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Fabrication of 3D Artificial Fine Blood Vessel Model Based on Personal Data

Research Project

Project/Area Number 17076015
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Science and Engineering
Research InstitutionFujita Health University

Principal Investigator

NEGORO Makoto  Fujita Health University, 医学部, 客員教授 (90115618)

Co-Investigator(Kenkyū-buntansha) ARAI Fumihito  東北大学, 大学院・工学研究科, 教授 (90221051)
Project Period (FY) 2005 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥92,500,000 (Direct Cost: ¥92,500,000)
Fiscal Year 2009: ¥11,300,000 (Direct Cost: ¥11,300,000)
Fiscal Year 2008: ¥21,500,000 (Direct Cost: ¥21,500,000)
Fiscal Year 2007: ¥16,600,000 (Direct Cost: ¥16,600,000)
Fiscal Year 2006: ¥24,800,000 (Direct Cost: ¥24,800,000)
Fiscal Year 2005: ¥18,300,000 (Direct Cost: ¥18,300,000)
Keywords微細加工 / 人工血管 / 3次元造形 / 生分解性材料 / 再生医学 / 脳神経外科 / ソルトリーチング / 個人情報 / 電界紡糸 / 血管内皮細胞 / スキャホールド / ポリ乳酸 / セグメント化ポリウレタン / カプロラクトン / 積層造形法 / 走査電子顕微鏡
Research Abstract

Based on the personal data obtained by the medical tomography, such as CT (Computed Tomography) and MRI (Magnetic Resonance Imaging) etc., basis of the innovative medical technologies are researched as follows. (1) Design and fabrication of 3 dimensional blood vessel scaffold based on the personal data of patient. (2) Formation of vascular endothelial cells on the scaffold. (3) Minimally invasive surgical procedure to deriver artificial vessel.

Report

(6 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (47 results)

All 2009 2008 2007 2006 2005 Other

All Journal Article (16 results) (of which Peer Reviewed: 9 results) Presentation (29 results) Remarks (2 results)

  • [Journal Article]2009

    • Author(s)
      中野琢磨, 吉田圭佑, 池田誠一, 大浦裕就, 福田敏男, 松田武久, 根来真, 新井史人
    • Journal Title

      日本ロボット学会誌 Vol.27,No.7

      Pages: 725-731

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] ネットワーク型細動脈モデルの製作2009

    • Author(s)
      中野琢磨, 吉田圭佑, 池田誠一, 大浦裕就, 福田敏男, 松田武久, 根来真, 新井史人
    • Journal Title

      化学とマイクロ・ナノシステム研究会誌 Vol.8, No.1

      Pages: 22-23

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 透明な細動脈膜モデルの製作方法の提案2009

    • Author(s)
      中野琢磨, 吉田圭佑, 池田誠一, 大浦裕就, 福田敏男, 松田武久, 根来真, 新井史人
    • Journal Title

      日本ロボット学会誌 Vol.27, No.7

      Pages: 23-29

    • NAID

      10025114163

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of biodegradable scaffolds based on patient-specific arterial configuration2008

    • Author(s)
      T. Uchida, S. Ikeda, H. Oura, M. Tada, T. Nakano, T. Fukuda, T. Matsuda, M. Negoro, F. Arai
    • Journal Title

      Journal of Biotechnology 133

      Pages: 213-218

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fabrication of Transparent Arteriole Membrane Models2008

    • Author(s)
      T. Nakano, K. Yoshida, S. Ikeda, H. Oura, T. Fukuda, T. Matsuda, M. Negoro, F. Arai
    • Journal Title

      Proc. 2008 Int. Symp. Micro-NanoMechatronics and Human Science

      Pages: 457-462

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Construction of Biodegradable Polymer Scaffold by Photolithography2008

    • Author(s)
      T. Itoyama, T. Nakano, H. Maruyama, S. Ikeda, H. Oura, T. Fukuda, T. Matsuda, M. Negoro, F. Arai
    • Journal Title

      Proc. 2008 Int. Symp. Micro-NanoMechatronics and Human Science

      Pages: 361-366

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of biodegradable scaffolds based on patient-specific arterial configuration2008

    • Author(s)
      Tomoyuki Uchida, Seiichi Ikeda, Hiroyuki Oura, Mika Tada, Ta kuma Nakano, Toshio Fukuda, Takehisa Matsuda, Makoto Negoro, Fumihito Arai
    • Journal Title

      Journal of Biotechnology 133

      Pages: 213-218

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fabrication of Cell-Adhesion Surface and Arteriole Model by Photolithography2007

    • Author(s)
      F. Arai, T. Nakano, M. Tada, Yu-Ching Lin, S. Ikeda, T. Uchida, H. Oura, T. Fukuda, T. Matsuda, M. Negoro
    • Journal Title

      Journal of Robotics and Mechatronics Vol.19,No.5

      Pages: 535-543

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Patient-Specific Blood Vessel Scaffold for Regenerative Medicine2007

    • Author(s)
      S. Ikeda, F. Arai, T. Fukuda, H. Oura, M. Negoro
    • Journal Title

      2007 IEEE International Conference on Robotics and Automation

      Pages: 1912-1917

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] メカノバイオシステム2007

    • Author(s)
      新井史人, 山西陽子, 林育菁
    • Journal Title

      精密工学会誌 73

      Pages: 524-527

    • NAID

      110006285624

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Fabrication of Cell-Adhesion Surface and Arteriole Model by Photolithography2007

    • Author(s)
      Fumihito Arai, Takuma Nakano, Mika Tada, Yu-Ching Lin, Seiichi Ikeda, Tomoyuki Uchida, Hiroyuki Oura, Toshio Fukuda, TakehisaMatsuda, Makoto Negoro
    • Journal Title

      Journal of Robotics and Mechatronics 19-5

      Pages: 535-543

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Patient-Specific Blood Vessel Scaffoid for Regenerative Medicine2007

    • Author(s)
      S.Ikeda, F.Arai, T.Fukuda, O.Hiroyuki, M.Negoro
    • Journal Title

      Proc.of IEEE International Conference on Robotics and Automation (to appear)(In press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Development of Patient-Specific Scaffold for Artificial Blood Vessel2006

    • Author(s)
      S.Ikeda, F.Arai, T.Fukuda, M.Negoro
    • Journal Title

      Proc.of IEEE Micro-NanoMechatronics and Human Science

      Pages: 108-113

    • Related Report
      2006 Annual Research Report
  • [Journal Article] CT angiography with electrocardiographically gated Reconstruction of intracranial aneurysm2005

    • Author(s)
      Hayakawa M, Negoro M et al.
    • Journal Title

      Am J Neuroradiology 26

      Pages: 1366-1369

    • Related Report
      2005 Annual Research Report
  • [Journal Article] An In Vitro Patient-Specific Biological Model of the Cerebral Artery2005

    • Author(s)
      Ikeda S, Arai F, Negoro M et al.
    • Journal Title

      Journal of Robotics and Mechatronics 17

      Pages: 327-334

    • Related Report
      2005 Annual Research Report
  • [Journal Article] An In Vitro Patient-Tailored Model of Human Cerebral Artery for Simulating Endovascular Intervention2005

    • Author(s)
      Ikeda S, Arai F, Negoro M et al.
    • Journal Title

      Proc.of International Conference on Medical Image Computer Assisted Intervention 10

      Pages: 925-932

    • Related Report
      2005 Annual Research Report
  • [Presentation] Fabrication of Biodegradable Scaffold by Powder Sintering Process2009

    • Author(s)
      Taro Itoyama, Takuma Nakano, Seiichi Ikeda, Toshio Fukuda, Takehisa Matsuda, Makoto Negoro, Fumihito Arai
    • Organizer
      IEEE International Symposium on Micro-NanoMechatronics and Human Science(MHS)
    • Place of Presentation
      名古屋, 名古屋大学
    • Year and Date
      2009-11-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] On-chip Particle-laden Droplet Dispensing by Disposable Inkjet System2009

    • Author(s)
      Takehito Mizunuma, Yoko Yamanishi, Shinya Sakuma, Hisataka Maruyama, Fumihito Arai
    • Organizer
      IEEE International Symposium on Micro-NanoMechatronics and Human Science(MHS)
    • Place of Presentation
      名古屋, 名古屋大学
    • Year and Date
      2009-11-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] 生分解性ポリマー製マイクロ流路の加工法と細胞培養2009

    • Author(s)
      吉田圭佑, 糸山太郎, 中野琢磨, 池田誠一, 福田敏男, 松田武久, 根来真, 新井史人
    • Organizer
      第20回化学とマイクロ・ナノシステム研究会
    • Place of Presentation
      金沢, 石川四高記念文化交流館
    • Year and Date
      2009-11-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] Circulation Type Blood Vessel Models Simulating Arteriole Network2009

    • Author(s)
      中野琢磨, 沢田悠, 池田誠一, 大浦裕就, 福田敏男, 松田武久, 根来真, 新井史人
    • Organizer
      The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences(μTAS)
    • Place of Presentation
      韓国, チェジュ島
    • Year and Date
      2009-11-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] On-chip Micro-droplet Dispenser with Disposable Structure2009

    • Author(s)
      Takehito Mizunuma, Mizunuma, Yoko Yamanishi, Shinya Sakuma, Hisataka Maruyama, Fumihito Arai
    • Organizer
      The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences(μTAS)
    • Place of Presentation
      韓国, チェジュ島
    • Year and Date
      2009-11-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] Multi-scale Transparent Arteriole and Capillary Vessel Models for Circulation Type Blood Vessel Simulator2009

    • Author(s)
      Takuma Nakano, Keisuke Yoshida, Seiichi Ikeda, Hiroyuki Oura, Toshio Fukuda, Takehisa Matsuda, Makoto Negoro, Fumihito Arai
    • Organizer
      IEEE/RSJ International Conference on Intelligent Robots and Systems
    • Place of Presentation
      アメリカ, セントルイス
    • Year and Date
      2009-10-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] マクロ-マイクロチャネルのシームレス接続方法と循環型血管モデルへの応用2009

    • Author(s)
      中野琢磨, 沢田悠, 池田誠一, 大浦裕就, 福田敏男, 松田武久, 根来真, 新井史人
    • Organizer
      第19回化学とマイクロ・ナノシステム研究会
    • Place of Presentation
      東広島, 広島大学
    • Year and Date
      2009-05-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] 細動脈網を模擬した循環型血管モデルの作製2009

    • Author(s)
      中野琢磨, 沢田悠, 池田誠一, 大浦裕就, 福田敏男, 松田武久, 根来真, 新井史人
    • Organizer
      日本機械学会ロボティクス・メカトロニクス部門ROBOMEC'09
    • Place of Presentation
      福岡, 福岡国際会議場
    • Year and Date
      2009-05-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] 生分解性ポリマーを用いた微細パターン形状の加工2008

    • Author(s)
      糸山太郎, 吉田圭佑, 丸山央峰, 中野琢磨, 池田誠一, 大浦裕就, 福田敏男, 松田武久, 根来真, 新井史人
    • Organizer
      第18回化学とマイクロ・ナノシステム研究会
    • Place of Presentation
      京都大学桂キャンパス船井哲良記念講堂
    • Year and Date
      2008-12-09
    • Related Report
      2008 Annual Research Report
  • [Presentation] ネットワーク型再動脈モデルの製作2008

    • Author(s)
      中野琢磨, 吉田圭佑, 池田誠一, 大浦裕就, 福田敏男, 松田武久, 根来真, 新井史人
    • Organizer
      第18回化学とマイクロ・ナノシステム研究会
    • Place of Presentation
      京都大学桂キャンパス船井哲良記念講堂
    • Year and Date
      2008-12-09
    • Related Report
      2008 Annual Research Report
  • [Presentation] ディスポ構造を有する微小液滴噴出機構の提案2008

    • Author(s)
      水沼赴人, 中野琢磨, 丸山央峰, 新井史人
    • Organizer
      第18回化学とマイクロ・ナノシステム研究会
    • Place of Presentation
      京都大学桂キャンパス船井哲良記念講堂
    • Year and Date
      2008-12-09
    • Related Report
      2008 Annual Research Report
  • [Presentation] Construction of Biodegradable Polymer Scaffold by Photolithography2008

    • Author(s)
      Taro Itoyama, Takuma Nakano, Hisataka Maruyama, Seiichi Ikeda, Hiroyuki Oura, Toshio Fukuda, Takehisa Matsuda, Makoto Negoro, Fumihito Arai
    • Organizer
      IEEE International Symposium on Micromechatronics and Human Science
    • Place of Presentation
      名古屋, 名古屋大学野依記念学術交流館
    • Year and Date
      2008-11-08
    • Related Report
      2008 Annual Research Report
  • [Presentation] Fabrication of Transparent Arteriole Membrane Models2008

    • Author(s)
      Takuma Nakano, Keisuke Yoshida, Seiichi Ikeda, Hiroyuki Oura, Toshio Fukuda, Takehisa Matsuda, Makoto Negoro, and Fumihito Arai
    • Organizer
      IEEE International Symposium on Micromechatronics and Human Science
    • Place of Presentation
      名古屋, 名古屋大学野依記念学術交流館
    • Year and Date
      2008-11-08
    • Related Report
      2008 Annual Research Report
  • [Presentation] Development of Multi-Layer Scaffolds Based on Artificial Configuration2008

    • Author(s)
      Hiroyuki Oura, Tomoyuki Uchida, Seiichi Ikeda, Takuma Nakano, Fumihito Arai, Makoto Negoro, Takehisa Matsuda, Toshio Futrudn
    • Organizer
      IEEE International Symposium on Micromechatronics and Human Science
    • Place of Presentation
      名古屋, 名古屋大学野依記念学術交流館
    • Year and Date
      2008-11-08
    • Related Report
      2008 Annual Research Report
  • [Presentation] 透明な細動脈膜モデルの製作2008

    • Author(s)
      中野琢磨, 吉田圭佑, 池田誠一, 内田智之, 大浦裕就, 福田敏男, 根来真, 松田武久, 新井史人
    • Organizer
      第26回日本ロボット学会学術講演会
    • Place of Presentation
      神戸市
    • Year and Date
      2008-09-09
    • Related Report
      2008 Annual Research Report
  • [Presentation] 生体血管の力学的特性を有する人工血管足場の開発2008

    • Author(s)
      大浦裕就, 池田誠一, カルロス・テルセロ, 中野琢磨, 新井史人, 根来直, 松田武久, 福田敏男
    • Organizer
      第26回日本ロボット学会学術講演会
    • Place of Presentation
      神戸市
    • Year and Date
      2008-09-09
    • Related Report
      2008 Annual Research Report
  • [Presentation] 円形断面を有する毛細血管モデルの作製と応用2008

    • Author(s)
      中野琢磨, 吉田圭佑, 池田誠一, 内田智之, 大浦裕就, 福田敏男, 根来真, 松田武久, 新井史人
    • Organizer
      Proc. 2008 JSME Conference on Robotics and Mechatronics
    • Place of Presentation
      長野市
    • Year and Date
      2008-06-07
    • Related Report
      2008 Annual Research Report
  • [Presentation] 孔密度の傾斜を有する多層構造の人工血管足場開発2008

    • Author(s)
      大浦裕就, 内田智之, 池田誠一, 中野琢磨, 新井史人, 根来真, 松田武久, 福田敏男
    • Organizer
      Proc. 2008 JSME Conference on Robotics and Mechatronics
    • Place of Presentation
      長野市
    • Year and Date
      2008-06-07
    • Related Report
      2008 Annual Research Report
  • [Presentation] 磁性果糖ビーズの自己組織化を利用した多孔質生分解性足場の造形2008

    • Author(s)
      内田智之, 大浦裕就, 池田誠一, 中野琢磨, 新井史人, 根来真, 松田武久, 福田敏男
    • Organizer
      Proc. 2008 JSME Conference on Robotics and Mechatronics
    • Place of Presentation
      長野市
    • Year and Date
      2008-06-07
    • Related Report
      2008 Annual Research Report
  • [Presentation] Fabrication of biodegradable scaffolds by use of self-assembled magnetic sugar particles as a casting template2008

    • Author(s)
      Tomoyuki Uchida, Hiroyuki Oura, Seiichi Ikeda, Fumihito Arai, Makoto Negoro, and Toshio Fukuda
    • Organizer
      2007 IEEE International Conference on Robotics and Automation
    • Place of Presentation
      アメリカ, パサディナ
    • Year and Date
      2008-04-21
    • Related Report
      2008 Annual Research Report
  • [Presentation] Fabrication of Cell-Adhesion Surface and Capillary Vessel Model by Photolithography2007

    • Author(s)
      Takuma Nakano, Mika Tada, Yu-Ching Lin, Seiichi Ikeda, Tomoyuki Uchida, Hiroyuki Oura, Toshio Fukuda, Takehisa Matsuda, Makoto Negoro and Fumihito Arai
    • Organizer
      IEEE International Symposium on Micromechatro nics and Human Science
    • Place of Presentation
      名古屋,名古屋大学野依記念学術交流館
    • Year and Date
      2007-11-13
    • Related Report
      2007 Annual Research Report
  • [Presentation] Development of biodegradable scaffolds by leaching self-assembled magnetic sugar particles2007

    • Author(s)
      Tomoyuki Uchida, Hiroyuki Oura, Seiichi Ikeda, Takuma Nakano, Fumihito Arai, Makoto Negoro, Takehisa Matsuda, Toshio Fukuda
    • Organizer
      IEEE International Symposium on Micromechatro nics and Human Science
    • Place of Presentation
      名古屋,名古屋大学野依記念学術交流館
    • Year and Date
      2007-11-13
    • Related Report
      2007 Annual Research Report
  • [Presentation] Development of Multi-Layer Scaffolds Based on Artificial Configuration2007

    • Author(s)
      Hiroyuki Oura, Tomoyuki Uchida, Seiichi Ikeda, Takuma Nakano, Fumihito Arai, Makoto Negoro, Takehisa Matsuda, Toshio Fukuda
    • Organizer
      IEEE International Symposium on Micromechatro nics and Human Science
    • Place of Presentation
      名古屋,名古屋大学野依記念学術交流館
    • Year and Date
      2007-11-12
    • Related Report
      2007 Annual Research Report
  • [Presentation] 毛細血管・細動脈モデルの製作2007

    • Author(s)
      中野琢磨, 吉田圭佑, 林 育菁, 池田誠一, 内田智之, 大浦裕就, 福田敏男, 松田武久, 根来 眞, 新井史人
    • Organizer
      第16化学とマイクロ・ナノシステム研究会
    • Place of Presentation
      産業技術総合研究所つくば中央共用講堂
    • Year and Date
      2007-10-31
    • Related Report
      2007 Annual Research Report
  • [Presentation] フォトリソグラフィによる細動脈・毛細血管モデルの製作2007

    • Author(s)
      中野琢磨, 林 育菁, 池田誠一, 内田智之, 大浦裕就, 福田敏男, 松田武久, 根来 眞, 新井史人
    • Organizer
      第25回日本ロボット学会学術講演会
    • Place of Presentation
      津田沼,千葉工業大学
    • Year and Date
      2007-09-15
    • Related Report
      2007 Annual Research Report
  • [Presentation] 多層構造人工血管足場に関する基礎研究2007

    • Author(s)
      大浦裕就, 内田智之, 池田誠一, 中野琢磨, 新井史人, 根来 眞, 松田武久, 福田敏男
    • Organizer
      第25回日本ロボット学会学術講演会
    • Place of Presentation
      津田沼,千葉工業大学
    • Year and Date
      2007-09-13
    • Related Report
      2007 Annual Research Report
  • [Presentation] 毛細血管・細動脈モデルの製作2007

    • Author(s)
      中野琢磨, 林 育菁, 池田誠一, 内田智之, 大浦裕就, 福田敏男, 松田武久, 根来 真, 新井史人
    • Organizer
      第15化学とマイクロ・ナノシステム研究会
    • Place of Presentation
      仙台,東北大学青葉記念会館
    • Year and Date
      2007-05-26
    • Related Report
      2007 Annual Research Report
  • [Presentation] 血管内皮細胞の行動形態に関する研究, -フォトリソグラフィーによる細胞接着表面の作製-2007

    • Author(s)
      新井史人, 中野琢磨, 多田美香, 林育菁, 池田誠一, 内田智之, 大浦裕就, 福田敏男, 松田武久, 根来 真
    • Organizer
      Proc. 2007 JSME Conference on Robotics and Mechatronics
    • Place of Presentation
      秋田拠点センターALVE
    • Year and Date
      2007-05-12
    • Related Report
      2007 Annual Research Report
  • [Presentation] Patient-Specific Blood Vessel Scaffold for Regenerative Medicine2007

    • Author(s)
      Seiichi Ikeda, Fumihito Arai, Toshio Fukuda, Hiroyuki Oura, Makoto Negoro
    • Organizer
      2007 IEEE International Conference on Robotics and Automation
    • Place of Presentation
      イタリア,ローマ
    • Year and Date
      2007-04-12
    • Related Report
      2007 Annual Research Report
  • [Remarks]

    • URL

      http://www.biorobotics.mech.nagoya-u.ac.jp/research/research.html

    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://www.imech.mech.tohoku.ac.jp/research/Robomec09/Robomec09_Nakano.pdf

    • Related Report
      2009 Annual Research Report

URL: 

Published: 2005-04-01   Modified: 2018-03-28  

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