Relationships between MR diffusion-weighted images, pathology, clinical findings, and genetics in patioents with muscular dystrophy.
| Project/Area Number |
17591312
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | National Center of Neurology and Psychiatry |
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Principal Investigator |
SATO Noriko National Center of Neurology and Psychiatry, National Center of Neurology and Psychiatry, Japan, 部長 (10322017)
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| Co-Investigator(Kenkyū-buntansha) |
OHYA Yasushi National Center of Neurology and Psychiatry, Japan, 武蔵病院神経内科, 医長 (40415568)
大西 隆 国立精神・神経センター, 精神保健研究所心身医学研究部, 協力研究員 (60244208)
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| Project Period (FY) |
2005 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥2,380,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥180,000)
Fiscal Year 2007: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2006: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2005: ¥900,000 (Direct Cost: ¥900,000)
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| Keywords | Myotonic dystrophy / MR / Diffusion-weighted images / Radiology / 拡散強調画像 |
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| Research Abstract |
We have investigated the relationships between clinical and MR imaging findings, especially focusing on intensity changes of diffusion-weighted images of the legs. 25 patients with muscular dystrophy ; 15 patients with myotonic type, 4 patients with Becker type, 6 patients with Lomb-girdle type muscular dystrophy. Their ages were from 15 to 55 years old(mean age ; 36 years old), 17 men and 8 women. T2-weighted images with fat suppression showed multiple or diffuse high signals and diffusion-weighted images represented high signals at the same areas. There were correlations between them. ADC map also showed high intensity, which mean the T2 high signal represented T2 shine-through, probably due to edematous changes. There were correlations between high signals on T2- and diffusion-weighted images and clinical symptoms and serum creatine kinase. The cause of myotonic dystrophy is overextension of CTG(cytosine-thymidine-guanine) trinucleotide on q13.3 of chromosome 19. The number of the triplet extension was not correlated with MR T2 high signals. On the other hand, the patients with muscular dystrophy have a high risk for venous thrombosis of the legs. This study also proved the merit of diffusion-weighted images on MR. Acute thrombosis was shown as bright signal on diffusion-weighted images and low or isointensity on ADC map. It is useful to detect the thrombosis without contrast media which has sometimes induce side effect.
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Report
(4 results)
Research Products
(35 results)
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[Journal Article] Assessment of Hemorrhage in Pituitary Macroadenoma by T2*-Weighted Gradient Echo MR Imaging.2007
Author(s)
Tosaka M, Sato N, Hirato J, Fujimaki H, Yamaguchi R, Kohga H, Hashimoto K,Yamada M, Mori M, Saito N, Yoshimoto Y.
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Journal Title
AJNR Am J Neuroradiol 2007 28(10)
Pages: 2023-2029
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] MR signal of the solid portion of pilocytic astrocytoma on T2-weighted images : it is useful for differentiation from medulloblastoma?2006
Author(s)
Arai K, Sato N, Aoki J, Yagi A, Taketomi-Takahashi A, Morita H, Koyama Y, Oba H, Ishiuchi S, Saito N, Endo K.
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Journal Title
Neuroradiology 48(4)
Pages: 233-237
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Diffusion abnormality in posterior cingulate fiber tracts in Alzheimer's disease : Tract-specific analysis (poster)2007
Author(s)
Yasuhiro Nakata, Noriko Sato, Osamu Abe, Shoko Shikakura, Kunimasa Arima, Nobuo Furuta, Masatake Uno, Shigeo Hirai, Yoshitaka Matsutani, Kuni Ohtomo, Shigeki Aoki
Organizer
American Society of Neuroradilogy
Place of Presentation
Chicago, USA
Description
「研究成果報告書概要(欧文)」より
Related Report
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