The genetic epidemiology of cerebrovascular disease with high risk genetic factors to establish the secondary prevention program targeting high risk subjects

• Project/Area Number: 17109007
• Research Category: Grant-in-Aid for Scientific Research (S)
• Allocation Type: Single-year Grants
• Research Field: Hygiene
• Research Institution: Kyoto University
• Principal Investigator: KOIZUMI Akio Kyoto University, 医学研究科, 教授 (50124574)
• Co-Investigator(Kenkyū-buntansha): HASHIMOTO Nobuo 国立循環器病センター, 総長 (40135570) ; SUZUKI Michiyasu 山口大学, 医学部, 教授 (80196873) ; NOZAKI Kazuhiko 滋賀医科大学, 医学部, 教授 (90252452) ; MATSUDA Fumihiko 京都大学, 医学研究科, 教授 (50212220) ; TOYOKUNI Shinya 名古屋大学, 大学院・医学系研究科, 教授 (90252460) ; INOUE Kayoko 京都大学, 医学研究科, 講師 (30402829) ; TOYOSHIMA Megumi 広島大学, 原爆放射線医科学研究所, 助教 (80423052) ; HARADA Kouji 京都大学, 医学研究科, 准教授 (80452340)
• Co-Investigator(Renkei-kenkyūsha): MINATA Mutsuko , 瀬戸内徳洲会病院・内科 (00456857) ; HITOMI Toshiaki 京都大学, 医学研究科, 助教 (90405275) ; KOBAYASHI Hatasu 京都大学, 医学研究科, 研究員 (70542091)
• Project Period (FY): 2005 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥87,490,000 (Direct Cost: ¥67,300,000、Indirect Cost: ¥20,190,000); Fiscal Year 2009: ¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000); Fiscal Year 2008: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000); Fiscal Year 2007: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000); Fiscal Year 2006: ¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000); Fiscal Year 2005: ¥22,230,000 (Direct Cost: ¥17,100,000、Indirect Cost: ¥5,130,000)
• Keywords: 遺伝子 / ゲノム / 脳・神経 / 遺伝学 / 社会医学 / 脳動脈瘤 / もやもや病 / 脳動静脈奇形 / 遺伝疫学 / 感受性遺伝子 / 候補領域 / 連鎖解析 / 相関研究 / 遺伝解析

Research Abstract

The major goal of the present study is to isolate the susceptibility genes for intracranial aneurysms (IA), cerebral arteriovenous malformation (AVM) and moyamoya disease (MMD). We identified TNFRSF13B as a susceptibility gene for IA. We concluded that any discernible genetic factor is not involved in AVM. The intensive sequencing in IBD revealed a novel gene named "mytserin" as a susceptibility gene for MMD.

Research Products

• [Journal Article] Confirmation of an association of SNP rs1333040 on 9p21 with familial and sporadic intracranial aneurysms in Japanese patients. (2010)
  • Author(s): Hashikata H. Koizumi A, et al.
  • Journal Title: Stroke 15(Accepted on Feb)
  • Peer Reviewed
• [Journal Article] より合理的なフィールド遺伝疫学をめざして (2010)
  • Author(s): 小泉昭夫
  • Journal Title: 日本衛生学雑誌 65巻1号 Pages: 37-47
  • NAID: 10027650069
  • Peer Reviewed
• [Journal Article] Confirmation of an association of SNP rs1333040 on 9p21 with familial and sporadic intracranial aneurysms in Japanese patients. (2010)
  • Author(s): Hashikata H.Koizumi A, et al
  • Journal Title: Stroke
  • Peer Reviewed
• [Journal Article] Spontaneous development of endoplasmic reticulum stress that can lead to diabetes mellitus is associated with higher calcium-independent phospholipase A2 expression : a role for regulation by SREBP-1. (2010)
  • Author(s): Lei X, Zhang S, Barbour SE, Bohrer A, Ford EL, Koizumi A, Papa FR, Ramanadham S.
  • Journal Title: J Biol Chem 285巻 Pages: 6693-6705
  • Peer Reviewed
• [Journal Article] より合理的なフィールド遺伝疫学をめざして (2010)
  • Author(s): 小泉昭夫
  • Journal Title: 日本衛生学雑誌 65巻 Pages: 37-47
  • NAID: 10027650069
  • Peer Reviewed
• [Journal Article] Spontaneous development of endoplasmic reticulum stress that can lead to diabetes mellitus is associated with higher calcium-independent phospholipase A2 expression: a role for regulation by SREBP-1. (2009)
  • Author(s): Lei X, Zhang S, Barbour SE, Bohrer A, Ford EL, Koizumi A, Papa FR, Ramanadham S
  • Journal Title: J Biol Chem. 285(9) Pages: 6693-705
  • Peer Reviewed
• [Journal Article] JACC Study Group. Coffee, green tea, black tea and oolong tea consumption and risk of mortality from cardiovascular disease in Japanese men and women. (2009)
  • Author(s): Mineharu Y, Koizumi A, et al.
  • Journal Title: J Epidemiol Community Health (Accepted)
  • Peer Reviewed
• [Journal Article] A rare Asian founder polymorphism in Raptor may explain the high prevalence of moyamoya disease in East Asian and low prevalence in Caucasian. Environ. (2009)
  • Author(s): Liu W, Hashikata H, Inoue K, Matsuura N, Mineharu Y, Kobayashi H, Kikuta K, Takagi Y, Hitomi T, Krischek B, Zou L, Fang F, Herzig R, Kim J, Kang H, Oh C, Tregouet D, Hashimoto N, Koizumi A
  • Journal Title: Health Prev Med. 15(2) Pages: 94-104
  • Peer Reviewed
• [Journal Article] もやもや病(ウイリス動脈輪閉塞症)診断 (2009)
  • Author(s): 橋本信夫, 冨永悌二, 宮本享, 永田泉, 寶金清博, 鈴木則宏, 小泉昭夫, 野川茂, 中川原譲二, 北川一夫, 黒田敏, 菊田健一郎, 藤村幹, 高橋淳, 林健太郎, 大木宏一, 星野晴彦, 高木康志
  • Journal Title: 治療ガイドライン・脳卒中の外科 37巻5号 Pages: 321-37
  • Peer Reviewed
• [Journal Article] A rare Asian founder polymorphism in Raptor may explain the high prevalence of moyamoya disease in East Asian and low prevalence in Caucasian. (2009)
  • Author(s): Liu W, Koizumi A, et al.
  • Journal Title: Environ. Health Prev Med 15巻 Pages: 94-104
  • Peer Reviewed
• [Journal Article] Coffee, green tea, black tea and oolong tea consumption and risk of mortality from cardiovascular disease in Japanese men and women. (2009)
  • Author(s): Mineharu Y, Koizumi A, et al., JACC Study Group.
  • Journal Title: J Epidemiol Community Health
  • Peer Reviewed
• [Journal Article] もやもや病(ウイリス動脈輪閉塞症)診断・治療ガイドライン (2009)
  • Author(s): 橋本信夫, 小泉昭夫, 他
  • Journal Title: 脳卒中の外科 37巻 Pages: 321-337
  • Peer Reviewed
• [Journal Article] もやもや病の遺伝要因の探索の現状 (2008)
  • Author(s): 箸方宏州, 劉万洋, 峰晴陽平, 井上佳代子, 竹中勝信, 池田秀敏, 寶金清博, 黒田敏, 菊池顕次, 木村充, 瀧琢有, 園部眞, 伴貞彦, 野垣秀和, 半田明, 菊田健一郎, 高木康志, 野崎和彦, 橋本信夫, 小泉昭夫
  • Journal Title: BRAIN and NERVE:神経研究の進歩 60巻11号 Pages: 1261-1269
  • Peer Reviewed
• [Journal Article] 専門医に求められる最新の知識脳血管障害家族性もやもや病 (2008)
  • Author(s): 峰晴陽平, 菊田健一郎, 高木康志, 野崎和彦, 橋本信夫, 小泉昭夫
  • Journal Title: 脳神経外科速報 18巻7号 Pages: 868-87
  • Peer Reviewed
• [Journal Article] Locus-wide association study confirms chromosome 14q23 as a susceptibility locus for intracranial aneurysm. (2008)
  • Author(s): Mineharu Y, Inoue K, Inoue S, Kikuchi K, Ohishi H, Nozaki K, Hashimoto N, Koizumi A
  • Journal Title: Journal of Human Genetics 53(4) Pages: 325-332
  • Peer Reviewed
• [Journal Article] Autosomal dominant moyamoya disease maps to chromosome 17q25. 3 (2008)
  • Author(s): Mineharu Y, Liu W, Inoue K, Matsuura N, Inoue S, Takenaka K, Ikeda H, Houkin K, Takagi Y, Kikuta K, Nozaki K, Hashimoto N, Koizumi A
  • Journal Title: NEUROLOGY 70 Pages: 2357-2363
  • Peer Reviewed
• [Journal Article] Nephronophthisis complicated with hepatic fibrosis: an autopsy case with rupture of the splenic artery after renal transplantation. (2008)
  • Author(s): Tsukamoto T, Tanaka M, Komiya T, Ueda S, Takasu K, Takahara S, Koizumi A, Muso E
  • Journal Title: Clin Exp Nephrol 12(1) Pages: 82-8
  • NAID: 10025351954
  • Peer Reviewed
• [Journal Article] Autosomal dominant moyamoya disease maps to chromosome17q25.3. (2008)
  • Author(s): Mineharu Y, Liu W, Inoue K, Matsuura N, Inoue S. Takenaka K, Ikeda H, Houkin K, Takagi Y, Kikuta K, Nozaki K, Hashimoto N, Koizumi A.
  • Journal Title: Neurology 70 Pages: 235-232
  • Peer Reviewed
• [Journal Article] Current knowledge on the genetic factors involved in moyamoya disease (2008)
  • Author(s): Hashikata H, et al.
  • Journal Title: Brain Nerve 60 Pages: 1261-1269
  • Peer Reviewed
• [Journal Article] Autosomal dominant moyamoya disease maps to chromosome 17q25.3 (2008)
  • Author(s): Mineharu Y, Liu W, Inoue K, Matsura N, Inoue S, Takenaka K, Ikeda H, Houkin K, Takagi Y, Kikuta K, Nozaki K, Hashimoto N, Koizumi A.
  • Journal Title: Neurology (In press)
  • Peer Reviewed
• [Journal Article] Combination of linkage and association studies for brain arteriovenous malformation. (2007)
  • Author(s): Inoue S, Liu W, Inoue K, Mineharu Y, Takenaka K, Yamakawa H, Abe M, Jafar J. Jafar, Herzig R, Koizumi A
  • Journal Title: Stroke 38 Pages: 1368-1370
  • NAID: 10018567226
  • Peer Reviewed
• [Journal Article] Model-Based Linkage Analyses Confirm Chromosome 19q13. 3 as a Susceptibility Locus for Intracranial Aneurysm. (2007)
  • Author(s): Mineharu Y, Inoue K, Inoue S, Yamada S, Nozaki K, Hashimoto N, Koizumi A
  • Journal Title: Stroke 38 Pages: 1174-1178
  • Peer Reviewed
• [Journal Article] ARMET is a soluble ER protein induced by the unfolded protein response via ERSE-II element. (2007)
  • Author(s): Mizobuchi N, Hoseki J, Kubota H, Toyokuni S, Nozaki J, Naitoh M, Koizumi A, Nagata K
  • Journal Title: Cell Struct Funct. 32(1) Pages: 41-50
  • NAID: 130004053859
  • Peer Reviewed
• [Journal Article] Analysis of published PKD1 gene sequence variants. (2007)
  • Author(s): Ravine D, Harris PC, Rossetti S, Peters D, Breuning M, Henske EP, Koizumi A, Inoue S, Shimizu Y, Thongnoppakhun W, Yenchitsomanus PT, Deltas C, Sandford R, Torra R, Turco AE, Jeffery S, Fontes M, Somlo S, Furu LM, Smulders YM, Mercier B, Ferec C, Burtey SRavine D, Harris PC, Rossetti S, Peters D, Breuning M, Henske EP, Koizumi A, Inoue S, Shimizu Y, Thongnoppakhun W, Yenchitsomanus PT
  • Journal Title: Nat Genet. 39(4) Pages: 427-8
  • Peer Reviewed
• [Journal Article] Inheritance pattern of familial moyamoya disease: autosomal dominant mode and genomic imprinting. (2007)
  • Author(s): Mineharu Y, Takenaka K, Yamakawa, Inoue K, Kikuta K, Takagi Y, Nozaki K, Hashimoto N, Koizumi A.
  • Journal Title: J Neurol Neurosurg Psychiatr 77 Pages: 1025-1029
  • Peer Reviewed
• [Journal Article] Locus-wide association study confirms chromosome 14q23 as a susceptibility locus for intracranial aneurysm (2007)
  • Author(s): Mineharu Y, Inoue K, Inoue S, Kikuchi K, Ohishi H, Nozaki K, Hashimoto N, Koizumi A.
  • Journal Title: Journal of Human Genetics 53 Pages: 325-332
  • Peer Reviewed
• [Journal Article] Model-Based Linkage Analyses Confirm Chromosome 19q13.3 as a Susceptibility Locus for Intracranial Aneurysm (2007)
  • Author(s): Mineharu Y, Inoue K, Inoue S, Yamada S, Nozaki K, Hashimoto N, Koizumi A.
  • Journal Title: Stroke. 38 Pages: 1174-1178
  • Peer Reviewed
• [Journal Article] Combination of linkage and association studies for brain arteriovenous malformation. (2007)
  • Author(s): Inoue S, Liu W, Inoue K, Mineharu Y, Takenaka K, Yamakawa H, Abe M, Jafar JJ. Herzig R, Koizumi A.
  • Journal Title: Stroke. 33 Pages: 1174-1173
  • NAID: 10018567226
  • Peer Reviewed
• [Journal Article] Combination of linkage and association studies for brain arteriovenous malformation (2007)
  • Author(s): Inoue S., Liu W., Inoue K., Mineharu Y., Takenaka K., Yamakawa H., Abe M., Jafar J.Jafar, Herzig R., Koizumi A.
  • Journal Title: Stroke (in press)
  • NAID: 10018567226
• [Journal Article] Model-Based Linkage Analyses Confirm Chromosome 19q13.3 as a Susceptibility Locus for Intracranial Aneurysm (2007)
  • Author(s): Mineharu Y., Inoue K., Inoue S., Yamada S., Nozaki K., Hashimoto N., Koizumi A.
  • Journal Title: Stroke (in press)
• [Journal Article] Inheritance pattern of familial moyamoya disease: autosomal dominant mode and genomic imprinting. (2006)
  • Author(s): Mineharu Y, Takenaka K, Yamakawa H, Inoue K, Ikeda H, Kikuta K, Takagi Y, Nozaki K, Hashimoto N, Koizumi A
  • Journal Title: J Neurol Neurosurg Psychiatry 77 Pages: 1025-1029
  • Peer Reviewed
• [Journal Article] A PTPN11 gene mutation (Y63C) causing Noonan syndrome is not associated with short stature in general population. (2006)
  • Author(s): Takahashi I, Utsunomiya M, Inoue K, Takahashi T, Nozaki J, Wada Y, Takada G, Koizumi A
  • Journal Title: Tohoku J Exp Med. 208(3) Pages: 255-9
  • NAID: 10017291462
  • Peer Reviewed
• [Journal Article] 脳神経外科領域疾患の遺伝子解析 (2006)
  • Author(s): 峰晴陽平, 小泉昭夫
  • Journal Title: 脳神経外科速報 16(5) Pages: 416-425
  • Peer Reviewed
• [Journal Article] Search on Chromosome 17 Centromere Reveals TNFRSF13B as a Susceptibility Gene for Intracranial Aneurysm. (2006)
  • Author(s): Inoue K, Mineharu Y, Inoue S, Yamada S, Matsuda F, Nozaki K, Takenaka K, Hashimoto N, Koizumi A
  • Journal Title: A Preliminary Study. Circulation 113(13) Pages: 2002-2010
  • Peer Reviewed
• [Journal Article] Association Analysis of Common Variants of ELN, NOS2A, APOE, and ACE2 to Intracranial Aneurysm. (2006)
  • Author(s): Mineharu Y, Inoue K, Inoue S, Yamada S, Nozaki K, Takenaka K, Hashimoto N, Koizumi A
  • Journal Title: Stroke 37 Pages: 1189-1194
  • Peer Reviewed
• [Journal Article] Inheritance pattern of familial moyamoya disease : autosomal dominant mode and genomic imprinting (2006)
  • Author(s): Mineharu Y., Takenaka K., Yamakawa H., Inoue K., Ikeda H., Kikuta K., Takagi Y., Nozaki K., Hashimoto N., Koizumi A.
  • Journal Title: J Neurol Neurosurg Psychiatry 77 Pages: 1025-1029
• [Journal Article] Search on Chromosome 17 Centromere Reveals TNFRSF13B as a Susceptibility Gene for Intracranial Aneurysm. A Preliminary Study (2006)
  • Author(s): Inoue K., Mineharu Y., Inoue S., Yamada S., Matsuda F., Nozaki K., Takenaka K., Hashimoto N., Koizumi A.
  • Journal Title: Circulation 113 Pages: 2002-2010
• [Journal Article] Association Analysis of Common Variants of ELN, NOS2A, APOE, and ACE2 to Intracranial Aneurysm (2006)
  • Author(s): Mineharu Y., Inoue K., Inoue S., Yamada S., Nozaki K., Takenaka K., Hashimoto N., Koizumi A.
  • Journal Title: Stroke 37 Pages: 1189-1194
• [Journal Article] Association analysis of common variants of ELN, NOS2A, APOE and Ace2 to intracranial aneurysm (2006)
  • Author(s): Mineharu Y. et al.
  • Journal Title: Stroke (In press)
• [Journal Article] Search on Chromosome 17 centromere reveals TNFRSF13B as a susceptibility gene for intracranial aneurysm : A preliminary study (2006)
  • Author(s): Inoue K et al.
  • Journal Title: Circulation (In press)
• [Journal Article] 脳神経外科領域疾患の遺伝子解析 (2005)
  • Author(s): 峰晴陽平, 小泉昭夫
  • Journal Title: 脳神経外科速報 Vol.16no.5 Pages: 416-425
  • Peer Reviewed
• [Journal Article] Endoplasmic reticulum stress induces Wfs1 gene expression in pancreatic beta-cells via transcriptional activation. (2005)
  • Author(s): Ueda K, Kawano J, Takeda K, Yujiri T, Tanabe K, Anno T, Akiyama M, Nozaki J, Yoshinaga T, Koizumi A, Shinoda K, Oka Y, Tanizawa Y
  • Journal Title: Eur J Endocrinol 153(1) Pages: 167-76
  • Peer Reviewed
• [Journal Article] JACC Study Group. History of blood transfusion before 1990 is a risk factor for stroke and cardiovascular diseases: the Japan collaborative cohort study (JACC study). (2005)
  • Author(s): Yamada S, Koizumi A, Iso H, Wada Y, Watanabe Y, Date C, Yamamoto A, Kikuchi S, Inaba Y, Kondo T, Toyoshima H, Tamakoshi A
  • Journal Title: Cerebrovasc. Dis. 20(3) Pages: 164-71
  • Peer Reviewed
• [Journal Article] History of blood transfusion before 1990 is a risk factor for stroke and cardiovascular diseases : the Japan collaborative cohort study (JACC study) (2005)
  • Author(s): Yamada S.Koizumi A.et al.
  • Journal Title: Cerebrovasc.Dis. 20 Pages: 164-171
• [Journal Article] A genome-wide scan for Japanese familial intracranial aneurysms (2004)
  • Author(s): Yamada S, Utsunomiya M, Inoue K, Inoue S, Nozaki K, Takenaka K, Hashimoto N, Koizumi A.
  • Journal Title: linkage to several chromosomal regions. Circulation 110(24) Pages: 3727-3733
  • Peer Reviewed
• [Presentation] 家族性脳動脈家系の追跡調査および全ゲノム連鎖解析 (2009)
  • Author(s): 箸方宏州, 山田茂樹, 峰晴陽平, 井上佳代子, 松浦範夫, 高木康志, 野崎和彦, 橋本信夫, 小泉昭夫, 宮本享
  • Organizer: 第68回日本脳神経外科学会総会
  • Place of Presentation: 京王プラザホテル
• [Presentation] 家族性脳動脈家系の追跡調査および、全ゲノム連鎖解析 (2009)
  • Author(s): 小泉昭夫, 箸方宏州, 劉万洋, 井上佳代子, 峰晴陽平, 山田茂樹, 松浦範夫, 井上純子, 竹中勝信, 人見敏明, 原田浩二
  • Organizer: 日本人類遺伝学会第54回大会
  • Place of Presentation: 川崎医療福祉大学
• [Presentation] 常染色体優性モヤモヤ病の候補領域の詳細なマッピングとアジアやヨーロッパにおける症例拡大 (2009)
  • Author(s): 小泉昭夫, 劉万洋, 箸方宏州, 峰晴陽平, 井上佳代子, 松浦範夫, 皆田睦子, 井上純子, 廣澤倫, Shanika Nanayakkara, 小林果, 竹中勝信, 原田浩二, 人見敏明
  • Organizer: 日本人類遺伝学会第54回大会
  • Place of Presentation: 川崎医療福祉大学
• [Presentation] Genetic dissection of intracranial aneurysm (2009)
  • Author(s): Akio Koizumi
  • Organizer: International Intracranial Stent Meeting 2009
  • Place of Presentation: 仙台
• [Presentation] 脳動脈瘤家系の追跡調査 (2009)
  • Author(s): 箸方宏州, 松浦範夫, 小泉昭夫
  • Organizer: 第79回日本衛生学会総会
  • Place of Presentation: 北里大学
• [Presentation] Moyamoya病感受性遺伝子同定のためのin vitro実験系での検討 (2009)
  • Author(s): 人見敏明, 劉万洋, 箸方宏州, 峰晴陽平, 松浦範夫, 廣澤倫, 井上純子, 皆田睦子, 原田浩二, 井上佳代子, 小泉昭夫
  • Organizer: 第79回日本衛生学会総会
  • Place of Presentation: 北里大学
• [Presentation] 常染色体優性もやもや病に対する候補領域の絞り込みとアジア、ヨーロッパの症例の収集 (2009)
  • Author(s): 劉万洋, 峰晴陽平, 井上佳代子, 松浦範夫, 井上純子, 人見敏明, 箸方宏州, 小泉昭夫
  • Organizer: 第79回日本衛生学会総会
  • Place of Presentation: 北里大学
• [Presentation] Genetic dissection of intracranial aneurysm (2009)
  • Author(s): 小泉昭夫
  • Organizer: International Intracranial Stent Meeting 2009
  • Place of Presentation: 仙台戦災復興記念館(仙台)
• [Presentation] 常染色体優性モヤモヤ病の候補領域の詳細なマッピングとアジアやヨーロッパにおける症例拡大 (2009)
  • Author(s): 小泉昭夫
  • Organizer: 日本人類遺伝学会 第54回大会
  • Place of Presentation: 川崎医療福祉大学(東京)
• [Presentation] 家族性脳動脈家系の追跡調査および、全ゲノム連鎖解析 (2009)
  • Author(s): 小泉昭夫
  • Organizer: 日本人類遺伝学会 第54回大会
  • Place of Presentation: 川崎医療福祉大学(東京)
• [Presentation] 家族性脳動脈家系の追跡調査および全ゲノム連鎖解析 (2009)
  • Author(s): 箸方宏州
  • Organizer: 第68回日本脳神経外科学会総会
  • Place of Presentation: 京王プラザホテル(東京)
• [Presentation] 常染色体優性もやもや病に対する候補領域の絞り込みとアジア、ヨーロッパの症例の収集 (2009)
  • Author(s): 劉万洋
  • Organizer: 第79回日本衛生学会
  • Place of Presentation: 東京
• [Presentation] Moyamoya病感受性遺伝子同定のためのin vitro実験系での検討 (2009)
  • Author(s): 人見敏明
  • Organizer: 第79回日本衛生学会
  • Place of Presentation: 東京
• [Presentation] 脳動脈瘤家系の追跡調査 (2009)
  • Author(s): 箸方宏州
  • Organizer: 第79回日本衛生学会
  • Place of Presentation: 東京
• [Presentation] 脳動脈瘤家系の追跡調査 (2008)
  • Author(s): 箸方宏州, 井上佳代子, 峰晴陽平, 劉万洋, 井上純子, 松浦範夫, 野崎和彦, 橋本信夫, 小泉昭夫
  • Organizer: 第78回日本衛生学会総会
  • Place of Presentation: 熊本市民会館
• [Presentation] Moyamoya病の遺伝子単離のロードマップ (2008)
  • Author(s): 人見敏明, 劉万洋, 峰晴陽平, 松浦範夫, 廣澤倫, 箸方宏州, 井上純子, 皆田睦子, 原田浩二, 井上佳代子, 小泉昭夫
  • Organizer: 第78回日本衛生学会総会
  • Place of Presentation: 熊本市民会館
• [Presentation] 常染色体優性遺伝形式のもやもや病の責任遺伝子座は17q25. 3に存在する (2008)
  • Author(s): 劉万洋, 峰晴陽平, 井上佳代子, 松浦範夫, 井上純子, 小泉昭夫
  • Organizer: 第78回日本衛生学会総会
  • Place of Presentation: 熊本市民会館
• [Presentation] 片側もやもや病はもやもや病と異なる疾患か?家系を用いた遺伝学的検証 (2008)
  • Author(s): 峰晴陽平, 高木康志, 菊田健一郎, 野崎和彦, 橋本信夫, 劉万洋, 松浦範夫, 井上純子, 井上佳代子, 小泉昭夫
  • Organizer: 第33回日本脳卒中学会総会
  • Place of Presentation: 京都国際会館
• [Presentation] 遺伝子診断による脳血管障害の分類:中大脳動脈閉塞症、片側もやもや病、もやもや病は異なる疾患か? (2008)
  • Author(s): 峰晴陽平, 箸方宏州, 高木康志, 菊田健一郎, 野崎和彦, 橋本信夫, 劉万洋, 井上佳代子, 井上純子, 松浦範夫, 廣澤倫, 人見敏明, 皆田睦子, 小泉昭夫
  • Organizer: 第33回日本脳卒中学会総会
  • Place of Presentation: 京都国際会館
• [Presentation] 脳動脈瘤家系の追跡調査 (2008)
  • Author(s): 箸方宏州
  • Organizer: 第78回 日本衛生学会総会
  • Place of Presentation: 熊本市民会館
• [Presentation] Moyamoya病の遺伝子単離のロードマップ (2008)
  • Author(s): 人見敏明
  • Organizer: 第78回 日本衛生学会総会
  • Place of Presentation: 熊本市民会館
• [Presentation] 常染色体優性遺伝形式のもやもや病の責任遺伝子座は17q25.3に存在する (2008)
  • Author(s): 劉万洋
  • Organizer: 第78回 日本衛生学会総会
  • Place of Presentation: 熊本市民会館
• [Presentation] Osler-Rendu-Weber病患者におけるendoglin遺伝子の新しい変異 (2008)
  • Author(s): 井上純子
  • Organizer: 第78回 日本衛生学会総会
  • Place of Presentation: 熊本市民会館
• [Presentation] 片側もやもや病はもやもや病と異なる疾患か? 家系を用いた遺伝学的検証 (2008)
  • Author(s): 峰晴陽平
  • Organizer: 第33回 日本脳卒中学会総会
  • Place of Presentation: 京都国際会館
• [Presentation] くも膜下出血の遺伝要因の探索と脳動脈瘤高集積性家系の追跡調査 (2007)
  • Author(s): 井上佳代子, 小泉昭夫
  • Organizer: 第80回日本産業衛生学会
  • Place of Presentation: 大阪国際会議場
• [Presentation] 脳動脈瘤高集積性家系の追跡調査 (2007)
  • Author(s): 井上佳代子, 峰晴陽平, 劉万洋, 井上純子, 小泉昭夫
  • Organizer: 第77回日本衛生学会総会
  • Place of Presentation: 大阪国際交流センター
• [Presentation] 連鎖解析および相関解析による脳動静脈奇形(AVM)の遺伝子検索 (2007)
  • Author(s): 井上純子, 劉万洋, 峰晴陽平, 井上佳代子, 竹中勝信, 小泉昭夫
  • Organizer: 第77回日本衛生学会総会
  • Place of Presentation: 大阪国際交流センター
• [Presentation] 家族性もやもや病の遺伝解析 (2007)
  • Author(s): 劉万洋, 峰晴陽平, 井上佳代子, 井上純子, 小泉昭夫
  • Organizer: 第77回日本衛生学会総会
  • Place of Presentation: 大阪国際交流センター
• [Presentation] くも膜下出血の遺伝要因の探索と脳動脈瘤高集積性家系の追跡調査 (2007)
  • Author(s): 井上佳代子
  • Organizer: 第80回 日本産業衛生学会
  • Place of Presentation: 大阪国際会議場
• [Presentation] Genetic Analysis of familial moyamoya disease (2006)
  • Author(s): Liu Wanyang, Kayoko Inoue, Youhei Mineharu, Sumiko Inoue, Akio Koizumi
  • Organizer: 第6回分子予防環境医学研究会
  • Place of Presentation: 京大会館
• [Presentation] 脳動脈瘤とTNF受容体の遺伝子多型～突然変異の同定～ (2006)
  • Author(s): 峰晴陽平, 山田茂樹, 井上佳代子, 井上純子, 小泉昭夫, 野崎和彦, 橋本信夫
  • Organizer: 第65回日本脳神経外科学会総会
  • Place of Presentation: 国立京都国際会館
• [Presentation] 脳動脈瘤の遺伝要因 (2006)
  • Author(s): 山田茂樹, 峰晴陽平, 高木康志, 野崎和彦, 井上佳代子, 小泉昭夫, 橋本信夫
  • Organizer: 第7回日本分子脳神経外科学会
  • Place of Presentation: 東京女子医科大学
• [Presentation] くも膜下出血および脳動脈瘤の遺伝要因の探索 (2006)
  • Author(s): 井上佳代子, 峰晴陽平, 井上純子, 小泉昭夫
  • Organizer: 第79回日本産業衛生学会
  • Place of Presentation: 仙台国際センター
• [Presentation] 脳動脈瘤の遺伝要因の探索 (2006)
  • Author(s): 井上佳代子, 峰晴陽平, 井上純子, 小泉昭夫
  • Organizer: 第76回日本衛生学会総会
  • Place of Presentation: 山口大学
• [Presentation] 同祖性を仮定できる地域における脳動静脈奇形およびモヤモヤ病のマイクロアレイを用いた相関解析 (2006)
  • Author(s): 井上純子, 井上佳代子, 峰晴陽平, 竹中勝信, 小泉昭夫
  • Organizer: 第76回日本衛生学会総会
  • Place of Presentation: 山口大学
• [Book] Annual Review腎臓2007 (2007)
  • Author(s): 小泉 昭夫
  • Total Pages: 308
  • Publisher: 中外医学社
• [Remarks]
  • URL: http://130.54.180.142/
• [Remarks]
  • URL: http://hes.pbh.med.kyoto-u.ac.jp/
• [Remarks]
  • URL: http://hes.pbh.med.kyoto-u.ac.jp/
• [Remarks]
  • URL: http://hes.pbh.med.kyoto-u.ac.jp/
• [Patent(Industrial Property Rights)] モヤモヤ病関連遺伝子及びその利用 (2009)
  • Inventor(s): 小泉昭夫, 永田和宏, 森戸大介, 高島成二, 山崎悟, 橋本信夫, 松浦範夫, 人見敏明
  • Industrial Property Rights Holder: 京都大学,小泉昭夫,永田和宏,森戸大介,高島成二,山崎悟,橋本信夫,松浦範夫,人見敏明
  • Industrial Property Number: 2009-244938
  • Filing Date: 2009-10-23
• [Patent(Industrial Property Rights)] モヤモヤ病関連遺伝子及びその利用 (2009)
  • Inventor(s): 小泉昭夫, 他
  • Industrial Property Rights Holder: 京都大学、小泉昭夫, 他
  • Industrial Property Number: 2009-244938
  • Filing Date: 2009-10-23