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Non-invasive hearing prosthesis using infrared laser

Research Project

Project/Area Number 17H01769
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Perceptual information processing
Research InstitutionDoshisha University

Principal Investigator

Kobaysi Kohta  同志社大学, 生命医科学部, 教授 (40512736)

Co-Investigator(Kenkyū-buntansha) 飛龍 志津子  同志社大学, 生命医科学部, 教授 (70449510)
古山 貴文  金沢医科大学, 医学部, 助教 (20802268)
Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2020: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2019: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2018: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2017: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Keywords赤外レーザー / 補聴器 / 人工内耳 / 言語知覚 / 赤外光レーザー / 人工感覚器 / スナネズミ / 難聴 / 神経刺激 / 新型補聴器 / 赤外線レーザー / げっ歯類 / フラビン蛍光タンパクイメージング / 老人性難聴 / 蝸牛 / トノトピー / フラビン蛋白蛍光イメージング / 近赤外レーザー
Outline of Final Research Achievements

This study focused on novel method for stimulating nerves with an infrared laser as a substitute for the highly invasive cochlear implants. We demonstrated that t sound perception is generated by stimulating auditory nerves without contacting tissues. In addition, for developing a non-invasive cochlear implant in the future, we conducted basic research on neurophysiological basis of it. The results show the feasibility of an infrared laser cochlear implant that does not require surgery, will lead to the solution of the deafness problem, which will become more serious due to the aging of society.

Academic Significance and Societal Importance of the Research Achievements

言葉や環境音などが聞きづらい、難聴の症状は、高齢者の2割以上が体験する、極めて大きな社会的な課題である。本研究では、赤外光レーザーによって非接触で聴覚神経を刺激することで音知覚が生まれるかを、実験動物(スナネズミ)を対象として検討した。行動実験・生理実験の結果、レーザー刺激は聴覚末梢および中枢を刺激可能であることおよび露光量を調節することで音の大きさ知覚を制御できることが示唆された。この結果は侵襲性が低いレーザー人工内耳・補聴器の実現性を示す

Report

(5 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (22 results)

All 2021 2020 2019 2018 2017 Other

All Int'l Joint Research (1 results) Journal Article (10 results) (of which Peer Reviewed: 9 results,  Open Access: 8 results) Presentation (11 results) (of which Int'l Joint Research: 6 results)

  • [Int'l Joint Research] Texas A&M(米国)

    • Related Report
      2018 Annual Research Report
  • [Journal Article] The effect of laser-hearing aid for age-related hearing loss2021

    • Author(s)
      重山 尭史, 玉井 湧太 , 松本 和之, 小林 耕太
    • Journal Title

      同志社大学ハリス理化学研究報告

      Volume: 61 Issue: 4 Pages: 215-220

    • DOI

      10.14988/00027856

    • NAID

      120006955147

    • ISSN
      21895937
    • URL

      https://doshisha.repo.nii.ac.jp/records/27864

    • Year and Date
      2021-01-31
    • Related Report
      2020 Annual Research Report
    • Open Access
  • [Journal Article] Auditory cortical activity elicited by infrared laser irradiation from the outer ear in Mongolian gerbils.2020

    • Author(s)
      Tamai Y, Ito Y, Furuyama T, Horinouchi K, Murashima N, Michimoto I, Hishida R, Shibuki K, Hiryu S, Kobayasi KI
    • Journal Title

      PLoS One

      Volume: 15 Issue: 10 Pages: 1-13

    • DOI

      10.1371/journal.pone.0240227

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Speech Encoding Scheme for The Extra-cochlear Laser Stimulation System2020

    • Author(s)
      Tamai Yuta、Matsumoto Kazuyuki、Ito Airi、Hiryu Shizuko、Kobayasi Kohta I.
    • Journal Title

      Proceedings of the IEEE Life Sciences and Technologies

      Volume: 2 Pages: 1-4

    • DOI

      10.1109/lifetech48969.2020.1570617446

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Brain Activity Related to Sound Symbolism: Cross-modal Effect of an Aurally Presented Phoneme on Judgment of Size2019

    • Author(s)
      S. Itagaki, S.Murai, K.I.Kobayasi
    • Journal Title

      Scientific Report

      Volume: 9 Issue: 1 Pages: 1-9

    • DOI

      10.1038/s41598-019-43457-3

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Infrared Laser Stimulation of Cochlear Nerve through a Tympanic Membrane2019

    • Author(s)
      Y. Tamai, K. Horinouchi, S. Hiryu, K. I. Kobayasi
    • Journal Title

      Proceedings of IEEE LifeTech2019

      Volume: 1 Pages: 1-4

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The suppression of neural epileptic activity on stimulation with a near-infrared laser2019

    • Author(s)
      T. Furuyama, J. Nakamura, K. I. Kobayasi
    • Journal Title

      Proceedings of IEEE LifeTech2019

      Volume: 1 Pages: 1-2

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Demonstration of a novel speech-coding method for single-channel cochlear stimulation2018

    • Author(s)
      Tamai, Yuta Hiryu, Shizuko Kobayasi, Kohta I.
    • Journal Title

      同志社大学ハリス理化学研究報告

      Volume: 58 Issue: 4 Pages: 224-229

    • DOI

      10.14988/pa.2017.0000016914

    • NAID

      120006394927

    • ISSN
      21895937
    • URL

      https://doshisha.repo.nii.ac.jp/records/26012

    • Year and Date
      2018-01-31
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cross-modal effect of an aurally presented phoneme on the judgment of a visual object's size2017

    • Author(s)
      Itagaki, Sachi Kobayasi, Kohta I.
    • Journal Title

      同志社大学ハリス理化学研究報告

      Volume: 57 Issue: 4 Pages: 239-243

    • DOI

      10.14988/pa.2017.0000015334

    • NAID

      120006023594

    • ISSN
      21895937
    • URL

      https://doshisha.repo.nii.ac.jp/records/24944

    • Year and Date
      2017-01-31
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Infrared neural stimulation evokes auditory brain stem responses following the acoustic feature of speech sounds2017

    • Author(s)
      Tamai, Yuta Shinpo, Yuka Horinouchi, Kensuke Hiryu, Shizuko Kobayasi, Kohta I.
    • Journal Title

      同志社大学ハリス理化学研究報告

      Volume: 57 Issue: 4 Pages: 254-261

    • DOI

      10.14988/pa.2017.0000015336

    • NAID

      120006023596

    • ISSN
      21895937
    • URL

      https://doshisha.repo.nii.ac.jp/records/24946

    • Year and Date
      2017-01-31
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Acoustic characteristics used by Japanese macaques for individual discrimination2017

    • Author(s)
      Furuyama Takafumi、Kobayasi Kohta I.、Riquimaroux Hiroshi
    • Journal Title

      The Journal of Experimental Biology

      Volume: 220 Pages: 3571-3578

    • DOI

      10.1242/jeb.154765

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Let there be sound: auditory perception evoked by trans-tympanic laser stimulation in Mongolian gerbils2020

    • Author(s)
      上中望生,玉井湧太,伊藤優樹,兎田幸司,飛龍志津子,小林耕太,
    • Organizer
      第80回 日本動物心理学会,オンライン
    • Related Report
      2020 Annual Research Report
  • [Presentation] Dose laser irradiation of auditory nerves create auditory perception?2020

    • Author(s)
      玉井湧太、上中望生、伊藤優樹、兎田幸司、古山貴文、飛龍志津子、小林耕太
    • Organizer
      第43回神経科学大会2020オンライン
    • Related Report
      2020 Annual Research Report
  • [Presentation] 赤外光レーザー人工内耳の開発:聴覚マスキングによる知覚の評価2020

    • Author(s)
      岡本彩, 上中望生, 玉井湧太
    • Organizer
      第23回 関西支部若手研究者交流研究発表会,オンライン
    • Related Report
      2020 Annual Research Report
  • [Presentation] Developing new auditory prosthesis: auditory perception evoked by trans-tympanic laser stimulation in Mongolian gerbil2020

    • Author(s)
      上中望生,玉井湧太,伊藤優樹,兎田幸司,飛龍志津子,小林耕太
    • Organizer
      第42回 日本比較生理生化学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Novel auditory prothesis with infrared laser: Flavoprotein fluorescence imaging revealed auditory cortical activity induced by trans tympanic membrane laser irradiation to cochlear nerves2019

    • Author(s)
      玉井 湧太, 伊藤 優樹, 古山 貴文, 飛龍 志津子, 小林 耕太
    • Organizer
      Neuro 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Speech encoding scheme for linguistic and paralinguistic information with infrared laser auditory prothesis2019

    • Author(s)
      山里 遥香,玉井 湧太,松本 和之,吉田 美紀, 飛龍 志津子, 小林 耕太
    • Organizer
      Neuro 2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] Auditory prosthesis with an infrared lasor: Replication of acoustic intensity information2018

    • Author(s)
      Yuta Tamai, Yuki Ito, Kensuke Horinouchi, Kazuyuki Matsumoto, Shizuko Hiryu, Kohta I. Kobayasi, Takafumi Furuyama
    • Organizer
      Annual meeting of society for Neuroscience 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Auditory brainstem responses recorded from inferior colliculus in Miniopterus fuliginosus2017

    • Author(s)
      T. FURUYAMA, K. HASE, S. HIRYU, K. I. KOBAYASI
    • Organizer
      Society for Neuroscience
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Amplification of auditory brainstem response by simultaneous infrared laser stimulation to cochlea2017

    • Author(s)
      K. HORINOUCHI, Y. TAMAI, S. HIRYU, K. I. KOBAYASHI
    • Organizer
      Society for Neuroscience
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Sound symbolism - Related brain area relative to language processing2017

    • Author(s)
      S. ITAGAKI, S. MURAI, K. I. KOBAYASI
    • Organizer
      Society for Neuroscience
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A new behavioral paradigm for investigating auditory perception of untrained animals: Application of novel object recognition procedure to hearing research2017

    • Author(s)
      Y. TAMAI, T. NOGUCHI, S. HIRYU, K. I. KOBAYASI
    • Organizer
      Society for Neuroscience
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research

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Published: 2017-04-28   Modified: 2022-01-27  

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