Analysis for genes specifically expressed in primate neocotical areas

• Project/Area Number: 17024055
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: National Institute for Basic Biology
• Principal Investigator: YAMAMORI Tetsuo National Institute for Basic Biology, 脳生物学研究部門, 教授 (80260206)
• Co-Investigator(Kenkyū-buntansha): WATAKABE Akiya 基礎生物学研究所, 脳生物学研究部門, 助教 (40290910) ; KOMINE Yuriko 基礎生物学研究所, 脳生物学研究部門, 助教 (90280586) ; SADAKANE Osamu 基礎生物学研究所, 脳生物学研究部門, 助教 (90446261) ; ONOE Hirotaka 独立行政法人理化学研究所, 分子イメージング科学研究センター 分子プローブ機能評価研究チーム, チームリーダー (80214196)
• Project Period (FY): 2005 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥133,600,000 (Direct Cost: ¥133,600,000); Fiscal Year 2009: ¥28,500,000 (Direct Cost: ¥28,500,000); Fiscal Year 2008: ¥26,800,000 (Direct Cost: ¥26,800,000); Fiscal Year 2007: ¥24,200,000 (Direct Cost: ¥24,200,000); Fiscal Year 2006: ¥25,800,000 (Direct Cost: ¥25,800,000); Fiscal Year 2005: ¥28,300,000 (Direct Cost: ¥28,300,000)
• Keywords: 大脳皮質 / 領野 / 遺伝子発現 / 連合野 / 視覚野 / PNMA5 / RBP / occl / セロトニン受容体 / 大脳皮質領野 / 活動依存性 / 遺伝子 / occ1 / マカカ / c-Fos / 視聴覚 / 脳特異的転写因子 / アンチセンスRNA / 行動装置

Research Abstract

We have identified the genes that are markedly expressed in primate neocortical areas by a large scale analysis and found that these genes can be classified into two groups: The primary visual area specific and association area specific genes. The two areas are highly developed in the primate neocortex and thus these genes may play certain important roles in the specification of the primate areas. We have also identified roles of 5HT1B and 5HT2A serotonin receptors.

Research Products

• [Journal Article] Prefrontal-Enriched SLIT1 Expression in Old World Monkey Cortex Established during the Postnatal Development. (2010)
  • Author(s): Sasaki T, Komatsu Y, Watakabe A, Sawada K, Yamamori T.
  • Journal Title: Cereb Cortex. (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Prefrontal-Enriched SLIT1 Expression in Old World Monkey Cortex Established during the Postnatal Development (2010)
  • Author(s): Sasaki T
  • Journal Title: Cereb Cortex. (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] araneoplastic antigen-like 5 gene (PNMA5) is preferentially expressed in the association areas in a primate specific manner. (2009)
  • Author(s): Takaji M, Komatsu Y, Watakabe A, Hashikawa T, Yamamori T.
  • Journal Title: Cereb Cortex. 19(12) Pages: 2865-79
  • Peer Reviewed
• [Journal Article] Enriched expression of serotonin 1B and 2A receptor genes in macaque visual cortex and their bidirectional modulatory effects on neuronal responses. (2009)
  • Author(s): Watakabe A, Komatsu Y, Sadakane O, Shimegi S, Takahata T, Higo N, Tochitani S, Hashikawa T, Naito T, Osaki H, Sakamoto H, Okamoto M, Ishikawa A, Hara S, Akasaki T, Sato H, Yamamori T.
  • Journal Title: Cereb Cortex. 19(8) Pages: 1915-1928
  • Peer Reviewed
• [Journal Article] Differential expression patterns of occ1-related genes in adult monkey visual cortex. (2009)
  • Author(s): Takahata T, Komatsu Y, Watakabe A, Hashikawa T, Tochitani S, Yamamori T.
  • Journal Title: Cereb Cortex. 19(8) Pages: 1937-1951
  • Peer Reviewed
• [Journal Article] Expression of immediate-early genes reveals functional compartments within ocular dominance columns after brief monocular inactivation. (2009)
  • Author(s): Takahata T, Higo N, Kaas JH, Yamamori T.
  • Journal Title: Proc Natl Acad Sci U S A. 106(29) Pages: 12151-12155
  • Peer Reviewed
• [Journal Article] Comparative molecular neuroanatomy of mammalian neocortex: what can gene expression tell us about areas and layers? (2009)
  • Author(s): Watakabe A.
  • Journal Title: Dev Growth Differ. 51(3) Pages: 343-354
  • NAID: 10025375561
  • Peer Reviewed
• [Journal Article] Expression of layer-specific markers in the adult neocortex of BCNU-Treated rat, a model of cortical dysplasia. (2009)
  • Author(s): Moroni RF, Inverardi F, Regondi MC, Watakabe A, Yamamori T, Spreafico R, Frassoni C.
  • Journal Title: Neuroscience. 159(2) Pages: 682-691
  • Peer Reviewed
• [Journal Article] Expression of immediate-early genes reveals functional compartments within ocular dominance columns after brief monocular inactivation (2009)
  • Author(s): Takahata T
  • Journal Title: Proc Natl Acad Sci USA. 106 Pages: 12151-12155
  • Peer Reviewed
• [Journal Article] Paraneoplastic Antigen-Like 5 Gene(PNMA5)Is Preferentially Expressed in the Association Areas in a Primate Specific Manner (2009)
  • Author(s): Takaji M
  • Journal Title: Cereb Cortex. 19 Pages: 2865-2879
  • Peer Reviewed
• [Journal Article] Comparative molecular neuroanatomy of mammalian neocortex : What can gene expression tell us about areas and lavers (2009)
  • Author(s): Watakabe A
  • Journal Title: Dev Growth Differ. (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Expression of layer-specific markers in the adult neocortex of BCNTJ-Treated rat, a model of cortical dysplasia (2009)
  • Author(s): Moroni RF
  • Journal Title: Neuroscience. (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Analysis of area-specific expression patterns of RORbeta, ER81 and Nurr1 mRNAs in rat neocortex by double in situ hybridization and cortical box method. (2008)
  • Author(s): Hirokawa J, Watakabe A, Ohsawa S, Yamamori T.
  • Journal Title: PLoS One. (9)
  • Peer Reviewed
• [Journal Article] Gene expression patterns in visual cortex during the critical period: synaptic stabilization and reversal by visual deprivation. (2008)
  • Author(s): Lyckman AW, Horng S, Leamey CA, Tropea D, Watakabe A, Van Wart A, McCurry C, Yamamori T, Sur M.
  • Journal Title: Proc Natl Acad Sci U S A. 105(27) Pages: 9409-9414
  • Peer Reviewed
• [Journal Article] Functional role of the secondary visual cortex in multisensory facilitation in rats. (2008)
  • Author(s): Hirokawa J, Bosch M, Sakata S, Sakurai Y, Yamamori T.
  • Journal Title: Neuroscience. 153(4) Pages: 1402-1417
  • Peer Reviewed
• [Journal Article] 霊長類大脳皮質領野特異的発現遺伝子の解析 (2008)
  • Author(s): 三品昌美、山森哲雄、狩野方伸、村上富士夫、貝淵弘三編
  • Journal Title: 蛋白質核酸酵素 53巻 Pages: 464-468
• [Journal Article] Difference in sensory dependence of occ1/Follistatin-related protein expression between macaques and mice. (2008)
  • Author(s): Takahata T, Hashikawa T, Higo N, Tochitani S, Yamamori T.
  • Journal Title: J Chem Neuroanat. 35(1) Pages: 146-157
  • Peer Reviewed
• [Journal Article] Differential Expression Patterns of occl-Related Genes in Adult Monkey Visual Cortex (2008)
  • Author(s): Takahata T
  • Journal Title: Cereb Cortex. (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Enriched Expression of Serotonin 1B and 2A Receptor Genes in Macaque Visual Cortex and their Bidirectional Modulatory Effects on Neuronal Responses (2008)
  • Author(s): Watakabe A
  • Journal Title: Cereb Cortex. (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Analysis of area-specific expression patterns of RORbeta, ER81 and Nurrl mRNAs in rat neocortex by double in situ hybridization and cortical box method (2008)
  • Author(s): Hirokawa J
  • Journal Title: PLoS ONE. 3
  • Peer Reviewed
• [Journal Article] Gene expression patterns in visual cortex during the critical period : synaptic stabilization and reversal by visual deprivation (2008)
  • Author(s): Lyckman AW
  • Journal Title: Proc Natl Acad Sci USA. 105 Pages: 9409-9414
  • Peer Reviewed
• [Journal Article] Functional role of the secondary visual cortex in multisensory facilitation in rats (2008)
  • Author(s): Neuroscience.
  • Journal Title: Hirokawa J 153 Pages: 1402-1417
  • Peer Reviewed
• [Journal Article] 霊長類大脳皮質領野特異的発現遺伝子の解析 (2008)
  • Author(s): 山森哲雄
  • Journal Title: 蛋白質核酸酵素(3月号増刊) 53 Pages: 464-468
• [Journal Article] Difference in sensory dependence of occ1/Follistatin-related protein expression between macaques and mice. (2008)
  • Author(s): Takahata T
  • Journal Title: J Chem Neuroanat 35 Pages: 146-157
  • Peer Reviewed
• [Journal Article] Transiently increased colocalization of vesicular glutamate transporters 1 and 2 at single axon terminals during postnatal development of mouse neocortex: a quantitative analysis with correlation coefficient. (2007)
  • Author(s): Nakamura K, Watakabe A, Hioki H, Fujiyama F, Tanaka Y, Yamamori T, Kaneko T.
  • Journal Title: Eur J Neurosci. 26(11) Pages: 3054-3067
  • Peer Reviewed
• [Journal Article] Comparative analysis of layer-specific genes in Mammalian neocortex. (2007)
  • Author(s): Watakabe A, Ichinohe N, Ohsawa S, Hashikawa T, Komatsu Y, Rockl, KS, Yamamori T.
  • Journal Title: Cereb Cortex. 17(8) Pages: 1918-1933
  • Peer Reviewed
• [Journal Article] Topological relationships between brain and social networks. (2007)
  • Author(s): Sakata S, Yamamori T.
  • Journal Title: Neural Netw. 20(1) Pages: 12-21
  • NAID: 10019931354
  • Peer Reviewed
• [Journal Article] Transiently increased colocalization of vesicular glutamate transporters 1 and 2 at single axon terminals during postnatal development of mouse neocortex:a quantitative analysis with correlation coefficient. (2007)
  • Author(s): Nakamura K
  • Journal Title: Eur J Neurosci 26 Pages: 3054-3067
  • Peer Reviewed
• [Journal Article] Comparative analysis of layer-specific genes in Mammalian neocortex. (2007)
  • Author(s): Watakabe A
  • Journal Title: Cereb Cortex. 17 Pages: 1918-1933
  • Peer Reviewed
• [Journal Article] Topological relationships between brain and social networks. (2007)
  • Author(s): Sakata S
  • Journal Title: Neural Networks 20 Pages: 12-21
• [Journal Article] Binding and complementary expression patterns of semaphorin 3E and plexin D1 in the mature neocortices of mice and monkeys. (2006)
  • Author(s): Watakabe A, Ohsawa S, Hashikawa T, Yamamori T.
  • Journal Title: J Comp Neurol. 499(2) Pages: 258-273
  • Peer Reviewed
• [Journal Article] Activity-dependent expression of occ1 in excitatory neurons is a characteristic feature of the primate visual cortex. (2006)
  • Author(s): Takahata T, Komatsu Y, Watakabe A, Hashikawa T, Tochitani S, Yamamori T.
  • Journal Title: Cereb Cortex. 16(7) Pages: 929-940
  • Peer Reviewed
• [Journal Article] Neocortical areas, layers, connections, and gene expression. (2006)
  • Author(s): Yamamori T, Rockl, KS.
  • Journal Title: Neurosci Res. 55(1) Pages: 11-27
  • NAID: 10020616329
  • Peer Reviewed
• [Journal Article] Gene expression profiling of primate neocortex: molecular neuroanatomy of cortical areas. (2006)
  • Author(s): Watakabe A, Komatsu Y, Nawa H, Yamamori T.
  • Journal Title: Genes Brain Behav. 5Suppl1 Pages: 38-43
  • Peer Reviewed
• [Journal Article] Novel transcription factor zfh-5 is negatively regulated by its own antisense RNA in mouse brain. (2006)
  • Author(s): Komine Y, Nakamura K, Katsuki M, Yamamori T.
  • Journal Title: Mol Cell Neurosci. 31(2) Pages: 273-283
  • Peer Reviewed
• [Journal Article] Neocortical areas, layers, connections, and gene expression. (2006)
  • Author(s): Yamamori T
  • Journal Title: Neurosci Res 55 Pages: 11-27
  • NAID: 10020616329
• [Journal Article] Comparative Analysis of Layer-Specific Genes in Mammalian Neocortex. (2006)
  • Author(s): Watakabe A
  • Journal Title: Cereb Cortex (in press)
• [Journal Article] Binding and complementary expression patterns of semaphorin 3E and plexin D1 in the mature neocortices of mice and monkeys. (2006)
  • Author(s): Watakabe A
  • Journal Title: J Comp Neurol 499 Pages: 258-273
• [Journal Article] Activity-dependent expression of occl in excitatory neurons is a characteristic feature of the primate visual cortex. (2006)
  • Author(s): Takahata T
  • Journal Title: Cereb Cortex 16 Pages: 929-940
• [Journal Article] Neocortical areas, layers, connections, and gene expression. (2006)
  • Author(s): Yamamori T.他
  • Journal Title: Neurosci.Res (In press)
  • NAID: 10020616329
• [Journal Article] Novel transcription factor zfh-5 is negatively regulated by its own antisense RNA in mouse brain. (2006)
  • Author(s): Komine Y.他
  • Journal Title: Mol Cell Neurosci 31 Pages: 273-283
• [Journal Article] Gene expression profiling of primate neocortex : molecular neuroanatomy of cortical areas (2006)
  • Author(s): Watakabe, A.他
  • Journal Title: Genes Brain Behav 5 Suppl1 Pages: 38-43
• [Journal Article] 7-12 Hz cortical oscillations: behavioral context and dynamics of prefrontal neuronal ensembles. (2005)
  • Author(s): Sakata S, Yamamori T, Sakurai Y.
  • Journal Title: Neuroscience. 134(4) Pages: 1099-1111
  • Peer Reviewed
• [Journal Article] Activity-dependent expression of occ1 in excitatory neurons is a characteistic feature of the primate visual cortex. (2005)
  • Author(s): Takahata T.他
  • Journal Title: Cerbral Cortex (Epub ahead of print)
• [Journal Article] 7-12 Hz cortical oscillations : behavioral contex and dynamic s of prefrontal neuronal ensembles. (2005)
  • Author(s): Sakata S.他
  • Journal Title: Neuroscience 134 Pages: 1099-1111
• [Journal Article] Local design principles of mammalian cortical networks. (2005)
  • Author(s): Sakata S.他
  • Journal Title: Neurosci Res 51 Pages: 309-315
• [Journal Article] Retinol-binding protein gene is highly expressed in higher-order association areas of the primate neocortex. (2005)
  • Author(s): Komatsu Y.
  • Journal Title: Cereb Cortex 15 Pages: 96-108
• [Book] シリーズ進化学第5巻ヒトの進化3章「脳の進化」 (2006)
  • Author(s): 山森哲雄
  • Publisher: 岩波書店
• [Book] ヒトの進化(シリーズ進化学第5巻) (2006)
  • Author(s): 斎藤成也
  • Total Pages: 240
  • Publisher: 岩波書店
• [Remarks]
  • URL: http://www.nibb.ac.jp/%7Edivspel/
• [Remarks]
  • URL: http://www.nibb.ac.jp/%7Edivspel/
• [Remarks]
  • URL: http://www.nibb.ac.jp/%7Edivspe1/