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Support of genotyping to identify genes involved in human diseases

Research Project

Project/Area Number 17020006
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionKyushu University

Principal Investigator

YAMAMOTO Ken  Kyushu University, 生体防御医学研究所, 准教授 (60274528)

Co-Investigator(Renkei-kenkyūsha) TOKUNAGA Katsusi  東京大学, 大学院・医学系研究科, 教授 (40163977)
KUWANO Ryozo  新潟大学, 脳研究所, 教授 (20111734)
Project Period (FY) 2005 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥507,500,000 (Direct Cost: ¥507,500,000)
Fiscal Year 2009: ¥126,600,000 (Direct Cost: ¥126,600,000)
Fiscal Year 2008: ¥125,800,000 (Direct Cost: ¥125,800,000)
Fiscal Year 2007: ¥85,800,000 (Direct Cost: ¥85,800,000)
Fiscal Year 2006: ¥85,800,000 (Direct Cost: ¥85,800,000)
Fiscal Year 2005: ¥83,500,000 (Direct Cost: ¥83,500,000)
Keywordsゲノム / 多型 / 多因子疾患 / 単一遺伝病 / SNP / マイクロサテライト / 相関解析 / 研究支援 / 多因子病 / アルツハイマー病 / 心筋梗塞 / 多系統委縮症 / 連鎖解析 / 遺伝子多型 / タイピング
Research Abstract

We supported the studies that aim to identify genes involved in human diseases such as diabetes, hypertension, CAD, brain aneurysm, schizophrenia, MSA, Alzheimer disease, FHL, AITD and osteoporosis, by large scale genotyping. The collaboration studies identified novel susceptible gene, KCNQ1 and MLF1 to diabetes and CAD, respectively. We also identified seven hypertension-related genes. The candidate loci of the other diseases were found for future research.

Report

(6 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (75 results)

All 2010 2009 2008 2007 2006 2005 Other

All Journal Article (43 results) (of which Peer Reviewed: 9 results) Presentation (25 results) Book (6 results) Remarks (1 results)

  • [Journal Article] A definitive haplotype map as determined by genotyping duplicated haploid genomes finds a predominant haplotype preference at copy number variation events2010

    • Author(s)
      Kukita Y, Yahara K, Tahira T, Higasa K, Sonoda M, Yamamoto K, Kato K, Wake N, Hayashi K.
    • Journal Title

      Am. J. Hum. Genet. (in press)

    • NAID

      120002239171

    • Related Report
      2009 Final Research Report
  • [Journal Article] Common variants at the GCK, GCKR, G6PC2-ABCB11 and MTNR1B loci are associated with fasting glucose in two Asian populations2010

    • Author(s)
      Takeuchi F, Katsuya T, Chakrewarthy S, Yamamoto K, Fujioka A, Serizawa M, Fujisawa T, Nakashima E, Ohnaka K, Ikegami H, Sugiyama T, Nabika T, Kasturiratne A, Yamaguchi S, Kono S, Takayanagi R, Yamori Y, Kobayashi S, Ogihara T, de Silva A, Wickremasinghe R, Kato N.
    • Journal Title

      Diabetologia 53(2)

      Pages: 299-308

    • Related Report
      2009 Final Research Report
  • [Journal Article] Common variants at the GCK, GCKR, G6PC2-ABCB11 and MTNR1Bloci are associated with fasting glucose in two Asian populations.2010

    • Author(s)
      Takeuchi F, et al.
    • Journal Title

      Diabetologia (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of single nucleotide polymorphisms in secreted frizzled-related protein 1 gene with bone mineral density in Japanese women2009

    • Author(s)
      Ohnaka K, Yamamoto K, Nakamura K, Adachi M, Kawate H, Kono S, Takayanagi R.
    • Journal Title

      Geriatr Gerontol Int 9(3)

      Pages: 304-9

    • NAID

      10025638117

    • Related Report
      2009 Final Research Report
  • [Journal Article] Megakaryoblastic leukemia factor-1 gene in the susceptibility to coronary artery disease2009

    • Author(s)
      Hinohara K, Nakajima T, Yasunami M, Houda S, Sasaoka T, Yamamoto K, Lee BS, Shibata H, Tanaka-Takahashi Y, Takahashi M, Arimura T, Sato A, Naruse T, Ban J, Inoko H, Yamada Y, Sawabe M, Park JE, Izumi T, Kimura A.
    • Journal Title

      Hum Genet. 126(4)

      Pages: 539-547

    • Related Report
      2009 Final Research Report
  • [Journal Article] Confirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population2009

    • Author(s)
      Takeuchi F, Serizawa M, Yamamoto K, Fujisawa T, Nakashima E, Ohnaka K, Ikegami H, Sugiyama T, Katsuya T, Miyagishi M, Nakashima N, Nawata H, Nakamura J, Kono S, Takayanagi R, Kato N.
    • Journal Title

      Diabetes 58(7)

      Pages: 1690-1699

    • NAID

      40017084738

    • Related Report
      2009 Final Research Report
  • [Journal Article] Construction of a prediction model for type 2 diabetes mellitus in the Japanese population based on 11 genes with strong evidence of the association2009

    • Author(s)
      Miyake K, Yang W, Hara K, Yasuda K, Horikawa Y, Osawa H, Furuta H, Ng MC, Hirota Y, Mori H, Ido K, Yamagata K, Hinokio Y, Oka Y, Iwasaki N, Iwamoto Y, Yamada Y, Seino Y, Maegawa H, Kashiwagi A, Wang HY, Tanahashi T, Nakamura N, Takeda J, Maeda E, Yamamoto K, Tokunaga K, Ma RC, So WY, Chan JC, Kamatani N, Makino H, Nanjo K, Kadowaki T, Kasuga M.
    • Journal Title

      J Hum Genet. 54(4)

      Pages: 236-241

    • NAID

      10030730081

    • Related Report
      2009 Final Research Report
  • [Journal Article] Megakaryoblastic leukemia factor-1 gene in the susceptibility to coronary artery disease.2009

    • Author(s)
      Hinohara K, et al.
    • Journal Title

      Hum Genet. 126

      Pages: 539-547

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Confirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 diabetes in the_ Japanese population.2009

    • Author(s)
      Takeuchi F, et al.
    • Journal Title

      Diabetes 58

      Pages: 1690-1699

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus2008

    • Author(s)
      Yasuda K, Miyake K, Horikawa Y, Hara K, Osawa H, Furuta H, Hirota Y, Mori H, Jonsson A, Sato Y, Yamagata K, Hinokio Y, Wang HY, Tanahashi T, Nakamura N, Oka Y, Iwasaki N, Iwamoto Y, Yamada Y, Seino Y, Maegawa H, Kashiwagi A, Takeda J, Maeda E, Shin HD, Cho YM, Park KS, Lee HK, Ng MC, Ma RC, So WY, Chan JC, LyssenkoV, Tuomi T, Nilsson P, Groop L, Kamatani N, Sekine A, Nakamura Y, Yamamoto K, Yoshida T, Tokunaga K, Itakura M, Makino H, Nanjo K, Kadowaki T, Kasuga M.
    • Journal Title

      Nat. Genet. 40(9)

      Pages: 1092-1097

    • Related Report
      2009 Final Research Report
  • [Journal Article] Hereditary motor and sensory neuropathy with proximal dominancy in the lower extremities, urinary disturbance, and paroxysmal dry cough2008

    • Author(s)
      Miura S, Shibata H, Kida H, Noda K, Tomiyasu K, Yamamoto K, Iwaki A, Ayabe M, Aizawa H, Taniwaki T, Fukumaki Y.
    • Journal Title

      J Neurol Sci. 273(1-2)

      Pages: 88-92

    • Related Report
      2009 Final Research Report
  • [Journal Article] Replication in Japanese of genome-wide association studies of type 2 diabetes2008

    • Author(s)
      Horikawa Y, Miyake K, Yasuda K, Enya M, Hirota Y, Yamagata K, Hinokio Y, Oka Y, Iwasaki N, Iwamoto Y, Yamada Y, Seino Y, Maegawa H, Kashiwagi A, Yamamoto K, Tokunaga K, Takeda J, Kasuga M.
    • Journal Title

      J Clin Endocrinol Metab. 93(8)

      Pages: 3136-41

    • Related Report
      2009 Final Research Report
  • [Journal Article] Onecut transcription factor OC2 is a direct target of T-bet in type-1 T-helper cells2008

    • Author(s)
      Furuno K, Ikeda K, Hamano S, Fukuyama K, Sonoda M, Hara T, Sasazuki T, Yamamoto K.
    • Journal Title

      Genes Immun 9(4)

      Pages: 302-308

    • Related Report
      2009 Final Research Report
  • [Journal Article] Fatal sibling cases of familial hemophagocytic lymphohistiocytosis (FHL) with MUNC13-4 mutations: case reports2008

    • Author(s)
      Nakao T, Shimizu T, Fukushima T, Saito M, Okamoto M, Sugiura M, Yamamoto K, Ueda I, Imashuku S, Kobayashi C, Koike K, Tsuchida M, Sumazaki R, Matsui A.
    • Journal Title

      Pediatr Hematol Oncol 25(3)

      Pages: 171-180

    • Related Report
      2009 Final Research Report
  • [Journal Article] Association of TCF7L2 polymorphisms with susceptibility to type 2 diabetes in 4, 087 Japanese subjects2008

    • Author(s)
      Miyake K, Horikawa Y, Hara K, Yasuda K, Osawa H, Furuta H, Hirota Y, Yamagata K, Hinokio Y, Oka Y, Iwasaki N, Iwamoto Y, Yamada Y, Seino Y, Maegawa H, Kashiwagi A, Yamamoto K, Tokunaga K, Takeda J, Makino H, Nanjo K, Kadowaki T, Kasuga M.
    • Journal Title

      J Hum Genet 53(2)

      Pages: 174-180

    • NAID

      10021248002

    • Related Report
      2009 Final Research Report
  • [Journal Article] Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus2008

    • Author(s)
      Yasuda K, et.al.
    • Journal Title

      Nat. Genet 40

      Pages: 1092-1097

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Replication in Japanese of genome-wide association studies of type2 diabetes2008

    • Author(s)
      Horikawa Y, et.al.
    • Journal Title

      J. Clin. Endocrinol. Metab 93

      Pages: 3136-3141

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of TCF7L2 polymorphisms with susceptibility to type 2 diabetes in 4,087 Japanese subiects2008

    • Author(s)
      Miyake K, et.al.
    • Journal Title

      J. Hum. Genet 53

      Pages: 174-180

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of TCF7L2 polymorphisms with susceptibility to type 2 diabetes in 4087 Japanese subjects.2008

    • Author(s)
      Miyake, K., et. al.
    • Journal Title

      J. Hum. Genet. 53

      Pages: 174-180

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nationwide survey of hemophagocytic lymphohistiocytosis in Japan2007

    • Author(s)
      Ishii E, Ohga S, Imashuku S, Yasukawa M, Tsuda H, Miura I, Yamamoto K, Horiuchi H, Takada K, Ohshima K, Nakamura S, Kinukawa N, Oshimi K, Kawa K.
    • Journal Title

      Int J Hematol. 86(1)

      Pages: 58-65

    • NAID

      10018515633

    • Related Report
      2009 Final Research Report
  • [Journal Article] Tissue inhibitor of metalloproteinase 2 and coronary artery lesions in Kawasaki disease2007

    • Author(s)
      Furuno K, Takada H, Yamamoto K, Ikeda K, Ohno T, Khajoee V, Mizuno Y, Hara T.
    • Journal Title

      J Pediatr. 151(2)

      Pages: 155-160

    • Related Report
      2009 Final Research Report
  • [Journal Article] Tyk2 mutation homologous to V617F Jak2 is not found in essential thrombocythaemia, although it induces constitutive signaling and growth factor independence2007

    • Author(s)
      Shide K, Shimoda K, Kamezaki K, Kakumitsu H, Kumano T, Numata A, Ishikawa F, Takenaka K, Yamamoto K, Matsuda T, Harada M.
    • Journal Title

      Leuk Res. 31(8)

      Pages: 1077-1084

    • Related Report
      2009 Final Research Report
  • [Journal Article] Japan Marrow Donor Program. Effects of HLA Allele and Killer Immunoglobulin-Like Receptor Ligand Matching on Clinical Outcome in Leukemia Patients Undergoing Transplantation With T-cell-Replete Marrow From an Unrelated Donor2007

    • Author(s)
      Morishima Y, Yabe T, Matsuo K, Kashiwase K, Inoko H, Saji H, Yamamoto K, Maruya E, Akatsuka Y, Onizuka M, Sakamaki H, Sao H, Ogawa S, Kato S, Juji T, Sasazuki T, Kodera Y
    • Journal Title

      Biol Blood Marrow Transplant. 13(3)

      Pages: 315-328

    • Related Report
      2009 Final Research Report
  • [Journal Article] Association of IL12RB1 polymorphisms with susceptibility to and severity of tuberculosis in Japanese: a gene-based association analysis of 21 candidate genes2007

    • Author(s)
      Kusuhara K, Yamamoto K, Okada K, Mizuno Y, Hara T.
    • Journal Title

      Int J Immunogenet 34(1)

      Pages: 35-44

    • NAID

      10026402713

    • Related Report
      2009 Final Research Report
  • [Journal Article] Tissue inhibitor of metalloproteinase 2 and coronary artery lesions in Kawasaki disease.2007

    • Author(s)
      Furuno, K., et. al.
    • Journal Title

      J. Pediatr. 151

      Pages: 155-160

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of IL12RB1 polymorphisms with sussceptibility to and severity of tuberculosis in Japanese: a gene based association analysis of 21 candidate genes.2007

    • Author(s)
      Kusuhara, K., et. al.
    • Journal Title

      Int. J. Immunogenet. 34

      Pages: 35-44

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tissue inhibitor of metalloproteinase 2 and coronary artery lesions in Kawasaki Disease.2007

    • Author(s)
      Furuno K. et al.
    • Journal Title

      J. Pediatr. (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Association of IL12RB1 polymorphisms with susceptibility to and severity of tuberculosis in Japanese : a gene-based association analysis of 21 candidate genes.2007

    • Author(s)
      Kusuhara K. et al.
    • Journal Title

      Int. J. Immunogenet. 34

      Pages: 35-44

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Rapid detection of SAG 926delA mutation using real-time polymerase chain reaction.2006

    • Author(s)
      Yoshida S, Yamaji Y, Yoshida A, Ikeda Y, Yamamoto K, Ishibashi T.
    • Journal Title

      Mol Vis. 12

      Pages: 1552-1557

    • Related Report
      2009 Final Research Report
  • [Journal Article] Novel triple missense mutations of GUCY2D gene in Japanese family with cone-rod dystrophy: possible use of genotyping microarray.2006

    • Author(s)
      Yoshida S, Yamaji Y, Yoshida A, Kuwahara R, Yamamoto K, Kubata T, Ishibashi T.
    • Journal Title

      Mol Vis. 12

      Pages: 1558-1564

    • Related Report
      2009 Final Research Report
  • [Journal Article] Familial hemophagocytic lymphohistiocytosis with the MUNC13-4 mutation2006

    • Author(s)
      Mizumoto H, Hata D, Yamamoto K, Shirakawa R, Kumakura A, Shiota M, Yokoyama A, Matsubara H, Kobayashi M, Nishikomori R, Adachi S, Nakahata T, Kita T, Horiuchi H, Yasukawa M, Ishii E.
    • Journal Title

      Eur J Pediatr 165(6)

      Pages: 384-388

    • Related Report
      2009 Final Research Report
  • [Journal Article] A novel perforin gene mutation in a Japanese family with hemophagocytic lymphohistiocytosis2006

    • Author(s)
      Ueda I, Kohdera U, Hibi S, Inaba T, Yamamoto K, Sugimoto T, Morimoto A, Ishii E, Imashuku S.
    • Journal Title

      Int J Hematol. 83(1)

      Pages: 51-54

    • NAID

      10017147884

    • Related Report
      2009 Final Research Report
  • [Journal Article] Rapid detection of SAG 926delA mutation using real-time polymerase chain reaction.2006

    • Author(s)
      Yoshida S. et al.
    • Journal Title

      Mol. Vis. 12

      Pages: 1552-1557

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Novel triple missense mutations of GUCY2D gene in Japanese family with cone-rod dystrophy : possible use of genotyping microarray.2006

    • Author(s)
      Yoshida S. et al.
    • Journal Title

      Mol. Vis. 12

      Pages: 1558-1564

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Familial hemophagocytic lymphohistiocytosis with the MUNC13-4 mutation.2006

    • Author(s)
      Mizumoto H. et al.
    • Journal Title

      Eur. J. Pediatr. 165

      Pages: 384-388

    • Related Report
      2006 Annual Research Report
  • [Journal Article] A novel perforin gene mutation in a Japanese family with hemophagocytic lymphohistiocytosis.2006

    • Author(s)
      Ueda I.et al.
    • Journal Title

      Int.J.Hematol. 83

      Pages: 51-54

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Familial hemophagocytic lymphohistiocytosis with the MUNC13-4 mutation : a case report.2006

    • Author(s)
      Mizumoto H. et al.
    • Journal Title

      Eur.J.Pediatr. (in press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Mutations of syntaxin 11 and SNAP23 genes as causes of familial hemophagocytic lymphohistiocytosis were not found in Japanese people2005

    • Author(s)
      Yamamoto K, Ishii E, Horiuchi H, Ueda I, Ohga S, Nishi M, Ogata Y, Zaitsu M, Morimoto A, Hara T, Imashuku S, Sasazuki T, Yasukawa M.
    • Journal Title

      J Hum Genet. 50(11)

      Pages: 600-603

    • NAID

      10016913189

    • Related Report
      2009 Final Research Report
  • [Journal Article] Genetic subtypes of familial hemophagocytic lymphohistiocytosis: correlations with clinical features and cytotoxic T lymphocyte/natural killer cell functions2005

    • Author(s)
      Ishii E, Ueda I, Shirakawa R, Yamamoto K, Horiuchi H, Ohga S, Furuno K, Morimoto A, Imayoshi M, Ogata Y, Sako M, Koike K, Sakata A, Takada H, Hara T, Imashuku S, Sasazuki T, Yasukawa M.
    • Journal Title

      Blood. 105(9)

      Pages: 3442-3448

    • Related Report
      2009 Final Research Report
  • [Journal Article] Genetic subtypes of familial hemophagocytis lymphohistiocytosis : correlation with clinical features and cytotoxic T lymphocyte/natural killer cell functions.2005

    • Author(s)
      Ishii E. et al.
    • Journal Title

      Blood 105

      Pages: 3442-3448

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Mutations of syntaxin 11 and SNAP23 genes as causes of familial hemophagocytic lymphohistiocytosis were not found in Japanese people.2005

    • Author(s)
      Yamamoto K. et al.
    • Journal Title

      J.Hum.Genet. 50

      Pages: 600-603

    • NAID

      10016913189

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 連鎖解析2005

    • Author(s)
      山本 健
    • Journal Title

      臨床遺伝子学‘05「多因子遺伝病研究の最前線」 60

      Pages: 16-24

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Blood pressure and hypertension are associated with seven loci in the Japanese population

    • Author(s)
      Takeuchi F, Isono M, Katsuya T, Yamamoto K, Yokota M, Sugiyama T, Nabika T, Fujioka A, Ohnaka K, Nakatochi M, Yamori Y, Yamaguchi S, Kobayashi S, Takayanagi R, Ogihara T, Kato N.
    • Journal Title

      Circulation (in press)

    • Related Report
      2009 Final Research Report
  • [Presentation] Genetics of coronary artery diseases2009

    • Author(s)
      Ken Yamamoto
    • Organizer
      10th International Symposium on Host Genetic Epidemiology
    • Place of Presentation
      Seoul
    • Year and Date
      2009-11-11
    • Related Report
      2009 Final Research Report
  • [Presentation] 日本人における冠動脈疾患の発症感受性遺伝子多型の解析2009

    • Author(s)
      北島秀俊, ほか
    • Organizer
      日本人類遺伝学会第54回大会
    • Place of Presentation
      東京
    • Year and Date
      2009-09-24
    • Related Report
      2009 Final Research Report
  • [Presentation] 各種プラットフォームでのSNP遺伝子型タイピング2008

    • Author(s)
      山本健
    • Organizer
      ゲノムワイド関連解析ワークショップ
    • Place of Presentation
      東京
    • Year and Date
      2008-06-13
    • Related Report
      2009 Final Research Report
  • [Presentation] 中高年一般集団における2型糖尿病関連遺伝子多型と生活習慣因子の評価2008

    • Author(s)
      山本健
    • Organizer
      第3回バイオインフォマティクス研究者と医学研究者の交流会
    • Place of Presentation
      柏
    • Related Report
      2009 Final Research Report
  • [Presentation] 日本人における急性心筋梗塞と9p21. 3遺伝子多型との相関2008

    • Author(s)
      北島秀俊, ほか
    • Organizer
      日本人類遺伝学会第53回大会
    • Place of Presentation
      横浜
    • Related Report
      2009 Final Research Report
  • [Presentation] 一般集団におけるCDKAL1およびCDKN2B遺伝子多型とHbA1c値との関連2008

    • Author(s)
      山本健, ほか
    • Organizer
      日本人類遺伝学会第53回大会
    • Place of Presentation
      横浜
    • Related Report
      2009 Final Research Report
  • [Presentation] 日本人における急性心筋梗塞と9p21.3遺伝子多型との相関2008

    • Author(s)
      北島秀俊, 他
    • Organizer
      日本人類遺伝学会第53回大会
    • Place of Presentation
      横浜
    • Related Report
      2008 Annual Research Report
  • [Presentation] ゲノムワイドな多因子疾患発症関連遺伝子同定戦略2007

    • Author(s)
      山本健
    • Organizer
      山形大学21世紀COEプログラム「分子疫学研究拠点合同シンポジウム-山形大学、九州大学、自治医科大学-」
    • Place of Presentation
      山形
    • Year and Date
      2007-09-08
    • Related Report
      2009 Final Research Report
  • [Presentation] Update on genetic analysis for HLH.2007

    • Author(s)
      山本健
    • Organizer
      第2回hlh講演会
    • Place of Presentation
      東京
    • Year and Date
      2007-03-30
    • Related Report
      2009 Final Research Report
  • [Presentation] Genome-wide approach for identification of common disease susceptibility locus.2007

    • Author(s)
      Yamamoto, K.
    • Organizer
      Kyushu University COE Program Frontier Research and Education on Lifestyle-Related Diseases based on the Large-scale Cohort Study The 4th International Symposium
    • Place of Presentation
      福岡市
    • Related Report
      2007 Annual Research Report
  • [Presentation] Genetic susceptibility to tuberculosis in Japanese: a gene-based analysis. the 38th European Human Genetics Conference (EHGC)2006

    • Author(s)
      T. Hara, ほか
    • Organizer
      Amsterdam
    • Place of Presentation
      Natherlands.
    • Related Report
      2009 Final Research Report
  • [Presentation] Genetic susceptibility to tuberculosis in Japanese: a gene-based analysis.2006

    • Author(s)
      K. Kusuhara, ほか
    • Organizer
      11th International Congress of Human Genetics, Brisbane
    • Place of Presentation
      Australia
    • Related Report
      2009 Final Research Report
  • [Presentation] Perforin gene mutations in familial hemophagocytic lymphohistiocytosis (FHL): Asian collaborative study2006

    • Author(s)
      I. Ueda, ほか
    • Organizer
      第68回日本血液学会総会・第48回日本臨床血液学会総会
    • Place of Presentation
      福岡
    • Related Report
      2009 Final Research Report
  • [Presentation] Update of familial hemophagocytic lymphohistiocytosis (FHL) studies in Japan. Histiocyte Society 22nd Annual Meeting2006

    • Author(s)
      I. Ueda, ほか
    • Organizer
      Buenos Aires
    • Place of Presentation
      Argentina
    • Related Report
      2009 Final Research Report
  • [Presentation] Perforin mutations in familial hemophagocytic lymphohistiocytosis(FHL): Collaborative study in Asia2006

    • Author(s)
      I. Ueda, ほか
    • Organizer
      2nd Congress of Asian Society for Pediatric Research
    • Place of Presentation
      Yokohama
    • Related Report
      2009 Final Research Report
  • [Presentation] Heterozygosities of 4703 microsatellite markers in the Japanese population2005

    • Author(s)
      K. Yamamoto, ほか
    • Organizer
      Human Genome Meeting 2005
    • Place of Presentation
      Kyoto
    • Related Report
      2009 Final Research Report
  • [Presentation] Identification of a target gene of T-box transcription factor Tbet in Th1 cell by human CpG microarray2005

    • Author(s)
      K. Furuno, ほか
    • Organizer
      Human Genome Meeting 2005
    • Place of Presentation
      Kyoto
    • Related Report
      2009 Final Research Report
  • [Presentation] Novel genetic markers predict the development of coronary artery lesions in Kawasaki disease2005

    • Author(s)
      K. Ikeda, ほか
    • Organizer
      Human Genome Meeting 2005
    • Place of Presentation
      Kyoto
    • Related Report
      2009 Final Research Report
  • [Presentation] 血小板放出制御因子Munc13-4の同定とその異常による家族性血球貪食症候群2005

    • Author(s)
      白川龍太郎, ほか
    • Organizer
      第42回日本臨床分子医学会
    • Place of Presentation
      京都
    • Related Report
      2009 Final Research Report
  • [Presentation] Heterozygosities of 4867 microsatellite markers in the Japanese population2005

    • Author(s)
      K. Yamamoto, ほか
    • Organizer
      The 5th Annual Meeting of the East Asian Union of Human Genetics Societies
    • Place of Presentation
      Okayama
    • Related Report
      2009 Final Research Report
  • [Presentation] Genetic subtypes of familial hemophagocytic lymphohistiocytosis: correlations with clinical features and functions of cytotoxic T lymphocytes2005

    • Author(s)
      E. Ishii, ほか
    • Organizer
      21th Annual Meeting of the Histiocyte Society
    • Place of Presentation
      Vancouver
    • Related Report
      2009 Final Research Report
  • [Presentation] Atypical features in type 2 familial hemophagocytic lymphosticocytosis (FHL)2005

    • Author(s)
      I. Ueda, ほか
    • Organizer
      21th Annual Meeting of the Histiocyte Society
    • Place of Presentation
      Vancouver
    • Related Report
      2009 Final Research Report
  • [Presentation] Susceptibility genes for type 1 diabetes in Japanese children: Association studies on immuno-regulatory genes2005

    • Author(s)
      K. Ihara, ほか
    • Organizer
      First Congress Asian Society of Pediatric Research
    • Place of Presentation
      Tokyo
    • Related Report
      2009 Final Research Report
  • [Presentation] Transcriptional Cross Regulation between T-bet and Onecut2 in Type 1 Helper T Cell2005

    • Author(s)
      K. Furuno, ほか
    • Organizer
      International Cytokine Society Council 2005
    • Place of Presentation
      Seul
    • Related Report
      2009 Final Research Report
  • [Presentation] 日本人小児1型糖尿病発症に関わる遺伝的背景:免疫を制御する遺伝子群の疾患関連解析2005

    • Author(s)
      井原健二, ほか
    • Organizer
      第39回日本小児内分泌学会
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Book] 日本臨床(多因子疾患遺伝子多型研究の現状, vol.67,No.6)2009

    • Author(s)
      山本健
    • Related Report
      2009 Final Research Report
  • [Book] 血液・腫瘍科(血球貪食症候群の発症機序, 57)2008

    • Author(s)
      古野憲司, 山本健
    • Related Report
      2009 Final Research Report
  • [Book] Crit Rev Oncol Hematol(Review of hemophagocytic lymphohistiocytosis (HLH) in children with focus on Japanese experiences)2005

    • Author(s)
      E. Ishii, S. Ohga, S. Imashuku, N. Kimura, I. Ueda, A. Morimoto, K. Yamamoto, M. Yasukawa.
    • Related Report
      2009 Final Research Report
  • [Book] 血液・腫瘍科(家族性血球貪食症候群の遺伝子異常, 50)2005

    • Author(s)
      石井榮一, 上田育代, 山本健, 堀内久徳, 今宿晋作, 安川正貴
    • Related Report
      2009 Final Research Report
  • [Book] 臨床免疫(MUNC13-4遺伝子異常による家族性血球貪食症候群, 43)2005

    • Author(s)
      石井榮一, 山本健, 堀内久徳, 今宿晋作, 安川正貴
    • Related Report
      2009 Final Research Report
  • [Book] 最新医学(連鎖解析.臨床遺伝子学'05「多因子遺伝病研究の最前線」), 9月増刊2005

    • Author(s)
      山本健
    • Related Report
      2009 Final Research Report
  • [Remarks] マイクロサテライトマーカーデータベース

    • URL

      http://www.gen.kyushu-u.ac.jp/~genome/

    • Related Report
      2009 Final Research Report

URL: 

Published: 2005-04-01   Modified: 2018-03-28  

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