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Physiological polymorphisms of blood flow regulation in environmental adaptability

Research Project

Project/Area Number 17207022
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field 生理人類学
Research InstitutionShibaura Institute of Technology

Principal Investigator

KUDO Susumu  Shibaura Institute of Technology, 工学部, 准教授 (70306926)

Co-Investigator(Kenkyū-buntansha) 浜崎 啓太 (濱崎 啓太)  芝浦工業大学, 工学部, 准教授 (50348900)
佐藤 方彦  九州大学, 名誉教授 (10038937)
岩永 光一  千葉大学, 大学院・自然科学研究科, 教授 (70160124)
福島 修一郎  大阪大学, 大学院・基礎工学研究科, 助教 (40362644)
世良 俊博  理化学研究所, 生体力学シミュレーション特別研究ユニット, 協力研究員 (40373526)
Co-Investigator(Renkei-kenkyūsha) HAMASAKI Keita  芝浦工業大学, 工学部, 准教授 (50348900)
SATO Masahiko  九州大学, 名誉教授 (10038937)
IWANAGA Koichi  千葉大学, 大学院・自然科学研究科, 教授 (70160124)
FUKUSHIMA Shuichiro  大阪大学, 大学院・基礎工学研究科, 助教 (40362644)
SERA Toshihiro  理化学研究所, 生体力学シミュレーション特別研究ユニット, 協力研究員 (40373526)
Project Period (FY) 2005 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥49,660,000 (Direct Cost: ¥38,200,000、Indirect Cost: ¥11,460,000)
Fiscal Year 2008: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2007: ¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2006: ¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2005: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
Keywords生理人類学 / 生理的多型性 / 環境適応能 / 一酸化窒素 / 血液循環系 / 血管内皮細胞
Research Abstract

ヒトは様々な環境下において生理的な応答をおこなう. その応答には個体差が存在し, その生理的な応答の個体差を解明することは困難を極めている. そこで, 本研究では, 低温環境での血液循環系の生理応答に絞り, 個体差がどのようなメカニズムに起因しているかに関して, ヒトの直接計測から細胞・タンパク質計測をおこない, マクロからミクロに至るまで統合的に解析した. その結果, 個体差発生に関連する要素を抽出することができた

Report

(5 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (51 results)

All 2009 2008 2007 2006 2005 Other

All Journal Article (21 results) (of which Peer Reviewed: 9 results) Presentation (25 results) Book (5 results)

  • [Journal Article] Intracellular Ca2+ Responses in Cultured Endothelial Cells to Mechanical Stimulation by Laser Tweezers2008

    • Author(s)
      Noriyuki Kataoka
    • Journal Title

      Journal of Biomechanical Science and Engineering 3

      Pages: 116-123

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of Hypoxia on Formation of Three-Dimensional Microvessel Net works by Endothelial Cells in vitro2008

    • Author(s)
      Akinori Ueda
    • Journal Title

      Journal of Biomechanical Science and Engineering 3

      Pages: 229-310

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intracellular Ca2+Responses in Cultured Endothelial Cells to Mechanical Stimulation by Laser Tweezers2008

    • Author(s)
      Noriyuki Kataoka
    • Journal Title

      Journal of Biomechanical Science and Engineering 3

      Pages: 116-123

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Growth of Endothelial Cells on Surfaces Modified by a Plasma-Polymerized Coating2007

    • Author(s)
      Hitoshi Muguruma, Naoya Murata, Naoto Kawasaki, Shogo Kuretoko, and Susumu Kudo
    • Journal Title

      IEICE Trans. Electron Vol.E90-C

      Pages: 1844-1847

    • NAID

      110007538951

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Growth of Endothehal Cels on Surfaces Modified by a Plasma-Polymerized Coating2007

    • Author(s)
      Hitoshi Muguruma,
    • Journal Title

      IEICE Trans.Electron E90-C

      Pages: 1844-1847

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prospect of Manufacturing and Design Based on Physiological Polymorphism2007

    • Author(s)
      Masashi Nakamura
    • Journal Title

      J.Physiological Anthropology 24

      Pages: 507-511

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interactions Between SNP Alleles at Multiple Loci and Variation in Skin Pigmentation in 122 Caucasians2007

    • Author(s)
      Sumiko Anno
    • Journal Title

      Evolutionary Bioinformatics 3

      Pages: 169-178

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 多遺伝子座におけるSNP対立遺伝子の相互作用が及ぼすヒトの皮膚色の多様性について2007

    • Author(s)
      安納住子
    • Journal Title

      日本生理人類学会誌 12・1

      Pages: 1-10

    • Related Report
      2006 Annual Research Report
  • [Journal Article] レーザー誘起ナノ秒蛍光寿命マッピングによる歯の形成と老化の可視化2007

    • Author(s)
      福島修一郎
    • Journal Title

      生体医工学 45・1(印刷中)

    • NAID

      110006249833

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Small airway changes in healthy and ovalbumin-treated mice during quasi-static lung inflation2007

    • Author(s)
      Toshihiro Sera
    • Journal Title

      Respir Physiol Neurobiol 156・3

      Pages: 304-311

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Initial bFGF Distribution Affects the Depth of Three-dimensinal Microvessel Networks in Vitro2006

    • Author(s)
      Akinori Ueda
    • Journal Title

      Journal of Biomechanical Science and Engineering 1

      Pages: 136-146

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Effect of Low Temperature on Endothelial Cell Nitric Oxide Synthase Activity2006

    • Author(s)
      Susumu Kudo
    • Journal Title

      Journal of PHYSIOLOGICAL ANTHROPOLOGY 26・2

      Pages: 277-277

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Interaction with SNP Allele in Multiple Loci Contributes to Human Skin Color Diversity - The Survey of SNP on 122 Causasians -2006

    • Author(s)
      Sumiko Anno
    • Journal Title

      Journal of PHYSIOLOGICAL ANTHROPOLOGY 26・2

      Pages: 278-278

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Neamine derivatives having a nucleobase with a lysine or an arginine as a linker, their synthesis and evaluation as potential inhibitors for HIV TAR-Tat2006

    • Author(s)
      Yajima S, Hionoya H, Akagi T, Hamasaki K
    • Journal Title

      Bioorg Med Chem 14・8

      Pages: 2799-2809

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Effect of Fluid Force on Vascular Cell Function2005

    • Author(s)
      Susumu Kudo, Ryuhei Yamaguchi, Mariko Ikeda, Kazuo Tanishita
    • Journal Title

      J. Physiological Anthropology and Applied Human Science Vol.24

      Pages: 459-461

    • NAID

      110002964081

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Albumin Permeability across Endothelial Monolayers under Long-term Shear Stress2005

    • Author(s)
      Susumu Kudo, Masanori Tsuzaka, Mariko Ikeda, Kazuo Tanishita
    • Journal Title

      JSME International Series C 48

      Pages: 419-424

    • NAID

      110004826660

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 血流に誘導された血管組織細胞レベルでの協関2005

    • Author(s)
      工藤奨, 細渕誠人, 山口隆平, 濱崎啓太, 福島修一郎, 谷下一夫
    • Journal Title

      日本生理人類学会誌 10・特別号(1)

      Pages: 136-137

    • NAID

      110002550460

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 動脈のカルシウム蓄積の血流の影響2005

    • Author(s)
      福島修一郎, 荒木勉, 工藤奨, 東野義之
    • Journal Title

      日本生理人類学会誌 10・特別号(1)

      Pages: 68-69

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 健常マウスと喘息マウスの肺の柔らかさの違い2005

    • Author(s)
      世良俊博, 上杉健太郎, 八木直人
    • Journal Title

      日本生理人類学会誌 10・特別号(1)

      Pages: 74-75

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Refraction-enhanced tomography of mouse and rabbit lung. Medical Physics2005

    • Author(s)
      Toshihiro SERA, Kentaro UESUGI, Naoto YAGI
    • Journal Title

      Medical Physics 32(9)

      Pages: 2787-2792

    • Related Report
      2005 Annual Research Report
  • [Journal Article] ATP Release from Cultured Endothelial Cells and Intercellular Calcium Signaling During Shear Stress Exposure

    • Author(s)
      Susumu KUDO, Kaoru HOSOE, Makoto HOSOBUCHI, Naoto KAWASAKI, and Kazuo TANISHITA
    • Journal Title

      Journal of Biomechanical Science and Engineering Vol.4 No.2(in press)

    • NAID

      130000128998

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Presentation] The Effect of Body temperature on the Hunting Response of the Finger Skin Blood Flow2009

    • Author(s)
      Susumu Kudo
    • Organizer
      The 3^<rd> South East Asian Technical University Consortium Symposium
    • Place of Presentation
      Johor Bahru, Malaysia
    • Year and Date
      2009-02-25
    • Related Report
      2008 Final Research Report
  • [Presentation] The Effect of Body tempera ture on the Hunt ing Response of the Finger Skin Blood Flow2009

    • Author(s)
      Susumu Kudo
    • Organizer
      The 3^<rd> SEATUC Symposium
    • Place of Presentation
      Johor Bahru, Malaysia
    • Year and Date
      2009-02-25
    • Related Report
      2008 Annual Research Report
  • [Presentation] Visualization of Dynamic Protein Movement in Living Cells Using Photochronic Protein2009

    • Author(s)
      Naoto Kawasaki
    • Organizer
      The 3^<rd> SEATUC Symposium
    • Place of Presentation
      Johor Bahru, Malaysia
    • Year and Date
      2009-02-25
    • Related Report
      2008 Annual Research Report
  • [Presentation] フォトクロミック蛍光タンパク質を用いた細胞膜タンパク質拡散の可視化2009

    • Author(s)
      川崎那緒人
    • Organizer
      日本機械学会第20回バイオエンジニアリング講演会
    • Place of Presentation
      札幌
    • Year and Date
      2009-01-23
    • Related Report
      2008 Annual Research Report
  • [Presentation] 神経活動に伴う脳血流調節機構に対してシナプス可塑性が及ぼす影響について2008

    • Author(s)
      青木健太郎
    • Organizer
      日本生理人類学会第2回研究奨励発表会
    • Place of Presentation
      東京
    • Year and Date
      2008-12-20
    • Related Report
      2008 Annual Research Report
  • [Presentation] フォトクロミック蛍光タンパク質による細胞膜タンパク質拡散の可視化2008

    • Author(s)
      川崎那緒人
    • Organizer
      日本生理人類学会第2回研究奨励発表会
    • Place of Presentation
      東京
    • Year and Date
      2008-12-20
    • Related Report
      2008 Annual Research Report
  • [Presentation] せん断応力と低温度負荷による血流の調節メカニズム2008

    • Author(s)
      Kamariah binti Md Isa
    • Organizer
      日本生理人類学会第2回研究奨励発表会
    • Place of Presentation
      東京
    • Year and Date
      2008-12-20
    • Related Report
      2008 Annual Research Report
  • [Presentation] Effect of fluid frictional force and low temperature on nitric oxide synthase activity in endothelial cells2008

    • Author(s)
      Susumu Kudo
    • Organizer
      9^<th> International Congress of Physiological Anthropology
    • Place of Presentation
      Delft, Netherland
    • Year and Date
      2008-08-25
    • Related Report
      2008 Final Research Report
  • [Presentation] Effect of Fluid Frictional Force and Low Temperature on nitric Oxide Synthase Activity in Endothelial Cells2008

    • Author(s)
      Susumu Kudo
    • Organizer
      ICPA 2009
    • Place of Presentation
      Delft, Netherland
    • Year and Date
      2008-08-25
    • Related Report
      2008 Annual Research Report
  • [Presentation] フォトクロミック蛍光タンパク質を用いた細胞内物質運動の可視化2008

    • Author(s)
      川崎那緒人
    • Organizer
      第36回可視化情報シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2008-07-23
    • Related Report
      2008 Annual Research Report
  • [Presentation] 局所低温刺激下におけるヒトの皮膚血流応答2008

    • Author(s)
      坂口雄紀
    • Organizer
      日本生理人類学会第58回大会
    • Place of Presentation
      大阪
    • Year and Date
      2008-06-08
    • Related Report
      2008 Annual Research Report
  • [Presentation] 血管内皮細胞の環境適応2008

    • Author(s)
      工藤奨
    • Organizer
      日本生理人類学会第58回大会
    • Place of Presentation
      大阪
    • Year and Date
      2008-06-07
    • Related Report
      2008 Annual Research Report
  • [Presentation] 低温負荷時における血管内皮細胞の一酸化窒素産生に関する研究2008

    • Author(s)
      長岡 弘樹
    • Organizer
      日本機械学会
    • Place of Presentation
      東京
    • Year and Date
      2008-03-15
    • Related Report
      2007 Annual Research Report
  • [Presentation] アストロサイトのCa2+オシレーションに関する研究2008

    • Author(s)
      伊藤 訓行
    • Organizer
      日本機械学会
    • Place of Presentation
      東京
    • Year and Date
      2008-03-15
    • Related Report
      2007 Annual Research Report
  • [Presentation] Caged化合物を用いたCa2+応答伝播による細胞間情報伝達2008

    • Author(s)
      島村 友理
    • Organizer
      日本機械学会
    • Place of Presentation
      東京
    • Year and Date
      2008-03-14
    • Related Report
      2007 Annual Research Report
  • [Presentation] 一酸化窒素を介した血流調節機構の分子生物学的研究2008

    • Author(s)
      Kamariah binti md isa
    • Organizer
      日本機械学会
    • Place of Presentation
      東京
    • Year and Date
      2008-03-14
    • Related Report
      2007 Annual Research Report
  • [Presentation] 海馬アストロサイトのCa2+オシレーションに関する研究2008

    • Author(s)
      小林 翔
    • Organizer
      日本機械学会
    • Place of Presentation
      東京
    • Year and Date
      2008-03-14
    • Related Report
      2007 Annual Research Report
  • [Presentation] フォトクロミック蛍光タンパク質を用いた血管内皮細胞におけるチューブリンの可視化2008

    • Author(s)
      川崎 那緒人
    • Organizer
      日本機械学会
    • Place of Presentation
      東京
    • Year and Date
      2008-01-26
    • Related Report
      2007 Annual Research Report
  • [Presentation] ヒトの局所冷水曝露時の皮膚血流応答2007

    • Author(s)
      坂口 雄紀
    • Organizer
      日本生理人類学会
    • Place of Presentation
      東京
    • Year and Date
      2007-12-15
    • Related Report
      2007 Annual Research Report
  • [Presentation] 低温刺激下における血管内皮細胞の一酸化窒素放出能に関する研究2007

    • Author(s)
      長岡 弘樹
    • Organizer
      日本生理人類学会
    • Place of Presentation
      東京
    • Year and Date
      2007-12-15
    • Related Report
      2007 Annual Research Report
  • [Presentation] フォトクロミック蛍光タンパクを用いた血管内皮細胞内物質拡散解析2007

    • Author(s)
      川崎 那緒人
    • Organizer
      日本機械学会
    • Place of Presentation
      福岡
    • Year and Date
      2007-10-07
    • Related Report
      2007 Annual Research Report
  • [Presentation] フォトクロミック蛍光タンパク質を用いた細胞内物質拡散2007

    • Author(s)
      川崎 那緒人
    • Organizer
      日本機械学会
    • Place of Presentation
      大阪
    • Year and Date
      2007-09-10
    • Related Report
      2007 Annual Research Report
  • [Presentation] Caged化合物を使用した内皮細胞間Ca2+情報伝達の観察2007

    • Author(s)
      紅床 省吾
    • Organizer
      日本機械学会
    • Place of Presentation
      大阪
    • Year and Date
      2007-09-10
    • Related Report
      2007 Annual Research Report
  • [Presentation] ミクロから見た生理的多型性2007

    • Author(s)
      工藤 奨
    • Organizer
      日本生理人類学
    • Place of Presentation
      秋田
    • Year and Date
      2007-06-17
    • Related Report
      2007 Annual Research Report
  • [Presentation] Effect of Low Temperature on Endothelial Cell Nitric Oxide Synthase Activity2006

    • Author(s)
      Susumu Kudo
    • Organizer
      8^<th> International Congress of Physiological Anthropology, p17
    • Place of Presentation
      Kamakura, Japan
    • Year and Date
      2006-10-12
    • Related Report
      2008 Final Research Report
  • [Book] からだの百科事典2009

    • Author(s)
      工藤奨, 他
    • Publisher
      丸善(株)(印刷中)
    • Related Report
      2008 Annual Research Report
  • [Book] Human Variation-from the laboratory to the field2008

    • Author(s)
      Susumu KUDO
    • Publisher
      Taylor&Francis
    • Related Report
      2007 Annual Research Report
  • [Book] 人間を科学する辞典2005

    • Author(s)
      佐藤方彦 編
    • Total Pages
      349
    • Publisher
      東京堂出版
    • Related Report
      2005 Annual Research Report
  • [Book] Chapter 2.3 Tissue and cell adaptability to physical and chemical factors

    • Author(s)
      Susumu Kudo and Kazuo Tanishita
    • Publisher
      Human Variation - from the laboratory to the field, Chapter title(Taylor & Francis)(in press)
    • Related Report
      2008 Final Research Report
  • [Book] からだの百科事典

    • Author(s)
      工藤奨
    • Publisher
      丸善(印刷中)
    • Related Report
      2008 Final Research Report

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Published: 2005-04-01   Modified: 2016-04-21  

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