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Molecular mechanism underlying neuronal polarity

Research Project

Project/Area Number 17024024
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionNagoya University

Principal Investigator

KAIBUCHI Kozo  Nagoya University, 大学院・医学系研究科, 教授 (00169377)

Co-Investigator(Kenkyū-buntansha) NARIKO Arimura  玉川大学, 脳科学研究所, グローバルCOE准教授 (20420375)
DAISUKE Mori  名古屋大学, 大学院・医学系研究科, COE特任講師 (00381997)
TOMOKI Nishioka  名古屋大学, 大学院・医学系研究科, 助教 (70435105)
Project Period (FY) 2005 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥19,100,000 (Direct Cost: ¥19,100,000)
Fiscal Year 2009: ¥4,100,000 (Direct Cost: ¥4,100,000)
Fiscal Year 2008: ¥3,900,000 (Direct Cost: ¥3,900,000)
Fiscal Year 2007: ¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2006: ¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 2005: ¥3,900,000 (Direct Cost: ¥3,900,000)
Keywords極性 / 軸索 / シグナル伝達 / CRMP-2 / 小胞体 / 細胞外因子 / 神経細胞 / 極性形成 / 細胞内輸送 / Par / カルシウム / 脳・神経 / 神経極性 / 軸索形成 / キネシン-1 / Sra-1 / WAVE1 / リン酸化
Research Abstract

Our project aimed at examining the molecular mechanisms underlying establishment and maintenance of neuronal polarity. We found that GSK-3β regulates neuronal polarity through the phosphorylation of CRMP-2. CRMP-2 complex directly links Kinesin-1 motor, and this association is required for the anterograde transport of signaling molecules and polarity related proteins-containing vesicles.

Report

(6 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (126 results)

All 2010 2009 2008 2007 2006 2005 Other

All Journal Article (54 results) (of which Peer Reviewed: 40 results) Presentation (69 results) Remarks (3 results)

  • [Journal Article] The PHCCEx domain of Tiam1/2 is a novel protein- and membrane-binding module.2010

    • Author(s)
      Terawaki S, et al.
    • Journal Title

      The EMBO journal 29

      Pages: 236-250

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CRMP-2 directly binds to cytoplasmic dynein and interferes with its activity2009

    • Author(s)
      Arimura, N., Hattori, A., Kimura, T., Nakamuta, S., Funahashi, Y., Hirotsune, S., Furuta, K., Urano, T., Toyoshima, YY.,, Kaibuchi, K.
    • Journal Title

      Journal of neurochemistry 111

      Pages: 380-90

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Anterograde transport of TrkB in axons is mediated by direct interaction with Slp1 and Rab272009

    • Author(s)
      Arimura, N., Kimura, T., Nakamuta, S., Taya, S., Funahashi, Y., Hattori, A., Shimada, A., Mnager, C., Kawabata, S., Fujii, K., Iwamatsu, A., Segal, RA., Fukuda, M.,, Kaibuchi, K.
    • Journal Title

      Developmental cell 16

      Pages: 675-86

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Unc5B associates with LARG to mediate the action of repulsive guidance molecule.2009

    • Author(s)
      Hata K, et al.
    • Journal Title

      The Journal of cell biology 184

      Pages: 737-750

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Direct interaction of Dysbindin with the AP-3 complex via its mu subunit.2009

    • Author(s)
      Taneichi-Kuroda S, et al.
    • Journal Title

      Neurochemistry international 54

      Pages: 431-438

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anterograde transport of TrkB in axons is mediated by direct interaction with Slp1 and Rab27.2009

    • Author(s)
      Arimura N, et al.
    • Journal Title

      Developmental cell 16

      Pages: 675-686

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association analysis between schizophrenia and the AP-3 complex genes.2009

    • Author(s)
      Hashimoto R, et al.
    • Journal Title

      Neuroscience research 65

      Pages: 113-115

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TDP-43 depletion induces neuronal cell damage through dysregulation of Rho family GTPases.2009

    • Author(s)
      Iguchi Y, et al.
    • Journal Title

      The Journal of biological chemistry 284

      Pages: 22059-22066

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Proteomic analysis reveals novel binding partners of dysbindin, a schizophrenia-related prntein.2009

    • Author(s)
      Hikita T, et al.
    • Journal Title

      Journal of neurochemistry 110

      Pages: 1567-1574

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phosphorylation of CLASP2 by GSK-3beta regulates its interaction with IQGAP1, EB1 and microtubules.2009

    • Author(s)
      Watanabe T, et al.
    • Journal Title

      Journal of cell science 122

      Pages: 2969-2979

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CRMP-2 directly binds to cytoplasmic dynein and interferes with its activity.2009

    • Author(s)
      Arimura N, et al.
    • Journal Title

      Journal of neurochemistry 111

      Pages: 380-390

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CaMKII phosphorylates collapsin response mediator protein 2 and modulates axonal damage during glutamate excitotoxicity.2009

    • Author(s)
      Hou ST, et al.
    • Journal Title

      Journal of neurochemistry 111

      Pages: 870-881

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Roles of disrupted-in-schizophrenia 1-interacting protein girdin in postnatal development of the dentate gyrus.2009

    • Author(s)
      Enomoto A, et al.
    • Journal Title

      Neuron 63

      Pages: 774-787

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anterograde transport of TrkB in axons is mediated by direct interaction with Slpl and Rab 272009

    • Author(s)
      Arimura, N, et.al.
    • Journal Title

      Dev Cell (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rho-kinase contributes to sustained RhoA activation through phosphorylation of p190A RhoGAP2009

    • Author(s)
      Mori, K, et.al.
    • Journal Title

      J Biol Chem 284

      Pages: 5067-5076

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ultrastructural study of Racl and its effectors beneath the substratum-facing membrane2008

    • Author(s)
      Watanabe, T, et.al.
    • Journal Title

      Cell Struct Funct 33

      Pages: 101-107

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of YWHAE, a gene encoding 14-3-3epsilon, as a possible susceptibility gene for schizophrenia2008

    • Author(s)
      Ikeda, M, et.al.
    • Journal Title

      Hum Mol Genet 17

      Pages: 3212-3222

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rho-kinase phosphorylates Par-3 and disrupts Par complex Formation.2008

    • Author(s)
      Nakayama. M
    • Journal Title

      Dev. Cell 14・2

      Pages: 205-215

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] NF1 tumor suppressor, neurofibromin, regulates the neuronal differentiation of PC12 cells via its associating protein, collapal differentiation of PC12 cells via its associating protsin response mediator protein-2.2008

    • Author(s)
      Patrakitkomjorn. S
    • Journal Title

      J. Cell Biol (In press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phosphorylation of claudin-5 and occludin by rho kinase in brain endothelial cells.2008

    • Author(s)
      Yamamoto. M
    • Journal Title

      Am. J. Pathol 172

      Pages: 521-533

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neuronal polarity: from extracellular signals to intracellular mechanisms2007

    • Author(s)
      Arimura, N.,, Kaibuchi, K.
    • Journal Title

      Nature reviews. Neuroscience 8

      Pages: 194-205

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] IQGAP3, a novel effector of Rac1 and Cdc42, regulates neurite outgrowth2007

    • Author(s)
      Wang, S., Watanabe, T., Noritake, J., Fukata, M., Yoshimura, T., Itoh, N., Harada, T., Nakagawa, M., Matsuura, Y., Arimura, N.,, Kaibuchi, K.
    • Journal Title

      Journal of cell science 120

      Pages: 567-77

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Numb controls integrin endocytosis for directional cell migration with aPKC and PAR-3.2007

    • Author(s)
      Nishimura. T
    • Journal Title

      Dev. Cell 13・2

      Pages: 15-28

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structural basis for tubulin recognition by cytoplasmic linker protein 170 and its autoinhibition.2007

    • Author(s)
      Mishima. M
    • Journal Title

      Proc. Natl. Acad. Sci. U S A 104・25

      Pages: 10346-10351

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dial and IQGAP1 interact in cell migration and phagocytic cup formation.2007

    • Author(s)
      Brandt. D.T
    • Journal Title

      J. Cell Biol 178

      Pages: 193-200

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Two LIM domain proteins and UNC-96 link UNC-97/pinch to myosin thick filaments in Caenorhabditis elegans muscle.2007

    • Author(s)
      Qadota. H
    • Journal Title

      Mol. Biol. Cell 18

      Pages: 4317-4326

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rho-kinase modulates the function of STEE, a Rac GEF, through its phosphorylation.2007

    • Author(s)
      Takefuji. M
    • Journal Title

      Biochem. Biophys. Res. Commu 355

      Pages: 788-794

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rho-kinase activation in endothelial cells contributes to expansion of infarction after focal cerebral ischemia.2007

    • Author(s)
      Yagita. Y
    • Journal Title

      J. Neurosci. Res 85

      Pages: 2460-2469

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A mass conserved reaction-diffusion system captures properties of cell polarity.2007

    • Author(s)
      Otsuji. M
    • Journal Title

      PLoS. Comput. Biol 3

      Pages: 108-108

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evidence that many of the DISC1 isoforms in C57BL/6J mice are also expressed in 129S6/SvEv mice.2007

    • Author(s)
      Ishizuka. K
    • Journal Title

      Mol. Psychiatry 12

      Pages: 897-899

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Establishment of a tissue-specific RNAi system in C. elegans.2007

    • Author(s)
      Qadota. H
    • Journal Title

      Gene 400

      Pages: 166-173

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rho-kinase phosphorylates eNOS at threonine 495 in endothelial cells.2007

    • Author(s)
      Sugimoto. M
    • Journal Title

      Biochem. Biophys. Res. Commun 361

      Pages: 462-467

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neuronal polarity : from extracellular signals to intracellular mechanisms.2007

    • Author(s)
      Arimura. N
    • Journal Title

      Nature Rev Neurosci 8・3

      Pages: 194-205

    • Related Report
      2006 Annual Research Report
  • [Journal Article] IQGAP3, a novel effector of Racl and Cdc42, regulates neurite outgrowth.2007

    • Author(s)
      Wang. S
    • Journal Title

      J Cell Sci 120

      Pages: 567-577

    • Related Report
      2006 Annual Research Report
  • [Journal Article] DISCI regulates the transport of the NUDEL/LISI/14-3-3epsilon complex through kinesin-1.2007

    • Author(s)
      Taya. S
    • Journal Title

      J Neurosci 27・1

      Pages: 15-26

    • Related Report
      2006 Annual Research Report
  • [Journal Article] DISCI regulates neurotrophin-induced axon elongation via interaction with Grb2.2007

    • Author(s)
      Shinoda. T
    • Journal Title

      J Neurosci 27・1

      Pages: 4-14

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Molecular mechanisms of axon specification and neuronal disorders2006

    • Author(s)
      Yoshimura, T., Arimura, N.,, Kaibuchi, K.
    • Journal Title

      Annals of the New York Academy of Sciences 1086

      Pages: 116-25

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Signaling networks in neuronal polarization2006

    • Author(s)
      Yoshimura, T., Arimura, N.,, Kaibuchi, K.
    • Journal Title

      The Journal of neuroscience: the official journal of the Society for Neuroscience 26

      Pages: 10626-30

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ras regulates neuronal polarity via the PI3-kinase/Akt/GSK-3beta/CRMP-2 pathway2006

    • Author(s)
      Yoshimura, T., Arimura, N., Kawano, Y., Kawabata, S., Wang, S.,, Kaibuchi, K.
    • Journal Title

      Biochemical and biophysical research communications 340

      Pages: 62-8

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular mechanisms of axon specification and neuronal disorders.2006

    • Author(s)
      Yoshimura. T
    • Journal Title

      Ann N Y Acad Sci 1086

      Pages: 116-125

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Essential roles for GSK-3s and GSK-3-primed substrates in neurotrophin-induced and hippocampal axon growth.2006

    • Author(s)
      Kim. WY
    • Journal Title

      Neuron 52・6

      Pages: 981-996

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Signaling networks in neuronal polarization.2006

    • Author(s)
      Yoshimura. T
    • Journal Title

      J Neurosci 26・42

      Pages: 10626-10630

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Sema4D/plexin-B1 activates GSK-3beta through R-Ras GAP activity, inducing growth cone collapse.2006

    • Author(s)
      Ito. Y
    • Journal Title

      EMBO Rep 7・7

      Pages: 704-709

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Role of Numb in Dendritic Spine Development with a Cdc42 GEF Intersectin and EphB2.2006

    • Author(s)
      Nishimura. T
    • Journal Title

      Mol Biol Cell (In press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Ras regulates neuronal polarity via the PI3-kinase/Akt/GSK-3beta/CRMP-2 pathway.2006

    • Author(s)
      Yoshimura. T
    • Journal Title

      Biochem Biophys Res Commun. 340・1

      Pages: 62-68

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Key regulators in neuronal polarity2005

    • Author(s)
      Arimura, N.,, Kaibuchi, K.
    • Journal Title

      Neuron 48

      Pages: 881-4

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Phosphorylation by Rho kinase regulates CRMP-2 activity in growth cones2005

    • Author(s)
      Arimura, N., Mnager, C., Kawano, Y., Yoshimura, T., Kawabata, S., Hattori, A., Fukata, Y., Amano, M., Goshima, Y., Inagaki, M., Morone, N., Usukura, J., Kaibuchi, K.
    • Journal Title

      Molecular and cellular biology 25

      Pages: 9973-84

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] CRMP-2 is involved in kinesin-1-dependent transport of the Sra-1/WAVE1 complex and axon formation2005

    • Author(s)
      Kawano, Y., Yoshimura, T., Tsuboi, D., Kawabata, S., Kaneko-Kawano, T., Shirataki, H., Takenawa, T.,, Kaibuchi, K.
    • Journal Title

      Molecular and cellular biology 25

      Pages: 9920-35

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regulatory machinery of UNC-33 Ce-CRMP localization in neurites during neuronal development in Caenorhabditis elegans2005

    • Author(s)
      Tsuboi, D., Hikita, T., Qadota, H., Amano, M.,, Kaibuchi, K.
    • Journal Title

      Journal of neurochemistry 95

      Pages: 1629-41

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Tubulin and CRMP-2 complex is transported via Kinesin-12005

    • Author(s)
      Kimura, T., Arimura, N., Watanabe, H., Iwamatsu, A.,, Kaibuchi, K.
    • Journal Title

      Journal of neurochemistry 93

      Pages: 1371-82

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Key regulators in neuronal polarity.2005

    • Author(s)
      Arimura. N
    • Journal Title

      Neuron 48・6

      Pages: 881-884

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Phosphorylation by Rho kinase regulates CRMP-2 activity in growth cones.2005

    • Author(s)
      Arimura. N
    • Journal Title

      Mol Cell Biol. 25・22

      Pages: 9973-9984

    • Related Report
      2005 Annual Research Report
  • [Journal Article] CRMP-2 is involved in kinesin-1-dependent transport of the Sra-1/WAVE1 complex and axon formation.2005

    • Author(s)
      Kawano. Y
    • Journal Title

      Mol Cell Biol. 25・22

      Pages: 9920-9935

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Regulatory machinery of UNC-33 Ce-CRMP localization in neurites during neuronal development in Caenorhabditis elegans.2005

    • Author(s)
      Tsuboi. D
    • Journal Title

      J Neurochem. 95・6

      Pages: 1629-1641

    • Related Report
      2005 Annual Research Report
  • [Presentation] Role of Par and Tiaml complex in polarized cell migration2009

    • Author(s)
      Kozo Kaibuchi
    • Organizer
      RAMIC, National Network on Cell Adhesion and Migration
    • Place of Presentation
      Madrid, Spain
    • Year and Date
      2009-10-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] Inositol 1, 4, 5-trisphosphate induced Ca2+ release is involved in neurite outgrowth and neuronal polarization2009

    • Author(s)
      中牟田信一, 船橋靖広, 上口裕之, 貝淵弘三
    • Organizer
      第32回日本神経科学会大会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-09-18
    • Related Report
      2009 Final Research Report
  • [Presentation] Neuronal polarity: From extracellular signals to intracellular mechanisms2009

    • Author(s)
      貝淵弘三
    • Organizer
      第32回日本神経科学会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-09-18
    • Related Report
      2009 Final Research Report
  • [Presentation] Neuronal polarity : From extracellular signals to intracellular mechanisms2009

    • Author(s)
      貝淵弘三
    • Organizer
      第32回日本神経科学会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-09-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] DISC1 serves a cargo receptor delivering signaling molecules and mRNAs2009

    • Author(s)
      Kozo Kaibuchi
    • Organizer
      From Gene Discovery to Cell Biology in Psychiatry
    • Place of Presentation
      California, USA
    • Year and Date
      2009-09-15
    • Related Report
      2009 Annual Research Report
  • [Presentation] Roles of Rho family GTPases and Par proteins in directional migration2009

    • Author(s)
      Kozo Kaibuchi
    • Organizer
      Gordon Research Conferences
    • Place of Presentation
      Oxford, UK
    • Year and Date
      2009-08-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] Role of Rho and Rho-kinase in vascular smooth muscle contraction2009

    • Author(s)
      Kozo Kaibuchi
    • Organizer
      Satellite Symposium of the IUPS 2009、ISSM2009
    • Place of Presentation
      名古屋
    • Year and Date
      2009-07-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] Axon formation and polarized transport2009

    • Author(s)
      貝淵弘三
    • Organizer
      第52回日本神経化学会大会
    • Place of Presentation
      伊香保
    • Year and Date
      2009-06-22
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] Identification of PI 3-kinase as an Slp1-interacting protein in neuron、神経細胞におけるSlp1相互作用タンパク質の同定2009

    • Author(s)
      船橋靖広, 有村奈利子, 中牟田信一, 貝淵弘三
    • Organizer
      第61回日本細胞生物学会大会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-06-03
    • Related Report
      2009 Final Research Report
  • [Presentation] The role of inositol 1, 4, 5-trisphosphate receptor-induced Ca2+ release in neuronal polarization and neurite outgrowth2009

    • Author(s)
      中牟田信一, 船橋靖広, 有村奈利子, 上口裕之, 貝淵弘三
    • Organizer
      第61回日本細胞生物学会大会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-06-03
    • Related Report
      2009 Final Research Report
  • [Presentation] Axon formation and polarized vesicle transport2009

    • Author(s)
      Kaibuchi, K.
    • Organizer
      ESF-EMBO Symposium CELL POLARITY AND MEMBRANE TRAFFIC
    • Place of Presentation
      Spain
    • Year and Date
      2009-05-23
    • Related Report
      2009 Final Research Report
  • [Presentation] Axon formation and polarized vesicle transport2009

    • Author(s)
      Kozo Kaibuchi
    • Organizer
      ESF-EMBO Symposium CELL POLARITY AND MEMBRANE TRAFFIC
    • Place of Presentation
      Sant Feliu de Guixols, Spain
    • Year and Date
      2009-05-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] Axon formation and polarized vesicle transport2008

    • Author(s)
      Kaibuchi, K.
    • Organizer
      日本分子生物学会年会日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-11
    • Related Report
      2009 Final Research Report
  • [Presentation] Identification of Slp1-interacting-proteins in neuron BMB20082008

    • Author(s)
      船橋靖広, 有村奈利子, 吉村武, 中牟田信一, 貝淵弘三
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-10
    • Related Report
      2009 Final Research Report
  • [Presentation] Axon formation and axonal transport2008

    • Author(s)
      Kaibuchi, K.
    • Organizer
      日本神経化学会シンポジウム
    • Place of Presentation
      富山
    • Year and Date
      2008-09-11
    • Related Report
      2009 Final Research Report
  • [Presentation] Neuronal polarity and small2008

    • Author(s)
      Kaibuchi, K.
    • Organizer
      GTPases FASEB summer research conferences
    • Place of Presentation
      Vermont, USA
    • Year and Date
      2008-07-16
    • Related Report
      2009 Final Research Report
  • [Presentation] Neuronal polarity and axonal transport2008

    • Author(s)
      Kaibuchi, K.
    • Organizer
      日本神経科学会
    • Place of Presentation
      東京
    • Year and Date
      2008-07-08
    • Related Report
      2009 Final Research Report
  • [Presentation] Neuronal polarity and axonal transport2008

    • Author(s)
      Kaibuchi, K.
    • Organizer
      Gordon research conference
    • Place of Presentation
      Hong Kong, China
    • Year and Date
      2008-06-11
    • Related Report
      2009 Final Research Report
  • [Presentation] Neuronal development and cargo transport2008

    • Author(s)
      Kozo Kaibuchi
    • Organizer
      Gordon Research Conference on Molecular & Cellular Neurobiology
    • Place of Presentation
      Hong Kong, China
    • Related Report
      2008 Annual Research Report
  • [Presentation] Rho Proteins and Neuronal Polarity2008

    • Author(s)
      Kozo Kaibuchi
    • Organizer
      FASEB Summer Research Conferences
    • Place of Presentation
      Vermont, USA
    • Related Report
      2008 Annual Research Report
  • [Presentation] 細胞遊走におけるRhoファミリーとPar複合体の役割2008

    • Author(s)
      貝淵弘三
    • Organizer
      第60回日本細胞生物学会大会
    • Place of Presentation
      横浜
    • Related Report
      2008 Annual Research Report
  • [Presentation] Rab27とSlp1によるTrkBの順行性輸送の制御2008

    • Author(s)
      有村奈利子
    • Organizer
      第60回日本細胞生物学会大会
    • Place of Presentation
      横浜
    • Related Report
      2008 Annual Research Report
  • [Presentation] Axon formation and polarized vesicle trnasport2008

    • Author(s)
      貝淵弘三
    • Organizer
      BMB 2008
    • Place of Presentation
      神戸
    • Related Report
      2008 Annual Research Report
  • [Presentation] Neuronal Polarity and Axonal Vesicle Transport2008

    • Author(s)
      貝淵 弘三
    • Organizer
      CDB symposium 2008
    • Place of Presentation
      神戸
    • Related Report
      2007 Annual Research Report
  • [Presentation] Identification of YWHAE as a novel susceptibility gene for schizophrenia2008

    • Author(s)
      浦口(朝来)淳子
    • Organizer
      第81回日本薬理学会年会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] Involvement of DISC1 in the dendritic localization of neuronal mRNA in rathippocampal neuron2008

    • Author(s)
      小林香織
    • Organizer
      第81回日本薬理学会年会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] Proteomic analysis of DISC1-interacting proteins2008

    • Author(s)
      村岡真輔
    • Organizer
      第81回日本薬理学会年会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] Rho-kinaseによるp190RhoGAPのリン酸化2008

    • Author(s)
      森和孝
    • Organizer
      第81回日本薬理学会年会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] Phosphorylation of CLASP2gamma by GSK-3beta regulates the interaction with IQGAP1 and EB12008

    • Author(s)
      Watanabe, T.
    • Organizer
      KEYSTONE SYMPOSIUM: Cell Migration in Invasion and Inflammation
    • Place of Presentation
      Taos, USA
    • Related Report
      2007 Annual Research Report
  • [Presentation] Identification of ULK1 as a novel CRMP-2 phosphorylation kinase2007

    • Author(s)
      島田明子, 有村奈利子, 貝淵弘三
    • Organizer
      BMB2007、第30回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-11
    • Related Report
      2009 Final Research Report
  • [Presentation] CRMP-2 and GSK-3beta regulate anterograde TrkB transport through Slp12007

    • Author(s)
      Arimura N.,, Kaibuchi, K.
    • Organizer
      ASCB 47th Annual meeting
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2007-12-01
    • Related Report
      2009 Final Research Report 2007 Annual Research Report
  • [Presentation] Neuronal polarity and axonal vesicle transport2007

    • Author(s)
      貝淵 弘三
    • Organizer
      第2回日韓神経科学シンポジウム"神経科学の最先端"
    • Place of Presentation
      横浜
    • Year and Date
      2007-09-13
    • Related Report
      2007 Annual Research Report
  • [Presentation] CRMP-2, Slp1 and Rab27B mediate anterograde transport of TrkB2007

    • Author(s)
      有村奈利子, 島田明子, 貝淵弘三
    • Organizer
      Neuro2007
    • Place of Presentation
      横浜
    • Year and Date
      2007-09-10
    • Related Report
      2009 Final Research Report
  • [Presentation] Rho-kinaseおよびGSK-3beta阻害剤による軸索伸長制御のメカニズム2007

    • Author(s)
      有村奈利子, 吉村武, 貝淵弘三
    • Organizer
      第18回日本末梢神経学会
    • Place of Presentation
      弘前
    • Year and Date
      2007-08-24
    • Related Report
      2009 Final Research Report 2007 Annual Research Report
  • [Presentation] 統合失調症脆弱性因子DISC1によるNUDEL複合体、Grb2の軸索への輸送制御2007

    • Author(s)
      匹田 貴夫
    • Organizer
      第111回日本薬理学会近畿部会
    • Place of Presentation
      名古屋
    • Year and Date
      2007-06-15
    • Related Report
      2007 Annual Research Report
  • [Presentation] Numb controls integrin endocytosis for directional cell migration with aPKC and Par32007

    • Author(s)
      貝淵弘三
    • Organizer
      BMB2007 第30回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] 統合失調症の発症脆弱性因子のプロテオミクス解析2007

    • Author(s)
      田谷真一郎
    • Organizer
      統合失調症の発症脆弱性因子のプロテオミクス解析.第5回日本ヒトプロテオーム機構大会
    • Place of Presentation
      東京
    • Related Report
      2007 Annual Research Report
  • [Presentation] DISC1 regulates neurotrophin-induced axon elongation via interaction with Grb22007

    • Author(s)
      篠田友靖
    • Organizer
      BMB2007 第30回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] CRMP-2, Slp1 and Rab27B mediate anterograde transport of TrkB2007

    • Author(s)
      有村奈利子
    • Organizer
      Neuro 2007
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] Regulation of DISC1 phosphorylation by ERK2007

    • Author(s)
      田谷真一郎
    • Organizer
      Neuro2007
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] 新規統合失調症脆弱性因子としての14-3-3epsionの同定2007

    • Author(s)
      匹田貴夫
    • Organizer
      Neuro2007
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] Identification of ULK1 as a novel CRMP-2 phosphorylation kinase2007

    • Author(s)
      島田明子
    • Organizer
      BMB2007 第30回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] Role of Numb in Dendritic Spine Development with a Cdc42 GEF Intersectin2007

    • Author(s)
      Kaibuchi, K.
    • Organizer
      Workshop on the Biology of Chromosome 21 Genes
    • Place of Presentation
      Detroit, USA.
    • Related Report
      2007 Annual Research Report
  • [Presentation] Phosphorylation of DISC1 regulates the interaction with Kinesin-12007

    • Author(s)
      Kuroda, K.
    • Organizer
      The 37th annual meeting of the Society for Neuroscience
    • Place of Presentation
      San Diego, USA
    • Related Report
      2007 Annual Research Report
  • [Presentation] Identification of YWHEA, a gene encoding 14-3-3epsilon, as a novelsusceptibility gene for schizophrenia2007

    • Author(s)
      Hikita, T.
    • Organizer
      The 37th annual meeting of the Society for Neuroscience
    • Place of Presentation
      San Diego, USA
    • Related Report
      2007 Annual Research Report
  • [Presentation] ERK phosphorylates and regulates Disrupted-In-Schizophrenia 1 (DISC1)2007

    • Author(s)
      Taya, S.
    • Organizer
      ASCB 47th Annual meeting
    • Place of Presentation
      Washington DC, USA
    • Related Report
      2007 Annual Research Report
  • [Presentation] DISC1 regulates the transport of the NUDEL/LIS1/14-3-3epsilon complex and Grb2 through kinesin-12007

    • Author(s)
      Hikita, T
    • Organizer
      Cell Polarity 2007
    • Place of Presentation
      Kanagawa, Japan
    • Related Report
      2007 Annual Research Report
  • [Presentation] CRMP-2 and Slp1 mediate anterograde transport of TrkB through Kinesin-12006

    • Author(s)
      Arimura N.,, Kaibuchi, K.
    • Organizer
      46th annual meeting of American Society of Cell Biology
    • Place of Presentation
      San Diego. USA
    • Year and Date
      2006-12-09
    • Related Report
      2009 Final Research Report
  • [Presentation] Ubiquitination of collapsin response mediator protein-2 participates in neuronal polarization2006

    • Author(s)
      李隼庸, 有村奈利子, 貝淵弘三
    • Organizer
      日本分子生物学会2006フォーラム
    • Place of Presentation
      名古屋
    • Year and Date
      2006-12-06
    • Related Report
      2009 Final Research Report
  • [Presentation] The role of CRMP-2 as a novel cytoplasmic dynein interacting molecule2006

    • Author(s)
      朋部敦志, 有村奈利子, 貝淵弘三
    • Organizer
      日本分子生物学会2006フォーラム
    • Place of Presentation
      名古屋
    • Year and Date
      2006-12-06
    • Related Report
      2009 Final Research Report
  • [Presentation] Dynamics of signaling molecules during axon specification2006

    • Author(s)
      Yoshimura, T.,, Kaibuchi, K.
    • Organizer
      36th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      Atlanta. USA
    • Year and Date
      2006-11-14
    • Related Report
      2009 Final Research Report
  • [Presentation] Cytoskeletal Dynamics and Signal Transduction in Neuronal Polarity2006

    • Author(s)
      Kaibuchi, K.
    • Organizer
      36th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      Atlanta
    • Year and Date
      2006-10-14
    • Related Report
      2009 Final Research Report
  • [Presentation] Signaling for neuronal polarization2006

    • Author(s)
      Kaibuchi, K.
    • Organizer
      36th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      Atlanta. USA
    • Year and Date
      2006-10-14
    • Related Report
      2009 Final Research Report
  • [Presentation] Role of Slp, a novel CRMP-2 interacting molecule, in hippocampal neurons2006

    • Author(s)
      吉村武, 有村奈利子, 貝淵弘三
    • Organizer
      第49回日本神経化学会大会
    • Place of Presentation
      名古屋
    • Year and Date
      2006-09-14
    • Related Report
      2009 Final Research Report
  • [Presentation] Signaling for neuronal polarization2006

    • Author(s)
      貝淵弘三
    • Organizer
      Neuroscience 2006
    • Place of Presentation
      名古屋
    • Year and Date
      2006-07-19
    • Related Report
      2009 Final Research Report
  • [Presentation] 新規Collapsin response mediator protein-2結合蛋白質synaptotagmin-like proteinの海馬神経細胞における機能解析2006

    • Author(s)
      有村奈利子, 川端紗枝子, 朋部敦志, 貝淵弘三
    • Organizer
      第29回日本神経科学大会
    • Place of Presentation
      京都
    • Year and Date
      2006-06-19
    • Related Report
      2009 Final Research Report
  • [Presentation] Key regulators in neuronal polarization2006

    • Author(s)
      Kaibuchi, K.,, Arimura N.
    • Organizer
      20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress
    • Place of Presentation
      Kyoto
    • Year and Date
      2006-06-18
    • Related Report
      2009 Final Research Report
  • [Presentation] Ras Regulates Neuronal Polarity via PI3-kinase/Akt/GSK-3β/CRMP-2 pathway2005

    • Author(s)
      Kaibuchi, K.
    • Organizer
      The American Society For Cell Biology 45th Annual Meeting
    • Place of Presentation
      San Francisco. USA
    • Year and Date
      2005-12-10
    • Related Report
      2009 Final Research Report
  • [Presentation] Neuronal polarity and cytoskeleton2005

    • Author(s)
      Yoshimura, T.,, Kaibuchi, K.
    • Organizer
      The American Society For Cell Biology 45th Annual Meeting
    • Place of Presentation
      San Francisco. USA
    • Year and Date
      2005-12-10
    • Related Report
      2009 Final Research Report
  • [Presentation] 細胞の極性形成と遊走を制御する分子機構の解明2005

    • Author(s)
      貝淵弘三
    • Organizer
      第28回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Year and Date
      2005-12-07
    • Related Report
      2009 Final Research Report
  • [Presentation] 伝達分子と軸索伸長制御の分子メカニズムシグナル2005

    • Author(s)
      貝淵弘三
    • Organizer
      伝達分子と軸索伸長制御の分子メカニズムシグナル
    • Place of Presentation
      岡崎
    • Year and Date
      2005-11-24
    • Related Report
      2009 Final Research Report
  • [Presentation] Microtubule dynamics and cell polarity2005

    • Author(s)
      Kaibuchi, K.
    • Organizer
      9th International Dahlem Symposium on Cellular Signal Recognition and Transduction
    • Place of Presentation
      Berlin
    • Year and Date
      2005-10-13
    • Related Report
      2009 Final Research Report
  • [Presentation] Neuronal polarity and axon formation2005

    • Author(s)
      貝淵弘三
    • Organizer
      第48回日本神経化学会年会
    • Place of Presentation
      福岡
    • Year and Date
      2005-09-28
    • Related Report
      2009 Final Research Report
  • [Presentation] IQGAP3, a novel effector of Rac1 and Cdc42, regulates neurite outgrowth through actin cytoskeleton reorganization2005

    • Author(s)
      王淑杰, 渡辺崇, 則武淳, 佐藤和正, 吉村武, 深田正紀, 貝淵弘三
    • Organizer
      第48回日本神経化学会大会
    • Place of Presentation
      福岡
    • Year and Date
      2005-09-28
    • Related Report
      2009 Final Research Report
  • [Presentation] Ras regulates neuronal polarity via the PI3-kinase/Akt/GSK-3β/CRMP-2 pathway2005

    • Author(s)
      吉村武, 貝淵弘三
    • Organizer
      第48回日本神経化学会大会
    • Place of Presentation
      福岡
    • Year and Date
      2005-09-28
    • Related Report
      2009 Final Research Report
  • [Presentation] Role of CRMP-2 in the establishment of neuronal polarity2005

    • Author(s)
      Kaibuchi, K.
    • Organizer
      20th Biennial Meeting of the ISN
    • Place of Presentation
      Innsbruck
    • Year and Date
      2005-08-21
    • Related Report
      2009 Final Research Report
  • [Presentation] 神経細胞の極性形成におけるPar複合体の役割2005

    • Author(s)
      西村隆史, 貝淵弘三
    • Organizer
      第28回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2005-07-26
    • Related Report
      2009 Final Research Report
  • [Presentation] 神経細胞の極性形成機構2005

    • Author(s)
      貝淵弘三
    • Organizer
      日本分子生物学会第5回春期シンポジウム
    • Place of Presentation
      新潟
    • Year and Date
      2005-05-15
    • Related Report
      2009 Final Research Report
  • [Presentation] Signaling for Neuronal Polarity2005

    • Author(s)
      Kaibuchi, K.
    • Organizer
      Keystone Symposia on Cell Migration and Adhesion
    • Place of Presentation
      Snowbird, Utah
    • Year and Date
      2005-04-09
    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://www.med.nagoya-u.ac.jp/Yakuri/

    • Related Report
      2009 Final Research Report
  • [Remarks] 名古屋大学大学院医学系研究科 神経情報薬理学講座ホームページ

    • URL

      http://www.med.nagoya-u.ac.jp/Yakuri/

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.med.nagoya-u.ac.jp/Yakuri/

    • Related Report
      2007 Annual Research Report

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Published: 2005-04-01   Modified: 2018-03-28  

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