| Project/Area Number |
17591267
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Dokkyo Medical University (2006)
Kobe University (2005) |
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Principal Investigator |
KAJI Yasushi Dokkyo Medical University, School of Medicine, Professor, 医学部, 教授 (10273947)
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| Co-Investigator(Kenkyū-buntansha) |
SUGIMURA Kazuro Kobe University, Graduate School of Medicine, Professor, 大学院医学系研究科, 教授 (00136384)
FUJII Masahiko Kobe University, Graduate School of Medicine, Associate Professor, 医学部附属病院, 助教授 (00228959)
FUJISAWA Masato Kobe University, Graduate School of Medicine, Professor, 大学院医学系研究科, 教授 (30243314)
KURODA Kagayaki Tokai University, Faculty of Information and Electronics, Associate Professor, 電子情報学部, 助教授 (70205243)
守殿 貞夫 神戸大学, 大学院医学系研究科, 教授(理事) (30030935)
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| Project Period (FY) |
2005 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 2006: ¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 2005: ¥2,100,000 (Direct Cost: ¥2,100,000)
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| Keywords | prostate cancer / citrate / MR spectroscopy |
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| Research Abstract |
80 patients with prostate cancer were included in this study. However, we could compare between spectra data and biopsy results in 29 patients. The (choline + creatine)/citrate (CC/C) ratio was significantly higher in cancer than in healthy prostate. CC/C ratio and Gleason score were correlated strongly (r=0.686). CC/C ratio at higher magnetic field may predict the tumor aggressiveness.
Development of spectral estimation method based on density matrix made it possible to measure T2-relaxation time of in-vivo citrate. The three-dimensional display software was developed in order to understand the location and volume of spectral abnormalities. This software will offer the important information to select treatments.
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