CREATION OF ARTIFICIAL COMPLEX CARBOHYDRATE PROBES AND MODULATION OF HIGHER BIOLOGICAL FUNCTIONS

• Project/Area Number: 17101007
• Research Category: Grant-in-Aid for Scientific Research (S)
• Allocation Type: Single-year Grants
• Research Field: Living organism molecular science
• Research Institution: Gifu University
• Principal Investigator: KISO Makoto Gifu University, 応用生物科学部, 教授 (90092931)
• Co-Investigator(Kenkyū-buntansha): ISHIDA Hideharu 岐阜大学, 応用生物科学部, 教授 (20203002) ; ANDO Hiromune 岐阜大学, 応用生物科学部, 准教授 (20372518) ; YABE Tomio 岐阜大学, 応用生物科学部, 准教授 (70356260) ; KANNAGI Reiji 愛知県がんセンター, 分子病態学部, 部長(研究職) (80161389) ; YUKI Nobuhiro 獨協医科大学, 神経内科, 助教授 (60285913)
• Project Period (FY): 2005 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥90,740,000 (Direct Cost: ¥69,800,000、Indirect Cost: ¥20,940,000); Fiscal Year 2009: ¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000); Fiscal Year 2008: ¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000); Fiscal Year 2007: ¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000); Fiscal Year 2006: ¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000); Fiscal Year 2005: ¥20,150,000 (Direct Cost: ¥15,500,000、Indirect Cost: ¥4,650,000)
• Keywords: 糖鎖 / ガングリオシド / 複合糖質 / 感染 / 癌 / 免疫 / 脳・神経 / 分子プローブ / シアル酸 / セレクチン / シグレック / 自己免疫疾患

Research Abstract

糖鎖の中でも特に多彩な生理機能を発現するシアル酸含有スフィンゴ糖脂質ガングリオシドの実践的大量合成法を開発し、800種に及ぶ人工複合糖質プローブの創出に成功しました。この成果は、インフルエンザや細菌毒素の感染、免疫応答、がん、炎症、自己免疫性神経疾患などの病態の理解に世界的な貢献をしました。現在、薬の開発や細胞生物学への先端的応用研究が進行しています。

Research Products

• [Journal Article] A cyclic glucosyl ceramide acceptor as a versatile building block for complex ganglioside synthesis. (2010)
  • Author(s): Fujikawa, K., Nohara, T., Imamura, A., Ando, H., Ishida, H., Kiso, M.
  • Journal Title: Tetrahedron Lett. 51 Pages: 1126-1130
• [Journal Article] A cyclic glucosyl ceramide acceptor as a versatile building block for complex ganglioside synthesis (2010)
  • Author(s): Fujikawa, K., Nohara, T., Imamura, A., Ando, H., Ishida, H., Kiso, M.
  • Journal Title: Tetrahedron Lett. 51 Pages: 1126-1130
  • Peer Reviewed
• [Journal Article] Efficient synthesis of three types of sialyl 6-O-sulfo Lewis X: probes for the comprehensive search for the interaction between carbohydrates and other biomoleclues. (2009)
  • Author(s): Yamaguchi, M., Ishida, H., Kiso, M.
  • Journal Title: HETEROCYCLES 77 Pages: 333-349
  • NAID: 40016405877
• [Journal Article] Receptor-binding specificity of pandemic influenza A (H1N1) 2009 virus determined by carbohydrate microarray. (2009)
  • Author(s): Childs, R.A., Palma, A.S., Wharton, S., Matrosovich, T., Liu, Y., Chai, W., Campanero-Rhodes, M.A., Zhang, Y., Eickmann, M., Kiso, M., Hay, A., Matrosovich, M., Feizi, T.
  • Journal Title: Nature Biotechnology 27 Pages: 797-799
• [Journal Article] Potent small molecule mouse CD22-inhibitors: Exploring the interaction of the residue at C-2 of sialic acid scaffold. (2009)
  • Author(s): Abdu-Allah., Hajjaj Hassan Mohamed, Watanabe, K., Hayashizaki, K., Takaku, C., Tamanaka, T., Takematsu, H., Kozutsumi, Y., Tsubata, T., Ishida, H., Kiso, M.
  • Journal Title: Bioorg. Med. Chem. Lett. 19 Pages: 5573-5575
• [Journal Article] Synthesis of biotinylated sialoside to probe CD22-ligand interactions. (2009)
  • Author(s): Abdu-Allah., Hajjaj Hassan Mohamed, Watanabe, K., Hayashizaki, K., Iwayama, Y., Takematsu, H., Kozutsumi, Y., Tsubata, T., Ishida, H., Kiso, M.
  • Journal Title: Tetrahedron Lett. 50 Pages: 4488-4491
• [Journal Article] Synthetic study on a(2-8)-linked oligosialic acid employing 1, 5-lactamization as a key step. (2009)
  • Author(s): Tanaka, H., Ando, H., Ishida, H., Kiso, M., Ishihara, H., Koketsu, M.
  • Journal Title: Tetrahedron Lett. 50 Pages: 4478-4481
• [Journal Article] A first total synthesis of ganglioside HLG-2. (2009)
  • Author(s): Iwayama, Y., Ando, H., Ishida, H., Kiso, M.
  • Journal Title: Chem. Euro. J. 15 Pages: 4637-4648
• [Journal Article] Ganglioside GQ1b: Efficient total synthesis and the expansion to synthetic derivatives to elucidate its biological roles. (2009)
  • Author(s): Imamura, A., Ando, H., Ishida, H., Kiso, M.
  • Journal Title: J. Org. Chem. 74 Pages: 3009-3023
• [Journal Article] Identification of amino acid residues of influenza A virus H3 HA contributing to the recognition of molecular species of sialic acid (2009)
  • Author(s): Takahashi, T., Hashimoto, A., Maruyama, M., Ishida, H., Kiso, M., Kawaoka, Y., Suzuki, Y., Suzuki, T.
  • Journal Title: FEBS Lett. 583 Pages: 3171-3174
  • Peer Reviewed
• [Journal Article] Receptor-binding specificity of pandemic influenza A (H1N1) 2009 virus determined by carbohydrate microarray (2009)
  • Author(s): Childs, R.A., Palma, A.S., Wharton, S., Matrosovich, T., Liu, Y., Chai, W., Campanero-Rhodes, M.A., Zhang, Y., Eickmann, M., Kiso, M., Hay, A., Matrosovich, M., Feizi, T.
  • Journal Title: Nature Biotechnology 27 Pages: 797-799
  • Peer Reviewed
• [Journal Article] Potent small molecule mouse CD22-inhibitors : Exploring the interaction of the residue at C-2 of sialic acid scaffold (2009)
  • Author(s): Abdu-Allah, Hajjaj Hassan Mohamed, Watanabe, K., Hayashizaki, K., Takaku, C., Tamanaka, T., Takematsu, H., Kozutsumi, Y., Tsubata, T., Ishida, H., Kiso, M.
  • Journal Title: Bioorg.Med.Chem.Lett. 19 Pages: 5573-5575
  • Peer Reviewed
• [Journal Article] Design, synthesis, and biological evaluation of 4-acetamido-5-acylamido-2-fluoro benzoic acids. (2009)
  • Author(s): Sadagopan, M., Vats, S., Moriya, S., Suzuki, T., Miyagi, T., Ishida, H., Kiso, M.
  • Journal Title: Bioorg.Med.Chem. 17 Pages: 4595-4603
  • Peer Reviewed
• [Journal Article] Transglycosylation-based fluorescent labeling of 6-gala series glycolipids by endogalactosylceramidase (2009)
  • Author(s): Ishibashi, Y., Nagamatsu, Y., Meyer, S., Imamura, A., Ishida, H., Kiso, M., Okino, N., Geyer, R., Ito, M.
  • Journal Title: Glycobiology 19 Pages: 797-807
  • Peer Reviewed
• [Journal Article] Synthesis of biotinylated sialoside to probe CD22-ligand interactions (2009)
  • Author(s): Abdu-Allah, Hajjaj Hassan Mohamed, Watanabe, K., Hayashizaki, K., Iwayama Y., Takematsu, H., Kozutsumi, Y., Tsubata, T., Ishida, H., Kiso, M. :
  • Journal Title: Tetrahedron Lett. 50 Pages: 4488-4491
  • Peer Reviewed
• [Journal Article] Synthetic study on α (2-8)-linked oligosialic acid employing 1, 5-lactamization as a kep step (2009)
  • Author(s): Tanaka, H., Ando, H., Ishida, H., Kiso, M., Ishihara, H., Koketsu, M.
  • Journal Title: Tetrahedron Lett. 50 Pages: 4478-4481
  • Peer Reviewed
• [Journal Article] A first total synthesis of ganglioside HLG-2 (2009)
  • Author(s): Iwayama, Y., Ando, H., Ishida, H., Kiso, M.
  • Journal Title: Chem.Euro.J. 15 Pages: 4637-4648
  • Peer Reviewed
• [Journal Article] Ganglioside GQ1b : Efficient total synthesis and the expansion to synthetic derivatives to elucidate its biological roles (2009)
  • Author(s): Imamura, A., Ando, H., Ishida, H., Kiso, M.
  • Journal Title: J.Org.Chem. 74 Pages: 3009-3023
  • Peer Reviewed
• [Journal Article] Di-tert-butylsilylene-directed α-selective synthesis of p-nitrophenyl T-antigen analogues (2009)
  • Author(s): Sato, T., Imamura, A., Ando, H., Ishida, H., Kiso, M.
  • Journal Title: Glycoconjugate J. 26 Pages: 83-98
  • Peer Reviewed
• [Journal Article] Di-tert-butvlsilylene-directed α-selective synthesis of p-nitrophenyl T-antigen analogues (2009)
  • Author(s): Sato, T.
  • Journal Title: Glycoconjugate J. 26 Pages: 83-98
  • Peer Reviewed
• [Journal Article] type a in complex with the cell surface co-receptor GT1b insight into the toxin-neuron interaction. (2008)
  • Author(s): Stenmark, P., Dupuy, J., Imamura, A., Kiso, M., Stevens, R.C.
  • Journal Title: PLoS Pathogens 4 Pages: 1-10
• [Journal Article] Design, synthesis, and structure-affinity relationships of novel series of sialosides as CD22-specific inhibitors. (2008)
  • Author(s): Abdu-Allah, Hajjaj Hassan Mohamed, Tamanaka, T., Yu, J., Lu, Z., Sadagopan, M., Adachi, T., Tsubata, T., Kelm, S., Ishida, H., Kiso, M.
  • Journal Title: J. Med. Chem. 51 Pages: 6665-6681
• [Journal Article] Synthesis of ganglioside GM3 analog carrying phytoceramide by employing intramolecular glycosylation as a key reaction. (2008)
  • Author(s): Fujikawa, K., Imamura, A., Ishida, H., Kiso, M.
  • Journal Title: Carbohydr. Res. 343 Pages: 2729-2734
• [Journal Article] A highly efficient construction of GM1 epitope tetrasaccharide and its conjugation with KLH. (2008)
  • Author(s): Yoshikawa, T., Kato, Y., Yuki, N., Yabe. T., Ishida, H., Kiso, M.
  • Journal Title: Glycoconjugate J. 25 Pages: 545-553
• [Journal Article] Effect of structural modifications of ganglioside GM2 on intra-molecular carbohydrate-to-carbohydrate interaction and enzymatic susceptibility. (2008)
  • Author(s): Li, Y.-T., Li, S.-C., Kiso, M., Ishida, H., Mauri, L., Raimondi, L., Bernardi, A., Sonnino, S.
  • Journal Title: Biochim. Biophys. Acta 1780 Pages: 353-361
• [Journal Article] Design and synthesis of versatile ganglioside probes for carbohydrate microarrays. (2008)
  • Author(s): Imamura, A., Yoshikawa, T., Komori, T., Ando, M., Ando, H., Wakao, M., Suda, Y., Ishida, H. Kiso, M.
  • Journal Title: Glycoconjugate J. 25 Pages: 269-278
• [Journal Article] Current relevance of incomplete synthesis and neo-synthesis for cancer-associated alteration of carbohydrate determinants. (2008)
  • Author(s): Kannagi, R., Yin, J., Miyazaki, K., Izawa, M.
  • Journal Title: Biochim. Biophys. Acta 1780 Pages: 525-531
• [Journal Article] Clinical application of functional glycoproteomics-dissection of glycotopes carried by soluble CD44 variants in sera of patients with cancers. (2008)
  • Author(s): Lim, K-T., Miyazaki, K., Kimura, N., Izawa, M., Kannagi, R.
  • Journal Title: Proteomics 8 Pages: 3263-3273
• [Journal Article] Significance of NF-κB/GATA axis in TNF-α-induced expression of 6-sulfated cell-recognition glycans in human T-lymphocytes. (2008)
  • Author(s): Chen, G.-Y., Sakuma, K., Kannagi, R.
  • Journal Title: J. Biol. Chem. 283 Pages: 34563-34570
• [Journal Article] The unique sterically driven director for α-galactosylation (2008)
  • Author(s): Imamura, A.
  • Journal Title: HETEROCYCLES 76 Pages: 883-908
  • Peer Reviewed
• [Journal Article] DTBS(di-tert-butylsilylene)-directed α-galactosylation for the synthesis of biologically relevant glycans (2008)
  • Author(s): Imamura, A.
  • Journal Title: Curr. Ore. Chem. 12 Pages: 675-689
  • Peer Reviewed
• [Journal Article] Design, synthesis, and biological evaluation of human sialidase inhibit ors. Part1 : Selective inhibitors of lysosomal sialidase (NEU1) (2008)
  • Author(s): Magesh, S.
  • Journal Title: Bioorg. Med. Chem. Lett 18 Pages: 532-537
  • Peer Reviewed
• [Journal Article] Design and synthesis of versatile ganglioside probes for carbohydrate microarrays (2008)
  • Author(s): Imamura, A.
  • Journal Title: Glycoconjugate J. 25 Pages: 269-278
  • Peer Reviewed
• [Journal Article] Effect of structural modifications of ganglioside GM2 on intra-molecular carbohydrate-to-carbohydrate interaction and enzymatic susceptibility (2008)
  • Author(s): Li, Y. -T
  • Journal Title: Biochim. Biophys. Acta 1780 Pages: 353-361
  • Peer Reviewed
• [Journal Article] Total synthesis of 6-O-sulfo-sialylparagloboside : a widely useful glycopr obe for biochemical research (2008)
  • Author(s): Yamaguchi, M
  • Journal Title: Carbohydr. Res. 343 Pages: 1849-1857
  • Peer Reviewed
• [Journal Article] A highly efficient construction of GM1 epitope tetrasaccharide and its conjugation with KLH (2008)
  • Author(s): Yoshikawa, T.
  • Journal Title: Glycoconjugaie J. 25 Pages: 647-661
  • Peer Reviewed
• [Journal Article] Synthesis of ganglioside GM3 analog carrying phytoceramide by employing intramolecular glycosylation as a key reaction (2008)
  • Author(s): Fujikawa, K.
  • Journal Title: Carboyydr. Res. 343 Pages: 2729-2734
  • Peer Reviewed
• [Journal Article] Characterization of two different endo-α-N-acetylgalactosaminidass from probiotic and pathogenic enterobacteria, Bifidobaceterium longum and Clostridium perfringens (2008)
  • Author(s): Ashida, H.
  • Journal Title: Glycobiology 18 Pages: 727-734
  • Peer Reviewed
• [Journal Article] Design, synthesis, and structure-affinity relationships of novel series of sialosides as CD22-specific inhibitors. (2008)
  • Author(s): Hajjaj Hassan Mohamed, Abdu-Allah
  • Journal Title: J. Med. Chem. 51 Pages: 6665-6681
  • Peer Reviewed
• [Journal Article] Ab initio fragment molecular orbital studies of influenza virus hemagglutinin-sialosaccharide complexes toward chemical clarification about the virus host range determination (2008)
  • Author(s): Sawada, T.
  • Journal Title: Glycoconjugate J. 25 Pages: 805-815
  • Peer Reviewed
• [Journal Article] Crystal structure of botulinum neurotoxin type a in complex with the cell surface co-receptor GT1b-insight into the toxin-neuron interaction (2008)
  • Author(s): Stenmark, P.
  • Journal Title: PLoS Pathogens 4 Pages: 1-10
  • Peer Reviewed
• [Journal Article] A highly efficient construction of GM1 epitope tetrasaccharide and its conjugation with KLH (2008)
  • Author(s): Yoshikawa, T.
  • Journal Title: Glycoconjugate J. (In Press)
  • Peer Reviewed
• [Journal Article] Design and efficient synthesis of novel GM2 analogues with respect to the elucidation of the function of GM2 activator (2008)
  • Author(s): Komori, T.
  • Journal Title: Glycoconjugate J. (In Press)
  • Peer Reviewed
• [Journal Article] DTBS(di-tert-butylsilylene)-directed α-galactosylation for the synthesis of biologically relevant glycans (2008)
  • Author(s): Imamura, A.
  • Journal Title: Curr. Org. Chem. (In Press)
  • Peer Reviewed
• [Journal Article] Synthetic glycan ligand excludes CD22 from antigen receptor-containing lipid rafts. (2007)
  • Author(s): Yu, J., Sawada, T., Adachi, T., Gao, X., Takematsu, H., Kozutsumi, Y., Ishida, H., Kiso, M., Tsubata, T.
  • Journal Title: Biochem. Biophys. Res. Commun 360 Pages: 759-764
• [Journal Article] The principal neuronal gD-type 3-O-sulfotransferases and their products in central and peripheral nervous system tissues. (2007)
  • Author(s): Lawrence, R., Yabe, T., HajMohammadi, S., Rhodes, J., McNeely, M., Liu, J., Lamperti, E.D., Toselli, P.A., Lech, M., Spear, P.G., Rosenberg, R.D., Shworak, N.W.
  • Journal Title: Matrix Biol. 26 Pages: 442-455
• [Journal Article] Human B-lymphocytes expressα2-6 sialylated 6-sulfo-N-acetyllactosamine serving as a preferred ligand for CD22/siglec-2. (2007)
  • Author(s): Kimura, N., Ohmori, K., Miyazaki, K., Izawa, M., Matsuzaki, Y., Yasuda, Y., Takematsu, H., Kozutsumi, Y., Moriyama, A., Kannagi, R.
  • Journal Title: J. Biol. Chem. 282 Pages: 32200-32207
• [Journal Article] A chemical synthesis of GlcNAcβ(1-4)GlcUA-UDP to elucidate to catalytic mechanism of hyaluronic acid synthases(HAS) (2007)
  • Author(s): Takaku, H.
  • Journal Title: Synlett 5 Pages: 818-820
  • Peer Reviewed
• [Journal Article] Influenza viral hemagglutinin complicated shape is advantageous to its binding affinity for sialosaccharide receptor (2007)
  • Author(s): Sawada, T.
  • Journal Title: Biochem. Biophys. Res. Commun. 355 Pages: 6-9
  • Peer Reviewed
• [Journal Article] Synthetic glycan ligand excludes CD22 from antigen receptor-containing lipid rafts (2007)
  • Author(s): Yu, J.
  • Journal Title: Biochem. Biophys. Res. Commun. 360 Pages: 759-764
  • Peer Reviewed
• [Journal Article] A novel endoglycoceramidase hydrolyzes oligogalactosylceramides toproduce galactooligosaccharides and ceramides (2007)
  • Author(s): Ishibashi, Y.
  • Journal Title: J. Biol. Chem. 282(15) Pages: 11386-11396
  • Peer Reviewed
• [Journal Article] Self-recognition of N-linked glycans with multivalent GlcNAc,determined as ceramide mimetic conjugate (2007)
  • Author(s): Yoon, S.-J.
  • Journal Title: Glycobiology 17 Pages: 1007-1014
  • Peer Reviewed
• [Journal Article] Design, synthesis, and biological evaluation of human sialidase inhibitors. Part 1: Selective inhibitors of lysosomal sialidase(NEU1) (2007)
  • Author(s): Magesh, S.
  • Journal Title: Bioorg. Med. Chem. Lett. 18 Pages: 532-537
  • Peer Reviewed
• [Journal Article] Siglec-7 undergoes a major conformational change when complexed with the (2, 8)-disialylganglioside GT1b. (2006)
  • Author(s): Attrill, H., Imamura, A., Sharma, R.S., Kiso, M., Crocker, P.R., van Aalten, D.M.F.
  • Journal Title: J. Biol. Chem. 281 Pages: 32774-32783
• [Journal Article] Haemagglutinin mutations responsible for the binding of H5N1 influenza A viruses to human-type receptors. (2006)
  • Author(s): Yamada, S., Suzuki, Y., Suzuki, T., Le, M.Q., Nidom, C.A., Sakai-Tagawa, Y., Muramoto, Y., Ito, M., Kiso, M., Horimoto, T., Sinya, K., Sawada, T., Kiso, M., Usui, T., Murata, T., Lin, Y., Hay, A., Haire, L.F., Stevens, D.J., Russell, R.J., Gamblin, S. Yamada, S., Suzu
  • Journal Title: Nature 444 Pages: 378-382
• [Journal Article] The structure of Siglec-7 in complex with sialosides: leads for rational structure-based inhibitor design. (2006)
  • Author(s): Attrill, H., Takazawa, H., Witt, S., Kelm, S., Isecke, R., Brossmer, R., Ando, T., Ishida, H., Kiso, M. Crocker, P.R., van Aalten, D.M.F.
  • Journal Title: Biochem. J. 397 Pages: 271-278
• [Journal Article] Identification of cutaneous lymphocyte-associated antigen as sialyl 6-sulfo Lewis x, a selectin ligand expressed on a subset of skin-homing helper memory T cells. (2006)
  • Author(s): Ohmori, K., Fukui, F., Kiso, M., Imai, T., Yoshie, O., Hasegawa, H., Matsushima, K., Kannagi, R.
  • Journal Title: Blood 107 Pages: 3197-3204
• [Journal Article] Idetification of cutaneous lymphocyte-associated anitigen as sialyl 6-sulfo Lewis X, a selectin ligand expressed on subset of skin-homing helper memory T cells. (2006)
  • Author(s): Ohmori, K.
  • Journal Title: Blood 107(8) Pages: 3197-3204
• [Journal Article] Homology modeling of human sialdase enzymes NEU1, NEU3 and NEU4 based on the crystal structure of NEU2 : Hints for the design of selective NEU3 inhibitors. (2006)
  • Author(s): Magesh, S.
  • Journal Title: Journal of Molecular Graphics and Modelling 25 Pages: 196-207
• [Journal Article] The structure of Siglec-7 in complex with sialosides : leads for rational structure-based inhibitor design. (2006)
  • Author(s): Attrill, H.
  • Journal Title: Biochemical Journal 397(2) Pages: 271-278
• [Journal Article] A chemical synthesis of UDP-LacNAc and its regioisomer for finding 'oligosaccharide transferases'. (2006)
  • Author(s): Takaku, H.
  • Journal Title: Glycoconjugate Journal 23 Pages: 565-573
• [Journal Article] Studies on the a-(1→4)- and a-(1→8)- fucosylation of sialic acid for the total assembly of the glycan portions of complex HPG-series gangliosides. (2006)
  • Author(s): Ando, H.
  • Journal Title: Carbohydrate Research 341 Pages: 1522-1532
• [Journal Article] Chemoenzymatic synthesis and application of a sialoglycopolymer with a chitosan backbone as a potent inhibitor of human influenza virus hemagglutination. (2006)
  • Author(s): Makimura, Y.
  • Journal Title: Carbohydrate Research 341 Pages: 1803-1808
• [Journal Article] Synthesis and enzymatic susceptibility of a series of novel GM2 analogs. (2006)
  • Author(s): Fuse, T.
  • Journal Title: Glycoconjugate Journal 23 Pages: 329-343
• [Journal Article] Why does avian influenza A virus hemagglutinin bind to avian receptor stronger than to human receptor? Ab initio fragment molecular orbital studies. (2006)
  • Author(s): Sawada, T.
  • Journal Title: Biochemical and Biophysical research communications 351 Pages: 40-43
• [Journal Article] Conformational study of a-N-acetyl-D-neuraminic acid by density functional theory. (2006)
  • Author(s): Sawada, T.
  • Journal Title: Journal of Carbohydrate Chemistry 25(5) Pages: 387-405
• [Journal Article] A novel synthetic route to a-galactosyl ceramides and iGb3 using DTBS-directed a-selective galactosylation. (2006)
  • Author(s): Kimura, A.
  • Journal Title: SYNLETT 15 Pages: 2379-2382
• [Journal Article] Carbohydrate microarrays reveal sulphation as a modulator of siglec binding. (2006)
  • Author(s): Campanero-Rhodes, M.A.
  • Journal Title: Biochemical and Biophysical research communications 344(4) Pages: 1141-1146
• [Journal Article] Haemagglutinin mutations responsible for the binding of H5N1 influenza A viruses to human-type receptors. (2006)
  • Author(s): Yamada, S.
  • Journal Title: Nature 444 Pages: 378-382
• [Journal Article] Extended applications of Di-tere-butylsilylene-Directed a-Preedominant galactosylation compatible with C2-Participating groups toward the assembly of various glycosides. (2006)
  • Author(s): Imamura, A.
  • Journal Title: Chem. Eur. J. 12 Pages: 8862-8870
• [Journal Article] Siglec-7 undergoes a major conformational change when complexed with the (2,8)-Disialylganglioside GT1b. (2006)
  • Author(s): Attrill, H.
  • Journal Title: Journal of biological chemistry 281(43) Pages: 32774-32783
• [Journal Article] A novel de-O-chloroacetylation reagent : 1-selenocarbamoylpiperidine (2006)
  • Author(s): Sogabe, S.
  • Journal Title: Tetrahedron Let 47 Pages: 6603-6606
• [Journal Article] Comprehensive analysis of bacterial risk factors for the development of Guillain-Barre syndrome after Campylobacter jejuni enteritis. (2006)
  • Author(s): Koga, M.
  • Journal Title: J Infect Dis. 193 Pages: 547-555
• [Journal Article] Rhinolalia after diarrhea : a sole motor symptom occurring in post-infectious neuropathy associated with anti-ganglioside antibodies. (2006)
  • Author(s): Kamitani, T.
  • Journal Title: Eur J Neurol 13 Pages: 203-204
• [Journal Article] Isolated abducens nerve palsy as a regional variant of Guillain-Barre syndrome. (2006)
  • Author(s): Tatsumoto, M.
  • Journal Title: J Neurol Sci 243 Pages: 35-38
• [Journal Article] Electrophysiological subtypes and prognosis of childhood Guillain-Barre syndrome in Japan (2006)
  • Author(s): Navasota, K.
  • Journal Title: Muscle Nerve 33 Pages: 766-770
• [Journal Article] Identification of a sialate O-acetyltransferase from Campylobacter jejuni : demonstration of direct transfer to the C-9 position of terminal 2,8-linked sialic acid. (2006)
  • Author(s): Houliston, R.S.
  • Journal Title: J Biol Chem 281 Pages: 11480-11486
• [Journal Article] Severe cranial nerve involvement in a patient with monoclonal anti-MAG/SGPG IgM antibody and Iocalized hard palate amyloidosis. (2006)
  • Author(s): Yoshida, T.
  • Journal Title: J Neurol Sci 244 Pages: 167-171
• [Journal Article] Campylobacter coli enteritis and Guillain-Barre syndrome : no evidence of molecular mimicry and serological relationship. (2006)
  • Author(s): Funakoshi, K.
  • Journal Title: J Neurol Sci 246 Pages: 163-168
• [Journal Article] Spectrum of neurological diseases associated with anibodies to minor gangliosides GM1b and Ga1NAc-GD1a. (2006)
  • Author(s): Tatsumoto, M.
  • Journal Title: J Neuroimmunol 177 Pages: 201-208
• [Journal Article] Ganglioside mimicry as a cause of Guillain-Barre syndrome. (2006)
  • Author(s): Komagamine, T.
  • Journal Title: CNS ＆ Neurological Disorders-Drug Targets 5 Pages: 391-400
• [Journal Article] Rituximab therapy in chronic inflammatory demyelinating polyradiculoneuropathy with anti-SGPG IgM antibody (2006)
  • Author(s): Gono, T.
  • Journal Title: J Clin Neurosci 13 Pages: 683-687
• [Journal Article] Bacterial infections in Guillain-Barre and Fisher syndromes (2006)
  • Author(s): Yuki, N.
  • Journal Title: Curr Opin Neurol 19 Pages: 451-457
• [Journal Article] Relationship of bacterial strains to clinical syndromes of Campylobacter-associated neuropathies. (2006)
  • Author(s): Kimoto, K.
  • Journal Title: Neurology 67 Pages: 1837-1843
• [Journal Article] Interaction of GATA-3/T-bed transcription factors regulates expression of sialyl Lewis X homing receptors on Th1/Th2 lymphocytes. (2006)
  • Author(s): Chen, G.-Y.
  • Journal Title: Proc. Natl. Acad. Sci. U.S.A 103 Pages: 16894-16899
• [Journal Article] Rapid demonstration of diversity of sulfatide molecular species from biological materials by MALDI-TOF MS. (2006)
  • Author(s): Kyogashima, M.
  • Journal Title: Glycobiology 16 Pages: 710-728
• [Journal Article] Hypoxic culture induces expression of sialin, a sialic acid transporter, and cancer-associated gangliosides containing non-human sialic acid on human cancer cells. (2006)
  • Author(s): Yin, J.
  • Journal Title: Cancer Res. 66 Pages: 2937-2945
• [Journal Article] Di-tert-butylsilylene(DTBS)-directedα-selective synthesis of 4-methylumbelliferyl T-antigen. (2005)
  • Author(s): Imamura, A., Ando, H., Ishida, H., Kiso, M.
  • Journal Title: Organic Lett. 7 Pages: 4415-4418
• [Journal Article] Design and synthesis of a novel neo-glycolipid containing sialyl Lewis X determinant carried on the mucin GlcNAcb1-6GalNAca core structure (2005)
  • Author(s): Otsubo, N.
  • Journal Title: Tetrahedron : Asymmetry 16(7) Pages: 1321-1327
• [Journal Article] 6-O-Sulfo sialylparagloboside and sialyl Lewis X neo-glycolipids containing lactamized neuraminic acid : synthesis and antigenic reactivity against G159 nomoclonal antibody (2005)
  • Author(s): Yamaguchi, M.
  • Journal Title: Glycoconjugate Journal 22 Pages: 95-108
• [Journal Article] Charactarization of a human H5N1 influenza A virus isolated in 2003 (2005)
  • Author(s): Shinya, K.
  • Journal Title: Journal of Virology 79(15) Pages: 9926-9932
• [Journal Article] Di-tert-butylsilylene(DTBS)-directed α-selective synthesis of 4-methylumbelliferyl T-antigen (2005)
  • Author(s): Imamura, A.
  • Journal Title: Organic Letters 7(20) Pages: 4415-4418
• [Journal Article] 1,5-Lactamized sialyl acceptors for various disialoside syntheses : Novel synthesis method for glycan portions of Hp-s6 and HLG-2 gangliosides (2005)
  • Author(s): Ando, H.
  • Journal Title: Angewandte Chemie, International Edition in English 44 Pages: 6759-6763
• [Journal Article] Developmental and regional expression of heparan sulfate sulfotransferase genes in the mouse brain (2005)
  • Author(s): Yabe, T.
  • Journal Title: Glycobiology 15(10) Pages: 982-993
• [Journal Article] Epidemiology of Campylobacter jejuni isolated from patients with Guillain-Barre and Fisher syndromes in Japan. (2005)
  • Author(s): Takahashi, M.
  • Journal Title: J Clin Microbiol 43 Pages: 335-339
• [Journal Article] Dose Campylobacter jejuni infection elicit "demylinating" Guillain-Barre syndrome? : reply. (2005)
  • Author(s): Kuwabara, S.
  • Journal Title: Neurology 64 Pages: 767-767
• [Journal Article] Patterns and serial changes in electrodiagnostic abnormalities of axonal Guillain-Barre syndrome. (2005)
  • Author(s): Hiraga, A.
  • Journal Title: Neurology 64 Pages: 856-860
• [Journal Article] Ganglioside mimicry as a cause of Guillain-Barre syndrome. (2005)
  • Author(s): Yuki, N.
  • Journal Title: Curr Opin Neurol 18 Pages: 557-561
• [Journal Article] Carbohydrate mimicry : a new paradigm of autoimmune diseases. (2005)
  • Author(s): Yuki, N.
  • Journal Title: Curr Opin Immunol 17 Pages: 577-582
• [Journal Article] Comprehensive analysis of bacterial risk factors for developing Guillain-Barre syndrome after Campylobacter jejuni enteritis. (2005)
  • Author(s): Koga, M.
  • Journal Title: J Intect Dis, 42 Pages: 547-555
• [Presentation] Synthetic sialosides: biological recognition at molecular and cellular levels, and applications in medicinal chemistry. Assiut Univ. (2010)
  • Author(s): Kiso, M., Ishida, H., Ando, H.
  • Organizer: 7th International Pharmaceutical Science Conference, Egypt
  • Place of Presentation: Egypt(Oral)
• [Presentation] Synthetic Ganglioside Probes: Versatile Tools for Bio-membrane Research. (2010)
  • Author(s): Kiso, M.
  • Organizer: The 13th International Membrane Research Forum, The 6th iCeMS International Symposium, Featuring Nano-Meso Membrane Mechanisms
  • Place of Presentation: Hotel Fujita Kyoto(Oral)
• [Presentation] 水酸基をアルキセレノ基で置換したセレノ糖鎖の合成研究 (2010)
  • Author(s): 鈴木達哉, 安藤弘宗, 石田秀治, 木曽真
  • Organizer: 2010年度大会 日本農芸化学会
  • Place of Presentation: 東京大学(東京)
• [Presentation] 環状GlcCer acceptorを用いたガングリオシドGa1NAc-GD1aの全合成 (2010)
  • Author(s): 藤川紘樹, 布施智明, 今村彰宏, 安藤弘宗, 石田秀治, 木曽真
  • Organizer: 2010年度大会 日本農芸化学会
  • Place of Presentation: 東京大学(東京)
• [Presentation] 部分修飾シアル酸二量体を有するガングリオシドLLG-3の全合成 (2010)
  • Author(s): 玉井秀樹, 安藤弘宗, 石田秀治, 木曽真
  • Organizer: 2010年度大会 日本農芸化学会
  • Place of Presentation: 東京大学(東京)
• [Presentation] ラフト分子の一分子追跡の為の蛍光GM3プローブの合成と機能評価 (2010)
  • Author(s): 河村奈緒子, 安藤弘宗, 田中賢治, 鈴木健一, 楠見明弘, 石田秀治, 木曽真
  • Organizer: 2010年度大会 日本農芸化学会
  • Place of Presentation: 東京大学(東京)
• [Presentation] パラ位置換ベンジルセレノグリコシド供与体を用いたグリコシル化反応の検討 (2010)
  • Author(s): 毛受雅典, 安藤弘宗, 石田秀治, 纐纈守, 木曽真
  • Organizer: 2010年度大会 日本農芸化学会
  • Place of Presentation: 東京大学(東京)
• [Presentation] 癌特異抗原としてのガングリオシドGM2同族体の合成研究 (2010)
  • Author(s): 斉藤里紗, 安藤弘宗, 石田秀治, 木曽真
  • Organizer: 2010年度大会 日本農芸化学会
  • Place of Presentation: 東京大学(東京)
• [Presentation] トラフナマコ由来生理活性ガングリオシドHPG-7の全合成研究 (2010)
  • Author(s): 岩山祐己, 安藤弘宗, 石田秀治, 木曽真
  • Organizer: 2010年度大会 日本農芸化学会
  • Place of Presentation: 東京大学(東京)
• [Presentation] Synthetic sialosides : biological recognition at molecular and cellular levels, and applications in medicinal chemistry (2010)
  • Author(s): Kiso, M.
  • Organizer: Assiut Univ. 7th International Pharmaceutical Science Conference
  • Place of Presentation: アシュート(エジプト)
• [Presentation] Synthetic Ganglioside Probes : Versatile Tools for Bio-membrane Research (2010)
  • Author(s): Kiso, M.
  • Organizer: The 13th International Membrane Research Forum, The 6th iCeMS International Symposium, Featuring Nano-Meso Membrane Mechanisms
  • Place of Presentation: 京都市(京都)
• [Presentation] 分子内グリコシル化を用いた効率的ガングリオシド合成法の開発 (2009)
  • Author(s): 藤川紘樹, 布施智明, 今村彰宏, 安藤弘宗, 石田秀治, 木曽真
  • Organizer: 第7回糖鎖科学名古屋拠点「若手の力」フォーラム
  • Place of Presentation: 名古屋大学(名古屋)
  • Year and Date: 2009-09-30
• [Presentation] 特異な構造を有するガングリオシドの精密合成 (2009)
  • Author(s): 中島慎也, 安藤弘宗, 石田秀治, 木曽真
  • Organizer: 第7回糖鎖科学名古屋拠点「若手の力」フォーラム
  • Place of Presentation: 名古屋大学(名古屋)
  • Year and Date: 2009-09-30
• [Presentation] 棘皮動物アオヒトデ由来ガングリオシドLLG-3の合成 (2009)
  • Author(s): 玉井秀樹, 安藤弘宗, 石田秀治, 木曽真
  • Organizer: 第7回糖鎖科学名古屋拠点「若手の力」フォーラム
  • Place of Presentation: 名古屋大学(名古屋)
  • Year and Date: 2009-09-30
• [Presentation] シアロ糖鎖の化学合成;分子・細胞レベルにおける生体認識と医学生物学への応用 (2009)
  • Author(s): 安藤弘宗, 石田秀治, 木曽真
  • Organizer: 、第7回糖鎖科学コンソーシアムシンポジウム
  • Place of Presentation: 、千里ライフサイエンスセンター(大阪)(Oral)
• [Presentation] A novel heparin-associated peptide as a visualizing probe. (2009)
  • Author(s): Yabe, T., Hosoda-Yabe, R., Kanamaru, Y., Kiso, M.
  • Organizer: 2009 Annual Meeting of the Society for Glycobiology
  • Place of Presentation: San Diego, California, USA(poster)
• [Presentation] A First Synthesis of Lacto-ganglio Series Ganglioside (2009)
  • Author(s): Nakashima, S., Ando, H., Ishida, H., Kiso, M.
  • Organizer: 15th European Carbohydrate Symposium
  • Place of Presentation: Vienna, Austria(Oral)
• [Presentation] Synthetic ganglioside probes: versatile tools for elucidation of carbohydrate functions. (2009)
  • Author(s): Kiso, M.
  • Organizer: Symposium on the MESO CONTROL of the cells, by the cells, for the cells-featuring transportsomes-.
  • Place of Presentation: Hotel Fujita Kyoto(Oral)
• [Presentation] シアロ糖鎖の化学合成;分子・細胞レベルにおける生体認識と医学生物学への応用 (2009)
  • Author(s): 安藤弘宗, 石田秀治, 木曽真
  • Organizer: 第7回糖鎖科学コンソーシアムシンポジウム
  • Place of Presentation: 千里ライフサイエンスセンター(大阪)
• [Presentation] アオヒトデ由来ガングリオンジLLG-3の合成研究 (2009)
  • Author(s): 玉井秀樹, 安藤弘宗, 石田秀治, 木曽真
  • Organizer: 第40回中部化学関係学協会支部連合秋季大会
  • Place of Presentation: 岐阜大学工学部(岐阜)
• [Presentation] 棘皮動物由来新規ガングリオシドの全合成 (2009)
  • Author(s): 岩山祐己, 安藤弘宗, 石田秀治, 木曽真
  • Organizer: 第40回中部化学関係学協会支部連合秋季大会
  • Place of Presentation: 岐阜大学工学部(岐阜)
• [Presentation] ハイブリッド型ガングリオシドの全合成研究 (2009)
  • Author(s): 中島慎也, 安藤弘宗, 石田秀治, 木曽真
  • Organizer: 第40回中部化学関係学協会支部連合秋季大会
  • Place of Presentation: 岐阜大学工学部(岐阜)
• [Presentation] 1, 5-ラクタム化を鍵反応としたα(2-8)オリゴシアル酸の合成研究 (2009)
  • Author(s): 田中秀則, 安藤弘宗, 石田秀治, 木曽真, 纐纈守
  • Organizer: 1st iCeMS Retreat
  • Place of Presentation: 京都府セミナーハウス(京都)
• [Presentation] 棘皮動物アオヒトデ由来ガングリオシドLLG-3の合成 (2009)
  • Author(s): 玉井秀樹, 安藤弘宗, 石田秀治, 木曽真
  • Organizer: 1st iCeMS Retreat
  • Place of Presentation: 京都府セミナーハウス(京都)
• [Presentation] ニセクロナマコ由来新規生理活性ガングリオシドHLG-2の全合成 (2009)
  • Author(s): 岩山祐己, 安藤弘宗, 石田秀治, 木曽真
  • Organizer: 1st iCeMS Retreat
  • Place of Presentation: 京都府セミナーハウス(京都)
• [Presentation] Synthestic Study on Glycosphingolipid Having Unique Branched Linkage (2009)
  • Author(s): 中島慎也, 安藤弘宗, 石田秀治, 木曽真
  • Organizer: 1st iCeMS Retreat
  • Place of Presentation: 京都府セミナーハウス(京都)
• [Presentation] 分子内グリコシル化を用いた効率的ガングリオシド合成法の開発 (2009)
  • Author(s): 藤川紘樹, 今村彰宏, 安藤弘宗, 石田秀治, 木曽真
  • Organizer: 第29回日本糖質学会年会
  • Place of Presentation: 岐阜県高山市(飛騨・世界生活文化センター)
• [Presentation] 1, 5-ラクタム化を鍵反応としたα(2-8)オリゴシアル酸の合成研究 (2009)
  • Author(s): 田中秀則, 安藤弘宗, 石田秀治, 木曽真, 纐纈守
  • Organizer: 第29回日本糖質学会年会
  • Place of Presentation: 岐阜県高山市(飛騨・世界生活文化センター)
• [Presentation] 棘皮動物アオヒトデ由来ガングリオシドLLG-3の合成 (2009)
  • Author(s): 玉井秀樹, 安藤弘宗, 石田秀治, 木曽真
  • Organizer: 第29回日本糖質学会年会
  • Place of Presentation: 岐阜県高山市(飛騨・世界生活文化センター)
• [Presentation] トラフナマコ由来新規生理活性ガングリオシドHPG-7の全合成(1)還元末端側2糖の効率的合成 (2009)
  • Author(s): 岩山祐己, 安藤弘宗, 石田秀治, 木曽真
  • Organizer: 第29回日本糖質学会年会
  • Place of Presentation: 岐阜県高山市(飛騨・世界生活文化センター)
• [Presentation] ラクト及びガングリオ系二系列を同一分子中のに有するハイブリッド型ガングリオシドの全合成 (2009)
  • Author(s): 中島慎也, 安藤弘宗, 石田秀治, 木曽真
  • Organizer: 第29回日本糖質学会年会
  • Place of Presentation: 岐阜県高山市(飛騨・世界生活文化センター)
• [Presentation] CD22 ligands : Design synthesis and applications (2009)
  • Author(s): Abdu-Allah, H.H.M., Tamanaka, T., Takaku, C., Yu, J., Lu, Z., Sadagopan, M., Adachi, T., Tsubata, T., Ishida, H., Kiso, M.
  • Organizer: The Fifth iCeMS International Symposium"Biomaterials at the interface of chemistry, physics, and biology"
  • Place of Presentation: 京都大学(京都)
• [Presentation] Synthesis and molecular modeling studies of specific inhibitors of influenza virus neuraminidase (2009)
  • Author(s): Sadagopan, M., Ando, H., Ishida, H., Kiso, M.
  • Organizer: The Fifth iCeMS International Symposium"Biomaterials at the interface of chemistry, physics, and biology"
  • Place of Presentation: 京都大学(京都)
• [Presentation] A First Synthesis of Lacto-ganglio Series Ganglioside (2009)
  • Author(s): Nakashima, S., Ando, H., Ishida, H., Kiso, M.
  • Organizer: 15th European Carbohydrate Symposium
  • Place of Presentation: ウィーン(オーストリア)
• [Presentation] Synthetic Study of Ganglioside LLG-3 from Echinoderms (2009)
  • Author(s): Tamai, H., Ando, H., Ishida, H., Kiso, M.
  • Organizer: 15th European Carbohydrate Symposium
  • Place of Presentation: ウィーン(オーストリア)
• [Presentation] An efficient synthesis of GM1 epitope-containing Octasaccharide from C. jejuni (2009)
  • Author(s): Yoshida, F., Saito, R., Komura, N., Ando, H., Ishida, H., Kiso, M.
  • Organizer: 15th European Carbohydrate Symposium
  • Place of Presentation: ウィーン(オーストリア)
• [Presentation] Synthetic Study on Lacto-ganglio Series Ganglioside (2009)
  • Author(s): Nakashima, S., Ando, H., Ishida, H., Kiso, M.
  • Organizer: The fourth iCeMS Symposium on Integrated Cell-Material Sciences
  • Place of Presentation: 京都市(京都)
• [Presentation] Synthetic Study of Ganglioside LLG-3 from Starfish Linckia laevigata (2009)
  • Author(s): Tamai, H., Ando, H., Ishida, H., Kiso, M.
  • Organizer: The fourth iCeMS Symposium on Integrated Cell-Material Sciences
  • Place of Presentation: 京都市(京都)
• [Presentation] Total Synthesis of Novel Bioactive Ganglioside HLG-2 from H. leucospilota (2009)
  • Author(s): Iwayama, Y., Koike, Y., Ando, H., Ishida, H., Kiso, M.
  • Organizer: The fourth iCeMS Symposium on Integrated Cell-Material Sciences
  • Place of Presentation: 京都市(京都)
• [Presentation] A structure guided approach for isofrom selective human sialidase inhibitors (2009)
  • Author(s): Sadagopan, M., Mitagi, T., Ando, H., Ishida, H., Kiso, M.
  • Organizer: The fourth iCeMS Symposium on Integrated Cell-Material Sciences
  • Place of Presentation: 京都市(京都)
• [Presentation] イソ体選択的ヒトシアリダーゼ阻害剤:シアリダーゼ理解のための化学ツール (2009)
  • Author(s): サダゴパンマゲッシュ, 宮城妙子, 安藤弘宗, 石田秀治, 木曽真
  • Organizer: 日本ケミカルバイオロジー学会第4回年会
  • Place of Presentation: 神戸市産業振興センター(兵庫)
• [Presentation] 新奇インフルエンザウィルス高親和性リガンドの合成研究 (2009)
  • Author(s): 野原偏弘
  • Organizer: 2009年度大会 日本農芸化学会
  • Place of Presentation: 福岡
• [Presentation] ラクト-ガングリオ系ガングリオシドの合成研究 (2009)
  • Author(s): 中島慎也
  • Organizer: 2009年度大会日本農芸化学会
  • Place of Presentation: 福岡
• [Presentation] 分子内グリコシル化を用いたa系列ガングリオシドGM2, GM1の合成 (2009)
  • Author(s): 藤川紘樹
  • Organizer: 2009年度大会日本農芸化学会
  • Place of Presentation: 福岡
• [Presentation] トラフナマコに由来する新規生理活性ガングリオシドHPG-7の全合成研究 (2009)
  • Author(s): 岩山祐己
  • Organizer: 2009年度大会日本農芸化学会
  • Place of Presentation: 福岡
• [Presentation] MBP糖鎖認識機構解明を目的としたLewisAタンデムの構築 (2009)
  • Author(s): 長尾和弥
  • Organizer: 2009年度大会日本農芸化学会
  • Place of Presentation: 福岡
• [Presentation] 2-アミノ糖セレノグリコシドの合成と抗酸化活性の評価 (2009)
  • Author(s): 玉井梨絵
  • Organizer: 2009年度大会日本農芸化学会
  • Place of Presentation: 福岡
• [Presentation] 1, 5-ラクタム化反応を基盤としたα(2-8)オリゴシアル酸の合成研究 (2009)
  • Author(s): 田中秀則
  • Organizer: 2009年度大会日本農芸化学会
  • Place of Presentation: 福岡
• [Presentation] 棘皮動物由来ガングリオシドLLG-3の合成研究 (2009)
  • Author(s): 玉井秀樹
  • Organizer: 2009年度大会日本農芸化学会
  • Place of Presentation: 福岡
• [Presentation] 新規KDOアクセプターを用いたC. jejuni由来八糖骨格の構築 (2009)
  • Author(s): 吉田文
  • Organizer: 2009年度大会日本農芸化学会
  • Place of Presentation: 福岡
• [Presentation] ガングリオシドGM1の効率的合成経路の探索 (2009)
  • Author(s): 河村奈緒子
  • Organizer: 2009年度大会日本農芸化学会
  • Place of Presentation: 福岡
• [Presentation] ラクタム化シアル酸誘導体の合成とその分解反応に関する研究 (2009)
  • Author(s): 大野ひろみ
  • Organizer: 2009年度大会日本農芸化学会
  • Place of Presentation: 福岡
• [Presentation] Synthetic ganglioside probes : versatile tools for elucidation of carbohydrate functions (2009)
  • Author(s): M. Kiso
  • Organizer: Symposium on the MESO CONTROL of the cells, by the cells, for the cells ---featuring transportsotmes---
  • Place of Presentation: Kyoto
• [Presentation] 糖鎖小宇宙への旅-ものづくりから生命科学へ その多彩な構造と生体機能を探る (2008)
  • Author(s): 木曽真
  • Organizer: 日本学術会議中部地区会議学術講演会
  • Place of Presentation: 岐阜
  • Year and Date: 2008-12-05
• [Presentation] Towards the selective inhibition of human plasma-membrane associate sialidase(NEU3)for therapeutic value (2008)
  • Author(s): Magesh, S.
  • Organizer: The Eleventh Membrane Research Forum
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2008-02-21
• [Presentation] Development of an efficient synthetic method of ganglioside GM3 as a cell membrane component (2008)
  • Author(s): Fujikawa, K.
  • Organizer: The Eleventh Membrane Research Forum
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2008-02-21
• [Presentation] Design, synthesis, and structural activity relationships of novel sialosides as CD22-specific inhibitors (2008)
  • Author(s): H. H. M. Abdu-Allah
  • Organizer: The Eleventh Membrane Research Forum
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2008-02-21
• [Presentation] Potential Synthetic Targets in Medicinal Chemistry and Cell Biology. (2008)
  • Author(s): Kiso, M.
  • Organizer: SialoGlyco Conference 2008
  • Place of Presentation: Moscow- St. Petersburg, Russia(Oral)
• [Presentation] An efficient synthesis of a series of gangliosides, GM3, GM2 and GM1, by employing intramolecularglycosylation as a key step. (2008)
  • Author(s): Fujikawa, K., Imamura, A., Ishida, H., Kiso, M.
  • Organizer: XXIV International Carbohydrate Symposium
  • Place of Presentation: Oslo, Norway(Oral)
• [Presentation] Occurrence of the Cyclic Sialic Acid in Mammalian Cells and Tissues As Demonstrated by Chemical Methods. (2008)
  • Author(s): Kitajima, K., Iwata, S., Kawakami, N., Sato, C., Ando, H., Ohno, H., Ishida, H., Kiso, M. Tagushi, O., Kannagi, R.
  • Organizer: XXIV International Carbohydrate Symposium
  • Place of Presentation: Oslo, Norway(Oral)
• [Presentation] Sialic Acid-Containing Glycoconjugates : Potential Synthetic Targets in Medicinal Chemistry and Cell Biology (2008)
  • Author(s): M. Kiso
  • Organizer: SialoGlyco Conference 2008
  • Place of Presentation: Moscow --St. Petersburg, ssia
• [Presentation] Design, synthesis, of novel sialosides as CD22-specific inhibitors. (2008)
  • Author(s): Hajjaj. H. M. Abdu-Allah
  • Organizer: 第28回日本糖質学会年会
  • Place of Presentation: つくば
• [Presentation] 構造的に複雑なガングリオシドの実用的合成法の開発と応用 (2008)
  • Author(s): 今村彰宏
  • Organizer: 第28回日本糖質学会年会
  • Place of Presentation: つくば
• [Presentation] C-1ハロエチルエステル基によるシアリル化の活性化促進と立体制御 (2008)
  • Author(s): 田中秀則
  • Organizer: 第28回日本糖質学会年会
  • Place of Presentation: つくば
• [Presentation] 分子内グリコシル化を鍵反応とするa系列ガングリオシドGM3, GM2, GM1の効率的合成 (2008)
  • Author(s): 藤川紘樹
  • Organizer: 第28回日本糖質学会年会
  • Place of Presentation: つくば
• [Presentation] ニセクロナマコに由来する新規生理活性ガングリオシドHLG-2の全合成 (2008)
  • Author(s): 岩山祐己
  • Organizer: 第28回日本糖質学会年会
  • Place of Presentation: つくば
• [Presentation] CD22 specific Inhibitors : Design, Synthesis, and Inhibitory poteny of Novel Sialosides (2008)
  • Author(s): Hajjaj. H. M. Abdu-Allah
  • Organizer: XXIV International Carbohydrate Symposium
  • Place of Presentation: Oslo, Norway
• [Presentation] Ganglioside GQ1b : Total Synthesis and the Expansion to Synthetic Probes toward Applications in Medicinal chemistry and Cell Biology (2008)
  • Author(s): A. Imamura
  • Organizer: XXIV International Carbohydrate Symposium
  • Place of Presentation: Oslo, Norway
• [Presentation] Total Synthesis of Novel Bioactive Ganglioside HLG-2 from H. leucospi lota (2008)
  • Author(s): Y. Iwayama
  • Organizer: XXIV International Carbohydrate Symposium
  • Place of Presentation: Oslo, Norway
• [Presentation] An efficient synthesis of a series of gangliosides, GM3, GM2 and GM1, by employing intramolecular glycosylation as a key step (2008)
  • Author(s): K. Fujikawa
  • Organizer: XXIV International Carbohydrate Symposium
  • Place of Presentation: Oslo, Norway
• [Presentation] Synthesis of Various Selenoglycosides by Using in Situ Glycosyl Selenolate Formation (2008)
  • Author(s): R. Tamai
  • Organizer: XXIV International Carbohydrate Symposium
  • Place of Presentation: Oslo, Norway
• [Presentation] Efficient synthesis of highly reactive KDO acceptor towards the assembly of octasaccharide from C. jejuni (2008)
  • Author(s): F. Yoshida
  • Organizer: XXIV International Carbohydrate Symposium
  • Place of Presentation: Oslo, Norway
• [Presentation] Sialylation Reactions with 5-N, 7-O-Oxazinanone Sialyl Donor 5-N, 7-0-Oxazinanone (2008)
  • Author(s): H. Tanaka
  • Organizer: XXIV International Carbohydrate Symposium
  • Place of Presentation: Oslo, Norway
• [Presentation] Occurrence of the Cyclic Sialic Acid in Mammalian Cells and Tissues As Demonstrated by Chemical Methods (2008)
  • Author(s): K. Kitajima
  • Organizer: XXIV International Carbohydrate Symposium
  • Place of Presentation: Oslo, Norway
• [Presentation] Exploration of the reason why DTBS group directs alpha-selective glycosylation (2008)
  • Author(s): N. Matsuzawa
  • Organizer: XXIV International Carbohydrate Symposium
  • Place of Presentation: Oslo, Norway
• [Presentation] 実用的合成戦略に基づいたガングリオシドプローブの合成 (2008)
  • Author(s): 吉川武
  • Organizer: 日本ケミカルバイオロジー研究会第3回年会
  • Place of Presentation: 東京
• [Presentation] Efficient Synthesis of GM3 Analog by Employing Intramolecular Glycosylation (2008)
  • Author(s): Fujikawa, K.
  • Organizer: 14th European Carbohydrate Symposium
  • Place of Presentation: Kyoto, Japan
• [Presentation] Synthetic ganglioside probes toward apphcations in medicinal chemistry and cell biology (2008)
  • Author(s): Kiso, M.
  • Organizer: The First iCeMS International Symposium
  • Place of Presentation: Kyoto, Japan
• [Presentation] Di-tert-butylsilylene (DTBS)-directed alpha-glycosidation of galactose/galactosamine toward the assembly of various glycosides. (2007)
  • Author(s): Kiso, M.
  • Organizer: Gordon Research Conferences Tilton School
  • Place of Presentation: Tilton(Oral)
• [Presentation] A synthesis of GM1 epitope-KLH conjugate for elucidation of the pathogenic mechanism of the Guillan- Barre Syndrome. (2007)
  • Author(s): Yoshikawa, T., Yuki, N., Yabe, T., Ishida, H., Kiso, M.
  • Organizer: XIX International Symposium on Glycoconjugates
  • Place of Presentation: Cairns, Australia
• [Presentation] Development of novel methods to construct glycolipids and glycopeptides (2007)
  • Author(s): Ishida, H.
  • Organizer: NIPER-ACCT(I)2007 CARBO-XXII
  • Place of Presentation: NIPER, India
• [Presentation] Di-tert-butylsilylene(DTBS)-directed alpha-glycosidation of galactose/gala ctosamine toward the assembly of various glycoside (2007)
  • Author(s): Kiso, M.
  • Organizer: Gordon Research Conferences Tilton School
  • Place of Presentation: Tilton, NH, USA
• [Presentation] Design and library synthesis of human sialidase NEU3 selective inhibitors. (2007)
  • Author(s): Magesh, S.
  • Organizer: 第27回日本糖質学会年会
  • Place of Presentation: 福岡、日本
• [Presentation] 合成ガングリオシドプローブを用いたSiglec-7との共結晶構造解析 (2007)
  • Author(s): 今村彰宏
  • Organizer: 第27回日本糖質学会年会
  • Place of Presentation: 福岡、日本
• [Presentation] ボツリヌス毒素のリガンド探索に向けたムチン型糖鎖の合成と生物活性 (2007)
  • Author(s): 大野ひろみ
  • Organizer: 第27回日本糖質学会年会
  • Place of Presentation: 福岡、日本
• [Presentation] GM2 activatorの作用機構解明を目的とした新規GM2類縁体の設計と合成 (2007)
  • Author(s): 小森達也
  • Organizer: 第27回日本糖質学会年会
  • Place of Presentation: 福岡、日本
• [Presentation] 非経験的フラグメント分子軌道法によるインフルエンザHAとシアロ糖鎖の相互作用解析 (2007)
  • Author(s): 澤田敏彦
  • Organizer: 第27回日本糖質学会年会
  • Place of Presentation: 福岡、日本
• [Presentation] 分子内グリコシル化を利用したフィトスフィンゴシン含有GM3の合成 (2007)
  • Author(s): 藤川紘樹
  • Organizer: 第27回日本糖質学会年会
  • Place of Presentation: 福岡、日本
• [Presentation] Design and synthesis of novel sialosides as potential CD22-specific inhibitors. XIX International Symposium on Glycoconjugates (2007)
  • Author(s): A. Hajjaj Hassan Mohamed
  • Organizer: XIX International Symposium on Glycoconjugates
  • Place of Presentation: Cairns, Australia
• [Presentation] Systematic synthesis of functional oligosaccharide probes for sugar_chips (2007)
  • Author(s): M. Ando
  • Organizer: XIX International Symposium on Glycoconjugates
  • Place of Presentation: Cairns, Australia
• [Presentation] Di-tert-butylsilylene-Directed α-Selective Synthesis of p-Nitrophenyl T-antigen analogs (2007)
  • Author(s): T. Sato
  • Organizer: XIX International Symposium on Glycoconjugates
  • Place of Presentation: Cairns, Australia
• [Presentation] A synthesis of GMl epitope-KLH conjugate for elucidation of the pathogenic mechanismof the Guillan-Barre Syndrome (2007)
  • Author(s): T. Yoshikawa
  • Organizer: XIX International Symposium on Glycoconjugates
  • Place of Presentation: Cairns, Australia
• [Presentation] CD22特異的阻害剤としての新規シアロシドの設計と合成 (2007)
  • Author(s): A. Hajjaj Hassan Mohamed
  • Organizer: 日本ケミカルバイオロジー研究会 第2回年会
  • Place of Presentation: 京都、日本
• [Presentation] ガングリオシドGT1b糖鎖プローブの合成とSiglec-7との共結晶構造解析 (2007)
  • Author(s): 今村彰宏
  • Organizer: 日本ケミカルバイオロジー研究会 第2回年会
  • Place of Presentation: 京都、日本
• [Presentation] Comparative Protein Modeling of Human Sialidases : Implications for the Design of Selective NEU3 Inhibitors. (2006)
  • Author(s): Magesh, S., Suzuki, T., Miyagi, T., Ishida, H., Kiso, M.
  • Organizer: XXIII International Carbohydrate Symposium
  • Place of Presentation: Whistler, Canada
• [Presentation] Lactamized sialyl 6-O-sulfo paragloboside & Lewis X neoglycolipids: synthesis and antigenic reactivity against G159 monoclonal antibody. (2005)
  • Author(s): Yamaguchi, M., Ishida, H., Kanamori, A., Kannagi, R., Kiso, M.
  • Organizer: XVIII International Symposium on Glycoconjugates
  • Place of Presentation: Florence, Italy
• [Book] 複合糖質の化学と最新応用技術(正田晋一郎, 稲津敏行編) (2009)
  • Author(s): 安藤弘宗, 石田秀治, 木曽真
  • Publisher: シーエムシー出版
• [Book] The Fragment molecular orbital method: Practical applications to large molecular systems(D. Fedorov and K. Kitaura, (eds),) (2009)
  • Author(s): Sawada, T., Hashimoto, T., Tokiwa, H., Suzuki, T., Nakano, H., Ishida, H., Kiso, M. Suzuki, Y.
  • Publisher: Boca Raton(CRC Press)
• [Book] Glycobiology Research Trends (2009)
  • Author(s): Tomio Yabe
  • Publisher: Science Publishers
• [Book] シアル酸化学の新局面-過去5年の動向から、複合糖質の化学と最新応用技術 (2009)
  • Author(s): 安藤弘宗, 石田秀治、木曽真
  • Total Pages: 298
  • Publisher: シーエムシー出版
• [Book] How does the FMO method help in studying viruses and their binding to receptors, In : The Fragment molecular orbital method : Practical applications to large molecular systems (2009)
  • Author(s): Sawada, T., Hashimoto, T., Tokiwa, H., Suzuki, T., Nakano, H., Ishida, H., Kiso, M., Suzuki, Y.
  • Total Pages: 215
  • Publisher: CRC Press
• [Book] "Heparan sulfate D-glucosaminyl 3-0-sulfotransferases"In"Glycobiology Research Trends" (2009)
  • Author(s): Tomio Yabe, Nobuaki Maeda
  • Total Pages: 232
  • Publisher: Nova Science Publishers
• [Book] 医薬応用に向けた糖鎖合成技術の活用「シアル酸グルコシル化反応の改良と共通構造から展開するガングリオシドの系統合成法の探求」遺伝子医学MOOK11 (2008)
  • Author(s): 木曽真, 安藤弘宗, 石田秀治
  • Publisher: 株式会社メディカルドゥ
• [Book] Selectiveα-sialylation. (2008)
  • Author(s): Ando, H., Kiso, M.
  • Publisher: Springer-Verlag
• [Book] 第2章 合成編 医薬応用に向けた糖鎖合成技術の活用「シアル酸グルコシル化反応の改良と共通構造から展開するガングリオシドの系統合成法の探求」遺伝子医学MOOKll臨床糖鎖バイオマーカーの開発-糖鎖機能の解明とその応用 (2008)
  • Author(s): 木曽真
  • Publisher: 株式会社メディカルドウ
• [Book] Selective α-sialylation. In : Glycoscience, 2nd Edition VOL 2 (2008)
  • Author(s): Ando, H.
  • Publisher: Springer-Verlag
• [Book] Comprehensive Glycoscience (2007)
  • Author(s): Ando, T.
  • Total Pages: 981
  • Publisher: Elsevier
• [Book] 糖鎖科学の新展開 (2005)
  • Author(s): 安藤 弘宗
  • Total Pages: 536
  • Publisher: (株)エヌ・ティー・エス
• [Book] 未来を拓く 糖鎖科学 (2005)
  • Author(s): 石田 秀治, 木曽 真
  • Total Pages: 467
  • Publisher: (株)金芳堂
• [Remarks]
  • URL: http://www1.gifu-u.ac.jp/~kassei/
• [Remarks]
  • URL: http://wwwl.gifu-u.ac.jp/~kassei/
• [Patent(Industrial Property Rights)] シアリダーゼ活性阻害剤及び抗インフルエンザ薬 (2009)
  • Inventor(s): 木曽真, 石田秀治, サダゴパンマゲッシュ, 鈴木康夫, 宮城妙子
  • Industrial Property Rights Holder: 岐阜大学、中部大学、宮城県
  • Industrial Property Number: 2009-298788
  • Filing Date: 2009-12-28
• [Patent(Industrial Property Rights)] CD22分子に対する高親和性を有しB細胞の増殖を増強する化合物 (2009)
  • Inventor(s): 鍔田武志, 木曽真, 石田秀治, アブドゥ・アラハジャジハッサンモハメッド
  • Industrial Property Rights Holder: 東京医科歯科大学、岐阜大学
  • Industrial Property Number: 2009-177776
  • Filing Date: 2009-07-30
• [Patent(Industrial Property Rights)] グリコサミノグリカンの検出法及びそのための分子プローブ (2009)
  • Inventor(s): 矢部富雄
  • Industrial Property Rights Holder: 国立大学法人岐阜大学
  • Industrial Property Number: 2009-243995
  • Filing Date: 2009-10-23
• [Patent(Industrial Property Rights)] シアリダーゼ活性阻害剤及び抗インフルエンザ薬 (2009)
  • Inventor(s): 木曽真、石田秀治、サダゴパンマゲッシュ、鈴木康夫、宮城妙子
  • Industrial Property Rights Holder: 岐阜大学 中部大学 宮城ガンセンター
  • Industrial Property Number: 2009-298788
  • Filing Date: 2009-12-28
• [Patent(Industrial Property Rights)] CD22分子に対する高親和性を有しB細胞の増殖を増強する化合物 (2009)
  • Inventor(s): 鍔田武志、木曽真、石田秀治、アブドゥ・アラハジャジハッサンモハメッド
  • Industrial Property Rights Holder: 東京医科歯科大学 岐阜大学
  • Industrial Property Number: 2009-177776
  • Filing Date: 2009-07-30
• [Patent(Industrial Property Rights)] 合成糖脂質含有リポソーム (2008)
  • Inventor(s): 岐阜大学応用生物科学部木曽真, 石田秀治, 山下泰治
  • Industrial Property Rights Holder: 国立大学法人岐阜大学片山化学工業株式会社
  • Filing Date: 2008-02-22
• [Patent(Industrial Property Rights)] 合成糖脂質含有リポソーム (2008)
  • Inventor(s): 岐阜大学応用生物科学部 木曽真、石田秀治、山下泰治
  • Industrial Property Rights Holder: 国立大学法人 岐阜大学 片山化学工業株式会社
  • Industrial Property Number: 2008-042262
  • Filing Date: 2008-02-22
• [Patent(Industrial Property Rights)] スフィンゴ糖脂質のケミカル合成法 (2007)
  • Inventor(s): 木曽真, 石田秀治, 藤川紘樹
  • Industrial Property Rights Holder: 片山化学工業株式会社
  • Industrial Property Number: 2008-557184
  • Filing Date: 2007-02-09