| Project/Area Number |
17591312
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | National Center of Neurology and Psychiatry |
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Principal Investigator |
SATO Noriko National Center of Neurology and Psychiatry, National Center of Neurology and Psychiatry, Japan, 部長 (10322017)
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| Co-Investigator(Kenkyū-buntansha) |
OHYA Yasushi National Center of Neurology and Psychiatry, Japan, 武蔵病院神経内科, 医長 (40415568)
大西 隆 国立精神・神経センター, 精神保健研究所心身医学研究部, 協力研究員 (60244208)
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| Project Period (FY) |
2005 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥2,380,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥180,000)
Fiscal Year 2007: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2006: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2005: ¥900,000 (Direct Cost: ¥900,000)
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| Keywords | Myotonic dystrophy / MR / Diffusion-weighted images / Radiology / 拡散強調画像 |
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| Research Abstract |
We have investigated the relationships between clinical and MR imaging findings, especially focusing on intensity changes of diffusion-weighted images of the legs. 25 patients with muscular dystrophy ; 15 patients with myotonic type, 4 patients with Becker type, 6 patients with Lomb-girdle type muscular dystrophy. Their ages were from 15 to 55 years old(mean age ; 36 years old), 17 men and 8 women. T2-weighted images with fat suppression showed multiple or diffuse high signals and diffusion-weighted images represented high signals at the same areas. There were correlations between them. ADC map also showed high intensity, which mean the T2 high signal represented T2 shine-through, probably due to edematous changes. There were correlations between high signals on T2- and diffusion-weighted images and clinical symptoms and serum creatine kinase. The cause of myotonic dystrophy is overextension of CTG(cytosine-thymidine-guanine) trinucleotide on q13.3 of chromosome 19. The number of the triplet extension was not correlated with MR T2 high signals. On the other hand, the patients with muscular dystrophy have a high risk for venous thrombosis of the legs. This study also proved the merit of diffusion-weighted images on MR. Acute thrombosis was shown as bright signal on diffusion-weighted images and low or isointensity on ADC map. It is useful to detect the thrombosis without contrast media which has sometimes induce side effect.
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