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Regulation of cellular localization and activation of the transpotsome by G proteins and MAP kinases

Research Project

Project/Area Number 17081005
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionTokyo Medical and Dental University

Principal Investigator

NISHINA Hiroshi  Tokyo Medical and Dental University, 難治疾患研究所, 教授 (60212122)

Co-Investigator(Kenkyū-buntansha) NAKAMURA Takashi  東京医科歯科大学, 難治疾患研究所, 助教 (80431948)
ASAOKA Yoichi  東京医科歯科大学, 難治疾患研究所, 助教 (10436644)
和田 悌司  東京医科歯科大学, 難治疾患研究所, 助手 (80401389)
Project Period (FY) 2005 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥40,800,000 (Direct Cost: ¥40,800,000)
Fiscal Year 2009: ¥7,800,000 (Direct Cost: ¥7,800,000)
Fiscal Year 2008: ¥7,800,000 (Direct Cost: ¥7,800,000)
Fiscal Year 2007: ¥10,200,000 (Direct Cost: ¥10,200,000)
Fiscal Year 2006: ¥10,200,000 (Direct Cost: ¥10,200,000)
Fiscal Year 2005: ¥4,800,000 (Direct Cost: ¥4,800,000)
Keywords発生生物学 / 細胞生物学 / 生体膜 / 輸送 / イオンチャネル / トランスポーター / 細胞増殖 / 細胞死 / RIN / Hippo / 細胞膜 / 細胞接着 / 細胞極性 / MAPキナーゼ / Hippoシグナル / メダカ / 小胞輸送 / 低分子量G蛋白質 / Rab5 / Rheb / アンフィファイシンII / 結節硬化症 / てんかん / G蛋白質
Research Abstract

Ion channels and transporters play essential roles in cellular hemeostasis. "Transportsome", which a complex of these molecules inside the cellmembrane, is known to be involved in cell proliferation, death, and polarity. We found thatstress-responsive SAPK/JNK and Hippo signaling pathways downstream of thetransportsome, regulate cellular survival and death, proliferation, and polarity.

Report

(6 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (152 results)

All 2010 2009 2008 2007 2006 2005 Other

All Journal Article (61 results) (of which Peer Reviewed: 11 results) Presentation (81 results) Book (6 results) Remarks (4 results)

  • [Journal Article] Involvement of JNK in the regulation of autophagic cell death.2010

    • Author(s)
      Shigeomi Shimizu, Akimitsu Konishi, Yuya Nishida, Takeshi Mizuta, Hiroshi Nishina, Akitsugu Yamamoto, Yoshihide Tsujimoto
    • Journal Title

      Oncogene (in press)

    • Related Report
      2009 Final Research Report
  • [Journal Article] Retinoic acid signaling positively regulates liver specification by inducing wnt2bb gene expression in medaka.2010

    • Author(s)
      Takahiro Negishi, Yoko Nagai, Yoichi Asaoka, Mami Ohno, Misako Namae, Hiroshi Mitani, Takashi Sasaki, Nobuyoshi Shimizu, Shuji Terai, Isao Sakaida, Hisato Kondoh, Toshiaki Katada, Makoto Furutani-Seiki, Hiroshi Nishina
    • Journal Title

      Hepatology (in press)

    • Related Report
      2009 Final Research Report
  • [Journal Article] Medaka as a Novel and Accurate Model for Human Nonalcoholic Steatohepatitis.2010

    • Author(s)
      Toshihiko Matsumoto, Shuji Terai, Toshiyuki Oishi, Shinya Kuwashiro, Koichi Fujisawa, Naoki Yamamoto, Yusuke Fujita, Yoshihiko Hamamoto, Makoto Furutani-Seiki, Hiroshi Nishina, Isao Sakaida
    • Journal Title

      Disease Models & Mechanisms (in press)

    • Related Report
      2009 Final Research Report
  • [Journal Article] A common origin: signaling similarities in the regulation of the circadian clock and DNA damage responses.2010

    • Author(s)
      Yoshimi Uchida, Jun Hirayama, Hiroshi Nishina
    • Journal Title

      Biol. Pharm. Bull. (in press)

    • NAID

      130000247995

    • Related Report
      2009 Final Research Report
  • [Journal Article] Utility and limitations of SP600125, an inhibitor of stressresponsive c-Jun N-terminal kinase.2010

    • Author(s)
      Shuhei Tanemura, Tokiwa Yamasaki, Toshiaki Katada, Hiroshi Nishina
    • Journal Title

      Curr. Enzym. Inhib. 6

      Pages: 26-33

    • Related Report
      2009 Final Research Report
  • [Journal Article] 「メタボロームの分布可視化法について」メタボロミクスと最新分子マーカー研究・メタボロミクスの基盤技術、メディカル・ドゥ2010

    • Author(s)
      中村貴、早坂孝宏、井上菜穂子、仁科博史、瀬藤光利
    • Journal Title

      遺伝子医学MOOK 16号(in press)

    • Related Report
      2009 Final Research Report
  • [Journal Article] Medaka: a promising model animal for comparative population genomics2009

    • Author(s)
      Yoshifumi Matsumoto, Hiroki Oota, Yoichi Asaoka, Hiroshi Nishina, Koji Watanabe, Janusz M Bujnicki, Shoji Oda, Shoji Kawamura, Hiroshi Mitani
    • Journal Title

      BMC Research Notes 2

      Pages: 88-88

    • Related Report
      2009 Final Research Report
  • [Journal Article] CLOCK:BMAL-independent circadian oscillation of zebrafish Cryptochrome1a gene.2009

    • Author(s)
      Norio Miyamura, Jun Hirayama, Kenji Sawanobori, Teruya Tamaru, Yoichi Asaoka, Reiko Honda, Takuro Yamamoto, Hatsume Uno, Ken Takamatsu, Hiroshi Nishina
    • Journal Title

      Biol. Pharm. Bull. 32

      Pages: 1183-1187

    • NAID

      130000117214

    • Related Report
      2009 Final Research Report
  • [Journal Article] Common light signaling pathways controlling DNA repair and circadian clock entrainment.2009

    • Author(s)
      Jun Hirayama, Norio Miyamura, Yoshimi Uchida, Yoichi Asaoka, Raiko Honda, Kenji Sawanobori, Takeshi Todo, Takuro Yamamoto, Paolo Sassone-Corsi, Hiroshi Nishina
    • Journal Title

      Cell Cycle 8

      Pages: 2794-27801

    • Related Report
      2009 Final Research Report
  • [Journal Article] Hematopoiesis-dependent expression of CD44 in murine hepatic progenitor cells.2009

    • Author(s)
      Shinya Ohata, Makiko Nawa, Takeshi Kasama, Tokiwa Yamasaki, Kenji Sawanobori, Shoji Hata, Takashi Nakamura, Yoichi Asaoka, Toshio Watanabe, Hitoshi Okamoto, Takahiko Hara, Shuji Terai, Isao Sakaida, Toshiaki Katada, Hiroshi Nishina
    • Journal Title

      Biochem. Biophys. Res. Commun. 379

      Pages: 817-823

    • Related Report
      2009 Final Research Report
  • [Journal Article] Blockage by SP600125 of Fce Receptor-induced degranulation and cytokine gene expression in mast cells is mediated through inhibition of phosphatidylinositol 3-kinase signaling pathway.2009

    • Author(s)
      Shuhei Tanemura, Haruka Momose, Nao Shimizu, Daiju Kitagawa, Jungwon Seo, Tokiwa Yamasaki, Kentaro Nakagawa, Hiroaki Kajiho, Josef M. Penninger, Toshiaki Katada, Hiroshi Nishina
    • Journal Title

      J. Biochem. 145

      Pages: 345-354

    • Related Report
      2009 Final Research Report
  • [Journal Article] CrxOS Maintains Self-Renewal Capacity of Murine Embryonic Stem Cells.2009

    • Author(s)
      Ryota Saito, Tokiwa Yamasaki, Yoko Nagai, Jinzhan Wu, Hiroaki Kajiho, Tadashi Yokoi, Eiichiro Noda, Sachiko Nishina, Hitoshi Niwa, Noriyuki Azuma, Toshiaki Katada, Hiroshi Nishina
    • Journal Title

      Biochem. Biophys. Res. Commun. 390

      Pages: 1129-1135

    • Related Report
      2009 Final Research Report
  • [Journal Article] Pax6-5a Promotes Neuronal Differentiation of Murine Embryonic Stem Cells.2009

    • Author(s)
      Nao Shimizu, Hajime Watanabe, Junko Kubota, Jinzhan Wu, Ryota Saito, Tadashi Yokoi, Takumi Era, Takeshi Iwatsubo, Takashi Watanabe, Sachiko Nishina, Noriyuki Azuma, Toshiaki Katada, Hiroshi Nishina
    • Journal Title

      Biol. Pharm. Bull. 32

      Pages: 999-1003

    • NAID

      130000117177

    • Related Report
      2009 Final Research Report
  • [Journal Article] Liver development: lessons from knockout mice and mutant fish.2009

    • Author(s)
      Takashi Nakamura, Hiroshi Nishina
    • Journal Title

      Hepatol. Res. 39

      Pages: 633-644

    • NAID

      10025326462

    • Related Report
      2009 Final Research Report
  • [Journal Article] Medaka : a promising model animal for comparative population genomics2009

    • Author(s)
      Matsumoto, Y, et al.
    • Journal Title

      BMC Research Notes 2

      Pages: 88-88

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Common light signaling pathways controlling DNA repair and circadian clock entrainment2009

    • Author(s)
      Hirayama, J, et al.
    • Journal Title

      Cell Cycle 8

      Pages: 2794-27801

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hematopoiesis-dependent expression of CD44 in murine hepatic progenitor cells2009

    • Author(s)
      Ohata, S, et al.
    • Journal Title

      Biochem.Biophys.Res.Commun. 379

      Pages: 817-823

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Upf1 potentially serves as a RING-related E3 ubiquitin ligase via its association with Upf3 in yeast.2008

    • Author(s)
      Shinya Takahashi, Yasuhiro Araki, Yuriko Ohya, Takeshi Sakuno, Shin-ichi Hoshino, Kenji Kontani, Hiroshi Nishina, Toshiaki Katada
    • Journal Title

      RNA 14

      Pages: 1950-1958

    • Related Report
      2009 Final Research Report
  • [Journal Article] RalA functions as an indispensable signal mediator for nutrient sensing system.2008

    • Author(s)
      Tomohiko Maehama, Masahiko Tanaka, Hiroshi Nishina, Makoto Murakami, Yasunori Kanaho, Kentaro Hanada
    • Journal Title

      J. Biol. Chem. 283

      Pages: 5053-35059

    • Related Report
      2009 Final Research Report
  • [Journal Article] Novel antibody to human BASP1 labels apoptotic cells post-caspase activation.2008

    • Author(s)
      Shizue Ohsawa, Tomomi Watanabe, Toshiaki Katada, Hiroshi Nishina, Masayuki Miura
    • Journal Title

      Biochem. Biophys. Res. Commun. 371

      Pages: 639-643

    • Related Report
      2009 Final Research Report
  • [Journal Article] Continuous high expression of XBP1 and GRP78 is important for the survival of bone marrow cells in CCl4-treated cirrhotic liver.2008

    • Author(s)
      Yoshio Marumoto, Shuji Terai, Yohei Urata, Toshihiko Matsumoto, Yuko Mizunaga, Naoki Yamamoto, Haiyan Jin, Koichi Fujisawa, Tomoaki Murata, Koh Shinoda, Hiroshi Nishina, Isao Sakaida
    • Journal Title

      Biochem. Biophys. Res. Commun. 367

      Pages: 546-552

    • Related Report
      2009 Final Research Report
  • [Journal Article] Antagonistic control of cell fates by JNK and p38-MAPK signaling.2008

    • Author(s)
      Wada T, Stepniak E, Hui L, Leibbrandt A, Katada T, Nishina H, Wagner EF, Penninger JM.
    • Journal Title

      Cell Death Differ. 15

      Pages: 89-93

    • Related Report
      2009 Final Research Report
  • [Journal Article] Antagonistic control of cell fates by JNK and p38-MAPK signaling2008

    • Author(s)
      Wada T, et.al.
    • Journal Title

      Cell Death Differ 15

      Pages: 89-93

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Continuous high expression of XBP1 and GRP78 is important for the survival of bone marrow cells in CCl4-treated cirrhotic liver2008

    • Author(s)
      Yoshio Marumoto, et.al.
    • Journal Title

      Biochem. Biophys. Res. Commun. 367 367

      Pages: 546-552

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel antibody to human BASP1 labels apoptotic cells post-caspase activation2008

    • Author(s)
      Shizue Ohsawa, et.al.
    • Journal Title

      Biochem. Biophys. Commun 371

      Pages: 639-643

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Upfl potentially serves as a RING-related E3 ubiquitin ligase via its association with Upf3 in yeast2008

    • Author(s)
      Shinya Takahashi, et.al.
    • Journal Title

      RNA 14

      Pages: 1950-1958

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] RalA functions as an indispensable signal mediator for nutrient sensing system2008

    • Author(s)
      Tomohiko Maehama, et.al.
    • Journal Title

      J. BIOL. Chem 371

      Pages: 35053-35059

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antagonistic control of cell fates by JNK and p38-MAPK signaling.2008

    • Author(s)
      Teiji Wada, et. al.
    • Journal Title

      Cell Death Differ. 15

      Pages: 89-93

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation of the JNK patyway by MST1 is essential and sufficient for the induction of chromatin condensation during apoptosis.2007

    • Author(s)
      Seiji Ura, Hiroshi Nishina*, Yukiko Gotoh, Toshiaki Katada
    • Journal Title

      Mol. Cell. Biol. 27

      Pages: 5514-5522

    • Related Report
      2009 Final Research Report
  • [Journal Article] Estrogen prevents bone loss via estrogen receptor alpha and induction of Fas ligand in osteoclasts.2007

    • Author(s)
      Nakamura, T., Imai, Y., Matsumoto, T., Sato, S., Takeuchi, K., Igarashi, K., Harada, Y., Azuma, Y., Krust, A., Yamamoto, Y., Nishina, H., Takeda, S., Takayanagi, H., Metzger, D., Kanno, J., Takaoka, K., Martin, TJ., Chambon, P., Kato, S.
    • Journal Title

      Cell 130

      Pages: 811-823

    • Related Report
      2009 Final Research Report
  • [Journal Article] Administration of. Administration of fibroblast growth factor 2 in combination with bone marrow transplantation synergistically improves carbon tetrachloride-induced liver fibrosis in mice.2007

    • Author(s)
      Tsuyoshi Ishikawa, Shuji Terai, Yohei Urata, Yoshio Marumoto, Koji Aoyama, Tomoaki Murata, Yuko Mizunaga, Naoki Yamamoto, Hiroshi Nishina, Koh Shinoda, Isao Sakaida
    • Journal Title

      Cell Tissue Res. 327

      Pages: 463-470

    • Related Report
      2009 Final Research Report
  • [Journal Article] Liver development and regeneration: from laboratory study to clinical therapy.2007

    • Author(s)
      Shoji Hata, Misako Namae, Hiroshi Nishina
    • Journal Title

      Develop. Growth Differ. 49

      Pages: 163-170

    • NAID

      10018878732

    • Related Report
      2009 Final Research Report
  • [Journal Article] Liver development and regeneration: from laboratory study to clinical therapy.2007

    • Author(s)
      Shoji Hata, et. al.
    • Journal Title

      Develop. Growth Differ. 49

      Pages: 163-170

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation of the JNK patyway by MST1 is essential and sufficient for the induction of chromatin condensation during apoptosis.2007

    • Author(s)
      Seiji Ura, et. al.
    • Journal Title

      Mol. Cell. Biol. 27

      Pages: 5514-5522

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Release of RASSF1C from the nucleus by DAXX degradation links DNA damage and SAPK/JNK activation.2006

    • Author(s)
      Daiju Kitagawa, Hiroaki Kajiho, Takahiro Negishi, Seiji Ura, Tomomi Watanabe, Teiji Wada, Hidenori Ichijo, Toshiaki Katada, Hiroshi Nishina
    • Journal Title

      EMBO J. 25

      Pages: 3286-3297

    • Related Report
      2009 Final Research Report
  • [Journal Article] Proteomic analysis of serum marker proteins in recipient mice with liver cirrhosis after bone marrow cell transplantation.2006

    • Author(s)
      Yuichiro Yokoyama, Shuji Terai, Tsuyoshi Ishikawa, Koji Aoyama, Yohei Urata, Yoshio Marumoto, Toshihiko Matsumoto, Hiroshi Nishina, Kazuyuki Nakamura, Kiwamu Okita, Isao Sakaida
    • Journal Title

      Proteomics 6

      Pages: 2564-2570

    • Related Report
      2009 Final Research Report
  • [Journal Article] Fibroblast growth factor 2 facilitates the differentiation of transplanted bone marrow cells into hepatocytes.2006

    • Author(s)
      Tsuyoshi Ishikawa, Shuji Terai, Yohei Urata, Yoshio Marumoto, Koji Aoyama, Isao Sakaida, Tomoaki Murata, Hiroshi Nishina, Koh Shinoda, Shunji Uchimura, Yoshihiko Hamamoto, Kiwamu Okita
    • Journal Title

      Cell Tissue Res. 323

      Pages: 221-231

    • Related Report
      2009 Final Research Report
  • [Journal Article] 多施設臨床研究:肝硬変症に対するAMBI療法の開発2006

    • Author(s)
      寺井崇二、浦田洋平、丸本芳雄、石川剛、青山浩司、大森薫、山本直樹、坂井田功、仁科博史、奥本和夫、斎藤貴史、河田純男、沖田極
    • Journal Title

      再生医療 5

      Pages: 79-87

    • Related Report
      2009 Final Research Report
  • [Journal Article] 新規核内複合体Daxx-RASSF1CはDNA損傷センサーとして機能してシグナルを核から細胞質へと伝達する2006

    • Author(s)
      北川大樹、堅田利明、仁科博史
    • Journal Title

      細胞工学 25

      Pages: 1178-1179

    • Related Report
      2009 Final Research Report
  • [Journal Article] 1枚の写真館 肝臓に生じたブラックホール?2006

    • Author(s)
      仁科博史
    • Journal Title

      細胞工学 25

    • Related Report
      2009 Final Research Report
  • [Journal Article] Release of RASSF1C from the nucleus by Daxx degradation links DNA damage and SAPK/JNK activation.2006

    • Author(s)
      Daiju Kitagawa, et al.
    • Journal Title

      EMBO J. 25

      Pages: 3286-3297

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Fibroblast growth factor 2 facilitates the differentiation of transplanted bone marrow cells into hepatocytes.2006

    • Author(s)
      Tsuyoshi Ishikawa, et al.
    • Journal Title

      Cell Tissue Res. 323

      Pages: 221-231

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Proteomic analysis of serum marker proteins in recipient mice with liver cirrhosis after bone marrow cell transplantation.2006

    • Author(s)
      Yuichiro Yokoyama, et al.
    • Journal Title

      Proteomics 6

      Pages: 2564-2570

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Premature ovarian failure in androgen receptor-deficient mice.2006

    • Author(s)
      Hiroko Shiina, et al.
    • Journal Title

      Proc Natl Acad Sci USA. 103

      Pages: 224-229

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Nuclear Receptor Mediated Gene Regulation through Chromatin Remodeling and Histone Modifications.2006

    • Author(s)
      Masahiko Kishimoto, et al.
    • Journal Title

      Endocrine J. 53

      Pages: 157-172

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 新規核内複合体Daxx-RASSF1CはDNA損傷センサーとして機能してシグナルを核から細胞質へと伝達する2006

    • Author(s)
      北川 大樹ら
    • Journal Title

      細胞工学 25

      Pages: 1178-1179

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Autoamplification of NFATc1 determines its essential role in bone homeostasis.2005

    • Author(s)
      Masataka Asagiri, Kojiro Sato, Takako Usami, Sae Ochi, Hiroshi Nishina, Hiroki Yoshida, Ikuo Morita, Erwin F. Wagner, Tak W. Mak, Edgar Serfling, Hiroshi Takayanagi
    • Journal Title

      J. Exp. Med. 202

      Pages: 1261-1269

    • Related Report
      2009 Final Research Report
  • [Journal Article] Human homologue of Maid (HHM) is a useful marker protein in hepatocarcinogenesis.2005

    • Author(s)
      Taro Takami, Shuji Terai, Yuichiro Yokoyama, Haruko Tanimoto, Kunihiko Tajima, Koichi Uchida, Takahiro Yamasaki, Isao Sakaida, Hiroshi Nishina, Snorri S. Thorgeirsson, Kiwamu Okita
    • Journal Title

      Gastroenterology 128

      Pages: 1369-1380

    • Related Report
      2009 Final Research Report
  • [Journal Article] Novel role of the small GTPase Rheb: Its implication in endocytic pathway independent of the activation of mammalian target of rapamycin.2005

    • Author(s)
      Saito K, Araki Y, Kontani K, Nishina H, Katada T.
    • Journal Title

      J. Biochem. 137

      Pages: 423-430

    • NAID

      10017344268

    • Related Report
      2009 Final Research Report
  • [Journal Article] RANK-RANKL signaling in osteoclastogenesis.2005

    • Author(s)
      Wada T, Nakashima T, Nishina H, Penninger JM
    • Journal Title

      Trends Mol Med. 12

      Pages: 17-25

    • Related Report
      2009 Final Research Report
  • [Journal Article] Lesson from the GFP/CCl4 model - Translational Research Project: the development of cell therapy using autologous bone marrow cells in patients with liver cirrhosis.2005

    • Author(s)
      Shuji Terai, Isao Sakaida, Hiroshi Nishina, Kiwamu Okita
    • Journal Title

      J. Hepat. Panc. Surg. 12

      Pages: 203-207

    • NAID

      10016432356

    • Related Report
      2009 Final Research Report
  • [Journal Article] Development of cell therapy using autologous bone marrow cells for liver cirrhosis.2005

    • Author(s)
      Sakaida I, Terai S, Nishina H, Okita K
    • Journal Title

      Med Mol Morphol. 38

      Pages: 197-202

    • NAID

      10018373531

    • Related Report
      2009 Final Research Report
  • [Journal Article] Purification and analysis of RIN family - novel Rab5 GEFs.2005

    • Author(s)
      Saito, K., Kajiho, H., Araki, Y., Kurosu, H., Kontani, K., Nishina, H., Katada, T.
    • Journal Title

      Methods Enzymol. 403

      Pages: 276-283

    • Related Report
      2009 Final Research Report
  • [Journal Article] MAPキナーゼとストレス応答2005

    • Author(s)
      浦誠司、仁科博史
    • Journal Title

      シグナル伝達集中マスター

    • Related Report
      2009 Final Research Report
  • [Journal Article] アダプター分子Gab2は骨密度を制御する2005

    • Author(s)
      和田悌司、中島友樹、仁科博史、Josef M Penninger
    • Journal Title

      細胞工学 24

      Pages: 704-705

    • Related Report
      2009 Final Research Report
  • [Journal Article] Novel role of the small GTPase Rheb : Its implication in endocytic pathway independent of the activation of mammalian target of rapamycin.2005

    • Author(s)
      Kota Saito, et al.
    • Journal Title

      J.Biochem. 137

      Pages: 423-430

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Human homologue of Maid (HHM) is a useful marker protein in hepatocarcinogenesis.2005

    • Author(s)
      Taro Takami, et al.
    • Journal Title

      Gastroenterology 128

      Pages: 1369-1380

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Fibroblast growth factor 2 facilitates the differentiation of transplanted bone marrow cells into hepatocytes.2005

    • Author(s)
      Tsuyoshi Ishikawa, et al.
    • Journal Title

      Cell Tissue Res. 14

      Pages: 1-11

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Autoamplification of NFATc1 determines its essential role in bone homeostasis.2005

    • Author(s)
      Masataka Asagiri, et al.
    • Journal Title

      J.Exp.Med. 202

      Pages: 1261-1269

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Lesson from the GFP/CCl4 model-Translational Research Project : the development of cell therapy using autologous bone marrow cells in patients with liver cirrhosis.2005

    • Author(s)
      Shuji Terai, et al.
    • Journal Title

      J.Hep.Panc.Surg. 12

      Pages: 203-207

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Development of cell therapy using autologous bone marrow cells for liver cirrhosis.2005

    • Author(s)
      Isao Sakaida, et al.
    • Journal Title

      Med Mol Morphol. 38

      Pages: 197-202

    • Related Report
      2005 Annual Research Report
  • [Presentation] 細胞死調節因子Daxxによる分子時計制御2010

    • Author(s)
      仁科博史
    • Organizer
      第9回細胞死研究会
    • Place of Presentation
      京都
    • Related Report
      2009 Final Research Report
  • [Presentation] Physiological roles of Hippo signaling pathway using Medaka, Oryzias Latipes2009

    • Author(s)
      Hiroshi Nishina
    • Organizer
      RASSF First International Symposium
    • Place of Presentation
      Banff, Canada
    • Year and Date
      2009-02-04
    • Related Report
      2008 Annual Research Report
  • [Presentation] Physiological roles of Hippo signaling pathway using Medaka, Oryzias Latipes.2009

    • Author(s)
      Hiroshi Nishina
    • Organizer
      RASSF First International Symposium
    • Place of Presentation
      Banff, Canada
    • Related Report
      2009 Final Research Report
  • [Presentation] JNK阻害剤SP600125の特異性について2009

    • Author(s)
      仁科博史
    • Organizer
      第9回日本肝臓医生物学研究会
    • Place of Presentation
      山口
    • Related Report
      2009 Final Research Report
  • [Presentation] モデル生物を用いた「細胞の生と死」を制御するシグナル伝達系の解析2009

    • Author(s)
      仁科博史
    • Organizer
      埼玉大学セミナー
    • Place of Presentation
      浦和
    • Related Report
      2009 Final Research Report
  • [Presentation] 小型魚類を用いたSAPK/JNKシグナル系の解析2009

    • Author(s)
      仁科博史
    • Organizer
      生理学研究所セミナー
    • Place of Presentation
      岡崎
    • Related Report
      2009 Final Research Report
  • [Presentation] MAPキナーゼ系を介したDNA損傷修復と概日リズムの制御2009

    • Author(s)
      宮村憲央, 他
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都
    • Related Report
      2009 Final Research Report
  • [Presentation] 肝臓の左右逆位を示すメダカ変異体kendamaの解析2009

    • Author(s)
      長井陽子, 他
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都
    • Related Report
      2009 Final Research Report
  • [Presentation] 顕微質量分析装置を用いた再生肝の解析2009

    • Author(s)
      中村貴、仁科博史
    • Organizer
      第10回日本肝臓医生物学研究会
    • Place of Presentation
      金沢
    • Related Report
      2009 Final Research Report
  • [Presentation] 顕微質量分析装置を用いた再生肝の解析2009

    • Author(s)
      中村貴、仁科博史
    • Organizer
      第16回肝細胞研究会
    • Place of Presentation
      山形
    • Related Report
      2009 Final Research Report
  • [Presentation] NMD制御因子Upf1はユビキチンリガーゼとして機能する2009

    • Author(s)
      高橋真也, 堅田利明, 仁科博史
    • Organizer
      RNA学会
    • Place of Presentation
      新潟
    • Related Report
      2009 Final Research Report
  • [Presentation] リゾホスファチジン酸産生酵素オートタキシンの血管形成過程における役割2009

    • Author(s)
      濱弘太郎、中永景太、田中将之、浅岡洋一、仁科博史、青木淳賢
    • Organizer
      第15回小型魚類研究会
    • Place of Presentation
      名古屋
    • Related Report
      2009 Final Research Report
  • [Presentation] 共培養系を用いた高効率なPrPSc伝播実験系の確立2009

    • Author(s)
      田中正彦、原英之、萩原健一、花田賢太郎、仁科博史、前濱朝彦
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸
    • Related Report
      2009 Final Research Report
  • [Presentation] 胎仔肝増殖シグナルを担うSAPK/JNK活性化機構の解析2009

    • Author(s)
      仁科博史
    • Organizer
      第11回日本肝臓医生物学研究会
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Presentation] メダカ扁平胚hirame変異体の単離と解析2009

    • Author(s)
      仁科博史
    • Organizer
      理化学研究所CDB
    • Place of Presentation
      神戸
    • Related Report
      2009 Final Research Report
  • [Presentation] 扁平胚の表現型を示すYAPメダカ変異体の単離と解析2009

    • Author(s)
      仁科博史、古谷-清木誠
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] P-body形成の生理的意義とその分子機構の解析2009

    • Author(s)
      櫻井京子、高橋真也, 他
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸
    • Related Report
      2009 Final Research Report
  • [Presentation] 紫外線照射時のJNK活性化制御機構におけるRASSF7の関与2009

    • Author(s)
      蛯原有紗、高橋真也, 他
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸
    • Related Report
      2009 Final Research Report
  • [Presentation] 共培養系を用いた高効率なPrPSc伝搬実験系の確立2009

    • Author(s)
      田中正彦, 他
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸
    • Related Report
      2009 Final Research Report
  • [Presentation] 初期胚形成不全メダカsakuraの解析2009

    • Author(s)
      大野真見, 他
    • Organizer
      第8回ファーマバイオフォーラム
    • Place of Presentation
      名古屋
    • Related Report
      2009 Final Research Report
  • [Presentation] 細胞死関連因子DAXXによる概日リズム制御機構の解明2009

    • Author(s)
      内田好海, 他
    • Organizer
      第8回ファーマバイオフォーラム
    • Place of Presentation
      名古屋
    • Related Report
      2009 Final Research Report
  • [Presentation] 小型魚類を用いた器官形成シグナルの解析2009

    • Author(s)
      仁科博史
    • Organizer
      東京大学薬学セミナー
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Presentation] Retinoic acid signaling positively regulates liver specification by inducing wnt2bb gene expression2008

    • Author(s)
      Takahiro Negishi and Hiroshi Nishina
    • Organizer
      FASEB Summer Research Conferences
    • Place of Presentation
      Snowmass, USA
    • Year and Date
      2008-08-04
    • Related Report
      2008 Annual Research Report
  • [Presentation] Mutations affecting liver development and function in Medaka, Oryzias Latipes.2008

    • Author(s)
      Hiroshi Nishina
    • Organizer
      The 54th NIBB Conference
    • Place of Presentation
      Okazaki, Japan
    • Related Report
      2009 Final Research Report
  • [Presentation] Retinoic acid signaling positively regulates liver specification by inducing wnt2bb gene expression.2008

    • Author(s)
      Takahiro Negishi, Hiroshi Nishina
    • Organizer
      FASEB Summer Research Conferences
    • Place of Presentation
      Snowmass, USA
    • Related Report
      2009 Final Research Report
  • [Presentation] Caf1 regulates translocation of ribonucleotide reductase by releasing nucleoplasmic Spd1-Suc22 assembly2008

    • Author(s)
      Shinya Takahashi, Toshiaki Katada, Hiroshi Nishina
    • Organizer
      RNA 2008 Thirteenth Annual Meeting of the RNA Society
    • Place of Presentation
      Berlin, Germany
    • Related Report
      2009 Final Research Report
  • [Presentation] 肝形成不全メダカの単離と解析2008

    • Author(s)
      根岸崇大、仁科博史
    • Organizer
      第6回日本肝臓医生物学研究会
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Presentation] 細胞の生死および組織・器官の形成を制御するHippoシグナル伝達系2008

    • Author(s)
      仁科博史
    • Organizer
      山口肝臓シンポジウム
    • Place of Presentation
      宇部
    • Related Report
      2009 Final Research Report
  • [Presentation] 小型魚類を用いた肝疾患モデルスクリーニング2008

    • Author(s)
      仁科博史
    • Organizer
      日本製薬工業協会・創薬部会
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Presentation] マウスやメダカを用いた器官形成の研究2008

    • Author(s)
      仁科博史
    • Organizer
      東京工業大学
    • Place of Presentation
      横浜
    • Related Report
      2009 Final Research Report
  • [Presentation] 小型魚類を用いた組織や器官形成に関わるシグナル伝達系の解析2008

    • Author(s)
      仁科博史
    • Organizer
      千葉大学医学部発生生物学セミナー
    • Place of Presentation
      千葉
    • Related Report
      2009 Final Research Report
  • [Presentation] ヒト疾患を模倣するメダカ変異体の単離と薬剤スクリーニング系の開発2008

    • Author(s)
      仁科博史
    • Organizer
      JAXA宇宙生物学研究室セミナー
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Presentation] 小型魚類を用いたシグナル伝達系の解析2008

    • Author(s)
      仁科博史
    • Organizer
      Metabolic Research: Cutting Edge
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Presentation] 肝臓学の動向2008

    • Author(s)
      仁科博史
    • Organizer
      早稲田大学先進理工学部
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Presentation] 肝臓位置異常メダカ変異体kendamaの解析2008

    • Author(s)
      長井陽子, 他
    • Organizer
      ファーマバイオフォーラム2008
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Presentation] DNA修復と概日リズムを共通に制御する光シグナル伝達系2008

    • Author(s)
      宮村憲央, 他
    • Organizer
      ファーマバイオフォーラム2008
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Presentation] 脊椎動物の初期胚形成制御におけるSAPK/JNKシグナル伝達系の役割2008

    • Author(s)
      仁科博史
    • Organizer
      BMB2008
    • Place of Presentation
      神戸
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] 肝臓形成異常メダカ変異体の単離と解析2008

    • Author(s)
      根岸崇大, 他
    • Organizer
      BMB2008
    • Place of Presentation
      神戸
    • Related Report
      2009 Final Research Report
  • [Presentation] Upf因子群によるNMD (Nonsense-mediated mRNA decay)経路の新規活性化機構2008

    • Author(s)
      高橋真也, 他
    • Organizer
      BMB2008
    • Place of Presentation
      神戸
    • Related Report
      2009 Final Research Report
  • [Presentation] マウスやメダカを用いた肝形成および肝再生機構の解明2007

    • Author(s)
      仁科博史
    • Organizer
      日本肝臓医生物学研究会
    • Place of Presentation
      秋田
    • Related Report
      2009 Final Research Report
  • [Presentation] 肝機能異常変異メダカを用いた脂質代謝・動態解析[特定領域研究「生体膜トランスポートソームの分子構築と生理機能」2007

    • Author(s)
      浅岡洋一, 他
    • Organizer
      第一回若手ワークショップ
    • Place of Presentation
      静岡
    • Related Report
      2009 Final Research Report
  • [Presentation] 肝形成および肝機能不全メダカの単離と解析2007

    • Author(s)
      仁科博史
    • Organizer
      日本再生医療学会
    • Place of Presentation
      横浜
    • Related Report
      2009 Final Research Report 2007 Annual Research Report
  • [Presentation] 細胞内輸送を制御するシグナル伝達系の解明2007

    • Author(s)
      仁科博史
    • Organizer
      日本生理学大会
    • Place of Presentation
      大阪
    • Related Report
      2009 Final Research Report
  • [Presentation] 眼形成遺伝子Pax6アイソフォームの機能解析2007

    • Author(s)
      仁科博史
    • Organizer
      日本眼科学会総会
    • Place of Presentation
      大阪
    • Related Report
      2009 Final Research Report
  • [Presentation] マウス胎仔肝特異抗原Liv8の同定と機能解析2007

    • Author(s)
      仁科博史
    • Organizer
      肝細胞研究会
    • Place of Presentation
      鹿児島
    • Related Report
      2009 Final Research Report
  • [Presentation] 脊椎動物モデル生物を用いたストレスシグナルおよび肝形成機構の解明2007

    • Author(s)
      仁科博史
    • Organizer
      東京大学医科学研究所学友会セミナー
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Presentation] マウスやメダカを用いた肝形成機構の解明2007

    • Author(s)
      仁科博史
    • Organizer
      生命科学研究会
    • Place of Presentation
      千葉
    • Related Report
      2009 Final Research Report
  • [Presentation] プログラム細胞死実行プロセスにおけるJNKの役割2007

    • Author(s)
      浦誠司、仁科博史
    • Organizer
      生命科学研究会
    • Place of Presentation
      千葉
    • Related Report
      2009 Final Research Report
  • [Presentation] ストレス応答性SAPK/JNK活性化と細胞の核内イベント2007

    • Author(s)
      仁科博史
    • Organizer
      生理学研究所セミナー
    • Place of Presentation
      岡崎
    • Related Report
      2009 Final Research Report
  • [Presentation] 細胞の生死および組織・器官の形成を制御するHippoシグナル伝達系2007

    • Author(s)
      仁科博史
    • Organizer
      秋田大学医学部
    • Place of Presentation
      秋田
    • Related Report
      2009 Final Research Report
  • [Presentation] ゼブラフィッシュ松果体に特異的に発現するエクソロドプシンの転写活性化機構2007

    • Author(s)
      浅岡洋一, 他
    • Organizer
      小型魚類研究会
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Presentation] 扁平胚の表現型を示すメダカ変異体hirameの解析2007

    • Author(s)
      阿部美穂子, 他
    • Organizer
      小型魚類研究会
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Presentation] 肝臓の左右逆位を示すメダカ変異体kendamaの表現型解析2007

    • Author(s)
      長井陽子, 他
    • Organizer
      小型魚類研究会
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Presentation] 女性ホルモンによる骨代謝制御メカニズム2007

    • Author(s)
      中村貴
    • Organizer
      分子代謝医学セミナー
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Presentation] メダカを用いた研究-その新規性また利点-2007

    • Author(s)
      仁科博史
    • Organizer
      第1回産学官連携新産業創出研究会
    • Place of Presentation
      宇部
    • Related Report
      2009 Final Research Report
  • [Presentation] アポトーシスにおける核凝集の初期プロセスにはJNKの活性化が必要である2007

    • Author(s)
      浦誠司, 他
    • Organizer
      BMB2007
    • Place of Presentation
      横浜
    • Related Report
      2009 Final Research Report
  • [Presentation] モデル生物を用いた生物学主催2007

    • Author(s)
      仁科博史、飯野雄一
    • Organizer
      BMB2007
    • Place of Presentation
      横浜
    • Related Report
      2009 Final Research Report
  • [Presentation] Mutations Affecting Liver Development and Function in Medaka, Oryzias Latipes.2006

    • Author(s)
      Hiroshi Nishina
    • Organizer
      The 2nd International Symposium on Developmental Biology and Tissue Engineering
    • Place of Presentation
      Tokyo, Japan
    • Related Report
      2009 Final Research Report
  • [Presentation] Release of RASSF1C from the nucleus by Daxx degradation links DNA damage and SAPK/JNK activation.2006

    • Author(s)
      Daiju Kitagawa, Toshiaki Katada, Hiroshi Nishina
    • Organizer
      20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2009 Final Research Report
  • [Presentation] Liver and defective spleen formation by a novel medaka mutation kendama affecting liver laterality.2006

    • Author(s)
      Yoko Nagai, Tomomi Watanabe, Hiroshi Mitani, Toshiaki Katada, Hisato Kondoh, Makoto Furutani-Seiki, Hiroshi Nishina
    • Organizer
      20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2009 Final Research Report
  • [Presentation] JNK is Essential and Sufficient in MST1-induced Caspase-independent Nuclear Condensation.2006

    • Author(s)
      Seiji Ura, Hiroshi Nishina, Yukiko Gotoh, Toshiaki Katada
    • Organizer
      20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2009 Final Research Report
  • [Presentation] Pineal photoreceptor cell-specific gene regulation in the zebrafish.2006

    • Author(s)
      Yoichi Asaoka, Hiroaki Mano, Daisuke Kojima, Yoshitaka Fukada
    • Organizer
      20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2009 Final Research Report
  • [Presentation] Identification and analysis of a homeobox gene, CrxOS, specifically expressed in murine embryonic stem cells.2006

    • Author(s)
      Ryota Saito, Hiroshi Nishina, Toshiaki Katada
    • Organizer
      20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2009 Final Research Report
  • [Presentation] Mutations affecting liver development and function in Medaka, Oryzias Latipes.2006

    • Author(s)
      Hiroshi Nishina
    • Organizer
      FASEB Summer Research Conferences
    • Place of Presentation
      Snowmass, USA
    • Related Report
      2009 Final Research Report
  • [Presentation] 細胞死研究の新たな展開と関連する素過程2006

    • Author(s)
      仁科博史
    • Organizer
      平成18年度生理学研究所研究会
    • Place of Presentation
      岡崎
    • Related Report
      2009 Final Research Report
  • [Presentation] ストレス応答に介在するプロテインキナーゼカスケード2006

    • Author(s)
      仁科博史
    • Organizer
      東京大学薬学部セミナー
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Presentation] マウスやメダカを用いた肝形成および肝再生機構の解明2006

    • Author(s)
      仁科博史
    • Organizer
      日本発生生物学会
    • Place of Presentation
      広島
    • Related Report
      2009 Final Research Report
  • [Presentation] 肝形成および肝機能変異メダカの単離と解析2006

    • Author(s)
      仁科博史
    • Organizer
      肝細胞研究会
    • Place of Presentation
      旭川
    • Related Report
      2009 Final Research Report
  • [Presentation] エストロゲンの骨代謝調節メカニズム2006

    • Author(s)
      中村貴, 他
    • Organizer
      日本骨代謝学会
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Presentation] ゼブラフィッシュ松果体の光受容細胞に特異的な遺伝子発現メカニズム2006

    • Author(s)
      浅岡洋一, 他
    • Organizer
      日本比較生理生化学会第28回大会
    • Place of Presentation
      浜松
    • Related Report
      2009 Final Research Report
  • [Presentation] 細胞外マトリクスとの相互作用の異常によりユニークな形態形成異常を示すメダカ変異体の解析2006

    • Author(s)
      浅香聡, 他
    • Organizer
      日本分子生物学会2006フォーラム
    • Place of Presentation
      名古屋
    • Related Report
      2009 Final Research Report
  • [Presentation] Mutations Affecting Liver Development and Function in Medaka, Oryzias Latipes.2005

    • Author(s)
      Hiroshi Nishina
    • Organizer
      4th Surugadai Symposium
    • Place of Presentation
      Tokyo, Japan
    • Related Report
      2009 Final Research Report
  • [Presentation] Non-alcoholic fatty liver and defective spleen formation in a novel medaka mutant kendama affecting liver laterality.2005

    • Author(s)
      Tomomi Watanabe, Hiroshi Mitani, Toshiaki Katada, Hisato Kondoh, Makoto Furutani-Seiki, Hiroshi Nishina
    • Organizer
      4th European Zebrafish Genetics and Development Meeting
    • Place of Presentation
      Dresden, Germany
    • Related Report
      2009 Final Research Report
  • [Presentation] Analysis of hirame mutation affecting migration and integration of organ progenitors.2005

    • Author(s)
      S Asaka, T Sasaki, Y Osada, N Shimizu, H Himmelbauer, R Geisler, H Mitani, T Katada, H Nishina, H Kondoh, M Furutani-Seiki
    • Organizer
      4th European Zebrafish Genetics and Development Meeting
    • Place of Presentation
      Dresden, Germany
    • Related Report
      2009 Final Research Report
  • [Presentation] 肝形成研究から肝再生医療へ2005

    • Author(s)
      仁科博史
    • Organizer
      第39回神戸バイオサイエンス研究会
    • Place of Presentation
      神戸
    • Related Report
      2009 Final Research Report
  • [Presentation] マウスやメダカを用いた肝形成および肝機能の解明2005

    • Author(s)
      仁科博史
    • Organizer
      静岡大学シンポジウム
    • Place of Presentation
      静岡
    • Related Report
      2009 Final Research Report
  • [Presentation] 細胞増殖、がん、老化~ストレスキナーゼのシーソーゲーム~2005

    • Author(s)
      和田悌司
    • Organizer
      東京大学薬学部セミナー
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Presentation] メンブラントラフィックに介在する新規Rab5ヌクレオチド交換因子の機能解析[文部科学省特定領域研究「メンブラントラフィック-分子機構から高次機能への展開-」2005

    • Author(s)
      仁科博史、梶保博昭、堅田利明
    • Organizer
      公開シンポジウム
    • Place of Presentation
      草津
    • Related Report
      2009 Final Research Report
  • [Presentation] 小型魚類を用いた肝発生及び肝機能の解析2005

    • Author(s)
      渡辺智美、仁科博史
    • Organizer
      第18回肝再生研究会
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Presentation] モデル生物を用いた肝発生と肝再生の解明2005

    • Author(s)
      仁科博史
    • Organizer
      第1回山口大学イブニングセミナー・イン東京
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Presentation] 細胞死・細胞増殖制御を司る新しいシグナル伝達系Hippo pathway

    • Author(s)
      仁科博史、畑裕
    • Organizer
      世話人シンポジウム
    • Related Report
      2009 Final Research Report
  • [Book] シグナル伝達の分子機構:ベーシックマスター生化学2008

    • Author(s)
      仁科博史
    • Publisher
      オーム社
    • Related Report
      2009 Final Research Report
  • [Book] ベーシックマスター生化学2008

    • Author(s)
      仁科博
    • Total Pages
      414
    • Publisher
      オーム社
    • Related Report
      2008 Annual Research Report
  • [Book] MAPキナーゼ;生物薬科学実験講座(石橋貞彦、市川厚、堅田利明編)2005

    • Author(s)
      仁科博史、堅田利明
    • Publisher
      廣川書店
    • Related Report
      2009 Final Research Report
  • [Book] 細胞を利用した治療;医薬品の開発と生産2005

    • Author(s)
      仁科博史
    • Publisher
      東京化学同人
    • Related Report
      2009 Final Research Report
  • [Book] The Biological Function of JNKKs (MKK4/MKK7 Knockout Mice)(Anning Lin, eds, in The JNK Signaling Pathway)2005

    • Author(s)
      Hiroshi Nishina, Toshiaki Katada
    • Publisher
      Landes Bioscience
    • Related Report
      2009 Final Research Report
  • [Book] The JNK Signaling Pathway2005

    • Author(s)
      Hiroshi Nishina, et al.
    • Total Pages
      93
    • Publisher
      Landes Bioscience, Texas, USA
    • Related Report
      2005 Annual Research Report
  • [Remarks] l#プレスリリース2009年12月4日時事ドットコム、日本経済新聞、12月6日朝日新聞、NHKニュース2010年2月4日読売新聞

    • URL

      http://www.tmd.ac.jp/mri/dbio/index.htm

    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://www.tmd.ac.jp/mri/dbio/index.html#

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.tmd.ac.jp/mri/dbio/index.html#

    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://www.tmd.ac.jp/mri/dbio/index.html

    • Related Report
      2007 Annual Research Report

URL: 

Published: 2005-04-01   Modified: 2018-11-08  

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