Regulation of cellular localization and activation of the transpotsome by G proteins and MAP kinases

• Project/Area Number: 17081005
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: NISHINA Hiroshi Tokyo Medical and Dental University, 難治疾患研究所, 教授 (60212122)
• Co-Investigator(Kenkyū-buntansha): NAKAMURA Takashi 東京医科歯科大学, 難治疾患研究所, 助教 (80431948) ; ASAOKA Yoichi 東京医科歯科大学, 難治疾患研究所, 助教 (10436644) ; 和田 悌司 東京医科歯科大学, 難治疾患研究所, 助手 (80401389)
• Project Period (FY): 2005 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥40,800,000 (Direct Cost: ¥40,800,000); Fiscal Year 2009: ¥7,800,000 (Direct Cost: ¥7,800,000); Fiscal Year 2008: ¥7,800,000 (Direct Cost: ¥7,800,000); Fiscal Year 2007: ¥10,200,000 (Direct Cost: ¥10,200,000); Fiscal Year 2006: ¥10,200,000 (Direct Cost: ¥10,200,000); Fiscal Year 2005: ¥4,800,000 (Direct Cost: ¥4,800,000)
• Keywords: 発生生物学 / 細胞生物学 / 生体膜 / 輸送 / イオンチャネル / トランスポーター / 細胞増殖 / 細胞死 / RIN / Hippo / 細胞膜 / 細胞接着 / 細胞極性 / MAPキナーゼ / Hippoシグナル / メダカ / 小胞輸送 / 低分子量G蛋白質 / Rab5 / Rheb / アンフィファイシンII / 結節硬化症 / てんかん / G蛋白質

Research Abstract

Ion channels and transporters play essential roles in cellular hemeostasis. "Transportsome", which a complex of these molecules inside the cellmembrane, is known to be involved in cell proliferation, death, and polarity. We found thatstress-responsive SAPK/JNK and Hippo signaling pathways downstream of thetransportsome, regulate cellular survival and death, proliferation, and polarity.

Research Products

• [Journal Article] Involvement of JNK in the regulation of autophagic cell death. (2010)
  • Author(s): Shigeomi Shimizu, Akimitsu Konishi, Yuya Nishida, Takeshi Mizuta, Hiroshi Nishina, Akitsugu Yamamoto, Yoshihide Tsujimoto
  • Journal Title: Oncogene (in press)
• [Journal Article] Retinoic acid signaling positively regulates liver specification by inducing wnt2bb gene expression in medaka. (2010)
  • Author(s): Takahiro Negishi, Yoko Nagai, Yoichi Asaoka, Mami Ohno, Misako Namae, Hiroshi Mitani, Takashi Sasaki, Nobuyoshi Shimizu, Shuji Terai, Isao Sakaida, Hisato Kondoh, Toshiaki Katada, Makoto Furutani-Seiki, Hiroshi Nishina
  • Journal Title: Hepatology (in press)
• [Journal Article] Medaka as a Novel and Accurate Model for Human Nonalcoholic Steatohepatitis. (2010)
  • Author(s): Toshihiko Matsumoto, Shuji Terai, Toshiyuki Oishi, Shinya Kuwashiro, Koichi Fujisawa, Naoki Yamamoto, Yusuke Fujita, Yoshihiko Hamamoto, Makoto Furutani-Seiki, Hiroshi Nishina, Isao Sakaida
  • Journal Title: Disease Models & Mechanisms (in press)
• [Journal Article] A common origin: signaling similarities in the regulation of the circadian clock and DNA damage responses. (2010)
  • Author(s): Yoshimi Uchida, Jun Hirayama, Hiroshi Nishina
  • Journal Title: Biol. Pharm. Bull. (in press)
  • NAID: 130000247995
• [Journal Article] Utility and limitations of SP600125, an inhibitor of stressresponsive c-Jun N-terminal kinase. (2010)
  • Author(s): Shuhei Tanemura, Tokiwa Yamasaki, Toshiaki Katada, Hiroshi Nishina
  • Journal Title: Curr. Enzym. Inhib. 6 Pages: 26-33
• [Journal Article] 「メタボロームの分布可視化法について」メタボロミクスと最新分子マーカー研究・メタボロミクスの基盤技術、メディカル・ドゥ (2010)
  • Author(s): 中村貴、早坂孝宏、井上菜穂子、仁科博史、瀬藤光利
  • Journal Title: 遺伝子医学MOOK 16号(in press)
• [Journal Article] Medaka: a promising model animal for comparative population genomics (2009)
  • Author(s): Yoshifumi Matsumoto, Hiroki Oota, Yoichi Asaoka, Hiroshi Nishina, Koji Watanabe, Janusz M Bujnicki, Shoji Oda, Shoji Kawamura, Hiroshi Mitani
  • Journal Title: BMC Research Notes 2 Pages: 88-88
• [Journal Article] CLOCK:BMAL-independent circadian oscillation of zebrafish Cryptochrome1a gene. (2009)
  • Author(s): Norio Miyamura, Jun Hirayama, Kenji Sawanobori, Teruya Tamaru, Yoichi Asaoka, Reiko Honda, Takuro Yamamoto, Hatsume Uno, Ken Takamatsu, Hiroshi Nishina
  • Journal Title: Biol. Pharm. Bull. 32 Pages: 1183-1187
  • NAID: 130000117214
• [Journal Article] Common light signaling pathways controlling DNA repair and circadian clock entrainment. (2009)
  • Author(s): Jun Hirayama, Norio Miyamura, Yoshimi Uchida, Yoichi Asaoka, Raiko Honda, Kenji Sawanobori, Takeshi Todo, Takuro Yamamoto, Paolo Sassone-Corsi, Hiroshi Nishina
  • Journal Title: Cell Cycle 8 Pages: 2794-27801
• [Journal Article] Hematopoiesis-dependent expression of CD44 in murine hepatic progenitor cells. (2009)
  • Author(s): Shinya Ohata, Makiko Nawa, Takeshi Kasama, Tokiwa Yamasaki, Kenji Sawanobori, Shoji Hata, Takashi Nakamura, Yoichi Asaoka, Toshio Watanabe, Hitoshi Okamoto, Takahiko Hara, Shuji Terai, Isao Sakaida, Toshiaki Katada, Hiroshi Nishina
  • Journal Title: Biochem. Biophys. Res. Commun. 379 Pages: 817-823
• [Journal Article] Blockage by SP600125 of Fce Receptor-induced degranulation and cytokine gene expression in mast cells is mediated through inhibition of phosphatidylinositol 3-kinase signaling pathway. (2009)
  • Author(s): Shuhei Tanemura, Haruka Momose, Nao Shimizu, Daiju Kitagawa, Jungwon Seo, Tokiwa Yamasaki, Kentaro Nakagawa, Hiroaki Kajiho, Josef M. Penninger, Toshiaki Katada, Hiroshi Nishina
  • Journal Title: J. Biochem. 145 Pages: 345-354
• [Journal Article] CrxOS Maintains Self-Renewal Capacity of Murine Embryonic Stem Cells. (2009)
  • Author(s): Ryota Saito, Tokiwa Yamasaki, Yoko Nagai, Jinzhan Wu, Hiroaki Kajiho, Tadashi Yokoi, Eiichiro Noda, Sachiko Nishina, Hitoshi Niwa, Noriyuki Azuma, Toshiaki Katada, Hiroshi Nishina
  • Journal Title: Biochem. Biophys. Res. Commun. 390 Pages: 1129-1135
• [Journal Article] Pax6-5a Promotes Neuronal Differentiation of Murine Embryonic Stem Cells. (2009)
  • Author(s): Nao Shimizu, Hajime Watanabe, Junko Kubota, Jinzhan Wu, Ryota Saito, Tadashi Yokoi, Takumi Era, Takeshi Iwatsubo, Takashi Watanabe, Sachiko Nishina, Noriyuki Azuma, Toshiaki Katada, Hiroshi Nishina
  • Journal Title: Biol. Pharm. Bull. 32 Pages: 999-1003
  • NAID: 130000117177
• [Journal Article] Liver development: lessons from knockout mice and mutant fish. (2009)
  • Author(s): Takashi Nakamura, Hiroshi Nishina
  • Journal Title: Hepatol. Res. 39 Pages: 633-644
  • NAID: 10025326462
• [Journal Article] Medaka : a promising model animal for comparative population genomics (2009)
  • Author(s): Matsumoto, Y, et al.
  • Journal Title: BMC Research Notes 2 Pages: 88-88
  • Peer Reviewed
• [Journal Article] Common light signaling pathways controlling DNA repair and circadian clock entrainment (2009)
  • Author(s): Hirayama, J, et al.
  • Journal Title: Cell Cycle 8 Pages: 2794-27801
  • Peer Reviewed
• [Journal Article] Hematopoiesis-dependent expression of CD44 in murine hepatic progenitor cells (2009)
  • Author(s): Ohata, S, et al.
  • Journal Title: Biochem.Biophys.Res.Commun. 379 Pages: 817-823
  • Peer Reviewed
• [Journal Article] Upf1 potentially serves as a RING-related E3 ubiquitin ligase via its association with Upf3 in yeast. (2008)
  • Author(s): Shinya Takahashi, Yasuhiro Araki, Yuriko Ohya, Takeshi Sakuno, Shin-ichi Hoshino, Kenji Kontani, Hiroshi Nishina, Toshiaki Katada
  • Journal Title: RNA 14 Pages: 1950-1958
• [Journal Article] RalA functions as an indispensable signal mediator for nutrient sensing system. (2008)
  • Author(s): Tomohiko Maehama, Masahiko Tanaka, Hiroshi Nishina, Makoto Murakami, Yasunori Kanaho, Kentaro Hanada
  • Journal Title: J. Biol. Chem. 283 Pages: 5053-35059
• [Journal Article] Novel antibody to human BASP1 labels apoptotic cells post-caspase activation. (2008)
  • Author(s): Shizue Ohsawa, Tomomi Watanabe, Toshiaki Katada, Hiroshi Nishina, Masayuki Miura
  • Journal Title: Biochem. Biophys. Res. Commun. 371 Pages: 639-643
• [Journal Article] Continuous high expression of XBP1 and GRP78 is important for the survival of bone marrow cells in CCl4-treated cirrhotic liver. (2008)
  • Author(s): Yoshio Marumoto, Shuji Terai, Yohei Urata, Toshihiko Matsumoto, Yuko Mizunaga, Naoki Yamamoto, Haiyan Jin, Koichi Fujisawa, Tomoaki Murata, Koh Shinoda, Hiroshi Nishina, Isao Sakaida
  • Journal Title: Biochem. Biophys. Res. Commun. 367 Pages: 546-552
• [Journal Article] Antagonistic control of cell fates by JNK and p38-MAPK signaling. (2008)
  • Author(s): Wada T, Stepniak E, Hui L, Leibbrandt A, Katada T, Nishina H, Wagner EF, Penninger JM.
  • Journal Title: Cell Death Differ. 15 Pages: 89-93
• [Journal Article] Antagonistic control of cell fates by JNK and p38-MAPK signaling (2008)
  • Author(s): Wada T, et.al.
  • Journal Title: Cell Death Differ 15 Pages: 89-93
  • Peer Reviewed
• [Journal Article] Continuous high expression of XBP1 and GRP78 is important for the survival of bone marrow cells in CCl4-treated cirrhotic liver (2008)
  • Author(s): Yoshio Marumoto, et.al.
  • Journal Title: Biochem. Biophys. Res. Commun. 367 367 Pages: 546-552
  • Peer Reviewed
• [Journal Article] Novel antibody to human BASP1 labels apoptotic cells post-caspase activation (2008)
  • Author(s): Shizue Ohsawa, et.al.
  • Journal Title: Biochem. Biophys. Commun 371 Pages: 639-643
  • Peer Reviewed
• [Journal Article] Upfl potentially serves as a RING-related E3 ubiquitin ligase via its association with Upf3 in yeast (2008)
  • Author(s): Shinya Takahashi, et.al.
  • Journal Title: RNA 14 Pages: 1950-1958
  • Peer Reviewed
• [Journal Article] RalA functions as an indispensable signal mediator for nutrient sensing system (2008)
  • Author(s): Tomohiko Maehama, et.al.
  • Journal Title: J. BIOL. Chem 371 Pages: 35053-35059
  • Peer Reviewed
• [Journal Article] Antagonistic control of cell fates by JNK and p38-MAPK signaling. (2008)
  • Author(s): Teiji Wada, et. al.
  • Journal Title: Cell Death Differ. 15 Pages: 89-93
  • Peer Reviewed
• [Journal Article] Activation of the JNK patyway by MST1 is essential and sufficient for the induction of chromatin condensation during apoptosis. (2007)
  • Author(s): Seiji Ura, Hiroshi Nishina*, Yukiko Gotoh, Toshiaki Katada
  • Journal Title: Mol. Cell. Biol. 27 Pages: 5514-5522
• [Journal Article] Estrogen prevents bone loss via estrogen receptor alpha and induction of Fas ligand in osteoclasts. (2007)
  • Author(s): Nakamura, T., Imai, Y., Matsumoto, T., Sato, S., Takeuchi, K., Igarashi, K., Harada, Y., Azuma, Y., Krust, A., Yamamoto, Y., Nishina, H., Takeda, S., Takayanagi, H., Metzger, D., Kanno, J., Takaoka, K., Martin, TJ., Chambon, P., Kato, S.
  • Journal Title: Cell 130 Pages: 811-823
• [Journal Article] Administration of. Administration of fibroblast growth factor 2 in combination with bone marrow transplantation synergistically improves carbon tetrachloride-induced liver fibrosis in mice. (2007)
  • Author(s): Tsuyoshi Ishikawa, Shuji Terai, Yohei Urata, Yoshio Marumoto, Koji Aoyama, Tomoaki Murata, Yuko Mizunaga, Naoki Yamamoto, Hiroshi Nishina, Koh Shinoda, Isao Sakaida
  • Journal Title: Cell Tissue Res. 327 Pages: 463-470
• [Journal Article] Liver development and regeneration: from laboratory study to clinical therapy. (2007)
  • Author(s): Shoji Hata, Misako Namae, Hiroshi Nishina
  • Journal Title: Develop. Growth Differ. 49 Pages: 163-170
  • NAID: 10018878732
• [Journal Article] Liver development and regeneration: from laboratory study to clinical therapy. (2007)
  • Author(s): Shoji Hata, et. al.
  • Journal Title: Develop. Growth Differ. 49 Pages: 163-170
  • Peer Reviewed
• [Journal Article] Activation of the JNK patyway by MST1 is essential and sufficient for the induction of chromatin condensation during apoptosis. (2007)
  • Author(s): Seiji Ura, et. al.
  • Journal Title: Mol. Cell. Biol. 27 Pages: 5514-5522
  • Peer Reviewed
• [Journal Article] Release of RASSF1C from the nucleus by DAXX degradation links DNA damage and SAPK/JNK activation. (2006)
  • Author(s): Daiju Kitagawa, Hiroaki Kajiho, Takahiro Negishi, Seiji Ura, Tomomi Watanabe, Teiji Wada, Hidenori Ichijo, Toshiaki Katada, Hiroshi Nishina
  • Journal Title: EMBO J. 25 Pages: 3286-3297
• [Journal Article] Proteomic analysis of serum marker proteins in recipient mice with liver cirrhosis after bone marrow cell transplantation. (2006)
  • Author(s): Yuichiro Yokoyama, Shuji Terai, Tsuyoshi Ishikawa, Koji Aoyama, Yohei Urata, Yoshio Marumoto, Toshihiko Matsumoto, Hiroshi Nishina, Kazuyuki Nakamura, Kiwamu Okita, Isao Sakaida
  • Journal Title: Proteomics 6 Pages: 2564-2570
• [Journal Article] Fibroblast growth factor 2 facilitates the differentiation of transplanted bone marrow cells into hepatocytes. (2006)
  • Author(s): Tsuyoshi Ishikawa, Shuji Terai, Yohei Urata, Yoshio Marumoto, Koji Aoyama, Isao Sakaida, Tomoaki Murata, Hiroshi Nishina, Koh Shinoda, Shunji Uchimura, Yoshihiko Hamamoto, Kiwamu Okita
  • Journal Title: Cell Tissue Res. 323 Pages: 221-231
• [Journal Article] 多施設臨床研究:肝硬変症に対するAMBI療法の開発 (2006)
  • Author(s): 寺井崇二、浦田洋平、丸本芳雄、石川剛、青山浩司、大森薫、山本直樹、坂井田功、仁科博史、奥本和夫、斎藤貴史、河田純男、沖田極
  • Journal Title: 再生医療 5 Pages: 79-87
• [Journal Article] 新規核内複合体Daxx-RASSF1CはDNA損傷センサーとして機能してシグナルを核から細胞質へと伝達する (2006)
  • Author(s): 北川大樹、堅田利明、仁科博史
  • Journal Title: 細胞工学 25 Pages: 1178-1179
• [Journal Article] 1枚の写真館 肝臓に生じたブラックホール? (2006)
  • Author(s): 仁科博史
  • Journal Title: 細胞工学 25
• [Journal Article] Release of RASSF1C from the nucleus by Daxx degradation links DNA damage and SAPK/JNK activation. (2006)
  • Author(s): Daiju Kitagawa, et al.
  • Journal Title: EMBO J. 25 Pages: 3286-3297
• [Journal Article] Fibroblast growth factor 2 facilitates the differentiation of transplanted bone marrow cells into hepatocytes. (2006)
  • Author(s): Tsuyoshi Ishikawa, et al.
  • Journal Title: Cell Tissue Res. 323 Pages: 221-231
• [Journal Article] Proteomic analysis of serum marker proteins in recipient mice with liver cirrhosis after bone marrow cell transplantation. (2006)
  • Author(s): Yuichiro Yokoyama, et al.
  • Journal Title: Proteomics 6 Pages: 2564-2570
• [Journal Article] Premature ovarian failure in androgen receptor-deficient mice. (2006)
  • Author(s): Hiroko Shiina, et al.
  • Journal Title: Proc Natl Acad Sci USA. 103 Pages: 224-229
• [Journal Article] Nuclear Receptor Mediated Gene Regulation through Chromatin Remodeling and Histone Modifications. (2006)
  • Author(s): Masahiko Kishimoto, et al.
  • Journal Title: Endocrine J. 53 Pages: 157-172
• [Journal Article] 新規核内複合体Daxx-RASSF1CはDNA損傷センサーとして機能してシグナルを核から細胞質へと伝達する (2006)
  • Author(s): 北川 大樹ら
  • Journal Title: 細胞工学 25 Pages: 1178-1179
• [Journal Article] Autoamplification of NFATc1 determines its essential role in bone homeostasis. (2005)
  • Author(s): Masataka Asagiri, Kojiro Sato, Takako Usami, Sae Ochi, Hiroshi Nishina, Hiroki Yoshida, Ikuo Morita, Erwin F. Wagner, Tak W. Mak, Edgar Serfling, Hiroshi Takayanagi
  • Journal Title: J. Exp. Med. 202 Pages: 1261-1269
• [Journal Article] Human homologue of Maid (HHM) is a useful marker protein in hepatocarcinogenesis. (2005)
  • Author(s): Taro Takami, Shuji Terai, Yuichiro Yokoyama, Haruko Tanimoto, Kunihiko Tajima, Koichi Uchida, Takahiro Yamasaki, Isao Sakaida, Hiroshi Nishina, Snorri S. Thorgeirsson, Kiwamu Okita
  • Journal Title: Gastroenterology 128 Pages: 1369-1380
• [Journal Article] Novel role of the small GTPase Rheb: Its implication in endocytic pathway independent of the activation of mammalian target of rapamycin. (2005)
  • Author(s): Saito K, Araki Y, Kontani K, Nishina H, Katada T.
  • Journal Title: J. Biochem. 137 Pages: 423-430
  • NAID: 10017344268
• [Journal Article] RANK-RANKL signaling in osteoclastogenesis. (2005)
  • Author(s): Wada T, Nakashima T, Nishina H, Penninger JM
  • Journal Title: Trends Mol Med. 12 Pages: 17-25
• [Journal Article] Lesson from the GFP/CCl4 model - Translational Research Project: the development of cell therapy using autologous bone marrow cells in patients with liver cirrhosis. (2005)
  • Author(s): Shuji Terai, Isao Sakaida, Hiroshi Nishina, Kiwamu Okita
  • Journal Title: J. Hepat. Panc. Surg. 12 Pages: 203-207
  • NAID: 10016432356
• [Journal Article] Development of cell therapy using autologous bone marrow cells for liver cirrhosis. (2005)
  • Author(s): Sakaida I, Terai S, Nishina H, Okita K
  • Journal Title: Med Mol Morphol. 38 Pages: 197-202
  • NAID: 10018373531
• [Journal Article] Purification and analysis of RIN family - novel Rab5 GEFs. (2005)
  • Author(s): Saito, K., Kajiho, H., Araki, Y., Kurosu, H., Kontani, K., Nishina, H., Katada, T.
  • Journal Title: Methods Enzymol. 403 Pages: 276-283
• [Journal Article] MAPキナーゼとストレス応答 (2005)
  • Author(s): 浦誠司、仁科博史
  • Journal Title: シグナル伝達集中マスター
• [Journal Article] アダプター分子Gab2は骨密度を制御する (2005)
  • Author(s): 和田悌司、中島友樹、仁科博史、Josef M Penninger
  • Journal Title: 細胞工学 24 Pages: 704-705
• [Journal Article] Novel role of the small GTPase Rheb : Its implication in endocytic pathway independent of the activation of mammalian target of rapamycin. (2005)
  • Author(s): Kota Saito, et al.
  • Journal Title: J.Biochem. 137 Pages: 423-430
• [Journal Article] Human homologue of Maid (HHM) is a useful marker protein in hepatocarcinogenesis. (2005)
  • Author(s): Taro Takami, et al.
  • Journal Title: Gastroenterology 128 Pages: 1369-1380
• [Journal Article] Fibroblast growth factor 2 facilitates the differentiation of transplanted bone marrow cells into hepatocytes. (2005)
  • Author(s): Tsuyoshi Ishikawa, et al.
  • Journal Title: Cell Tissue Res. 14 Pages: 1-11
• [Journal Article] Autoamplification of NFATc1 determines its essential role in bone homeostasis. (2005)
  • Author(s): Masataka Asagiri, et al.
  • Journal Title: J.Exp.Med. 202 Pages: 1261-1269
• [Journal Article] Lesson from the GFP/CCl4 model-Translational Research Project : the development of cell therapy using autologous bone marrow cells in patients with liver cirrhosis. (2005)
  • Author(s): Shuji Terai, et al.
  • Journal Title: J.Hep.Panc.Surg. 12 Pages: 203-207
• [Journal Article] Development of cell therapy using autologous bone marrow cells for liver cirrhosis. (2005)
  • Author(s): Isao Sakaida, et al.
  • Journal Title: Med Mol Morphol. 38 Pages: 197-202
• [Presentation] 細胞死調節因子Daxxによる分子時計制御 (2010)
  • Author(s): 仁科博史
  • Organizer: 第9回細胞死研究会
  • Place of Presentation: 京都
• [Presentation] Physiological roles of Hippo signaling pathway using Medaka, Oryzias Latipes (2009)
  • Author(s): Hiroshi Nishina
  • Organizer: RASSF First International Symposium
  • Place of Presentation: Banff, Canada
  • Year and Date: 2009-02-04
• [Presentation] Physiological roles of Hippo signaling pathway using Medaka, Oryzias Latipes. (2009)
  • Author(s): Hiroshi Nishina
  • Organizer: RASSF First International Symposium
  • Place of Presentation: Banff, Canada
• [Presentation] JNK阻害剤SP600125の特異性について (2009)
  • Author(s): 仁科博史
  • Organizer: 第9回日本肝臓医生物学研究会
  • Place of Presentation: 山口
• [Presentation] モデル生物を用いた「細胞の生と死」を制御するシグナル伝達系の解析 (2009)
  • Author(s): 仁科博史
  • Organizer: 埼玉大学セミナー
  • Place of Presentation: 浦和
• [Presentation] 小型魚類を用いたSAPK/JNKシグナル系の解析 (2009)
  • Author(s): 仁科博史
  • Organizer: 生理学研究所セミナー
  • Place of Presentation: 岡崎
• [Presentation] MAPキナーゼ系を介したDNA損傷修復と概日リズムの制御 (2009)
  • Author(s): 宮村憲央, 他
  • Organizer: 日本薬学会第129年会
  • Place of Presentation: 京都
• [Presentation] 肝臓の左右逆位を示すメダカ変異体kendamaの解析 (2009)
  • Author(s): 長井陽子, 他
  • Organizer: 日本薬学会第129年会
  • Place of Presentation: 京都
• [Presentation] 顕微質量分析装置を用いた再生肝の解析 (2009)
  • Author(s): 中村貴、仁科博史
  • Organizer: 第10回日本肝臓医生物学研究会
  • Place of Presentation: 金沢
• [Presentation] 顕微質量分析装置を用いた再生肝の解析 (2009)
  • Author(s): 中村貴、仁科博史
  • Organizer: 第16回肝細胞研究会
  • Place of Presentation: 山形
• [Presentation] NMD制御因子Upf1はユビキチンリガーゼとして機能する (2009)
  • Author(s): 高橋真也, 堅田利明, 仁科博史
  • Organizer: RNA学会
  • Place of Presentation: 新潟
• [Presentation] リゾホスファチジン酸産生酵素オートタキシンの血管形成過程における役割 (2009)
  • Author(s): 濱弘太郎、中永景太、田中将之、浅岡洋一、仁科博史、青木淳賢
  • Organizer: 第15回小型魚類研究会
  • Place of Presentation: 名古屋
• [Presentation] 共培養系を用いた高効率なPrPSc伝播実験系の確立 (2009)
  • Author(s): 田中正彦、原英之、萩原健一、花田賢太郎、仁科博史、前濱朝彦
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸
• [Presentation] 胎仔肝増殖シグナルを担うSAPK/JNK活性化機構の解析 (2009)
  • Author(s): 仁科博史
  • Organizer: 第11回日本肝臓医生物学研究会
  • Place of Presentation: 東京
• [Presentation] メダカ扁平胚hirame変異体の単離と解析 (2009)
  • Author(s): 仁科博史
  • Organizer: 理化学研究所CDB
  • Place of Presentation: 神戸
• [Presentation] 扁平胚の表現型を示すYAPメダカ変異体の単離と解析 (2009)
  • Author(s): 仁科博史、古谷-清木誠
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸
• [Presentation] P-body形成の生理的意義とその分子機構の解析 (2009)
  • Author(s): 櫻井京子、高橋真也, 他
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸
• [Presentation] 紫外線照射時のJNK活性化制御機構におけるRASSF7の関与 (2009)
  • Author(s): 蛯原有紗、高橋真也, 他
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸
• [Presentation] 共培養系を用いた高効率なPrPSc伝搬実験系の確立 (2009)
  • Author(s): 田中正彦, 他
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸
• [Presentation] 初期胚形成不全メダカsakuraの解析 (2009)
  • Author(s): 大野真見, 他
  • Organizer: 第8回ファーマバイオフォーラム
  • Place of Presentation: 名古屋
• [Presentation] 細胞死関連因子DAXXによる概日リズム制御機構の解明 (2009)
  • Author(s): 内田好海, 他
  • Organizer: 第8回ファーマバイオフォーラム
  • Place of Presentation: 名古屋
• [Presentation] 小型魚類を用いた器官形成シグナルの解析 (2009)
  • Author(s): 仁科博史
  • Organizer: 東京大学薬学セミナー
  • Place of Presentation: 東京
• [Presentation] Retinoic acid signaling positively regulates liver specification by inducing wnt2bb gene expression (2008)
  • Author(s): Takahiro Negishi and Hiroshi Nishina
  • Organizer: FASEB Summer Research Conferences
  • Place of Presentation: Snowmass, USA
  • Year and Date: 2008-08-04
• [Presentation] Mutations affecting liver development and function in Medaka, Oryzias Latipes. (2008)
  • Author(s): Hiroshi Nishina
  • Organizer: The 54th NIBB Conference
  • Place of Presentation: Okazaki, Japan
• [Presentation] Retinoic acid signaling positively regulates liver specification by inducing wnt2bb gene expression. (2008)
  • Author(s): Takahiro Negishi, Hiroshi Nishina
  • Organizer: FASEB Summer Research Conferences
  • Place of Presentation: Snowmass, USA
• [Presentation] Caf1 regulates translocation of ribonucleotide reductase by releasing nucleoplasmic Spd1-Suc22 assembly (2008)
  • Author(s): Shinya Takahashi, Toshiaki Katada, Hiroshi Nishina
  • Organizer: RNA 2008 Thirteenth Annual Meeting of the RNA Society
  • Place of Presentation: Berlin, Germany
• [Presentation] 肝形成不全メダカの単離と解析 (2008)
  • Author(s): 根岸崇大、仁科博史
  • Organizer: 第6回日本肝臓医生物学研究会
  • Place of Presentation: 東京
• [Presentation] 細胞の生死および組織・器官の形成を制御するHippoシグナル伝達系 (2008)
  • Author(s): 仁科博史
  • Organizer: 山口肝臓シンポジウム
  • Place of Presentation: 宇部
• [Presentation] 小型魚類を用いた肝疾患モデルスクリーニング (2008)
  • Author(s): 仁科博史
  • Organizer: 日本製薬工業協会・創薬部会
  • Place of Presentation: 東京
• [Presentation] マウスやメダカを用いた器官形成の研究 (2008)
  • Author(s): 仁科博史
  • Organizer: 東京工業大学
  • Place of Presentation: 横浜
• [Presentation] 小型魚類を用いた組織や器官形成に関わるシグナル伝達系の解析 (2008)
  • Author(s): 仁科博史
  • Organizer: 千葉大学医学部発生生物学セミナー
  • Place of Presentation: 千葉
• [Presentation] ヒト疾患を模倣するメダカ変異体の単離と薬剤スクリーニング系の開発 (2008)
  • Author(s): 仁科博史
  • Organizer: JAXA宇宙生物学研究室セミナー
  • Place of Presentation: 東京
• [Presentation] 小型魚類を用いたシグナル伝達系の解析 (2008)
  • Author(s): 仁科博史
  • Organizer: Metabolic Research: Cutting Edge
  • Place of Presentation: 東京
• [Presentation] 肝臓学の動向 (2008)
  • Author(s): 仁科博史
  • Organizer: 早稲田大学先進理工学部
  • Place of Presentation: 東京
• [Presentation] 肝臓位置異常メダカ変異体kendamaの解析 (2008)
  • Author(s): 長井陽子, 他
  • Organizer: ファーマバイオフォーラム2008
  • Place of Presentation: 東京
• [Presentation] DNA修復と概日リズムを共通に制御する光シグナル伝達系 (2008)
  • Author(s): 宮村憲央, 他
  • Organizer: ファーマバイオフォーラム2008
  • Place of Presentation: 東京
• [Presentation] 脊椎動物の初期胚形成制御におけるSAPK/JNKシグナル伝達系の役割 (2008)
  • Author(s): 仁科博史
  • Organizer: BMB2008
  • Place of Presentation: 神戸
• [Presentation] 肝臓形成異常メダカ変異体の単離と解析 (2008)
  • Author(s): 根岸崇大, 他
  • Organizer: BMB2008
  • Place of Presentation: 神戸
• [Presentation] Upf因子群によるNMD (Nonsense-mediated mRNA decay)経路の新規活性化機構 (2008)
  • Author(s): 高橋真也, 他
  • Organizer: BMB2008
  • Place of Presentation: 神戸
• [Presentation] マウスやメダカを用いた肝形成および肝再生機構の解明 (2007)
  • Author(s): 仁科博史
  • Organizer: 日本肝臓医生物学研究会
  • Place of Presentation: 秋田
• [Presentation] 肝機能異常変異メダカを用いた脂質代謝・動態解析[特定領域研究「生体膜トランスポートソームの分子構築と生理機能」 (2007)
  • Author(s): 浅岡洋一, 他
  • Organizer: 第一回若手ワークショップ
  • Place of Presentation: 静岡
• [Presentation] 肝形成および肝機能不全メダカの単離と解析 (2007)
  • Author(s): 仁科博史
  • Organizer: 日本再生医療学会
  • Place of Presentation: 横浜
• [Presentation] 細胞内輸送を制御するシグナル伝達系の解明 (2007)
  • Author(s): 仁科博史
  • Organizer: 日本生理学大会
  • Place of Presentation: 大阪
• [Presentation] 眼形成遺伝子Pax6アイソフォームの機能解析 (2007)
  • Author(s): 仁科博史
  • Organizer: 日本眼科学会総会
  • Place of Presentation: 大阪
• [Presentation] マウス胎仔肝特異抗原Liv8の同定と機能解析 (2007)
  • Author(s): 仁科博史
  • Organizer: 肝細胞研究会
  • Place of Presentation: 鹿児島
• [Presentation] 脊椎動物モデル生物を用いたストレスシグナルおよび肝形成機構の解明 (2007)
  • Author(s): 仁科博史
  • Organizer: 東京大学医科学研究所学友会セミナー
  • Place of Presentation: 東京
• [Presentation] マウスやメダカを用いた肝形成機構の解明 (2007)
  • Author(s): 仁科博史
  • Organizer: 生命科学研究会
  • Place of Presentation: 千葉
• [Presentation] プログラム細胞死実行プロセスにおけるJNKの役割 (2007)
  • Author(s): 浦誠司、仁科博史
  • Organizer: 生命科学研究会
  • Place of Presentation: 千葉
• [Presentation] ストレス応答性SAPK/JNK活性化と細胞の核内イベント (2007)
  • Author(s): 仁科博史
  • Organizer: 生理学研究所セミナー
  • Place of Presentation: 岡崎
• [Presentation] 細胞の生死および組織・器官の形成を制御するHippoシグナル伝達系 (2007)
  • Author(s): 仁科博史
  • Organizer: 秋田大学医学部
  • Place of Presentation: 秋田
• [Presentation] ゼブラフィッシュ松果体に特異的に発現するエクソロドプシンの転写活性化機構 (2007)
  • Author(s): 浅岡洋一, 他
  • Organizer: 小型魚類研究会
  • Place of Presentation: 東京
• [Presentation] 扁平胚の表現型を示すメダカ変異体hirameの解析 (2007)
  • Author(s): 阿部美穂子, 他
  • Organizer: 小型魚類研究会
  • Place of Presentation: 東京
• [Presentation] 肝臓の左右逆位を示すメダカ変異体kendamaの表現型解析 (2007)
  • Author(s): 長井陽子, 他
  • Organizer: 小型魚類研究会
  • Place of Presentation: 東京
• [Presentation] 女性ホルモンによる骨代謝制御メカニズム (2007)
  • Author(s): 中村貴
  • Organizer: 分子代謝医学セミナー
  • Place of Presentation: 東京
• [Presentation] メダカを用いた研究-その新規性また利点- (2007)
  • Author(s): 仁科博史
  • Organizer: 第1回産学官連携新産業創出研究会
  • Place of Presentation: 宇部
• [Presentation] アポトーシスにおける核凝集の初期プロセスにはJNKの活性化が必要である (2007)
  • Author(s): 浦誠司, 他
  • Organizer: BMB2007
  • Place of Presentation: 横浜
• [Presentation] モデル生物を用いた生物学主催 (2007)
  • Author(s): 仁科博史、飯野雄一
  • Organizer: BMB2007
  • Place of Presentation: 横浜
• [Presentation] Mutations Affecting Liver Development and Function in Medaka, Oryzias Latipes. (2006)
  • Author(s): Hiroshi Nishina
  • Organizer: The 2nd International Symposium on Developmental Biology and Tissue Engineering
  • Place of Presentation: Tokyo, Japan
• [Presentation] Release of RASSF1C from the nucleus by Daxx degradation links DNA damage and SAPK/JNK activation. (2006)
  • Author(s): Daiju Kitagawa, Toshiaki Katada, Hiroshi Nishina
  • Organizer: 20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress
  • Place of Presentation: Kyoto, Japan
• [Presentation] Liver and defective spleen formation by a novel medaka mutation kendama affecting liver laterality. (2006)
  • Author(s): Yoko Nagai, Tomomi Watanabe, Hiroshi Mitani, Toshiaki Katada, Hisato Kondoh, Makoto Furutani-Seiki, Hiroshi Nishina
  • Organizer: 20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress
  • Place of Presentation: Kyoto, Japan
• [Presentation] JNK is Essential and Sufficient in MST1-induced Caspase-independent Nuclear Condensation. (2006)
  • Author(s): Seiji Ura, Hiroshi Nishina, Yukiko Gotoh, Toshiaki Katada
  • Organizer: 20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress
  • Place of Presentation: Kyoto, Japan
• [Presentation] Pineal photoreceptor cell-specific gene regulation in the zebrafish. (2006)
  • Author(s): Yoichi Asaoka, Hiroaki Mano, Daisuke Kojima, Yoshitaka Fukada
  • Organizer: 20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress
  • Place of Presentation: Kyoto, Japan
• [Presentation] Identification and analysis of a homeobox gene, CrxOS, specifically expressed in murine embryonic stem cells. (2006)
  • Author(s): Ryota Saito, Hiroshi Nishina, Toshiaki Katada
  • Organizer: 20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress
  • Place of Presentation: Kyoto, Japan
• [Presentation] Mutations affecting liver development and function in Medaka, Oryzias Latipes. (2006)
  • Author(s): Hiroshi Nishina
  • Organizer: FASEB Summer Research Conferences
  • Place of Presentation: Snowmass, USA
• [Presentation] 細胞死研究の新たな展開と関連する素過程 (2006)
  • Author(s): 仁科博史
  • Organizer: 平成18年度生理学研究所研究会
  • Place of Presentation: 岡崎
• [Presentation] ストレス応答に介在するプロテインキナーゼカスケード (2006)
  • Author(s): 仁科博史
  • Organizer: 東京大学薬学部セミナー
  • Place of Presentation: 東京
• [Presentation] マウスやメダカを用いた肝形成および肝再生機構の解明 (2006)
  • Author(s): 仁科博史
  • Organizer: 日本発生生物学会
  • Place of Presentation: 広島
• [Presentation] 肝形成および肝機能変異メダカの単離と解析 (2006)
  • Author(s): 仁科博史
  • Organizer: 肝細胞研究会
  • Place of Presentation: 旭川
• [Presentation] エストロゲンの骨代謝調節メカニズム (2006)
  • Author(s): 中村貴, 他
  • Organizer: 日本骨代謝学会
  • Place of Presentation: 東京
• [Presentation] ゼブラフィッシュ松果体の光受容細胞に特異的な遺伝子発現メカニズム (2006)
  • Author(s): 浅岡洋一, 他
  • Organizer: 日本比較生理生化学会第28回大会
  • Place of Presentation: 浜松
• [Presentation] 細胞外マトリクスとの相互作用の異常によりユニークな形態形成異常を示すメダカ変異体の解析 (2006)
  • Author(s): 浅香聡, 他
  • Organizer: 日本分子生物学会2006フォーラム
  • Place of Presentation: 名古屋
• [Presentation] Mutations Affecting Liver Development and Function in Medaka, Oryzias Latipes. (2005)
  • Author(s): Hiroshi Nishina
  • Organizer: 4th Surugadai Symposium
  • Place of Presentation: Tokyo, Japan
• [Presentation] Non-alcoholic fatty liver and defective spleen formation in a novel medaka mutant kendama affecting liver laterality. (2005)
  • Author(s): Tomomi Watanabe, Hiroshi Mitani, Toshiaki Katada, Hisato Kondoh, Makoto Furutani-Seiki, Hiroshi Nishina
  • Organizer: 4th European Zebrafish Genetics and Development Meeting
  • Place of Presentation: Dresden, Germany
• [Presentation] Analysis of hirame mutation affecting migration and integration of organ progenitors. (2005)
  • Author(s): S Asaka, T Sasaki, Y Osada, N Shimizu, H Himmelbauer, R Geisler, H Mitani, T Katada, H Nishina, H Kondoh, M Furutani-Seiki
  • Organizer: 4th European Zebrafish Genetics and Development Meeting
  • Place of Presentation: Dresden, Germany
• [Presentation] 肝形成研究から肝再生医療へ (2005)
  • Author(s): 仁科博史
  • Organizer: 第39回神戸バイオサイエンス研究会
  • Place of Presentation: 神戸
• [Presentation] マウスやメダカを用いた肝形成および肝機能の解明 (2005)
  • Author(s): 仁科博史
  • Organizer: 静岡大学シンポジウム
  • Place of Presentation: 静岡
• [Presentation] 細胞増殖、がん、老化~ストレスキナーゼのシーソーゲーム~ (2005)
  • Author(s): 和田悌司
  • Organizer: 東京大学薬学部セミナー
  • Place of Presentation: 東京
• [Presentation] メンブラントラフィックに介在する新規Rab5ヌクレオチド交換因子の機能解析[文部科学省特定領域研究「メンブラントラフィック-分子機構から高次機能への展開-」 (2005)
  • Author(s): 仁科博史、梶保博昭、堅田利明
  • Organizer: 公開シンポジウム
  • Place of Presentation: 草津
• [Presentation] 小型魚類を用いた肝発生及び肝機能の解析 (2005)
  • Author(s): 渡辺智美、仁科博史
  • Organizer: 第18回肝再生研究会
  • Place of Presentation: 東京
• [Presentation] モデル生物を用いた肝発生と肝再生の解明 (2005)
  • Author(s): 仁科博史
  • Organizer: 第1回山口大学イブニングセミナー・イン東京
  • Place of Presentation: 東京
• [Presentation] 細胞死・細胞増殖制御を司る新しいシグナル伝達系Hippo pathway
  • Author(s): 仁科博史、畑裕
  • Organizer: 世話人シンポジウム
• [Book] シグナル伝達の分子機構:ベーシックマスター生化学 (2008)
  • Author(s): 仁科博史
  • Publisher: オーム社
• [Book] ベーシックマスター生化学 (2008)
  • Author(s): 仁科博
  • Total Pages: 414
  • Publisher: オーム社
• [Book] MAPキナーゼ;生物薬科学実験講座(石橋貞彦、市川厚、堅田利明編) (2005)
  • Author(s): 仁科博史、堅田利明
  • Publisher: 廣川書店
• [Book] 細胞を利用した治療;医薬品の開発と生産 (2005)
  • Author(s): 仁科博史
  • Publisher: 東京化学同人
• [Book] The Biological Function of JNKKs (MKK4/MKK7 Knockout Mice)(Anning Lin, eds, in The JNK Signaling Pathway) (2005)
  • Author(s): Hiroshi Nishina, Toshiaki Katada
  • Publisher: Landes Bioscience
• [Book] The JNK Signaling Pathway (2005)
  • Author(s): Hiroshi Nishina, et al.
  • Total Pages: 93
  • Publisher: Landes Bioscience, Texas, USA
• [Remarks] l#プレスリリース2009年12月4日時事ドットコム、日本経済新聞、12月6日朝日新聞、NHKニュース2010年2月4日読売新聞
  • URL: http://www.tmd.ac.jp/mri/dbio/index.htm
• [Remarks]
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• [Remarks]
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