| Project/Area Number |
17H00873
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Department of Clinical Research, National Hospital Organization Tokushima National Hospital |
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Principal Investigator |
Mitsui Takao 独立行政法人国立病院機構徳島病院(臨床研究部), その他部局等, その他 (80294726)
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| Co-Investigator(Kenkyū-buntansha) |
黒田 由紀子 独立行政法人国立病院機構徳島病院(臨床研究部), その他部局等, 研究員(移行) (70398014)
有井 敬治 独立行政法人国立病院機構徳島病院(臨床研究部), その他部局等, その他 (70644855)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥43,680,000 (Direct Cost: ¥33,600,000、Indirect Cost: ¥10,080,000)
Fiscal Year 2019: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Fiscal Year 2018: ¥15,860,000 (Direct Cost: ¥12,200,000、Indirect Cost: ¥3,660,000)
Fiscal Year 2017: ¥20,020,000 (Direct Cost: ¥15,400,000、Indirect Cost: ¥4,620,000)
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| Keywords | 反復脊髄磁気刺激(rTSMS) / 神経リハビリテーション / パーキンソン病 / 反復脊髄磁気刺激（ｒTMS) / リハビリテーション / 反復脊髄磁気刺激法 |
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| Outline of Final Research Achievements |
Parkinson's disease is a typical intractable neurological disease with characteristic motor and non-motor symptoms. As the disease progresses, the therapeutic effect diminishes and various complications occur. We devised a unique neurorehabilitation from a new perspective for intractable neurological diseases including Parkinson's disease, and achieved results. We performed repeated spinal magnetic stimulation (rTSMS) on patients with Parkinson's disease. As a result, it was observed that postural abnormalities including "camptocormia" were significantly improved. Furthermore, when nerve rehabilitation combined with rTSMS was performed for 4 weeks, the effect was significantly higher than that of the neurorehabilitation alone group for 6 months. It was estimated that rTSMS enhances the effect of nerve rehabilitation by enhancing nerve plasticity.
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| Academic Significance and Societal Importance of the Research Achievements |
我々の行ったrTSMSによりPDの姿勢異常のみならず運動症状が改善される可能性は高い。またリハビリテーションを併用することでその効果はさらに増強された。さらに、PD以外の神経変性疾患に対しても同様の効果が期待できると考えられる。rTSMSは全く侵襲性がなく、我々が実施した100人以上のPD患者において特記すべき有害事象は全く見られていない。すなわち、rTSMSは簡易かつ安全に実施できる処置で、PDや神経難病に対する画期的な治療法となる可能性がある。さらにリハビリテーションと併用することで、薬物療法の効果の十分ではない運動症状に悩まされる患者にも有望な治療オプションを提供しうると考えられる。
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