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LPA signaling molecules and basic diagnostic and therapeutic studies on chronic pain

Research Project

Project/Area Number 17H01586
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Anesthesiology
Research InstitutionProduction Development Science Research Institute (2020-2021)
Kyoto University (2019)
Nagasaki University (2017-2018)

Principal Investigator

UEDA HIROSHI  一般財団法人生産開発科学研究所, その他部局等, 研究員 (00145674)

Co-Investigator(Kenkyū-buntansha) 金子 周司  京都大学, 薬学研究科, 教授 (60177516)
塚原 完  長崎大学, 医歯薬学総合研究科(薬学系), 准教授 (00529943)
崔 翼龍  国立研究開発法人理化学研究所, 生命機能科学研究センター, チームリーダー (60312229)
酒井 佑宜  横浜薬科大学, 薬学部, 講師 (70588095)
藤田 和歌子  長崎大学, 医歯薬学総合研究科(医学系), 准教授 (30382328)
Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥42,510,000 (Direct Cost: ¥32,700,000、Indirect Cost: ¥9,810,000)
Fiscal Year 2020: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Fiscal Year 2019: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2018: ¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000)
Fiscal Year 2017: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
KeywordsLPA / 神経障害性疼痛 / 線維筋痛症 / 糖尿病性神経障害性疼痛 / 脳卒中後痛 / 脳画像解析 / 免疫 / 創薬 / 脳卒中後疼痛 / 画像解析 / リゾホスファチジン酸 / 慢性疼痛 / 疼痛メモリー / 受容体拮抗薬 / 生合成酵素阻害剤 / 創薬基盤研究 / 質量顕微鏡 / PET解析 / eRNA-CAGE解析 / リゾフォスファチジン酸 / 有痛性糖尿病 / eRNA-CAGE法 / 創薬スクリーニング / エピゲノム / 痛みメモリー / in vivoイメージング / Centralized Pain / Empathy / LPA受容体 / 脳卒中後慢性疼痛 / Imaging MS解析
Outline of Final Research Achievements

In addition to the cases with nerve injury-induced and chemotherapy-induced neuropathic pain (NeuP), the present study revealed that LPA signaling plays crucial roles in diabetic NeuP, thrombosis+hemorrhage-type poststroke pain and post spinal cord injury-induced central NeuP. The studies were also proved by the measurement of LPA molecules by LC-MS/MS and MS-imaging. The blockade of LPA signaling was also found to show therapeutic actions against established chronic pain. Astrocyte activation and chemokine production were proved to play roles in the chronic pain maintenance. The fact that splenic T cells from FM model mice caused a hyperalgesia in naive mice indicates that brain pain memory is transmitted to the peripheral immune system.

Academic Significance and Societal Importance of the Research Achievements

LPAシグナルがほぼ全ての慢性疼痛の形成と維持に関与することを初めて明らかにして以来(Nature Med 2004)、一貫してその役割の証明を継続し、その正当性確かめる我が国発の独創的な研究となっている。疼痛解析における新しい動物モデルや評価系についても開発を続け、すべてがこれまでの仮説を証明することに成功している。本研究では国内外で主張されている末梢性の免疫機構の関与も全身性疼痛におけるフィードフォワード機構という枠組みにおいてキチンと組み込むことにも成功している。こうした研究は難治性と呼ばれる慢性疼痛を症状抑制治療でなく根治療法の足がかりを形成するいみにおいて高い価値がある。

Report

(5 results)
  • 2021 Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (64 results)

All 2021 2020 2019 2018 2017 Other

All Int'l Joint Research (1 results) Journal Article (27 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 25 results,  Open Access: 15 results) Presentation (34 results) (of which Int'l Joint Research: 13 results,  Invited: 16 results) Book (1 results) Remarks (1 results)

  • [Int'l Joint Research] McGill大学(カナダ)

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Secreted PLA2-III is a possible therapeutic target to treat neuropathic pain2021

    • Author(s)
      Tanaka Keigo、Dozono Naoki、Neyama Hiroyuki、Nagai Jun、Tsukahara Ryoko、Nagayasu Kazuki、Kaneko Shuji、Ueda Hiroshi
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 568 Pages: 167-173

    • DOI

      10.1016/j.bbrc.2021.06.058

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chronic generalized pain disrupts whole brain functional connectivity in mice2021

    • Author(s)
      Nasseef Md Taufiq、Ma Weiya、Singh Jai Puneet、Dozono Naoki、Lan?on Kevin、S?gu?la Philippe、Darcq Emmanuel、Ueda Hiroshi、Kieffer Brigitte L.
    • Journal Title

      Brain Imaging and Behavior

      Volume: 15 Issue: 5 Pages: 2406-2416

    • DOI

      10.1007/s11682-020-00438-9

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Pathogenic mechanisms of lipid mediator lysophosphatidic acid in chronic pain2021

    • Author(s)
      Ueda Hiroshi
    • Journal Title

      Progress in Lipid Research

      Volume: 81 Pages: 101079-101079

    • DOI

      10.1016/j.plipres.2020.101079

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Review of Kyotorphin Research: A Mysterious Opioid Analgesic Dipeptide and Its Molecular, Physiological, and Pharmacological Characteristics2021

    • Author(s)
      Ueda Hiroshi
    • Journal Title

      Frontiers in Medical Technology

      Volume: 3 Pages: 662697-662697

    • DOI

      10.3389/fmedt.2021.662697

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Editorial: Differences in Pain Biology, Perception, and Coping Strategies: Towards Sex and Gender Specific Treatments2021

    • Author(s)
      Gazerani Parisa、Aloisi Anna Maria、Ueda Hiroshi
    • Journal Title

      Frontiers in Neuroscience

      Volume: 15 Pages: 697285-697285

    • DOI

      10.3389/fnins.2021.697285

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Beneficial actions of prothymosin alpha-mimetic hexapeptide on central post-stroke pain, reduced social activity, learning-deficit and depression following cerebral ischemia in mice2020

    • Author(s)
      Sasaki Keita、Halder Sebok Kumar、Matsunaga Hayato、Ueda Hiroshi
    • Journal Title

      Peptides

      Volume: 126 Pages: 170265-170265

    • DOI

      10.1016/j.peptides.2020.170265

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mirtazapine, an <i>α</i>2 Antagonist-Type Antidepressant, Reverses Pain and Lack of Morphine Analgesia in Fibromyalgia-Like Mouse Models2020

    • Author(s)
      Neyama Hiroyuki、Dozono Naoki、Uchida Hitoshi、Ueda Hiroshi
    • Journal Title

      Journal of Pharmacology and Experimental Therapeutics

      Volume: 375 Issue: 1 Pages: 1-9

    • DOI

      10.1124/jpet.120.265942

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] NR2A-NMDA Receptor Blockade Reverses the Lack of Morphine Analgesia Without Affecting Chronic Pain Status in a Fibromyalgia-Like Mouse Model2020

    • Author(s)
      Neyama Hiroyuki、Dozono Naoki、Ueda Hiroshi
    • Journal Title

      Journal of Pharmacology and Experimental Therapeutics

      Volume: 373 Issue: 1 Pages: 103-112

    • DOI

      10.1124/jpet.119.262642

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Allodynia by Splenocytes From Mice With Acid-Induced Fibromyalgia-Like Generalized Pain and Its Sexual Dimorphic Regulation by Brain Microglia2020

    • Author(s)
      Ueda Hiroshi、Dozono Naoki、Tanaka Keigo、Kaneko Shuji、Neyama Hiroyuki、Uchida Hitoshi
    • Journal Title

      Frontiers in Neuroscience

      Volume: 14 Pages: 600166-600166

    • DOI

      10.3389/fnins.2020.600166

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Lysophosphatidic Acid Receptor 1- and 3-Mediated Hyperalgesia and Hypoalgesia in Diabetic Neuropathic Pain Models in Mice2020

    • Author(s)
      Ueda Hiroshi、Neyama Hiroyuki、Matsushita Yosuke
    • Journal Title

      Cells

      Volume: 9 Issue: 8 Pages: 1906-1906

    • DOI

      10.3390/cells9081906

    • NAID

      120007175420

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] LPA receptor signaling as a therapeutic target for radical treatment of neuropathic pain and fibromyalgia2020

    • Author(s)
      Ueda Hiroshi
    • Journal Title

      Pain Management

      Volume: 10 Issue: 1 Pages: 43-53

    • DOI

      10.2217/pmt-2019-0036

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Systems Pathology of Neuropathic Pain and Fibromyalgia2019

    • Author(s)
      Ueda Hiroshi
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 42 Issue: 11 Pages: 1773-1782

    • DOI

      10.1248/bpb.b19-00535

    • NAID

      130007740598

    • ISSN
      0918-6158, 1347-5215
    • Year and Date
      2019-11-01
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Lysophosphatidic acid LPA1 and LPA3 receptors play roles in the maintenance of late tissue plasminogen activator-induced central poststroke pain in mice2019

    • Author(s)
      Ueda Hiroshi、Neyama Hiroyuki、Sasaki Keita、Miyama Chiho、Iwamoto Ryusei
    • Journal Title

      Neurobiology of Pain

      Volume: 5 Pages: 100020-100020

    • DOI

      10.1016/j.ynpai.2018.07.001

    • NAID

      120006987738

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Regulation of a opioid receptor chaperone protein, RTP4, by morphine.2019

    • Author(s)
      Wakako Fujita, Mini Yokote, Ivone Gomes, Achla Gupta, Hiroshi Ueda, Lakshmi A. Devi,
    • Journal Title

      Mol Pharmacol.

      Volume: 95 Issue: 1 Pages: 11-19

    • DOI

      10.1124/mol.118.112987

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Critical Functionality Effects from Storage Temperature on Human Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium Cell Suspensions2019

    • Author(s)
      Kitahata Shohei、Tanaka Yuji、Hori Kanji、Kime Cody、Sugita Sunao、Ueda Hiroshi、Takahashi Masayo
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 3960-3971

    • DOI

      10.1038/s41598-018-38065-6

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Amlexanox Inhibits Cerebral Ischemia-Induced Delayed Astrocytic High-Mobility Group Box 1 Release and Subsequent Brain Damage2018

    • Author(s)
      Halder Sebok Kumar、Ueda Hiroshi
    • Journal Title

      Journal of Pharmacology and Experimental Therapeutics

      Volume: 365 Issue: 1 Pages: 27-36

    • DOI

      10.1124/jpet.117.245340

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Blockade of analgesic effects following systemic administration of N-methyl-kyotorphin, NMYR and arginine in mice deficient of preproenkephalin or proopiomelanocortin gene2018

    • Author(s)
      Neyama H, Hamada Y, Tsukahara R, Narita M, Tsukamoto K, Ueda H
    • Journal Title

      Peptides

      Volume: 107 Pages: 10-16

    • DOI

      10.1016/j.peptides.2018.06.010

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ecto-F0/F1 ATPase as a novel candidate of prothymosin α receptor2018

    • Author(s)
      Ueda Hiroshi、Matsunaga Hayato、Matsushita Yosuke、Maeda Shiori、Iwamoto Ryusei、Yokoyama Shigeyuki、Shirouzu Mikako
    • Journal Title

      Expert Opinion on Biological Therapy

      Volume: 18 Issue: sup1 Pages: 89-94

    • DOI

      10.1080/14712598.2018.1454427

    • NAID

      120006987980

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of lysophosphatidic acid-induced astrocyte activation underlying the maintenance of partial sciatic nerve injury-induced neuropathic pain2018

    • Author(s)
      Ueda Hiroshi、Neyama Hiroyuki、Nagai Jun、Matsushita Yosuke、Tsukahara Tamotsu、Tsukahara Ryoko
    • Journal Title

      PAIN

      Volume: 159 Issue: 11 Pages: 2170-2178

    • DOI

      10.1097/j.pain.0000000000001316

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tyrosyl-tRNA synthetase: a potential kyotorphin synthetase in mammals.2018

    • Author(s)
      Tsukahara T, Yamagishi S, Neyama H, Ueda H
    • Journal Title

      Peptides

      Volume: 101 Pages: 60-68

    • DOI

      10.1016/j.peptides.2017.12.026

    • NAID

      130007901638

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] LPA5 signaling is involved in multiple sclerosis-mediated neuropathic pain in the cuprizone mouse model2018

    • Author(s)
      Tsukahara Ryoko、Yamamoto Shinji、Yoshikawa Keisuke、Gotoh Mari、Tsukahara Tamotsu、Neyama Hiroyuki、Ishii Satoshi、Akahoshi Noriyuki、Yanagida Keisuke、Sumida Hayakazu、Araki Masatake、Araki Kimi、Yamamura Ken-ichi、Murakami-Murofushi Kimiko、Ueda Hiroshi
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 136 Issue: 2 Pages: 93-96

    • DOI

      10.1016/j.jphs.2018.01.001

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association between polymorphisms in the purinergic P2Y12 receptor gene and severity of both cancer pain and postoperative pain2018

    • Author(s)
      Sumitani M, Nishizawa D, Nagashima M, Ikeda K, Abe H, Kato R, Ueda H, Yamada Y
    • Journal Title

      Pain Med

      Volume: 19(2) Issue: 2 Pages: 348-354

    • DOI

      10.1093/pm/pnx102

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] LPA1 receptor involvement in fibromyalgia-like pain induced by intermittent psychological stress, empathy.2017

    • Author(s)
      Ueda H, Neyama H
    • Journal Title

      Neurobiology of Pain

      Volume: 1 Pages: 16-25

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A mimetic of the mSin3-binding helix of NRSF/REST ameliorates abnormal pain behavior in chronic pain models.2017

    • Author(s)
      Ueda H, Kurita J, Neyama H, Hirao Y, Kouji H,Mishina T,Kasai M,Nakano H,Yoshimori A, Nishimura Y
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters

      Volume: 27 Issue: 20 Pages: 4705-4709

    • DOI

      10.1016/j.bmcl.2017.09.006

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lysophosphatidic acid signaling is the definitive mechanism underlying neuropathic pain.2017

    • Author(s)
      Ueda H
    • Journal Title

      PAIN

      Volume: 158 Issue: 1 Pages: 55-67

    • DOI

      10.1097/j.pain.0000000000000813

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] オピオイド受容体概論2017

    • Author(s)
      植田弘師、藤田和歌子
    • Journal Title

      ペインクリニック38 別冊春号

      Volume: 38(15) Pages: 157-166

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 神経障害性疼痛と線維筋痛症様モデルマウスにおけるLPA受容体を介する痛みメモリー機構2017

    • Author(s)
      植田弘師
    • Journal Title

      PAIN RESEARCH

      Volume: 32(4) Pages: 240-245

    • NAID

      130007378656

    • Related Report
      2017 Annual Research Report
    • Open Access
  • [Presentation] Systems pathology on neuropathic pain and fibromyalgia/centralized pain2019

    • Author(s)
      Hiroshi Ueda
    • Organizer
      Annual Meeting for Taiwan Neuroscience, Tainan
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Chronic pain status and loss of morphine analgesia have independent brain mechanisms in mice with fibromyalgia-like generalized pain2019

    • Author(s)
      Hiroshi Ueda
    • Organizer
      International Narcotics Research Conference
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Advances in the studies on LPA roles in chronic pain2019

    • Author(s)
      Hiroshi Ueda
    • Organizer
      2019 FASEB SRC on Lysophospholipid and Related Mediators: From Bench to Clinic
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] モルヒネが効かない慢性疼痛におけるメサドンの鎮痛効果2019

    • Author(s)
      根山広行、植田弘師
    • Organizer
      第92回日本薬理学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 慢性疼痛におけるフィードフォワード性の 痛みメモリー機構とオピオイド機能低下2019

    • Author(s)
      植田弘師
    • Organizer
      第139年会薬学会賞受賞講演
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Centralized Pain脳可塑性疼痛について2018

    • Author(s)
      植田弘師
    • Organizer
      第40回日本疼痛学会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] TPA誘発性脳卒中後疼痛CPSP マウスモデルとLPAの関与2018

    • Author(s)
      植田弘師
    • Organizer
      第40回日本疼痛学会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 線維筋痛症モデルにおけるモルヒネ鎮痛如欠如メカニズム2018

    • Author(s)
      根山広行、吾郷由希夫、橋本均、植田弘師
    • Organizer
      第40回日本疼痛学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 神経障害誘発性疼痛鈍麻並びにモルヒネ鎮痛欠如におけるLPA受容体の関与2018

    • Author(s)
      居塚詔子、根山広行、植田弘師
    • Organizer
      第40回日本疼痛学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 中枢性脳卒中後疼痛モデルにおけるLPAの関与2018

    • Author(s)
      岩元隆征、見山知穂、植田弘師
    • Organizer
      第40回日本疼痛学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 脊髄損傷モデルにおけるLPA受容体の関与2018

    • Author(s)
      河田和彦、根山広行、永井潤、植田弘師
    • Organizer
      第40回日本疼痛学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 線維筋痛症モデルにおける疼痛治療薬ごとに異なるオピオイド鎮痛回復2018

    • Author(s)
      堂園直貴、根山広行、植田弘師
    • Organizer
      第40回日本疼痛学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Lysophosphatidic acid signaling is involved in the development and maintenance of neuropathic pain and fibromyalgia2018

    • Author(s)
      Hiroshi Ueda
    • Organizer
      World Congress on Pharmacology and Clinical Pharmacology 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Differential sensory fiber specificity and LPA receptor-involvement between partial sciatic nerve injury-induced and high-fat diet-induced neuropathic pain2018

    • Author(s)
      Noriko Izuka, Chiho Miyama, Shintaro Fukuzoe and Hiroshi Ueda
    • Organizer
      World Congress on Pharmacology and Clinical Pharmacology 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Novel receptor mechanisms of prothymosin alpha, a neuroprotective DAMPs molecule2018

    • Author(s)
      Ryusei Iwamoto, Shiori Maeda and Hiroshi Ueda
    • Organizer
      World Congress on Pharmacology and Clinical Pharmacology 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Tyrosyl-tRNA synthetase: a potential kyotorphin synthetase in mammals2018

    • Author(s)
      Hiroshi Ueda, Tamotsu Tsukahara
    • Organizer
      World Congress on Pharmacology and Clinical Pharmacology 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Further in vitro and in vivo studies of newly discovered LPA2 agonists against radiation-induced damages2018

    • Author(s)
      Kazuhiko Kawata, Yoshiki Iwanaga and Hiroshi Ueda
    • Organizer
      World Congress on Pharmacology and Clinical Pharmacology 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Intermittent psychological (Empathy) stress-induced generalized pain syndrome in mice mimics pathophysiological and pharmacotherapeutic characters in fibromyalgia in clinic2018

    • Author(s)
      Naoki Dozono, Hiroyuki Neyama and Hiroshi Ueda
    • Organizer
      World Congress on Pharmacology and Clinical Pharmacology 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Brain opioid-mediated analgesia by systemic administration of dipeptide kyotorphin analog2018

    • Author(s)
      Hiroyuki Neyama, Yusuke Hamada, Minoru Narita, Hiroshi Ueda
    • Organizer
      World Congress on Pharmacology and Clinical Pharmacology 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Lysophosphatidic acid (LPA) involvement in central poststroke pain (CPSP)2018

    • Author(s)
      Chiho Miyama, Ryusei Iwamoto and Hiroshi Ueda
    • Organizer
      World Congress on Pharmacology and Clinical Pharmacology 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Neurobiology of prothymosin α, a DAMPs molecule, which protects ischemic brain2018

    • Author(s)
      Hiroshi Ueda
    • Organizer
      神経科学2018
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Prothymosin α has a robustness role to protect brain from ischemia-induced damages2018

    • Author(s)
      Hiroshi Ueda and Ryusei Iwamoto
    • Organizer
      2018年日本神経化学会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Centralized Painとしての線維筋痛症動物モデル-病態生理学と治療薬理学2018

    • Author(s)
      植田弘師、根山広行、堂園直貴
    • Organizer
      第10回日本線維筋痛症学会抄録
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Imaging MS(質量顕微鏡)を用いた中枢性脳卒中後疼痛モデルにおけるLPA産生の可視化2018

    • Author(s)
      岩元隆征、根山広行、見山知穂、杉浦悠毅、植田弘師
    • Organizer
      第71回日本薬理学会西南部会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 心理ストレス型線維筋痛症モデルの病態生理と治療薬理学ならびにLPAシグナル機構2018

    • Author(s)
      植田弘師
    • Organizer
      第47回日本慢性疼痛学会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] モルヒネ耐性形成機序における Receptor transporter protein 4 および MOPr-DOPr ヘテロ二量体の関与2018

    • Author(s)
      横手未仁、植田弘師、 Lakshmi A. Devi、藤田和歌子
    • Organizer
      第138回薬学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 痛みメモリーを消去するLPA シグナル制御創薬研究2017

    • Author(s)
      植田弘師
    • Organizer
      平成29年度 東北医科薬科大学 創薬研究センターシンポジウム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Therapeutic recovery from diminished morphine analgesia in chronic pain state.2017

    • Author(s)
      Ueda H,Neyama H
    • Organizer
      The International Narcotics Research Conference 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Brain mechanisms of LPA-signaling in the central pain.2017

    • Author(s)
      Ueda H,Neyama H
    • Organizer
      2017 FASEB(Federation of American Societies for Experimental Biology)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 慢性疼痛時のモルヒネ感受性低下のメカニズムにもとづく治療と創薬2017

    • Author(s)
      植田弘師
    • Organizer
      第37回鎮痛薬・オピオイドペプチドシンポジウム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 断続的繰り返し精神ストレス(Empathy)による新しい線維筋痛症モデルとLPAシグナルを介するメカニズム2017

    • Author(s)
      植田弘師
    • Organizer
      日本線維筋痛症学会第9回学術集会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 線維筋痛症モデルマウスにおける痛みとモルヒネ鎮痛欠如に関する脳内責任部位2017

    • Author(s)
      植田弘師、根山広行
    • Organizer
      第39回日本疼痛学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] MoPr-DOPrヘテロ二量体シャペロン蛋白質 RTP4 野μオピオイド受容体刺激に伴う発現変化とその役割2017

    • Author(s)
      藤田和歌子、横手未仁、植田弘師、 Lakshmi A. Devi
    • Organizer
      第70回日本薬理学会西南部会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 心理的ストレスによる線維筋痛症モデルの確立とLPA受容体機構の関与2017

    • Author(s)
      根山広行、植田弘師
    • Organizer
      第70回日本薬理学会西南部会
    • Related Report
      2017 Annual Research Report
  • [Book] 線維筋痛症ガイドライン2017 疾患の解説とトピックス:慢性疼痛の基礎科学の進歩2017

    • Author(s)
      国立研究開発法人 日本医療研究開発機構線維筋痛症研究班
    • Total Pages
      216
    • Publisher
      線維筋痛症学会(日本医事新報社出版局)
    • Related Report
      2017 Annual Research Report
  • [Remarks]

    • URL

      http://www.ph.nagasaki-u.ac.jp/lab/soyakuri/index-j.html

    • Related Report
      2018 Annual Research Report

URL: 

Published: 2017-04-28   Modified: 2024-12-25  

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