| Co-Investigator(Kenkyū-buntansha) |
YOSHIDA Mitsutoshi 鹿児島大学, 農学部, 教授 (00174954)
ATO Masahiro 鹿児島大学, フロンティアサイエンス研究推進センター, 教授 (30287099)
MARUYAMA Ikuro 鹿児島大学, 大学院・医歯学総合研究科, 教授 (20082282)
BABA Masanori 鹿児島大学, 大学院・医歯学総合研究科, 教授 (70181039)
MATSUYAMA Takami 鹿児島大学, 大学院・医歯学総合研究科, 教授 (30145479)
FUJIYOSHI Toshinobu 鹿児島大学, フロンティアサイエンス研究推進センター, 准教授 (50173480)
MATSUBARA Shuichiro 鹿児島大学, フロンティアサイエンス研究推進センター, 准教授 (60199841)
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| Budget Amount *help |
¥101,920,000 (Direct Cost: ¥78,400,000、Indirect Cost: ¥23,520,000)
Fiscal Year 2009: ¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2008: ¥20,800,000 (Direct Cost: ¥16,000,000、Indirect Cost: ¥4,800,000)
Fiscal Year 2007: ¥20,800,000 (Direct Cost: ¥16,000,000、Indirect Cost: ¥4,800,000)
Fiscal Year 2006: ¥20,800,000 (Direct Cost: ¥16,000,000、Indirect Cost: ¥4,800,000)
Fiscal Year 2005: ¥22,360,000 (Direct Cost: ¥17,200,000、Indirect Cost: ¥5,160,000)
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| Research Abstract |
In our study, the cloned Clawn miniature pigs with normal growth and breeding were firstly produced by the somatic cell nuclear transfer (SCNT) technique. Then, we are promoting new technical development for production of the miniature pig with gene manuplation as a donor of xenotransplantation. Concerning the porcine endogenous retrovirus (PERV) in the Clawn miniature pig, its infectiousness to human was low, and anti-AIDS drug AZT showed the efficacy in PERV. In addition, we clarified that high mobility group box-1 and CD4+CD25+ regulatory T cells are associated in xenogeneic immune responses.
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