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New mechanisms for heat stroke through hyperthemic-hyperventilation and development of the countermesures

Research Project

Project/Area Number 17H00876
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Sports science
Research InstitutionUniversity of Tsukuba

Principal Investigator

Nishiyasu Takeshi  筑波大学, 体育系, 教授 (90237751)

Co-Investigator(Kenkyū-buntansha) 林 恵嗣  静岡県立大学短期大学部, 短期大学部, 教授 (00431677)
藤井 直人  筑波大学, 体育系, 助教 (00796451)
辻 文  県立広島大学, 公私立大学の部局等(広島キャンパス), 准教授 (40707212)
小川 剛司  大阪教育大学, 教育学部, 准教授 (70451698)
本田 靖  筑波大学, 体育系, 教授 (20165616)
Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥42,640,000 (Direct Cost: ¥32,800,000、Indirect Cost: ¥9,840,000)
Fiscal Year 2020: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Fiscal Year 2019: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
Fiscal Year 2018: ¥14,820,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥3,420,000)
Fiscal Year 2017: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
Keywords熱中症 / 換気亢進 / 体温 / 運動 / 体温上昇 / 換気反応 / 暑熱 / 換気
Outline of Final Research Achievements

Elevation in body temperature leads to increase ventilation, which is called hyperthermic hyperventilation and might be one of the mechanisms for heat stroke. The purpose of this study was to explore the mechanisms under the hyperthermic hyperventilation and to develop the new countermeasure against heat stroke during exercise. We conclude that 1) the carotid chemoreceptors and skin sensory input could be a little effect on hyperthermic hyperventilation, 2) caffeine induced stimuli on central respiratory center can modulate hyperthermic hyperventilation, 3) cooling methods by cold air inhalation between exercise intervals in hot environment can suppress hyperthermic hyperventilation and raise in body temperature, reducing the risk for heat stroke.

Academic Significance and Societal Importance of the Research Achievements

我々は、暑熱下運動時の熱中症について、換気反応を加味した新しい発症メカニズムを提唱して国際的にも高く評価されており、本研究では、1)高体温誘発性換気亢進反応のメカニズム探求、さらに、2)関連した新しい熱中症予防法の開発を同時進行で行うことで、地球温暖化が進むと考えられる今後の体育・スポーツの現場における熱中症予防への新しい知見が得ることを目的とした。得られた結果から、メカニズムにおける新知見が得られ、さらに、冷気吸入による口腔・気道・肺胞冷却は、暑熱下運動時の安全かつ効果的な身体冷却による新しい熱中症予防法として有効であることが明らかとなった。

Report

(5 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (28 results)

All 2021 2020 2019 2018 2017 Other

All Int'l Joint Research (5 results) Journal Article (14 results) (of which Int'l Joint Research: 11 results,  Peer Reviewed: 14 results,  Open Access: 11 results) Presentation (9 results) (of which Int'l Joint Research: 6 results,  Invited: 1 results)

  • [Int'l Joint Research] Loughborough University(英国)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] Massey University(ニュージーランド)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] University of Otawa(カナダ)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] University of Ottawa(Canada)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Louughborough University(英国)

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Caffeine Exacerbates Hyperventilation and Reductions in Cerebral Blood Flow in Physically Fit Men Exercising in the Heat2020

    • Author(s)
      Fujii Naoto、Fujimoto Tomomi、Yinhang Cao、Dobashi Kohei、Matsutake Ryoko、Amano Tatsuro、Watanabe Koichi、Nishiyasu Takeshi
    • Journal Title

      Medicine & Science in Sports & Exercise

      Volume: 53 Issue: 4 Pages: 845-852

    • DOI

      10.1249/mss.0000000000002537

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] The nitric oxide dependence of cutaneous microvascular function to independent and combined hypoxic cold exposure2020

    • Author(s)
      Arnold Josh T.、Lloyd Alex B.、Bailey Stephen J.、Fujimoto Tomomi、Matsutake Ryoko、Takayanagi Masataka、Nishiyasu Takeshi、Fujii Naoto
    • Journal Title

      Journal of Applied Physiology

      Volume: 129 Issue: 4 Pages: 947-956

    • DOI

      10.1152/japplphysiol.00487.2020

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Voluntary hypocapnic hyperventilation lasting 5?min and 20?min similarly reduce aerobic metabolism without affecting power outputs during Wingate anaerobic test2020

    • Author(s)
      Dobashi Kohei、Fujii Naoto、Ichinose Masashi、Fujimoto Tomomi、Nishiyasu Takeshi
    • Journal Title

      European Journal of Sport Science

      Volume: 17 Issue: 8 Pages: 1-8

    • DOI

      10.1080/17461391.2020.1812728

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Effect of inspiratory muscle-loaded exercise training on peak oxygen uptake and ventilatory response during incremental exercise under normoxia and hypoxia2020

    • Author(s)
      Ogawa Takeshi、Nagao Maiko、Fujii Naoto、Nishiyasu Takeshi
    • Journal Title

      BMC Sports Science, Medicine and Rehabilitation

      Volume: 12 Issue: 1 Pages: 25-25

    • DOI

      10.1186/s13102-020-00172-1

    • NAID

      120007147841

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nicotinic receptors modulate skin perfusion during normothermia, and have a limited role in skin vasodilatation and sweating during hyperthermia.2019

    • Author(s)
      Fujii N, Amano T, Kenny GP, Honda Y, Kondo N, Nishiyasu T.
    • Journal Title

      Exp Physiol.

      Volume: 104 Pages: 1808-1818

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Evidence for TRPV4 channel induced skin vasodilatation through NOS, COX, and KCa channel mechanisms with no effect on sweat rate in humans.2019

    • Author(s)
      Fujii N, Kenny GP, Amano T, Honda Y, Kondo N, Nishiyasu T.
    • Journal Title

      Eur J Pharmacol.

      Volume: -

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Carotid chemoreceptors have a limited role in mediating the hyperthermia-induced hyperventilation in exercising humans2019

    • Author(s)
      Fujii Naoto、Kashihara Miki、Kenny Glen P.、Honda Yasushi、Fujimoto Tomomi、Cao Yinhang、Nishiyasu Takeshi
    • Journal Title

      Journal of Applied Physiology

      Volume: 126 Issue: 2 Pages: 305-313

    • DOI

      10.1152/japplphysiol.00562.2018

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Respiratory mechanics and cerebral blood flow during heat-induced hyperventilation and its voluntary suppression in passively heated humans2019

    • Author(s)
      Tsuji Bun、Hoshi Yuta、Honda Yasushi、Fujii Naoto、Sasaki Yosuke、Cheung Stephen S.、Kondo Narihiko、Nishiyasu Takeshi
    • Journal Title

      Physiological Reports

      Volume: 7 Issue: 1 Pages: e13967-e13967

    • DOI

      10.14814/phy2.13967

    • NAID

      120007133487

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Expiratory flow limitation under moderate hypobaric hypoxia does not influence ventilatory responses during incremental running in endurance runners2019

    • Author(s)
      Cao Yinhang、Ichikawa Yuhei、Sasaki Yosuke、Ogawa Takeshi、Hiroyama Tsutomu、Enomoto Yasushi、Fujii Naoto、Nishiyasu Takeshi
    • Journal Title

      Physiological Reports

      Volume: 7 Issue: 3 Pages: e13996-e13996

    • DOI

      10.14814/phy2.13996

    • NAID

      120007133483

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of work-matched moderate- and high-intensity warm-up on power output during 2-min supramaximal cycling2018

    • Author(s)
      Fujii Naoto、Nishida Yuya、Ogawa Takeshi、Tanigawa Satoru、Nishiyasu Takeshi
    • Journal Title

      Biology of Sport

      Volume: 35 Issue: 3 Pages: 223-228

    • DOI

      10.5114/biolsport.2018.74633

    • NAID

      120007133814

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of hypocapnia on the sensitivity of hyperthermic hyperventilation and the cerebrovascular response in resting heated humans.2018

    • Author(s)
      113.Tsuji B, Filingeri D, Honda Y, Eguchi T, Fujii N, Kondo N, Nishiyasu T.
    • Journal Title

      J Appl Physiol

      Volume: 124(1) Issue: 1 Pages: 225-233

    • DOI

      10.1152/japplphysiol.00232.2017

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Wearing graduated compression stockings augments cutaneous vasodilation in heat-stressed resting humans.2017

    • Author(s)
      Fujii N, Nikawa T, Tsuji B, Kondo N, Kenny GP, Nishiyasu T.
    • Journal Title

      Eur J Appl Physiol.

      Volume: 117(5) Issue: 5 Pages: 921-929

    • DOI

      10.1007/s00421-017-3581-5

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effect of voluntary hypocapnic hyperventilation or moderate hypoxia on metabolic and heart rate responses during high-intensity intermittent exercise.2017

    • Author(s)
      109.Dobashi K, Fujii N, Watanabe K, Tsuji B, Sasaki Y, Fujimoto T, Tanigawa S, Nishiyasu T.
    • Journal Title

      Eur J Appl Physiol.

      Volume: 117(8) Issue: 8 Pages: 1573-1583

    • DOI

      10.1007/s00421-017-3646-5

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Body temperature and cold sensation during and following exercise under temperate room conditions in cold-sensitive young trained females2017

    • Author(s)
      Fujii Naoto、Aoki-Murakami Erii、Tsuji Bun、Kenny Glen P.、Nagashima Kei、Kondo Narihiko、Nishiyasu Takeshi
    • Journal Title

      Physiological Reports

      Volume: 5 Issue: 20 Pages: e13465-e13465

    • DOI

      10.14814/phy2.13465

    • NAID

      120007134664

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Hypocapnia attenuate local skin thermal sensation in normothermic humans.2021

    • Author(s)
      Fujimoto T, Dobashi K, Matsutake R, Fujii N, Nishiyasu T.
    • Organizer
      ARIHHP science week
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effect of heat acclimation at a fixed daily time on cerebral blood flow in heated humans.2021

    • Author(s)
      Tsuji B, Yamamoto M, Yamashita S, Katagiri A, Fujii N, Nishiyasu T.
    • Organizer
      ARIHHP science week
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The nitric oxide dependence of cutaneous microvascular function to independent and combined hypoxic cold exposure.2020

    • Author(s)
      Lloyd AB, Arnold JT, Bailey SJ, Fujimoto T, Matsutake R, Takayanagi M, Nishiyasu T, Fujii N.
    • Organizer
      virtual 8th International Conference on the Physiology and Pharmacology of Temperature Regulation (vPPTR) 2020
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Menthol application on the skin modulates thermal perceptions but not heat loss, ventilatory, and cerebrovascular responses in resting heated humans.2019

    • Author(s)
      Takayanagi M, Fujimoto T, Kondo N, Nishiyasu T, Fujii N.
    • Organizer
      The 18th International Conference On Environmental Ergonomics
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 段階的着圧機能を持つタイツの着用が日射を伴う暑熱下運動時の呼吸循環および体温調節反応に及ぼす影響2019

    • Author(s)
      北野 孟,小久保 一樹,藤本 知臣,藤井 直人,本田 靖,近藤 徳彦,西保 岳
    • Organizer
      第74回日本体力医学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 皮膚表面へのメントール塗布が安静加温時の熱放散反応および呼吸循環応答に及ぼす影響2019

    • Author(s)
      髙栁 俊隆,藤本 知臣,近藤 徳彦,西保 岳,藤井 直人
    • Organizer
      第74回日本体力医学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 炭酸水素ナトリウムの摂取が暑熱下持続的運動時の換気および脳血流反応に及ぼす影響2019

    • Author(s)
      片桐 陽,西保 岳,辻 文
    • Organizer
      第33回運動と体温の研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Effect of pre-exercise voluntary hyperventilation on physiological responses during and following supramaximal exercise2018

    • Author(s)
      Takeshi Nishiyasu,Kohei Dobashi, Tomomi Fujimoto, Naoto Fujii, Masashi Ichinose
    • Organizer
      International Symposium of Sports Medical Science for Persons with Impairments in Wakayama 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Do Carotid Chemoreceptors Contribute to Hyperthermia Induced Hyperventilation in Exercising Humans?2018

    • Author(s)
      Naoto Fujii, Yasushi Honda, Glen P Kenny, Takeshi Nishiyasu
    • Organizer
      Experimental Biology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research

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Published: 2017-04-28   Modified: 2022-03-29  

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