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The systematic analysis on the diseases through the integration of the clinical data with the genomic information

Research Project

Project/Area Number 17019008
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionThe University of Tokyo

Principal Investigator

NAGAI Ryozo  The University of Tokyo, 医学部付属病院, 教授 (60207975)

Co-Investigator(Kenkyū-buntansha) HARA Kazuo  東京大学, 医学部附属病院, 講師 (50359600)
MORITA Hiroyuki  東京大学, 医学部附属病院, 特任准教授 (60323573)
戸辺 一之  東京大学, 医学部附属病院, 講師 (30251242)
Project Period (FY) 2005 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥161,600,000 (Direct Cost: ¥161,600,000)
Fiscal Year 2009: ¥30,000,000 (Direct Cost: ¥30,000,000)
Fiscal Year 2008: ¥30,000,000 (Direct Cost: ¥30,000,000)
Fiscal Year 2007: ¥33,700,000 (Direct Cost: ¥33,700,000)
Fiscal Year 2006: ¥34,000,000 (Direct Cost: ¥34,000,000)
Fiscal Year 2005: ¥33,900,000 (Direct Cost: ¥33,900,000)
Keywordsデータベース / ゲノム / 生活習慣病 / 臨床情報 / ゲノム解析 / 動脈硬化 / 一塩基多型 / 転写制御 / 虚血性心疾患 / 生命システム
Research Abstract

The onset and/or progression of the diseases could mean the expression of the "failure of the life system". The purpose of this study is to understand the life system and the mechanism of the diseases through the integration of the clinical data with the genomic information. In addition, applying its outcomes to the basic research, we could get the theoretical rationale for the best individualized medicine. In this study, we realized the construction and practical use of the systematic database system unifying the comprehensive clinical data and genomic information in the University of Tokyo Hospital. Using this database system, we examined many SNPs which were reported to be associated with cardiovascular diseases and/or diabetes, and identified novel significant SNPs. For example, the SNP in the promoter region of transcription factor KLF5 is here demonstrated to be related to the progression of cardiovascular analysis. The pathophysiological meaning of this KLF5 SNP was also clarified in this study. Like this, in this study, the integration of the clinical data with the genomic information was performed to find out the novel useful clinical markers as well as the pathophysiological mechanisms, both of which are applicable to the individualized medicine.

Report

(6 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (54 results)

All 2009 2008 2007 2006 2005 Other

All Journal Article (47 results) (of which Peer Reviewed: 35 results) Presentation (3 results) Book (3 results) Remarks (1 results)

  • [Journal Article] Smoking exposure, 17q21 variants, and early-onset asthma2009

    • Author(s)
      Morita H, Nagai R.
    • Journal Title

      N Engl J Med. 360(12)

      Pages: 1255-1255

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genetically elevated C-reactive protein and vascular disease2009

    • Author(s)
      Morita H, Nagai R.
    • Journal Title

      N Engl J Med. 360(9)

      Pages: 934-934

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Replication study for the association of new meta-analysis-derived risk loci with susceptibility to type 2 diabetes in 6, 244 Japanese individuals2009

    • Author(s)
      Omori S, Tanaka Y, Horikoshi M, Takahashi A, Hara K, Hirose H, Kashiwagi A, Kaku K, Kawamori R, Kadowaki T, Nakamura Y, Maeda S.
    • Journal Title

      Diabetologia 52(8)

      Pages: 1554-60

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Construction of a prediction model for type 2 diabetes mellitus in the Japanese population based on 11 genes with strong evidence of the association2009

    • Author(s)
      Miyake K, Yang W, Hara K, Yasuda K, Horikawa Y, Osawa H, Furuta H, Ng MC, Hirota Y, Mori H, Ido K, Yamagata K, Hinokio Y, Oka Y, Iwasaki N, Iwamoto Y, Yamada Y, Seino Y, Maegawa H, Kashiwagi A, Wang HY, Tanahashi T, Nakamura N, Takeda J, Maeda E, Yamamoto K, Tokunaga K, Ma RC, So WY, Chan JC, Kamatani N, Makino H, Nanjo K, Kadowaki T, Kasuga M.
    • Journal Title

      J Hum Genet 54(4)

      Pages: 236-41

    • NAID

      10030730081

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity2009

    • Author(s)
      Nishimura S, Manabe I, Nagasaki M, Eto K, Yamashita H, Ohsugi M, Otsu M, Hara K, Ueki K, Sugiura S, Yoshimura K, Kadowaki T, Nagai R.
    • Journal Title

      Nat Med 15(8)

      Pages: 914-920

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Kruppel-like factor 5 shows proliferation-specific roles in vascular remodeling, direct stimulation of cell growth, and inhibition of apoptosis2009

    • Author(s)
      Suzuki T, Sawaki D, Aizawa K, Munemasa Y, Matsumura T, Ishida J, Nagai R.
    • Journal Title

      J Biol Chem 284(14)

      Pages: 9549-9557

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Smoking exposure, 17q21 variants, and early-onset asthma2009

    • Author(s)
      Morita H, Nagai R
    • Journal Title

      N Engl J Med 360

      Pages: 1255-1255

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetically elevated C-reactive protein and vascular disease2009

    • Author(s)
      Morita H, Nagai R
    • Journal Title

      N Engl J Med 360

      Pages: 934-934

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CD8+effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity2009

    • Author(s)
      Nishimura S, Nagai R, et al.
    • Journal Title

      Nat Med 15

      Pages: 914-920

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus2008

    • Author(s)
      Yasuda K, Miyake K, Horikawa Y, Hara K, Osawa H, Furuta H, Hirota Y, Mori H, Jonsson A, Sato Y, Yamagata K, Hinokio Y, Wang HY, Tanahashi T, Nakamura N, Oka Y, Iwasaki N, Iwamoto Y, Yamada Y, Seino Y, Maegawa H, Kashiwagi A, Takeda J, Maeda E, Shin HD, Cho YM, Park KS, Lee HK, Ng MC, Ma RC, So WY, Chan JC, Lyssenko V, Tuomi T, Nilsson P, Groop L, Kamatani N, Sekine A, Nakamura Y, Yamamoto K, Yoshida T, Tokunaga K, Itakura M, Makino H, Nanjo K, Kadowaki T, Kasuga M.
    • Journal Title

      Nat Genet 40(9)

      Pages: 1092-7

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations2008

    • Author(s)
      Unoki H, Takahashi A, Kawaguchi T, Hara K, Horikoshi M, Andersen G, Ng DP, Holmkvist J, Borch-Johnsen K, Jorgensen T, Sandbaek A, Lauritzen T, Hansen T, Nurbaya S, Tsunoda T, Kubo M, Babazono T, Hirose H, Hayashi M, Iwamoto Y, Kashiwagi A, Kaku K, Kawamori R, Tai ES, Pedersen O, Kamatani N, Kadowaki T, Kikkawa R, Nakamura Y, Maeda S.
    • Journal Title

      Nat Genet 40(9)

      Pages: 1098-102

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Rationale and design of a study to examine lower targets for low-density lipoprotein-cholesterol and blood pressure in coronary artery disease patients2008

    • Author(s)
      Nagai R, Izumi T, Kurabayashi M, Daida H, Tojo T, Hasegawa A, Miyauchi K, Hayashi D, Kohro T, Okada Y, Yamazaki T; JCADII Investigators
    • Journal Title

      Circ J 72(4)

      Pages: 515-520

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genetic variations of Mrf-2/ARID5B confer risk of coronary atherosclerosis in the Japanese population2008

    • Author(s)
      Wang G, Watanabe M, Imai Y, Hara K, Manabe I, Maemura K, Horikoshi M, Kohro T, Amiya E, Sugiyama T, Fujita T, Kadowaki T, Yamazaki T, Nagai R.
    • Journal Title

      Int Heart J. 49(3)

      Pages: 313-327

    • NAID

      130000069020

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] SUMOylation of Kruppel-like transcription factor 5 acts as a molecular switch in transcriptional programs of lipid metabolism involving PPAR-delta2008

    • Author(s)
      Oishi Y, Manabe I, Tobe K, Ohsugi M, Kubota T, Fujiu K, Maemura K, Kubota N, Kadowaki T, Nagai R.
    • Journal Title

      Nat Med. 14(6)

      Pages: 656-666

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Acyclic retinoid inhibits functional interaction of transcription factors Kruppel-like factor 5 and retinoic acid receptor-alpha2008

    • Author(s)
      Kada N, Suzuki T, Aizawa K, Munemasa Y, Matsumura T, Sawaki D, Nagai R.
    • Journal Title

      FEBS Lett. 582(12)

      Pages: 1755-60

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Adiponectin induces insulin secretion in vitro and in vivo at a low glucose concentration2008

    • Author(s)
      Okamoto M, Ohara-Imaizumi M, Kubota N, Hashimoto S, Eto K, Kanno T, Kubota T, Wakui M, Nagai R, Noda M, Nagamatsu S, Kadowaki T.
    • Journal Title

      Diabetologia 51(5)

      Pages: 827-35

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] In vivo imaging in mice reveals local cell dynamics and inflammation in obese adipose tissue2008

    • Author(s)
      Nishimura S, Manabe I, Nagasaki M, Seo K, Yamashita H, Hosoya Y, Ohsugi M, Tobe K, Kadowaki T, Nagai R, Sugiura S.
    • Journal Title

      J Clin Invest. 118(2)

      Pages: 710-21

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Promoter region-specific histone incorporation by the novel histone chaperone ANP32B and DNA-binding factor KLF52008

    • Author(s)
      Munemasa Y, Suzuki T, Aizawa K, Miyamoto S, Imai Y, Matsumura T, Horikoshi M, Nagai R.
    • Journal Title

      Mol Cell Biol. 28(3)

      Pages: 1171-81

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dynamic functional relay between insulin receptor substrate 1 and 2 in hepatic insulin signaling during fasting and feeding2008

    • Author(s)
      Kubota N, Kubota T, Itoh S, Kumagai H, Kozono H, Takamoto I, Mineyama T, Ogata H, Tokuyama K, Ohsugi M, Sasako T, Moroi M, Sugi K, Kakuta S, Iwakura Y, Noda T, Ohnishi S, Nagai R, Tobe K, Terauchi Y, Ueki K, Kadowaki T
    • Journal Title

      Cell Metab. 8(1)

      Pages: 49-64

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Manganese superoxide dismutase polymorphism affects the oxidized low-density lipoprotein-induced apoptosis of macrophages and coronary artery disease2008

    • Author(s)
      Fujimoto H, Taguchi JI, Imai Y, Ayabe S, Hashimoto H, Kobayashi H, Ogasawara K, Aizawa T, Yamakado M, Nagai R, Ohno M.
    • Journal Title

      Eur Heart J. 29(10)

      Pages: 1267-74

    • NAID

      10017243406

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] SUMOylation of Kruppel-like transcription factor 5 acts as a molecular switch in transcriptional programs of lipid metabolism involving PPAR-delta2008

    • Author(s)
      Oishi Y, Manabe I, Tobe K, Ohsugi M, Kubota T, Fujiu K, Maemura K, Kubota N, Kadowaki T, Nagai R
    • Journal Title

      Nature Medicine 14

      Pages: 656-666

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A crucial role of a high mobility group protein HMGA2 in cardiogenesis2008

    • Author(s)
      Monzen K, Ito Y, Naito Al, Kasai H, Hiroi Y, Hayashi D, Shiojima I, Yamazakl T, Miyazono K, Asashima M, Nagai R, Komuro I
    • Journal Title

      Nature Cell Biology 10

      Pages: 567-574

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rationale and design of a study to examine lower targets for low-density lipoprotein-cholesterol and blood pressure in coronary artery disease patients2008

    • Author(s)
      Nagai R, Izumi T, Kurabayashi M, Daida H, Tojo T, Hasegawa A, Miyauchi K, Hayashi D, Kohro T, Okada Y, Yamazaki T : JCADIL Investigators
    • Journal Title

      Circulation Journal 72

      Pages: 515-520

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vivo imaging in mice reveals local cell dynamics and inflammation in obese adipose tissue.2008

    • Author(s)
      Nishimura S, Nagai R, et. al.
    • Journal Title

      J Clin Invest. 118(2)

      Pages: 710-721

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Critical role of bone marrow angiotensin II type 1 receptor in the pathogenesis of atherosclerosis in apolipoprotein E deficient mice.2008

    • Author(s)
      Fukuda D, Sata M, Ishizaka N, Nagai R.
    • Journal Title

      Arterioscler Thromb Vasc Biol. 28(1)

      Pages: 90-96

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Variations in the HHEX gene are associated with increased risk of type 2 diabetes in the Japanese population2007

    • Author(s)
      Horikoshi M, Hara K, Ito C, Shojima N, Nagai R, Ueki K, Froguel P, Kadowaki T.
    • Journal Title

      Diabetologia 50(12)

      Pages: 2461-6

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions2007

    • Author(s)
      Yamauchi T, Nio Y, Maki T, Kobayashi M, Takazawa T, Iwabu M, Okada-Iwabu M, Kawamoto S, Kubota N, Kubota T, Ito Y,Kamon J, Tsuchida A, Kumagai K, Kozono H, Hada Y, Ogata H, Tokuyama K, Tsunoda M, Ide T, Murakami K, Awazawa M, Takamoto I, Froguel P, Hara K, Tobe K, Nagai R, Ueki K, Kadowaki T.
    • Journal Title

      Nat Med. 13(3)

      Pages: 332-9

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] A genetic variation of the transcription factor 7-like 2 gene is associated with risk of type 2 diabetes in the Japanese population2007

    • Author(s)
      Horikoshi M, Hara K, Ito C, Nagai R, Froguel P, Kadowaki T.
    • Journal Title

      Diabetologia. 50(4)

      Pages: 747-51

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Adiponectin stimulates AMP-activated protein kinase in the hypothalamus and increases food intake2007

    • Author(s)
      Kubota N, Yano W, Kubota T, Yamauchi T, Itoh S, Kumagai H, Kozono H, Takamoto I, Okamoto S, Shiuchi T, Suzuki R, Satoh H, Tsuchida A, Moroi M, Sugi K, Noda T, Ebinuma H, Ueta Y, Kondo T, Araki E, Ezaki O, Nagai R, Tobe K, Terauchi Y, Ueki K, Minokoshi Y, Kadowaki T.
    • Journal Title

      Cell Metab. 6(1)

      Pages: 55-68

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Thrombomodulin is a clock-controlled gene in vascular endothelial cells.2007

    • Author(s)
      Takeda N, Nagai R, et. al.
    • Journal Title

      J Biol Chem 282(45)

      Pages: 32561-32567

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions.2007

    • Author(s)
      Yamauchi T
    • Journal Title

      Nat Med 13・3

      Pages: 332-339

    • Related Report
      2006 Annual Research Report
  • [Journal Article] A polymorphism in the AMPKalpha2 subunit gene is associated with insulin resistance and type 2 diabetes in the Japanese population2006

    • Author(s)
      Horikoshi, M., Hara, K., Ohashi, J., Miyake, K., Tokunaga, K., Ito, C., Kasuga, M., Nagai, R.,, Kadowaki, T.
    • Journal Title

      Diabetes. 55(4)

      Pages: 919-23

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hepatocyte nuclear factor-4alpha P2 promoter haplotypes are associated with type 2 diabetes in the Japanese population2006

    • Author(s)
      Hara, K., Horikoshi, M., Kitazato, H., Ito, C., Noda, M., Ohashi, J., Froguel, P., Tokunaga, K., Tobe, K., Nagai, R., Kadowaki, T.
    • Journal Title

      Diabetes 55(5)

      Pages: 1260-4

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Measurement of the high-molecular weight form of adiponectin in plasma is useful for the prediction of insulin resistance and metabolic syndrome2006

    • Author(s)
      Hara K, Horikoshi M, Yamauchi T, Yago H, Miyazaki O, Ebinuma H, Imai Y, Nagai R, Kadowaki T.
    • Journal Title

      Diabetes Care 29(6)

      Pages: 1357-62

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] A polymorphism in the AMPKalpha2 subunit gene is associated with insulin resistance and type 2 diabetes in the Japanese population.2006

    • Author(s)
      Horikoshi M
    • Journal Title

      Diabetes 55・4

      Pages: 919-923

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Hepatocyte nuclear factor-4alpha P2 promoter haplotypes are associated with type 2 diabetes in the Japanese population.2006

    • Author(s)
      Hara K
    • Journal Title

      Diabetes 55・5

      Pages: 1260-1264

    • Related Report
      2006 Annual Research Report
  • [Journal Article] DeltaEF1 mediates TGF-beta signaling in vascular smooth muscle cell differentiation.2006

    • Author(s)
      Nishimura G
    • Journal Title

      Dev Cell 11・1

      Pages: 93-104

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Measurement of the high-molecular weight form of adiponectin in plasma is useful for the prediction of insulin resistance and metabolic syndrome.2006

    • Author(s)
      Hara K
    • Journal Title

      Diabetes Care 29・6

      Pages: 1357-1362

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Overexpression of Monocyte Chemoattractant Protein-1 in Adipose Tissues Causes Macrophage Recruitment and Insulin Resistance.2006

    • Author(s)
      Kamei N
    • Journal Title

      J Biol Chem 281・36

      Pages: 26602-26614

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Synthetic Retinoid Am80 Reduces Scavenger Receptor Expression and Atherosclerosis in Mice by Inhibiting IL-62006

    • Author(s)
      Takeda N
    • Journal Title

      Arterioscler Thromb Vasc Biol

    • Related Report
      2005 Annual Research Report
  • [Journal Article] C-reactive protein induces VCAM-1 gene expression through NF-kappaB activation in vascular endothelial cells2006

    • Author(s)
      Kawanami D
    • Journal Title

      Atherosclerosis 185・1

      Pages: 39-46

    • Related Report
      2005 Annual Research Report
  • [Journal Article] The deacetylase HDAC1 negatively regulates the cardiovascular transcription factor Kruppel-like factor 5 through direct interaction2005

    • Author(s)
      Matsumura T, Suzuki T, Aizawa K, Munemasa Y, Muto S, Horikoshi M, Nagai R.
    • Journal Title

      J Biol Chem. 280(13)

      Pages: 12123-9

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Absence of an association between the polymorphisms in the genes encoding adiponectin receptors and type 2 diabetes2005

    • Author(s)
      Hara K, Horikoshi M, Kitazato H, Yamauchi T, Ito C, Noda M, Ohashi J, Froguel P, Tokunaga K, Nagai R, Kadowaki T.
    • Journal Title

      Diabetologia 48(7)

      Pages: 1307-14

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synthetic retinoid Am80 suppresses smooth muscle phenotypic modulation and in-stent neointima formation by inhibiting KLF52005

    • Author(s)
      Fujiu K
    • Journal Title

      Circ Res 97・11

      Pages: 1132-1141

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Significance of the transcription factor KLF5 in cardiovascular remodeling2005

    • Author(s)
      Nagai R
    • Journal Title

      J Thromb Haemost 3・8

      Pages: 1569-1576

    • Related Report
      2005 Annual Research Report
  • [Journal Article] The deacetylase HDAC1 negatively regulates the tcardiovascular transcription factor Kruppel-like factor 5 through direct interaction2005

    • Author(s)
      Matsumura T
    • Journal Title

      J Biol Chem 280・13

      Pages: 12123-12129

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Administration of ANG II induces iron deposition and upregulation of TGF-beta1 mRNA in the rat liver2005

    • Author(s)
      Ishizaka N
    • Journal Title

      Am J Physiol 288・4

    • Related Report
      2005 Annual Research Report
  • [Presentation] Cardiovascular remodeling and energy metabolism through Kruppel-like transcription factor 5.2009

    • Author(s)
      Nagai R.
    • Organizer
      International Symposium on Atherosclerosis
    • Place of Presentation
      Boston, USA
    • Year and Date
      2009-06-16
    • Related Report
      2009 Final Research Report
  • [Presentation] Cardiovascular remodeling and energy metabolism through Kruppel-like transcription factor 52009

    • Author(s)
      Nagai R
    • Organizer
      XV International Symposium on Atherosclerosis
    • Place of Presentation
      Boston MA, USA
    • Year and Date
      2009-06-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] 心血管系ストレス応答因子KLF5の意義2008

    • Author(s)
      永井良三
    • Organizer
      第37回日本心脈管作動物質学会
    • Place of Presentation
      仙台
    • Year and Date
      2008-02-02
    • Related Report
      2007 Annual Research Report
  • [Book] 循環器疾患と遺伝子異常2009

    • Author(s)
      森田啓行、永井良三
    • Publisher
      中山書店
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Book] 循環器疾患最新の治療2008-20092008

    • Author(s)
      堀正二、永井良三
    • Total Pages
      561
    • Publisher
      南江堂
    • Related Report
      2008 Annual Research Report
  • [Book] 循環器大規模臨床試験要約集20072007

    • Author(s)
      永井良三、山崎力、林同文
    • Total Pages
      71
    • Publisher
      協和発酵工業株式会社
    • Related Report
      2007 Annual Research Report
  • [Remarks]

    • URL

      http://plaza.umin.ac.jp/nagai

    • Related Report
      2007 Annual Research Report

URL: 

Published: 2005-04-01   Modified: 2018-03-28  

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