Molecular mechanism underlying neuronal polarity

• Project/Area Number: 17024024
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Nagoya University
• Principal Investigator: KAIBUCHI Kozo Nagoya University, 大学院・医学系研究科, 教授 (00169377)
• Co-Investigator(Kenkyū-buntansha): NARIKO Arimura 玉川大学, 脳科学研究所, グローバルCOE准教授 (20420375) ; DAISUKE Mori 名古屋大学, 大学院・医学系研究科, COE特任講師 (00381997) ; TOMOKI Nishioka 名古屋大学, 大学院・医学系研究科, 助教 (70435105)
• Project Period (FY): 2005 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥19,100,000 (Direct Cost: ¥19,100,000); Fiscal Year 2009: ¥4,100,000 (Direct Cost: ¥4,100,000); Fiscal Year 2008: ¥3,900,000 (Direct Cost: ¥3,900,000); Fiscal Year 2007: ¥3,500,000 (Direct Cost: ¥3,500,000); Fiscal Year 2006: ¥3,700,000 (Direct Cost: ¥3,700,000); Fiscal Year 2005: ¥3,900,000 (Direct Cost: ¥3,900,000)
• Keywords: 極性 / 軸索 / シグナル伝達 / CRMP-2 / 小胞体 / 細胞外因子 / 神経細胞 / 極性形成 / 細胞内輸送 / Par / カルシウム / 脳・神経 / 神経極性 / 軸索形成 / キネシン-1 / Sra-1 / WAVE1 / リン酸化

Research Abstract

Our project aimed at examining the molecular mechanisms underlying establishment and maintenance of neuronal polarity. We found that GSK-3β regulates neuronal polarity through the phosphorylation of CRMP-2. CRMP-2 complex directly links Kinesin-1 motor, and this association is required for the anterograde transport of signaling molecules and polarity related proteins-containing vesicles.

Research Products

• [Journal Article] The PHCCEx domain of Tiam1/2 is a novel protein- and membrane-binding module. (2010)
  • Author(s): Terawaki S, et al.
  • Journal Title: The EMBO journal 29 Pages: 236-250
  • Peer Reviewed
• [Journal Article] CRMP-2 directly binds to cytoplasmic dynein and interferes with its activity (2009)
  • Author(s): Arimura, N., Hattori, A., Kimura, T., Nakamuta, S., Funahashi, Y., Hirotsune, S., Furuta, K., Urano, T., Toyoshima, YY.,, Kaibuchi, K.
  • Journal Title: Journal of neurochemistry 111 Pages: 380-90
  • Peer Reviewed
• [Journal Article] Anterograde transport of TrkB in axons is mediated by direct interaction with Slp1 and Rab27 (2009)
  • Author(s): Arimura, N., Kimura, T., Nakamuta, S., Taya, S., Funahashi, Y., Hattori, A., Shimada, A., Mnager, C., Kawabata, S., Fujii, K., Iwamatsu, A., Segal, RA., Fukuda, M.,, Kaibuchi, K.
  • Journal Title: Developmental cell 16 Pages: 675-86
  • Peer Reviewed
• [Journal Article] Unc5B associates with LARG to mediate the action of repulsive guidance molecule. (2009)
  • Author(s): Hata K, et al.
  • Journal Title: The Journal of cell biology 184 Pages: 737-750
  • Peer Reviewed
• [Journal Article] Direct interaction of Dysbindin with the AP-3 complex via its mu subunit. (2009)
  • Author(s): Taneichi-Kuroda S, et al.
  • Journal Title: Neurochemistry international 54 Pages: 431-438
  • Peer Reviewed
• [Journal Article] Anterograde transport of TrkB in axons is mediated by direct interaction with Slp1 and Rab27. (2009)
  • Author(s): Arimura N, et al.
  • Journal Title: Developmental cell 16 Pages: 675-686
  • Peer Reviewed
• [Journal Article] Association analysis between schizophrenia and the AP-3 complex genes. (2009)
  • Author(s): Hashimoto R, et al.
  • Journal Title: Neuroscience research 65 Pages: 113-115
  • Peer Reviewed
• [Journal Article] TDP-43 depletion induces neuronal cell damage through dysregulation of Rho family GTPases. (2009)
  • Author(s): Iguchi Y, et al.
  • Journal Title: The Journal of biological chemistry 284 Pages: 22059-22066
  • Peer Reviewed
• [Journal Article] Proteomic analysis reveals novel binding partners of dysbindin, a schizophrenia-related prntein. (2009)
  • Author(s): Hikita T, et al.
  • Journal Title: Journal of neurochemistry 110 Pages: 1567-1574
  • Peer Reviewed
• [Journal Article] Phosphorylation of CLASP2 by GSK-3beta regulates its interaction with IQGAP1, EB1 and microtubules. (2009)
  • Author(s): Watanabe T, et al.
  • Journal Title: Journal of cell science 122 Pages: 2969-2979
  • Peer Reviewed
• [Journal Article] CRMP-2 directly binds to cytoplasmic dynein and interferes with its activity. (2009)
  • Author(s): Arimura N, et al.
  • Journal Title: Journal of neurochemistry 111 Pages: 380-390
  • Peer Reviewed
• [Journal Article] CaMKII phosphorylates collapsin response mediator protein 2 and modulates axonal damage during glutamate excitotoxicity. (2009)
  • Author(s): Hou ST, et al.
  • Journal Title: Journal of neurochemistry 111 Pages: 870-881
  • Peer Reviewed
• [Journal Article] Roles of disrupted-in-schizophrenia 1-interacting protein girdin in postnatal development of the dentate gyrus. (2009)
  • Author(s): Enomoto A, et al.
  • Journal Title: Neuron 63 Pages: 774-787
  • Peer Reviewed
• [Journal Article] Anterograde transport of TrkB in axons is mediated by direct interaction with Slpl and Rab 27 (2009)
  • Author(s): Arimura, N, et.al.
  • Journal Title: Dev Cell (in press)
  • Peer Reviewed
• [Journal Article] Rho-kinase contributes to sustained RhoA activation through phosphorylation of p190A RhoGAP (2009)
  • Author(s): Mori, K, et.al.
  • Journal Title: J Biol Chem 284 Pages: 5067-5076
  • Peer Reviewed
• [Journal Article] Ultrastructural study of Racl and its effectors beneath the substratum-facing membrane (2008)
  • Author(s): Watanabe, T, et.al.
  • Journal Title: Cell Struct Funct 33 Pages: 101-107
  • Peer Reviewed
• [Journal Article] Identification of YWHAE, a gene encoding 14-3-3epsilon, as a possible susceptibility gene for schizophrenia (2008)
  • Author(s): Ikeda, M, et.al.
  • Journal Title: Hum Mol Genet 17 Pages: 3212-3222
  • Peer Reviewed
• [Journal Article] Rho-kinase phosphorylates Par-3 and disrupts Par complex Formation. (2008)
  • Author(s): Nakayama. M
  • Journal Title: Dev. Cell 14・2 Pages: 205-215
  • Peer Reviewed
• [Journal Article] NF1 tumor suppressor, neurofibromin, regulates the neuronal differentiation of PC12 cells via its associating protein, collapal differentiation of PC12 cells via its associating protsin response mediator protein-2. (2008)
  • Author(s): Patrakitkomjorn. S
  • Journal Title: J. Cell Biol (In press)
  • Peer Reviewed
• [Journal Article] Phosphorylation of claudin-5 and occludin by rho kinase in brain endothelial cells. (2008)
  • Author(s): Yamamoto. M
  • Journal Title: Am. J. Pathol 172 Pages: 521-533
  • Peer Reviewed
• [Journal Article] Neuronal polarity: from extracellular signals to intracellular mechanisms (2007)
  • Author(s): Arimura, N.,, Kaibuchi, K.
  • Journal Title: Nature reviews. Neuroscience 8 Pages: 194-205
  • Peer Reviewed
• [Journal Article] IQGAP3, a novel effector of Rac1 and Cdc42, regulates neurite outgrowth (2007)
  • Author(s): Wang, S., Watanabe, T., Noritake, J., Fukata, M., Yoshimura, T., Itoh, N., Harada, T., Nakagawa, M., Matsuura, Y., Arimura, N.,, Kaibuchi, K.
  • Journal Title: Journal of cell science 120 Pages: 567-77
  • Peer Reviewed
• [Journal Article] Numb controls integrin endocytosis for directional cell migration with aPKC and PAR-3. (2007)
  • Author(s): Nishimura. T
  • Journal Title: Dev. Cell 13・2 Pages: 15-28
  • Peer Reviewed
• [Journal Article] Structural basis for tubulin recognition by cytoplasmic linker protein 170 and its autoinhibition. (2007)
  • Author(s): Mishima. M
  • Journal Title: Proc. Natl. Acad. Sci. U S A 104・25 Pages: 10346-10351
  • Peer Reviewed
• [Journal Article] Dial and IQGAP1 interact in cell migration and phagocytic cup formation. (2007)
  • Author(s): Brandt. D.T
  • Journal Title: J. Cell Biol 178 Pages: 193-200
  • Peer Reviewed
• [Journal Article] Two LIM domain proteins and UNC-96 link UNC-97/pinch to myosin thick filaments in Caenorhabditis elegans muscle. (2007)
  • Author(s): Qadota. H
  • Journal Title: Mol. Biol. Cell 18 Pages: 4317-4326
  • Peer Reviewed
• [Journal Article] Rho-kinase modulates the function of STEE, a Rac GEF, through its phosphorylation. (2007)
  • Author(s): Takefuji. M
  • Journal Title: Biochem. Biophys. Res. Commu 355 Pages: 788-794
  • Peer Reviewed
• [Journal Article] Rho-kinase activation in endothelial cells contributes to expansion of infarction after focal cerebral ischemia. (2007)
  • Author(s): Yagita. Y
  • Journal Title: J. Neurosci. Res 85 Pages: 2460-2469
  • Peer Reviewed
• [Journal Article] A mass conserved reaction-diffusion system captures properties of cell polarity. (2007)
  • Author(s): Otsuji. M
  • Journal Title: PLoS. Comput. Biol 3 Pages: 108-108
  • Peer Reviewed
• [Journal Article] Evidence that many of the DISC1 isoforms in C57BL/6J mice are also expressed in 129S6/SvEv mice. (2007)
  • Author(s): Ishizuka. K
  • Journal Title: Mol. Psychiatry 12 Pages: 897-899
  • Peer Reviewed
• [Journal Article] Establishment of a tissue-specific RNAi system in C. elegans. (2007)
  • Author(s): Qadota. H
  • Journal Title: Gene 400 Pages: 166-173
  • Peer Reviewed
• [Journal Article] Rho-kinase phosphorylates eNOS at threonine 495 in endothelial cells. (2007)
  • Author(s): Sugimoto. M
  • Journal Title: Biochem. Biophys. Res. Commun 361 Pages: 462-467
  • Peer Reviewed
• [Journal Article] Neuronal polarity : from extracellular signals to intracellular mechanisms. (2007)
  • Author(s): Arimura. N
  • Journal Title: Nature Rev Neurosci 8・3 Pages: 194-205
• [Journal Article] IQGAP3, a novel effector of Racl and Cdc42, regulates neurite outgrowth. (2007)
  • Author(s): Wang. S
  • Journal Title: J Cell Sci 120 Pages: 567-577
• [Journal Article] DISCI regulates the transport of the NUDEL/LISI/14-3-3epsilon complex through kinesin-1. (2007)
  • Author(s): Taya. S
  • Journal Title: J Neurosci 27・1 Pages: 15-26
• [Journal Article] DISCI regulates neurotrophin-induced axon elongation via interaction with Grb2. (2007)
  • Author(s): Shinoda. T
  • Journal Title: J Neurosci 27・1 Pages: 4-14
• [Journal Article] Molecular mechanisms of axon specification and neuronal disorders (2006)
  • Author(s): Yoshimura, T., Arimura, N.,, Kaibuchi, K.
  • Journal Title: Annals of the New York Academy of Sciences 1086 Pages: 116-25
  • Peer Reviewed
• [Journal Article] Signaling networks in neuronal polarization (2006)
  • Author(s): Yoshimura, T., Arimura, N.,, Kaibuchi, K.
  • Journal Title: The Journal of neuroscience: the official journal of the Society for Neuroscience 26 Pages: 10626-30
  • Peer Reviewed
• [Journal Article] Ras regulates neuronal polarity via the PI3-kinase/Akt/GSK-3beta/CRMP-2 pathway (2006)
  • Author(s): Yoshimura, T., Arimura, N., Kawano, Y., Kawabata, S., Wang, S.,, Kaibuchi, K.
  • Journal Title: Biochemical and biophysical research communications 340 Pages: 62-8
  • Peer Reviewed
• [Journal Article] Molecular mechanisms of axon specification and neuronal disorders. (2006)
  • Author(s): Yoshimura. T
  • Journal Title: Ann N Y Acad Sci 1086 Pages: 116-125
• [Journal Article] Essential roles for GSK-3s and GSK-3-primed substrates in neurotrophin-induced and hippocampal axon growth. (2006)
  • Author(s): Kim. WY
  • Journal Title: Neuron 52・6 Pages: 981-996
• [Journal Article] Signaling networks in neuronal polarization. (2006)
  • Author(s): Yoshimura. T
  • Journal Title: J Neurosci 26・42 Pages: 10626-10630
• [Journal Article] Sema4D/plexin-B1 activates GSK-3beta through R-Ras GAP activity, inducing growth cone collapse. (2006)
  • Author(s): Ito. Y
  • Journal Title: EMBO Rep 7・7 Pages: 704-709
• [Journal Article] Role of Numb in Dendritic Spine Development with a Cdc42 GEF Intersectin and EphB2. (2006)
  • Author(s): Nishimura. T
  • Journal Title: Mol Biol Cell (In press)
• [Journal Article] Ras regulates neuronal polarity via the PI3-kinase/Akt/GSK-3beta/CRMP-2 pathway. (2006)
  • Author(s): Yoshimura. T
  • Journal Title: Biochem Biophys Res Commun. 340・1 Pages: 62-68
• [Journal Article] Key regulators in neuronal polarity (2005)
  • Author(s): Arimura, N.,, Kaibuchi, K.
  • Journal Title: Neuron 48 Pages: 881-4
  • Peer Reviewed
• [Journal Article] Phosphorylation by Rho kinase regulates CRMP-2 activity in growth cones (2005)
  • Author(s): Arimura, N., Mnager, C., Kawano, Y., Yoshimura, T., Kawabata, S., Hattori, A., Fukata, Y., Amano, M., Goshima, Y., Inagaki, M., Morone, N., Usukura, J., Kaibuchi, K.
  • Journal Title: Molecular and cellular biology 25 Pages: 9973-84
  • Peer Reviewed
• [Journal Article] CRMP-2 is involved in kinesin-1-dependent transport of the Sra-1/WAVE1 complex and axon formation (2005)
  • Author(s): Kawano, Y., Yoshimura, T., Tsuboi, D., Kawabata, S., Kaneko-Kawano, T., Shirataki, H., Takenawa, T.,, Kaibuchi, K.
  • Journal Title: Molecular and cellular biology 25 Pages: 9920-35
  • Peer Reviewed
• [Journal Article] Regulatory machinery of UNC-33 Ce-CRMP localization in neurites during neuronal development in Caenorhabditis elegans (2005)
  • Author(s): Tsuboi, D., Hikita, T., Qadota, H., Amano, M.,, Kaibuchi, K.
  • Journal Title: Journal of neurochemistry 95 Pages: 1629-41
  • Peer Reviewed
• [Journal Article] Tubulin and CRMP-2 complex is transported via Kinesin-1 (2005)
  • Author(s): Kimura, T., Arimura, N., Watanabe, H., Iwamatsu, A.,, Kaibuchi, K.
  • Journal Title: Journal of neurochemistry 93 Pages: 1371-82
  • Peer Reviewed
• [Journal Article] Key regulators in neuronal polarity. (2005)
  • Author(s): Arimura. N
  • Journal Title: Neuron 48・6 Pages: 881-884
• [Journal Article] Phosphorylation by Rho kinase regulates CRMP-2 activity in growth cones. (2005)
  • Author(s): Arimura. N
  • Journal Title: Mol Cell Biol. 25・22 Pages: 9973-9984
• [Journal Article] CRMP-2 is involved in kinesin-1-dependent transport of the Sra-1/WAVE1 complex and axon formation. (2005)
  • Author(s): Kawano. Y
  • Journal Title: Mol Cell Biol. 25・22 Pages: 9920-9935
• [Journal Article] Regulatory machinery of UNC-33 Ce-CRMP localization in neurites during neuronal development in Caenorhabditis elegans. (2005)
  • Author(s): Tsuboi. D
  • Journal Title: J Neurochem. 95・6 Pages: 1629-1641
• [Presentation] Role of Par and Tiaml complex in polarized cell migration (2009)
  • Author(s): Kozo Kaibuchi
  • Organizer: RAMIC, National Network on Cell Adhesion and Migration
  • Place of Presentation: Madrid, Spain
  • Year and Date: 2009-10-23
• [Presentation] Inositol 1, 4, 5-trisphosphate induced Ca2+ release is involved in neurite outgrowth and neuronal polarization (2009)
  • Author(s): 中牟田信一, 船橋靖広, 上口裕之, 貝淵弘三
  • Organizer: 第32回日本神経科学会大会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-09-18
• [Presentation] Neuronal polarity: From extracellular signals to intracellular mechanisms (2009)
  • Author(s): 貝淵弘三
  • Organizer: 第32回日本神経科学会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-09-18
• [Presentation] Neuronal polarity : From extracellular signals to intracellular mechanisms (2009)
  • Author(s): 貝淵弘三
  • Organizer: 第32回日本神経科学会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-09-18
• [Presentation] DISC1 serves a cargo receptor delivering signaling molecules and mRNAs (2009)
  • Author(s): Kozo Kaibuchi
  • Organizer: From Gene Discovery to Cell Biology in Psychiatry
  • Place of Presentation: California, USA
  • Year and Date: 2009-09-15
• [Presentation] Roles of Rho family GTPases and Par proteins in directional migration (2009)
  • Author(s): Kozo Kaibuchi
  • Organizer: Gordon Research Conferences
  • Place of Presentation: Oxford, UK
  • Year and Date: 2009-08-24
• [Presentation] Role of Rho and Rho-kinase in vascular smooth muscle contraction (2009)
  • Author(s): Kozo Kaibuchi
  • Organizer: Satellite Symposium of the IUPS 2009、ISSM2009
  • Place of Presentation: 名古屋
  • Year and Date: 2009-07-24
• [Presentation] Axon formation and polarized transport (2009)
  • Author(s): 貝淵弘三
  • Organizer: 第52回日本神経化学会大会
  • Place of Presentation: 伊香保
  • Year and Date: 2009-06-22
• [Presentation] Identification of PI 3-kinase as an Slp1-interacting protein in neuron、神経細胞におけるSlp1相互作用タンパク質の同定 (2009)
  • Author(s): 船橋靖広, 有村奈利子, 中牟田信一, 貝淵弘三
  • Organizer: 第61回日本細胞生物学会大会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-06-03
• [Presentation] The role of inositol 1, 4, 5-trisphosphate receptor-induced Ca2+ release in neuronal polarization and neurite outgrowth (2009)
  • Author(s): 中牟田信一, 船橋靖広, 有村奈利子, 上口裕之, 貝淵弘三
  • Organizer: 第61回日本細胞生物学会大会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-06-03
• [Presentation] Axon formation and polarized vesicle transport (2009)
  • Author(s): Kaibuchi, K.
  • Organizer: ESF-EMBO Symposium CELL POLARITY AND MEMBRANE TRAFFIC
  • Place of Presentation: Spain
  • Year and Date: 2009-05-23
• [Presentation] Axon formation and polarized vesicle transport (2009)
  • Author(s): Kozo Kaibuchi
  • Organizer: ESF-EMBO Symposium CELL POLARITY AND MEMBRANE TRAFFIC
  • Place of Presentation: Sant Feliu de Guixols, Spain
  • Year and Date: 2009-05-23
• [Presentation] Axon formation and polarized vesicle transport (2008)
  • Author(s): Kaibuchi, K.
  • Organizer: 日本分子生物学会年会日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-11
• [Presentation] Identification of Slp1-interacting-proteins in neuron BMB2008 (2008)
  • Author(s): 船橋靖広, 有村奈利子, 吉村武, 中牟田信一, 貝淵弘三
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-10
• [Presentation] Axon formation and axonal transport (2008)
  • Author(s): Kaibuchi, K.
  • Organizer: 日本神経化学会シンポジウム
  • Place of Presentation: 富山
  • Year and Date: 2008-09-11
• [Presentation] Neuronal polarity and small (2008)
  • Author(s): Kaibuchi, K.
  • Organizer: GTPases FASEB summer research conferences
  • Place of Presentation: Vermont, USA
  • Year and Date: 2008-07-16
• [Presentation] Neuronal polarity and axonal transport (2008)
  • Author(s): Kaibuchi, K.
  • Organizer: 日本神経科学会
  • Place of Presentation: 東京
  • Year and Date: 2008-07-08
• [Presentation] Neuronal polarity and axonal transport (2008)
  • Author(s): Kaibuchi, K.
  • Organizer: Gordon research conference
  • Place of Presentation: Hong Kong, China
  • Year and Date: 2008-06-11
• [Presentation] Neuronal development and cargo transport (2008)
  • Author(s): Kozo Kaibuchi
  • Organizer: Gordon Research Conference on Molecular & Cellular Neurobiology
  • Place of Presentation: Hong Kong, China
• [Presentation] Rho Proteins and Neuronal Polarity (2008)
  • Author(s): Kozo Kaibuchi
  • Organizer: FASEB Summer Research Conferences
  • Place of Presentation: Vermont, USA
• [Presentation] 細胞遊走におけるRhoファミリーとPar複合体の役割 (2008)
  • Author(s): 貝淵弘三
  • Organizer: 第60回日本細胞生物学会大会
  • Place of Presentation: 横浜
• [Presentation] Rab27とSlp1によるTrkBの順行性輸送の制御 (2008)
  • Author(s): 有村奈利子
  • Organizer: 第60回日本細胞生物学会大会
  • Place of Presentation: 横浜
• [Presentation] Axon formation and polarized vesicle trnasport (2008)
  • Author(s): 貝淵弘三
  • Organizer: BMB 2008
  • Place of Presentation: 神戸
• [Presentation] Neuronal Polarity and Axonal Vesicle Transport (2008)
  • Author(s): 貝淵 弘三
  • Organizer: CDB symposium 2008
  • Place of Presentation: 神戸
• [Presentation] Identification of YWHAE as a novel susceptibility gene for schizophrenia (2008)
  • Author(s): 浦口(朝来)淳子
  • Organizer: 第81回日本薬理学会年会
  • Place of Presentation: 横浜
• [Presentation] Involvement of DISC1 in the dendritic localization of neuronal mRNA in rathippocampal neuron (2008)
  • Author(s): 小林香織
  • Organizer: 第81回日本薬理学会年会
  • Place of Presentation: 横浜
• [Presentation] Proteomic analysis of DISC1-interacting proteins (2008)
  • Author(s): 村岡真輔
  • Organizer: 第81回日本薬理学会年会
  • Place of Presentation: 横浜
• [Presentation] Rho-kinaseによるp190RhoGAPのリン酸化 (2008)
  • Author(s): 森和孝
  • Organizer: 第81回日本薬理学会年会
  • Place of Presentation: 横浜
• [Presentation] Phosphorylation of CLASP2gamma by GSK-3beta regulates the interaction with IQGAP1 and EB1 (2008)
  • Author(s): Watanabe, T.
  • Organizer: KEYSTONE SYMPOSIUM: Cell Migration in Invasion and Inflammation
  • Place of Presentation: Taos, USA
• [Presentation] Identification of ULK1 as a novel CRMP-2 phosphorylation kinase (2007)
  • Author(s): 島田明子, 有村奈利子, 貝淵弘三
  • Organizer: BMB2007、第30回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-11
• [Presentation] CRMP-2 and GSK-3beta regulate anterograde TrkB transport through Slp1 (2007)
  • Author(s): Arimura N.,, Kaibuchi, K.
  • Organizer: ASCB 47th Annual meeting
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2007-12-01
• [Presentation] Neuronal polarity and axonal vesicle transport (2007)
  • Author(s): 貝淵 弘三
  • Organizer: 第2回日韓神経科学シンポジウム"神経科学の最先端"
  • Place of Presentation: 横浜
  • Year and Date: 2007-09-13
• [Presentation] CRMP-2, Slp1 and Rab27B mediate anterograde transport of TrkB (2007)
  • Author(s): 有村奈利子, 島田明子, 貝淵弘三
  • Organizer: Neuro2007
  • Place of Presentation: 横浜
  • Year and Date: 2007-09-10
• [Presentation] Rho-kinaseおよびGSK-3beta阻害剤による軸索伸長制御のメカニズム (2007)
  • Author(s): 有村奈利子, 吉村武, 貝淵弘三
  • Organizer: 第18回日本末梢神経学会
  • Place of Presentation: 弘前
  • Year and Date: 2007-08-24
• [Presentation] 統合失調症脆弱性因子DISC1によるNUDEL複合体、Grb2の軸索への輸送制御 (2007)
  • Author(s): 匹田 貴夫
  • Organizer: 第111回日本薬理学会近畿部会
  • Place of Presentation: 名古屋
  • Year and Date: 2007-06-15
• [Presentation] Numb controls integrin endocytosis for directional cell migration with aPKC and Par3 (2007)
  • Author(s): 貝淵弘三
  • Organizer: BMB2007 第30回日本分子生物学会年会
  • Place of Presentation: 横浜
• [Presentation] 統合失調症の発症脆弱性因子のプロテオミクス解析 (2007)
  • Author(s): 田谷真一郎
  • Organizer: 統合失調症の発症脆弱性因子のプロテオミクス解析.第5回日本ヒトプロテオーム機構大会
  • Place of Presentation: 東京
• [Presentation] DISC1 regulates neurotrophin-induced axon elongation via interaction with Grb2 (2007)
  • Author(s): 篠田友靖
  • Organizer: BMB2007 第30回日本分子生物学会年会
  • Place of Presentation: 横浜
• [Presentation] CRMP-2, Slp1 and Rab27B mediate anterograde transport of TrkB (2007)
  • Author(s): 有村奈利子
  • Organizer: Neuro 2007
  • Place of Presentation: 横浜
• [Presentation] Regulation of DISC1 phosphorylation by ERK (2007)
  • Author(s): 田谷真一郎
  • Organizer: Neuro2007
  • Place of Presentation: 横浜
• [Presentation] 新規統合失調症脆弱性因子としての14-3-3epsionの同定 (2007)
  • Author(s): 匹田貴夫
  • Organizer: Neuro2007
  • Place of Presentation: 横浜
• [Presentation] Identification of ULK1 as a novel CRMP-2 phosphorylation kinase (2007)
  • Author(s): 島田明子
  • Organizer: BMB2007 第30回日本分子生物学会年会
  • Place of Presentation: 横浜
• [Presentation] Role of Numb in Dendritic Spine Development with a Cdc42 GEF Intersectin (2007)
  • Author(s): Kaibuchi, K.
  • Organizer: Workshop on the Biology of Chromosome 21 Genes
  • Place of Presentation: Detroit, USA.
• [Presentation] Phosphorylation of DISC1 regulates the interaction with Kinesin-1 (2007)
  • Author(s): Kuroda, K.
  • Organizer: The 37th annual meeting of the Society for Neuroscience
  • Place of Presentation: San Diego, USA
• [Presentation] Identification of YWHEA, a gene encoding 14-3-3epsilon, as a novelsusceptibility gene for schizophrenia (2007)
  • Author(s): Hikita, T.
  • Organizer: The 37th annual meeting of the Society for Neuroscience
  • Place of Presentation: San Diego, USA
• [Presentation] ERK phosphorylates and regulates Disrupted-In-Schizophrenia 1 (DISC1) (2007)
  • Author(s): Taya, S.
  • Organizer: ASCB 47th Annual meeting
  • Place of Presentation: Washington DC, USA
• [Presentation] DISC1 regulates the transport of the NUDEL/LIS1/14-3-3epsilon complex and Grb2 through kinesin-1 (2007)
  • Author(s): Hikita, T
  • Organizer: Cell Polarity 2007
  • Place of Presentation: Kanagawa, Japan
• [Presentation] CRMP-2 and Slp1 mediate anterograde transport of TrkB through Kinesin-1 (2006)
  • Author(s): Arimura N.,, Kaibuchi, K.
  • Organizer: 46th annual meeting of American Society of Cell Biology
  • Place of Presentation: San Diego. USA
  • Year and Date: 2006-12-09
• [Presentation] Ubiquitination of collapsin response mediator protein-2 participates in neuronal polarization (2006)
  • Author(s): 李隼庸, 有村奈利子, 貝淵弘三
  • Organizer: 日本分子生物学会2006フォーラム
  • Place of Presentation: 名古屋
  • Year and Date: 2006-12-06
• [Presentation] The role of CRMP-2 as a novel cytoplasmic dynein interacting molecule (2006)
  • Author(s): 朋部敦志, 有村奈利子, 貝淵弘三
  • Organizer: 日本分子生物学会2006フォーラム
  • Place of Presentation: 名古屋
  • Year and Date: 2006-12-06
• [Presentation] Dynamics of signaling molecules during axon specification (2006)
  • Author(s): Yoshimura, T.,, Kaibuchi, K.
  • Organizer: 36th Annual Meeting of the Society for Neuroscience
  • Place of Presentation: Atlanta. USA
  • Year and Date: 2006-11-14
• [Presentation] Cytoskeletal Dynamics and Signal Transduction in Neuronal Polarity (2006)
  • Author(s): Kaibuchi, K.
  • Organizer: 36th Annual Meeting of the Society for Neuroscience
  • Place of Presentation: Atlanta
  • Year and Date: 2006-10-14
• [Presentation] Signaling for neuronal polarization (2006)
  • Author(s): Kaibuchi, K.
  • Organizer: 36th Annual Meeting of the Society for Neuroscience
  • Place of Presentation: Atlanta. USA
  • Year and Date: 2006-10-14
• [Presentation] Role of Slp, a novel CRMP-2 interacting molecule, in hippocampal neurons (2006)
  • Author(s): 吉村武, 有村奈利子, 貝淵弘三
  • Organizer: 第49回日本神経化学会大会
  • Place of Presentation: 名古屋
  • Year and Date: 2006-09-14
• [Presentation] Signaling for neuronal polarization (2006)
  • Author(s): 貝淵弘三
  • Organizer: Neuroscience 2006
  • Place of Presentation: 名古屋
  • Year and Date: 2006-07-19
• [Presentation] 新規Collapsin response mediator protein-2結合蛋白質synaptotagmin-like proteinの海馬神経細胞における機能解析 (2006)
  • Author(s): 有村奈利子, 川端紗枝子, 朋部敦志, 貝淵弘三
  • Organizer: 第29回日本神経科学大会
  • Place of Presentation: 京都
  • Year and Date: 2006-06-19
• [Presentation] Key regulators in neuronal polarization (2006)
  • Author(s): Kaibuchi, K.,, Arimura N.
  • Organizer: 20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress
  • Place of Presentation: Kyoto
  • Year and Date: 2006-06-18
• [Presentation] Ras Regulates Neuronal Polarity via PI3-kinase/Akt/GSK-3β/CRMP-2 pathway (2005)
  • Author(s): Kaibuchi, K.
  • Organizer: The American Society For Cell Biology 45th Annual Meeting
  • Place of Presentation: San Francisco. USA
  • Year and Date: 2005-12-10
• [Presentation] Neuronal polarity and cytoskeleton (2005)
  • Author(s): Yoshimura, T.,, Kaibuchi, K.
  • Organizer: The American Society For Cell Biology 45th Annual Meeting
  • Place of Presentation: San Francisco. USA
  • Year and Date: 2005-12-10
• [Presentation] 細胞の極性形成と遊走を制御する分子機構の解明 (2005)
  • Author(s): 貝淵弘三
  • Organizer: 第28回日本分子生物学会年会
  • Place of Presentation: 福岡
  • Year and Date: 2005-12-07
• [Presentation] 伝達分子と軸索伸長制御の分子メカニズムシグナル (2005)
  • Author(s): 貝淵弘三
  • Organizer: 伝達分子と軸索伸長制御の分子メカニズムシグナル
  • Place of Presentation: 岡崎
  • Year and Date: 2005-11-24
• [Presentation] Microtubule dynamics and cell polarity (2005)
  • Author(s): Kaibuchi, K.
  • Organizer: 9th International Dahlem Symposium on Cellular Signal Recognition and Transduction
  • Place of Presentation: Berlin
  • Year and Date: 2005-10-13
• [Presentation] Neuronal polarity and axon formation (2005)
  • Author(s): 貝淵弘三
  • Organizer: 第48回日本神経化学会年会
  • Place of Presentation: 福岡
  • Year and Date: 2005-09-28
• [Presentation] IQGAP3, a novel effector of Rac1 and Cdc42, regulates neurite outgrowth through actin cytoskeleton reorganization (2005)
  • Author(s): 王淑杰, 渡辺崇, 則武淳, 佐藤和正, 吉村武, 深田正紀, 貝淵弘三
  • Organizer: 第48回日本神経化学会大会
  • Place of Presentation: 福岡
  • Year and Date: 2005-09-28
• [Presentation] Ras regulates neuronal polarity via the PI3-kinase/Akt/GSK-3β/CRMP-2 pathway (2005)
  • Author(s): 吉村武, 貝淵弘三
  • Organizer: 第48回日本神経化学会大会
  • Place of Presentation: 福岡
  • Year and Date: 2005-09-28
• [Presentation] Role of CRMP-2 in the establishment of neuronal polarity (2005)
  • Author(s): Kaibuchi, K.
  • Organizer: 20th Biennial Meeting of the ISN
  • Place of Presentation: Innsbruck
  • Year and Date: 2005-08-21
• [Presentation] 神経細胞の極性形成におけるPar複合体の役割 (2005)
  • Author(s): 西村隆史, 貝淵弘三
  • Organizer: 第28回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2005-07-26
• [Presentation] 神経細胞の極性形成機構 (2005)
  • Author(s): 貝淵弘三
  • Organizer: 日本分子生物学会第5回春期シンポジウム
  • Place of Presentation: 新潟
  • Year and Date: 2005-05-15
• [Presentation] Signaling for Neuronal Polarity (2005)
  • Author(s): Kaibuchi, K.
  • Organizer: Keystone Symposia on Cell Migration and Adhesion
  • Place of Presentation: Snowbird, Utah
  • Year and Date: 2005-04-09
• [Remarks]
  • URL: http://www.med.nagoya-u.ac.jp/Yakuri/
• [Remarks] 名古屋大学大学院医学系研究科 神経情報薬理学講座ホームページ
  • URL: http://www.med.nagoya-u.ac.jp/Yakuri/
• [Remarks]
  • URL: http://www.med.nagoya-u.ac.jp/Yakuri/