Study on molecular mechanisms for regulating proliferation and differentiation of embryonic neural stem cells

• Project/Area Number: 17024001
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Tohoku University
• Principal Investigator: OSUMI Noriko Tohoku University, 大学院・医学系研究科, 教授 (00220343)
• Co-Investigator(Kenkyū-buntansha): TAKAHASHI Masanori 東北大学, 大学院・医学系研究科, 助教 (20361074) ; 野村 真 東北大学, 大学院・医学系研究科, 助教 (10323007)
• Project Period (FY): 2005 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥77,400,000 (Direct Cost: ¥77,400,000); Fiscal Year 2009: ¥15,400,000 (Direct Cost: ¥15,400,000); Fiscal Year 2008: ¥14,800,000 (Direct Cost: ¥14,800,000); Fiscal Year 2007: ¥14,200,000 (Direct Cost: ¥14,200,000); Fiscal Year 2006: ¥14,200,000 (Direct Cost: ¥14,200,000); Fiscal Year 2005: ¥18,800,000 (Direct Cost: ¥18,800,000)
• Keywords: 神経発生 / 細胞増殖 / 細胞分化 / 転写因子 / Pax6 / タイムラプス解析 / マイクロアレイ解析 / 神経幹細胞 / マイクロアレイ法 / RNA干渉法

Research Abstract

We investigated molecular mechanisms of proliferation and differentiation of neural stem cells especially focusing on Pax6 transcription factor, a key regulator of brain development, and its downstream molecules. We also revealed that subcellular localization of Cyclin D2, a cell cycle regulator, is crucial to keep the neural stem cells proliferative.

Research Products

• [Journal Article] The Method of Rodent Whole Embryo Culture using the Rotator-type Bottle Culture System. (2010)
  • Author(s): Takahashi, M., Osumi, N.
  • Journal Title: Journal of Visualized Experiments. 42
  • Peer Reviewed
• [Journal Article] Downstream genes of Pax6 revealed by comprehensive transcriptome profiling in the developing rat hindbrain. (2010)
  • Author(s): Numayama-Tsuruta, K., Arai, Y., Takahashi, M., Sasaki-Hoshino, M., Funatsu, N., Nakamura, S., Osumi, N.
  • Journal Title: BMC.Dev.Biol. 10(6)
  • Peer Reviewed
• [Journal Article] The Method of Rodent Whole Embryo Culture using the Rotator-type Bottle Culture System. (2010)
  • Author(s): Takahashi, M., Osumi, N.
  • Journal Title: Journal of Visualized Experiments Volume: 42
  • Peer Reviewed
• [Journal Article] Expression study of cadherin 7 and cadherin 20 in the embryonic and adult rat central nervous system. (2008)
  • Author(s): Takahashi, M., Osumi, N.
  • Journal Title: BMC.Dev.Biol. 8(1)
  • Peer Reviewed
• [Journal Article] Transferring genes into cultured mammalian embryos by electroporation. (2008)
  • Author(s): Takahashi, M., Nomura, T., Osumi, N.
  • Journal Title: Dev.Growth Differ. 50(6) Pages: 485-497
  • NAID: 10021097252
  • Peer Reviewed
• [Journal Article] Pax6 transcription factor contributes to both embryonic and adult neurogenesis as a multifunctional regulator. (2008)
  • Author(s): Osumi, N., Shinohara, H., Numayama-Tsuruta, K., Maekawa, M.
  • Journal Title: Stem Cells. 26(7) Pages: 1663-1672
  • Peer Reviewed
• [Journal Article] Patterns of neurogenesis and amplitude of Reelin expression are essential for making a mammalian-typec ortex. (2008)
  • Author(s): Nomura, T., Takahashi, M., Hara, Y., Osumi, N.
  • Journal Title: PLosONE. 3(1)
  • Peer Reviewed
• [Journal Article] The neurogenesis-controlling factor, Pax 6, inhibits proliferation and promotes maturation in murine astrocytes (2008)
  • Author(s): Sakurai, K., Osumi, N.
  • Journal Title: J. Neurosci 28 Pages: 4604-4612
  • Peer Reviewed
• [Journal Article] Pax 6 transcription factor contributes to both embryonic and adult neurogenesis as a multifunctional regulator (2008)
  • Author(s): Osumi, N. Shinohara, H. Numayama-Tsuruta, K. and Maekawa, M.
  • Journal Title: Stem Cells 26 Pages: 1663-1672
  • Peer Reviewed
• [Journal Article] Transferring genes into cultured mammalian embryos by electroporation (2008)
  • Author(s): Takahashi, M., Nomura, T. and Osumi, N.
  • Journal Title: Dev. Growth Differ 50 Pages: 485-497
  • NAID: 10021097252
  • Peer Reviewed
• [Journal Article] Expression study of cadherin 7 and cadherin 20 in the embryonic and adult rat central nervous system (2008)
  • Author(s): Takahashi, T., Osumi, N.
  • Journal Title: BMC. Dev. Biol 8
  • Peer Reviewed
• [Journal Article] Development of the mouse amygdala as revealed by enhanced green fluorescent protein gene transfer by means of in utero electroporation (2008)
  • Author(s): Soma, M., Aizawa, H., Ito, Y., Maekawa, M., Osumi, N., Nakahira, E., Okamoto, H., Tanaka K. and Yuasa, S.
  • Journal Title: J Comp Neurol 513 Pages: 113-128
  • Peer Reviewed
• [Journal Article] Patterns of neurogenesis and amplitude of Reelin expression are essential for making a mammalian-type cortex. (2008)
  • Author(s): Nomura, T., Takahashi, M., Hara, Y. and Osumi, N
  • Journal Title: PLoS ONE 3
  • Peer Reviewed
• [Journal Article] Live Imaging of neuroepithelial cells in the rat spinal cord by confocal laser-scanning microscopy. (2007)
  • Author(s): Takahashi, M., Osumi, N.
  • Journal Title: Bionanotechnology Based Future Medical Engineering Proceedings of the Final Symposium of the Tohoku University 21st Century Center of Excellence Programme, Imperial College Press. 1 Pages: 211-220
• [Journal Article] Labeling of neuroepithelial cells using whole embryo culture and gene transfer methods to characterize the cell cycle. (2007)
  • Author(s): Tsunekawa, Y., Takahashi, M., Osumi, N.
  • Journal Title: Bionanotechnology Based Future Medical Engineering Proceedings of the Final Symposium of the Tohoku University 21st Century Center of Excellence Programme, Imperial College Press. 1 Pages: 203-210
• [Journal Article] The rat small eye homozygote (rSey2/rSey2) can be regarded as a Pax6 null mutant. (2007)
  • Author(s): Numayama-Tsuruta, K. Arai, Y., Osumi, N.
  • Journal Title: Bionanotechnology Based Future Medical Engineering Proceedings of the Final Symposium of the Tohoku University 21st Century Center of Excellence Programme, Imperial College Press. 1 Pages: 151-162
• [Journal Article] Manupilating mammalian embryos for research on the developing cerebral cortex. (2007)
  • Author(s): Nomura, T., Osumi, N.
  • Journal Title: Bionanotechnology Based Future Medical Engineering Proceedings of the FinalS ymposium of the Tohoku University 21st Century Center of Excellence Programme, Imperial College Press. 1 Pages: 17-22
• [Journal Article] Role of a transcription factor Pax6 in the developing vertebrate olfactory system. (2007)
  • Author(s): Nomura, T., Haba, H., Osumi, N.
  • Journal Title: Dev Growth Differ. 49(9) Pages: 683-690
  • NAID: 10019984020
  • Peer Reviewed
• [Journal Article] Pax6 transcription factor is required for the interkinetic nuclear movement of neuroepithelial cells. (2007)
  • Author(s): Tamai, H., Shinohara, H., Miyata, T., Saito, K., Nishizawa, Y., Nomura, T., Osumi, N.
  • Journal Title: Genes Cells. 12(9) Pages: 983-996
  • Peer Reviewed
• [Journal Article] Pax6 transcription factor is required for the interkinetic nuclear movement of neuroepithelial cells. (2007)
  • Author(s): Tamai, H. Shinohara, H. Miyata, T. Saito, K. Nishizawa, Y. Nomura T. and Osumi, N
  • Journal Title: Genes Cells 12 Pages: 983-996
  • Peer Reviewed
• [Journal Article] Role of a transcription factor Pax6 in the developing vertebrate olfactory system. (2007)
  • Author(s): Nomura, T. Haba, H. and Osumi, N
  • Journal Title: Dev. Growth Differ 49 Pages: 683-690
  • NAID: 10019984020
  • Peer Reviewed
• [Journal Article] Manupilating mammalian embryos for research on the developing cerebral cortex (2007)
  • Author(s): Nomura, T., Osumi, N.
  • Journal Title: Bionanotechnology Based Future Medical Engineering Proceedings of the Final Symposium of the Tohoku University 21st Century Center of Excellence Programme (Imperial College Press) 2007.1 Pages: 17-22
• [Journal Article] The rat small eye homozygote (rSey2/rSey2) can be regarded as a Pax6 null mutant (2007)
  • Author(s): Numayama-Tsuruta, K., Arai, Y., Osumi, N.
  • Journal Title: Bionanotechnology Based Future Medical Engineering Proceedings of the Final Symposium of the Tohoku University 21st Century Center of Excellence Programme (Imperial College Press) 2007.1 Pages: 151-162
• [Journal Article] Labeling of neuroepithelial cells using whole embryo culture and gene transfer methods to characterize the cell cycle. (2007)
  • Author(s): Tsunekawa, Y., Takahashi, M., Osumi, N.
  • Journal Title: Bionanotechnology Based Future Medical Engineering Proceedings of the Final Symposium of the Tohoku University 21st Century Center of Excellence Programme (Imperial College Press) 2007.1 Pages: 203-210
• [Journal Article] Live Imaging of neuroepithelial cells in the rat spinal cord by confocal laser-scanning microscopy. (2007)
  • Author(s): Takahashi, M, Osumi, N.
  • Journal Title: Bionanotechnology Based Future Medical Engineering Proceedings of the Final Symposium of the Tohoku University 21st Century Center of Excellence Program (Imperial College Press) Pages: 211-220
• [Journal Article] Abnormal migration and distribution of neural crest cells in Pax6 heterozygous mutant eye, a model for human eye diseases. (2006)
  • Author(s): Kanakubo, S., Nomura, T., Yamamura, K., Miyazaki, J., Tamai, M., Osumi, N.
  • Journal Title: Genes Cells 11(8) Pages: 919-933
• [Journal Article] Pax6-dependent boundary defines alignment of migrating olfactory cortex neurons via the repulsive activity of ephrin-A5. (2006)
  • Author(s): Nomura, T., Holmberg, J., Frisen, J., Osumi, N.
  • Journal Title: Development 133 Pages: 1335-1345
• [Journal Article] Role of Fabp7, a downstream gene of Pax6, in the meintenance of neuroepithelial cells during early embryonic development of the rat cortex. (2005)
  • Author(s): Arai, Y., Funatsu, N., Numayama-Tsuruta, K., Nomura, T., Nakamura, S., Osumi, N.
  • Journal Title: J Neurosci. 25(42) Pages: 9752-9761
  • Peer Reviewed
• [Journal Article] NSSRs/TASRs/SRp38s function as splicing modulators via binding to pre-mRNAs. (2005)
  • Author(s): Fushimi K, Osumi N, Tsukahara T.
  • Journal Title: Genes to Cells 10 Pages: 531-541
• [Journal Article] Pax6 is required for making specific subpopulations of granule and periglomerular neurons in the olfactory bulb. (2005)
  • Author(s): Kohwi, M., Osumi, N, Rubenstein, JLR, Alvarez-Buylla, A.
  • Journal Title: The Journal of Neuroscience 25(30) Pages: 6997-7003
• [Journal Article] Pax6 is required for production and maintenance of progenitorcells in postnatal hipocampal neurogenesis. (2005)
  • Author(s): Maekawa, M., Takashima, N.Arai, Y., Nomura, T., Inokuchi, K., Yuasa, S., Osumi, N.
  • Journal Title: Genes to Cells 10 Pages: 1001-1014
• [Journal Article] Cardiac neural crest cells as dormant multipotential stem cells in the mammalian heart. (2005)
  • Author(s): Tomita, Y., Matsumura, K., Wakamatsu, Y., Matsuzaki, Y., Shibuya, I., Kawaguchi, H., Ieda, M., Kanakubo, S., Shimazaki, T., Ogawa, S., Osumi, N., Okano, H., Fukuda, K.
  • Journal Title: The Journal of Cell Biology 170(7) Pages: 1135-1146
• [Journal Article] Role of Fabp7, a downstream gene of Pax6, in maintenance of neuroepithelialcells during early embryonic development of the rat cortex. (2005)
  • Author(s): Arai, Y., Funatsu, N., Numayama-Tsuruta, K., Nomura, T., Nakamura, S., Osumi, N.
  • Journal Title: The Journal of Neuroscience 25(42) Pages: 9752-9761
• [Presentation] Centrosomal protein ninein may control interkinetic nuclear migration in neuroepithelial cells. (2010)
  • Author(s): Shinohara, H., Miyata, T., Takahashi, M., Osumi, N.
  • Organizer: Society of Neuroscience 40th Annual Meeting, Neuroscience 2010
  • Place of Presentation: San Diego, CA, USA
  • Year and Date: 2010-11-14
• [Presentation] Spatiotemporal post-transcriptional regulation of Cyclin D2 mRNA induces asymmetrical cell fates in neuroepithelial cells and self-organization of corticogenesis. (2010)
  • Author(s): Tsunekawa, Y., Joanne, Brito., Takahashi, M., Seng-Song, Tan., Osumi, N.
  • Organizer: Society of Neuroscience 40th Annual Meeting, Neuroscience 2010
  • Place of Presentation: San Diego, CA, USA
  • Year and Date: 2010-11-14
• [Presentation] Analysis of Dmrt4 as a downstream gene of Pax6 in early development of the telencephalon. (2010)
  • Author(s): Kikkawa, T., Fukuzaki, U., Numayama-Tsuruta, K., Takahashi, M., Osumi, N.
  • Organizer: Society of Neuroscience 40th Annual Meeting, Neuroscience 2010
  • Place of Presentation: San Diego, CA, USA
  • Year and Date: 2010-11-14
• [Presentation] Proliferation of glial cells : its implication for the healthy brain. (2010)
  • Author(s): Osumi, N.
  • Organizer: 第29回内藤コンファレンス
  • Place of Presentation: 神奈川
  • Year and Date: 2010-10-06
• [Presentation] Centrosomal Protein Ninein May Control Interkinetic Nuclear Migration in Neuroepithelial Cells. (2010)
  • Author(s): Shinohara, H., Takahashi, M., Osumi, N.
  • Organizer: The third Brain Science Summer Retreat in Sendai.
  • Place of Presentation: 仙台
  • Year and Date: 2010-08-01
• [Presentation] Asymmetric inheritance of locally-translated Cyclin D2 confers self-renewing fates to daughters of apical progenitor cell divisions. (2010)
  • Author(s): 恒川雄二、Joanne Brito, 高橋将文、Seng-song Tan, 大隅典子
  • Organizer: The third Brain Science Summer Retreat in Sendai.
  • Place of Presentation: 仙台
  • Year and Date: 2010-08-01
• [Presentation] Centrosomal protein ninein may control interkinetic nuclear migration in neuroepithelial cells. (2010)
  • Author(s): Shinohara, H., Takahashi, M., Osumi, N.
  • Organizer: 第43回日本発生生物学会年会
  • Place of Presentation: 京都
  • Year and Date: 2010-06-21
• [Presentation] Centrosomal protein ninein may control interkinetic nuclear migration in neuroepithelial cells. (2010)
  • Author(s): Shinohara, H., Miyata, T., Takahashi, M., Osumi, N.
  • Organizer: 日本分子生物学会第10回春期シンポジウム
  • Place of Presentation: 松島
  • Year and Date: 2010-06-07
• [Presentation] Pax6 is involved in specification of rhombomere boundary cells in the rat hindbrain. (2010)
  • Author(s): 高橋将文、大隅典子
  • Organizer: 日本分子生物学会第10回春期シンポジウム
  • Place of Presentation: 松島
  • Year and Date: 2010-06-07
• [Presentation] Pax6 is involved in specification of rhombomere boundary cells in the rathindbrain. (2010)
  • Author(s): 高橋将文、大隅典子
  • Organizer: 日本分子生物学会第10回春期シンポジウム
  • Place of Presentation: 松島
  • Year and Date: 2010-06-07
• [Presentation] Neurogenesis-Its implication in and application for mental diseases. (2010)
  • Author(s): Osumi, N.
  • Organizer: Cold Spring Harbor Asia Francis Crick Neurobiology Symposium
  • Place of Presentation: 中国・蘇州
  • Year and Date: 2010-04-13
• [Presentation] Spatiotemporal post-transcriptional regulation of Cyclin D2 mRNA induces asymmetrical cell fates in neuroepithelial cells and self-organization of corticogenesis. (2010)
  • Author(s): 恒川雄二、高橋将文、大隅典子
  • Organizer: 第4回神経発生討論会
  • Place of Presentation: 岡崎
  • Year and Date: 2010-03-19
• [Presentation] Molecular mechanisms of interkinetic nuclear migration and asymmetrical fate decision in neuroepithelial cells. (2010)
  • Author(s): 大隅典子
  • Organizer: 特定領域研究「細胞増殖制御」主催国際シンポジウム"Cell Cycle and Development"
  • Place of Presentation: 京都
  • Year and Date: 2010-03-17
• [Presentation] Spatiotemporal Post-Transcriptional Regulation of Cyclin D2 mRNA Induces Asymmetrical Cell Fates in Neuroepithelial Cells and Self-Organization of Corticogenesis. (2010)
  • Author(s): Osumi, N.
  • Organizer: The 56th NIBB Conference Neocortical Organization.
  • Place of Presentation: 岡崎
  • Year and Date: 2010-03-12
• [Presentation] Molecular mechanisms of neurogenesis, a key event in development and maintenance of the brain. (2009)
  • Author(s): Osumi, N.
  • Organizer: Construction and Reconstruction of the Brain.
  • Place of Presentation: 淡路島
  • Year and Date: 2009-10-08
• [Presentation] Spatiotemporal post-transcriptional regulation of Cyclin D2 mRNA induces asymmetrical cell fates in neuroepithelial cells and self-organization of corticogenesis. (2009)
  • Author(s): 恒川雄二、高橋将文、大隅典子
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-09-17
• [Presentation] Increasing your brain cells! (2008)
  • Author(s): Osumi, N.
  • Organizer: Tohoku University Forum in Beijing
  • Place of Presentation: 北京, 中国
  • Year and Date: 2008-12-13
• [Presentation] Transcriptional regulation of Fabp7 by Pax6 in the developing brain (2008)
  • Author(s): Numayama-Tsuruta, K., Arai, Y., Sasaki-Hoshino, M. and Osumi. N.
  • Organizer: BMB2008(第31回日本分子生物学会年会第81回日本生化学会合同年会)
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-10
• [Presentation] The neuorgenesis-controling factor, Pax6, inhibits proliferation and promotes mauration in murine astrocytes. (2008)
  • Author(s): Osumi. N
  • Organizer: 38th Annual Meeting of Society of Neuroscientists
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2008-11-16
• [Presentation] The neuorgenesis-controling factor, Pax6, inhibits proliferation and promotes mauration in murine astrocytes (2008)
  • Author(s): Noriko, Osumi
  • Organizer: 38th Annual Meeting of Society of Neuroscientists
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2008-11-16
• [Presentation] Development of a novel post-stroke depression model in mice (2008)
  • Author(s): Shinohara, H.,Hayashi, K., Miyata, T., Takahashi, M. and Osumi, N.
  • Organizer: Tohoku University_Fudan University Neuroscience Workshop for Young Scientists
  • Place of Presentation: 上海, 中国
  • Year and Date: 2008-10-16
• [Presentation] The neurogenesis-controlling factor, Pax 6, inhibits proliferation and promotes in murine astrocytes (2008)
  • Author(s): 櫻井勝康、天隅典子
  • Organizer: 日本発生生物学会サマースクール
  • Place of Presentation: 長野
  • Year and Date: 2008-08-27
• [Presentation] 神経幹細胞における細胞周期調節因子CyclinD2の輸送メカニズムとその意義 (2008)
  • Author(s): 恒川雄二、高橋将文、大隅典子
  • Organizer: 日本発生生物学会サマースクール
  • Place of Presentation: 長野
  • Year and Date: 2008-08-27
• [Presentation] Pax6 : a multiple regulator for neurogenesis and gliogenesis. (2008)
  • Author(s): Osumi, N.
  • Organizer: Tohoku Neuroscience Global COE The 1st Brain Science Summer Retreat in Matsushima "New Era of Neuroscience-From molecules to Society"
  • Place of Presentation: 松島
  • Year and Date: 2008-08-20
• [Presentation] Downregulation of ninein, delta-catenin and FEZ1 at the apical side of neuroepithelial cells of the Pax6 mutant (2008)
  • Author(s): Shinohara, H., Hayashi, K., Miyata, T., Takahashi, M. and Osumi. N.
  • Organizer: Tohoku, Neuroscience Global The 1st Brain Science Summer Retreat in Matsushima "New Era of Neuroscience-From molecules to Society"
  • Place of Presentation: 松島
  • Year and Date: 2008-08-20
• [Presentation] The localization of CyclinD2 mRNAs and protein in endfeet of neuroepithelial cells during murine neurogenesis (2008)
  • Author(s): Tsunekawa,Y., Takahashi, M. and Osumi, N.
  • Organizer: Tohoku Neuroscience Global COE The 1st Brain Science Summer Retreat in Matsushima "New Era of Neuroscience-From molecules to Society"
  • Place of Presentation: 松島
  • Year and Date: 2008-08-20
• [Presentation] Pax6 : a multiple regulator for neurogenesis and gliogenesis (2008)
  • Author(s): Osumi, N.
  • Organizer: Tohoku Neuroscience Global COE The 1st Brain Science Summer Retreat in Matsushima "New Era of Neuroscience-From molecules to Society"
  • Place of Presentation: 松島
  • Year and Date: 2008-08-20
• [Presentation] The neurogenesis controlling factor,Pax 6, inhibits proliferation and oromotes maturation in murine astrocvtes (2008)
  • Author(s): Sakurai, K. and Osumi, N.
  • Organizer: CSHL meeting 2008 Glia in health and disease
  • Place of Presentation: Cold spring harbor USA
  • Year and Date: 2008-07-19
• [Presentation] Premature neurogenesis in the Pax6 heterozyrous mutant cer ebral cortex (2008)
  • Author(s): Umeda, T., Nomura, T., Suto, F. and Osumi, N.
  • Organizer: 第31回日本神経科学大会Neuroscience 2008
  • Place of Presentation: 東京
  • Year and Date: 2008-07-11
• [Presentation] Biological importance of neurogenesis in regard with etiology of mental diseases (2008)
  • Author(s): Osumi, N.
  • Organizer: 第31回日本神経科学大会Neuroscience 2008
  • Place of Presentation: 東京
  • Year and Date: 2008-07-09
• [Presentation] The role of Pax6 and its downstream molecules in embryonic and postnatal neurogenesis. (2008)
  • Author(s): Osumi, N.
  • Organizer: 第41回日本発生生物学会
  • Place of Presentation: 徳島
  • Year and Date: 2008-05-28
• [Presentation] Downregulation of ninein, δ-catenin and FEZ1 at the apical side of neuroepithelial cells on the Pax6 mutant (2008)
  • Author(s): Shinohara, H., Hayashi, K, Miyata, T,. Takahashi, M. and Osumi, N.
  • Organizer: 第41回日本発生生物学会
  • Place of Presentation: 徳島
  • Year and Date: 2008-05-28
• [Presentation] Premature neurogenesis in the Pax 6 heterozyrous mutant cerebral cortex (2008)
  • Author(s): Umeda. T., No mura,T., Suto, F. and Osumi. N.
  • Organizer: 第41回日本発生生物学会
  • Place of Presentation: 徳島
  • Year and Date: 2008-05-28
• [Presentation] Imaging analysis of the apical structure of neuroepithelial cells : evidence of hindbrain cytonemes (2008)
  • Author(s): Takahashi, M. and Osumi, N.
  • Organizer: 第41回日本発生生物学会
  • Place of Presentation: 徳島
  • Year and Date: 2008-05-28
• [Presentation] The localization of CyclinD 2 mRNAs and protein in neuroepit helial cells during murine neurogenesis (2008)
  • Author(s): Tsunekawa, Y., Takahashi, M. and Osumi, N.
  • Organizer: 第41回日本発生生物学会
  • Place of Presentation: 徳島
  • Year and Date: 2008-05-28
• [Presentation] The role of Pax6 and its downstream molecules in embryonic and postnatal neurogenesis (2008)
  • Author(s): Osumi, N.
  • Organizer: 第41回日本発生生物学会
  • Place of Presentation: 徳島
  • Year and Date: 2008-05-28
• [Presentation] Pax6ヘテロ接合変異ラットの大脳皮質発生期における早熟神経新生 (2008)
  • Author(s): 梅田稔子、野村真、須藤文和、大隅典子
  • Organizer: 第1回リトリート大学院研究発表
  • Place of Presentation: 仙台
  • Year and Date: 2008-02-16
• [Presentation] The role of Pax6 in embryonic and postnatal neurogenesis. (2008)
  • Author(s): Osumi, N.
  • Organizer: 1st international conference of GCOE in ZAO
  • Place of Presentation: 蔵王
  • Year and Date: 2008-01-23
• [Presentation] lmaging analysis of the apical structure of neuroepithelial cells: evidence for cytone mes in the vertebrate hindbrain (2008)
  • Author(s): Takahashi, M. and Osumi, N.
  • Organizer: 1st international conference of GCOE in ZAO
  • Place of Presentation: 蔵王
  • Year and Date: 2008-01-23
• [Presentation] Downregulation of δ-catenin and FEZ1 at the apical side of neuroepithelial cells of the Pax6 mutant (2008)
  • Author(s): Shinohara, H., Tamai, H., Miyata, T., Saito, K., Nishizawa, Y., Takahashi, M,, Osumi, N.
  • Organizer: 1st international conference of GCOE in ZAO
  • Place of Presentation: 蔵王
  • Year and Date: 2008-01-23
• [Presentation] The role of Pax6 in embryonic and postnatal neurogenesis (2008)
  • Author(s): Osumi, N.
  • Organizer: 1st international conference of GCOE in ZAO
  • Place of Presentation: 蔵王
  • Year and Date: 2008-01-23
• [Presentation] Imaging analysis of the apical structure of neuroepithelial cells: evidence for hindbrain cytonemes as a novel aspect during vertebrate brain development (2007)
  • Author(s): Takahashi, M. and Osumi, N.
  • Organizer: The American Society Cell biology 2007 47th Annual Meeting
  • Place of Presentation: Washington DC
  • Year and Date: 2007-12-05
• [Presentation] Transcriptional regulation of Fabp7 by Pax6 in the proliferating neuroepithelial cells (2007)
  • Author(s): Numayama-Tsuruta, K., Hoshino, M. and Osumi N.
  • Organizer: 遺伝情報DECODE・冬のワークショップ(転写研究会共催)
  • Place of Presentation: 越後湯沢
  • Year and Date: 2007-12-05
• [Presentation] A reduction of specific subtypes of GABAergic interneurons in the Pax6 mutant mouse olfactory (2007)
  • Author(s): Haba, H. Nomura, T. Osumi, N.
  • Organizer: Neuroscience 2007, the Society's 37th annual meeting
  • Place of Presentation: San Diego
  • Year and Date: 2007-11-04
• [Presentation] Neurogenesis : a key for brain development and maintenance. (2007)
  • Author(s): Osumi, N.
  • Organizer: 京都大学再生医科学研究所国際シンポジウム2007
  • Place of Presentation: 京都
  • Year and Date: 2007-09-19
• [Presentation] Neurogenesis: a key for brain development and maintenance (2007)
  • Author(s): 大隅典子
  • Organizer: 京都大学再生医科学研究所国際シンポジウム2007
  • Place of Presentation: 京都
  • Year and Date: 2007-09-19
• [Presentation] 菱脳運動神経の回路形成におけるRho/Rho-kinaseシグナル伝達系の役割 (2007)
  • Author(s): 小林憲太、増田知之、高橋将文、宮崎純一、中川まさ弘、八木沼洋行、大隅典子、貝淵弘三、小林和人
  • Organizer: Neuro2007(第30回日本神経科学大会)
  • Place of Presentation: 横浜
  • Year and Date: 2007-09-12
• [Presentation] Dicreased interneurons in the Pax6 mutant mouse olfactory bulb (2007)
  • Author(s): Haba, H. Nomura, T. Osumi, N
  • Organizer: Neuro2007(第30回日本神経科学大会)
  • Place of Presentation: 横浜
  • Year and Date: 2007-09-10
• [Presentation] Premature Neurogenesis in the Pax6 heterozygous Mutant Cerebral Cortex (2007)
  • Author(s): Umeda, T, Nomura, T. Osumi, N
  • Organizer: Neuro2007(第30回日本神経科学大会)
  • Place of Presentation: 横浜
  • Year and Date: 2007-09-10
• [Presentation] 哺乳類型の脳をつくる分子メカニズム (2007)
  • Author(s): 野村真、大隅典子
  • Organizer: 日本進化学会第9回大会
  • Place of Presentation: 京都
  • Year and Date: 2007-09-02
• [Presentation] Developmental Biology of Compartment and signaling center (2007)
  • Author(s): Takahashi, M. and Osumi, N.
  • Organizer: Toward innovative research: Lessons from the Kornbergs
  • Place of Presentation: 東京
  • Year and Date: 2007-07-24
• [Presentation] The role of Reelin-positive marginal zone cells in the cortical/pallial radial glial fibers among vertebrate species (2007)
  • Author(s): Nomura, T and Osumi, N.
  • Organizer: IBRO(7th World Congress of lnternastional Brain Research Organization)
  • Place of Presentation: Melbourne
  • Year and Date: 2007-07-13
• [Presentation] The localization of CyclinD2 mRNA and protein in endfeet of neuroepithelial cells during murine cortical development. (2007)
  • Author(s): Tsunekawa, Y., Takahashi, M., Osumi, N.
  • Organizer: IBRO world congress of neuroscience, Satellite Meetings
  • Place of Presentation: Cairns
  • Year and Date: 2007-07-09
• [Presentation] The localization of CyclinD2 mRNA and protein in endfeet of neuroepithelial cells during murine cortical development (2007)
  • Author(s): Tsunekawa, Y. Takahashi, M. and Osumi, N.
  • Organizer: IBRO world congress of neuroscience, Satellite Meetings
  • Place of Presentation: Cairns
  • Year and Date: 2007-07-09
• [Presentation] Pax6ヘテロ接合変異ラットの大脳皮質発生期における早熟神経新生 (2007)
  • Author(s): Umeda, T. Nomura, T and Osumi, N.
  • Organizer: 第4回東北大学サイエンスシンポジウム
  • Place of Presentation: 仙台
  • Year and Date: 2007-06-04
• [Presentation] The expression of cadherin7 and cadherin20 defines specific subdomains and boundaries in the primordium of rat embryos, and the proper expression of cad7 is dependent on function of a transcription factor Pax6 (2007)
  • Author(s): Takahashi, M. and Osumi, N.
  • Organizer: 第40回日本発生生物学会 第59回細胞生物学会合同大会
  • Place of Presentation: 福岡
  • Year and Date: 2007-05-30
• [Presentation] The subcellular localization of cyclinD2 mRNAs and proteins in the mammalian neuroepithelial cells (2007)
  • Author(s): Tsunekawa, Y., Takahashi, M. and Osumi, N.
  • Organizer: 第40回日本発生生物学会 第59回細胞生物学会合同大会
  • Place of Presentation: 福岡
  • Year and Date: 2007-05-30
• [Presentation] The role of er81 in speciflcation of extra-cortical/pallial projection neurons during mammalian and avian brain development (2007)
  • Author(s): Nomura, T and Osumi, N.
  • Organizer: 第40回日本発生生物学会 第59回細胞生物学会合同大会
  • Place of Presentation: 福岡
  • Year and Date: 2007-05-30
• [Presentation] Downregulation of d-catenin and FEZ1 at the apical side of neuroepithelial cells of the Pax6 mutant. (2007)
  • Author(s): Shinohara, H. Tamai, H. Miyata, T. Saito, K. Nishizawa, Y. Takahashi, M and Osumi, N.
  • Organizer: 第40回日本発生生物学会 第59回細胞生物学会合同大会
  • Place of Presentation: 福岡
  • Year and Date: 2007-05-29
• [Presentation] Comparative analysis of neuronal specification and migration in the developing mam malian and avian gallium (2007)
  • Author(s): Nomura, T and Osumi, N.
  • Organizer: Hakone meeting
  • Place of Presentation: 箱根
  • Year and Date: 2007-05-19
• [Presentation] The expression of cadherin7 and cadherin20 defines specific subdomains and boundaries in the primordium of rat embryos, and the proper expression of cad7 is dependent on function of a transcription factor Pax6 (2007)
  • Author(s): Takahashi, M. and Osumi, N.
  • Organizer: Neurogenesis 2007
  • Place of Presentation: 東京
  • Year and Date: 2007-05-15
• [Presentation] 発生期の哺乳類と鳥類終脳における神経細胞分化、移動過程の比較解析 (2006)
  • Author(s): 野村真、大隅典子
  • Organizer: 日本分子生物学会2006フォーラム
  • Place of Presentation: 名古屋
  • Year and Date: 2006-12-08
• [Book] Electroporation into cultured mammalian embryos. (2009)
  • Author(s): Nomura, T., Takahashi, M., Osumi, N.
  • Publisher: Springer
• [Book] Springer (2009)
  • Author(s): Nomura, T., Takahashi, M. and Osumi. N.
  • Publisher: Electroporation into cultured mammalian embryos
• [Book] 神経新生の分子生物学と生理機能:学習 (2008)
  • Author(s): 松本葉子、大隅典子
  • Publisher: Clinical Neuroscience
• [Book] 分子精神医学 (2008)
  • Author(s): 前川素子、大隅典子
  • Publisher: FABP7遺伝子先端医学社
• [Book] RAIN and NERVE(脳発生におけるPax6の機能とその異常) (2008)
  • Author(s): 松本葉子、大隅典子
  • Publisher: 医学書院
• [Book] BRAIN and NERVE (2008)
  • Author(s): 松本葉子、大隅典子
  • Publisher: 脳発生におけるPax6の機能とその異常
• [Book] 分子精神医学 (2008)
  • Author(s): 前川素子、大隅典子
  • Publisher: FABP7遺伝子
• [Book] Clinical Neuroscience (2008)
  • Author(s): 松本葉子、大隅典子
  • Publisher: 神経新生の分子生物学と生理機能 : 学習
• [Book] 実験医学(「Neurogenesis 2007」にみるニューロン新生研究の新風)25(12) (2007)
  • Author(s): 大隅典子、久恒辰博
  • Publisher: 羊土社
• [Book] Jonathan Slack著(エッセンシャル発生生物学改訂第2版) (2007)
  • Author(s): 大隅典子訳
  • Total Pages: 333
  • Publisher: 羊土社
• [Book] 実験医学 (2007)
  • Author(s): 大隅典子、久恒辰博
  • Publisher: 「Neurogenesis 2007」にみるニューロン新生研究の新風
• [Book] エッセンシャル発生生物学 改訂第2版 (2007)
  • Author(s): 大隅典子訳, Jonathan Slack著
  • Total Pages: 373
  • Publisher: 羊土社
• [Remarks] ホームページ等
• [Patent(Industrial Property Rights)] 神経再生剤 (2006)
  • Inventor(s): 大隅典子、前川素子
  • Industrial Property Rights Holder: 大隅典子、前川素子
  • Filing Date: 2006-11-07
• [Patent(Industrial Property Rights)] 神経再生剤 (2006)
  • Inventor(s): 大隅典子, 前川素子
  • Industrial Property Rights Holder: 大隅典子, 前川素子
  • Filing Date: 2006-11-07