International collaborative study on subclinical atherosclerosis and its risk factors in three populations in the US and Japan

• Project/Area Number: 17209023
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Public health/Health science
• Research Institution: Shiga University of Medical Science
• Principal Investigator: UESHIMA Hirotsugu Shiga University of Medical Science, 医学部, 教授 (70144483)
• Co-Investigator(Kenkyū-buntansha): KASHIWAGI Atsunori 滋賀医科大学, 医学部, 教授 (20127210) ; MITSUNAMI Kenichi 滋賀医科大学, 医学部, 教授 (10127037) ; MURATA Kiyoshi 滋賀医科大学, 医学部, 教授 (20127038) ; HORIE Minoru 滋賀医科大学, 医学部, 教授 (90183938) ; MIURA Ktsuyuki 滋賀医科大学, 医学部, 教授 (90257452) ; OKAMURA Tomonori 国立循環器病センター, 予防検診部, 部長 (00324567) ; KITA Yoshikuni 滋賀医科大学, 医学部, 助教 (30147524) ; KADOWAKI Takashi 滋賀医科大学, 医学部, 助教 (30324578) ; NAKAMURA Yasuyuki 京都女子大学, 家政学部, 教授 (20144371) ; 喜多 義邦 滋賀医科大学, 医学部, 助教 (80161462)
• Research Collaborator: SEKIKWA Akira ピッツバーク大学, 医学部, 准教授
• Project Period (FY): 2005 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥51,090,000 (Direct Cost: ¥39,300,000、Indirect Cost: ¥11,790,000); Fiscal Year 2008: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000); Fiscal Year 2007: ¥14,300,000 (Direct Cost: ¥11,000,000、Indirect Cost: ¥3,300,000); Fiscal Year 2006: ¥14,300,000 (Direct Cost: ¥11,000,000、Indirect Cost: ¥3,300,000); Fiscal Year 2005: ¥15,470,000 (Direct Cost: ¥11,900,000、Indirect Cost: ¥3,570,000)
• Keywords: 潜在性動脈硬化 / 冠動脈石灰化 / 頸動脈内膜中膜肥厚 / 危険因子 / 国際共同研究 / 頚動脈内膜中膜肥厚 / 疫学 / 動脈硬化 / EBCT / IMT / ゲノム / リスクファクター / 日米比較 / 国際情報交換 / アメリカ合衆国

Research Abstract

本研究は過去に実施した「若年男性の冠動脈石灰化と頸動脈肥厚による動脈硬化度と循環器疾患危険因子との関連」(基盤(A)(2)H.13～16)を発展させたものである。元の研究では対象を40歳代男性に限定し、300名の調査を行ったが、本研究課題では、これを50～70歳代に拡大し約1000名の調査を行った。また、異人種である米国白人、人種的には日本人であるが米国の生活習慣を持つ日系米人のフィールドとの比較検討を進め、動脈硬化の進展に関わるのは、遺伝要因(人種)よりも環境要因(生活習慣)の影響の方が重要であることを明らかにした。

Research Products

• [Journal Article] Association of serum n-6 and n-3 polyunsaturated fatty acids with lipids in 3 populations of middle-aged men (2009)
  • Author(s): Motoyama KR, Curb JD, Kadowaki T, El-Saed A, Abbott RD, Okamura T, Evans RW, Nakamura Y, Sutton-Tyrrell K, Rodriquez BL, Kadota A, Edmundowicz D, Willcox BJ, Choo J, Katsumi N, Otake T, Kadowaki S, Kuller LH, Ueshima H, Sekikawa A.
  • Journal Title: Am J Clin Nutr. 90(1) Pages: 49-55
  • Peer Reviewed
• [Journal Article] Higher liver fat content among Japanese in Japan compared with non-Hispanic whites in the United States (2009)
  • Author(s): Azuma K, Kadowaki T, Cetinel C, Kadota A, El-Saed A, Kadowaki S, Edmundowicz D, Nishio Y, Sutton-Tyrrell K, Okamura T, Evans RW, Takamiya T, Ueshima H, Curb JD, Abbott RD, Kuller LH, Kelley DE, Sekikawa A
  • Journal Title: ERA JUMP study group 58(8) Pages: 1200-7
  • Peer Reviewed
• [Journal Article] Marine-derived n-3 fatty acids and atherosclerosis in Japanese, Japanese-American, and white men : a cross-sectional study (2008)
  • Author(s): Sekikawa A, Curb JD, Ueshima H, El-Saed A, Kadowaki T, Abbott RD, Evans RW, Rodriguez BL, Okamura T, Sutton-Tyrrell K, Nakamura Y, Masaki K, Edmundowicz D, Kashiwagi A, Willcox BJ, Takamiya T, Mitsunami K, Seto TB, Murata K, White RL, Kuller LH
  • Journal Title: J Am Coll Cardiol 52(6) Pages: 417-24
  • Peer Reviewed
• [Journal Article] Intima-media thickness of the carotid artery and the distribution of lipoprotein subclasses in men aged 40 to 49 years between whites in the United States and the Japanese in Japan for the ERA JUMP study (2008)
  • Author(s): Sekikawa A, Ueshima H, Sutton-Tyrrell K, Kadowaki T, El-Saed A, Okamura T, Takamiya T, Ueno Y, Evans RW, Nakamura Y, Edmundowicz D, Kashiwagi A, Maegawa H, Kuller LH
  • Journal Title: Metabolism 57(2) Pages: 177-82
  • Peer Reviewed
• [Journal Article] Marine-derived n-3 fatty acids and atherosclerosis in Japanese, Japanese-American, and white men : a cross-sectional study. (2008)
  • Author(s): Sekikawa A, Curb JD, Ueshima H, et al.
  • Journal Title: J Am Coll Cardiol. 52 Pages: 417-424
  • Peer Reviewed
• [Journal Article] Intima-media thickness of the carotid artery and the distribution of lipoprotein subclasses in men aged 40 to 49 years between whites in the United States and the Japanese in Japan for the ERA JUMP study (2008)
  • Author(s): Sekikawa A, Ueshima H, Sutton-Tyrrell K, Kadowaki T, El-Saed A, Okamura T, Takamiya T, Ueno Y, Evans RW, Nakamura Y, Edmundowicz D, Kashiwagi A, Maegawa H, Kuller LH.
  • Journal Title: Metabolism 57 Pages: 177-82
  • Peer Reviewed
• [Journal Article] Coronary artery calcification in Japanese men in Japan and Hawaii (2007)
  • Author(s): Abbott RD, Ueshima H, Rodriguez BL, Kadowaki T, Masaki KH, Willcox BJ, Sekikawa A, Kuller LH, Edmundowicz D, Shin C, Kashiwagi A, Nakamura Y, El-Saed A, Okamura T, White R, Curb JD
  • Journal Title: Am J Epidemiol 166(11) Pages: 1280-7
  • Peer Reviewed
• [Journal Article] Less subclinical atherosclerosis in Japanese men in Japan than in White men in the United States in the post-World War II birth cohort (2007)
  • Author(s): Sekikawa A, Ueshima H, Kadowaki T, El-Saed A, Okamura T, Takamiya T, Kashiwagi A, Edmundowicz D, Murata K, Sutton-Tyrrell K, Maegawa H, Evans RW, Kita Y, Kuller LH
  • Journal Title: Am J Epidemiol 165(6) Pages: 617-24
  • Peer Reviewed
• [Journal Article] Association of lipoprotein-associated phospholipase A2 with coronary calcification among American and Japanese men (2007)
  • Author(s): El-Saed A, Sekikawa A, Zaky RW, Kadowaki T, Takamiya T, Okamura T, Edmundowicz D, Kita Y, Kuller LH, Ueshima H.
  • Journal Title: J Epidemiol. 17 Pages: 179-85
  • NAID: 10025811498
  • Peer Reviewed
• [Presentation] Evaluation of the soy isoflavones, daidzein and genistein (2009)
  • Author(s): Evans RW, Sekikawa A, Kadowaki T, Miura K, Ueshima H, Curb JD, Kuller LH
  • Organizer: Society of Epidemiologic Research 2009
• [Presentation] Differential Association of Brachial-Ankle and Carotid-Femoral Pulse-Wave Velocity with Lipoprotein Subclasses in White Men Aged 40 to 49 Years : A Cross-Sectional Study (2009)
  • Author(s): Assi T, Sutton-Tyrrell K, El-Saed A, Evans RW, Edmundowicz D, Kadowaki T, Ueshima H, Curb JD, Kuller LH, Sekikawa A
  • Organizer: AHA EPI Council March 2009 Florida
• [Presentation] Metabolic syndrome affects coronary calcification differently among white, Japanese American, and Japanese men : ERA JUMP Study (2009)
  • Author(s): Kadowaki T, Sekikawa A, Curb JD, Kadowaki S, Edmundowicz D, Rodriguez B, El-Saed A, Kadota A, Masaki K, Sutton-Tyrrell K, Miura K, Kuller LH, Ueshima H
  • Organizer: AHA EPI Council March 2009 Florida
• [Presentation] Comparison of fat distribution among Caucasians in the US, Japanese-Americans in Hawaii, and Japanese in Japan : ERA-JUMP Study (2009)
  • Author(s): Kadowaki S, Miura K, Curb JD, Kadowaki T, El-Saed A, Masaki K, Okamura T, Edmundowicz D, Rodriguez BL, Nakamura Y, Sutton-Tyrrell K, Kadota A, Ueshima H, Sekikawa A
  • Organizer: AHA EPI Council March 2009 Florida
• [Presentation] Assessment of subclinical atherosclerosis with carotid intima-media thickness in Japanese Americans in Hawaii and Japanese in Japan with and without metabolic syndrome : ERA JUMP Study (2009)
  • Author(s): Kadota A, Miura K, Sekikawa A, Rodriguez BL, Kadowaki T, Masaki K, Sutton-Tyrrell K, Ueno Y, El-Saed A, Kadowaki S, Edmundowicz D, Okamura T, Maegawa H, Nakamura Y, Kuller LH, Curb JD
  • Organizer: AHA EPI Council March 2009 Florida