥101,800,000 (Direct Cost: ¥101,800,000)
Fiscal Year 2009: ¥19,200,000 (Direct Cost: ¥19,200,000)
Fiscal Year 2008: ¥19,100,000 (Direct Cost: ¥19,100,000)
Fiscal Year 2007: ¥18,900,000 (Direct Cost: ¥18,900,000)
Fiscal Year 2006: ¥18,600,000 (Direct Cost: ¥18,600,000)
Fiscal Year 2005: ¥26,000,000 (Direct Cost: ¥26,000,000)
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| Keywords | ゲノム / 遺伝子 / 発生・分化 / モデル化 / ライブイメージング / 画像処理 / バイオイメージインフォマティクス / 線虫 / RNAi / 細胞分裂 / 表現型 / 胚発生 |
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| Research Abstract |
To understand the genetic networks that control animal development, the following were performed using the early embryogenesis of the nematode C.elegans
as a model system. 1) Development of tools (such as GFP/RFP-tagged protein markers and monoclonal antibodies) and imaging techniques, and imaging data collection, 2) Computational analysis of the phenotype image data, and 3) Development of research strategy that integrate quantitative phenotype analysis and simulation.
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Report
(6 results)
Research Products
(109 results)
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[Journal Article] Caenorhabditis elegans geminin homologue participates in cell cycle regulation and germ line development.2005
Author(s)
Yanagi, K., Mizuno, T., Tsuyama, T., Tada, S., Iida, Y., Sugimoto, A., Eki, T., Enomoto, T., Hanaoka, F.
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Journal Title
J Biol Chem 280
Pages: 19689-19694
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[Presentation] Computational analysis of quantitative information of cell division dynamics of early embryos.2009
Author(s)
Kyoda, K., Adachi, E., Shimada, K., Kuramochi, J., Onami, S.
Organizer
17th International C. elegans Meeting.
Place of Presentation
LA, USA
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