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Elucidation of Brain Functions in ASD by Entropy Analysis of Resting State functional MRI using 7.0T

Research Project

Project/Area Number 17H02191
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Childhood science (childhood environment science)
Research InstitutionNiigata University

Principal Investigator

Suzuki Yuji  新潟大学, 脳研究所, 准教授 (90529851)

Co-Investigator(Kenkyū-buntansha) 中村 ゆきみ  新潟大学, 脳研究所, 助教 (70377208)
山田 謙一  新潟大学, 脳研究所, 准教授 (70436773)
鈴木 清隆  新潟大学, 脳研究所, 准教授 (40303169)
中田 力  新潟大学, 脳研究所, 特任教授 (50281720)
Project Period (FY) 2017-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2021: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2020: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2019: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2018: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Keywordsエントロピー解析 / 高磁場MRI / 自閉症スペクトラム / functional MRI / 自閉症 / 安静時賦活 / エントロピー脳機能解析 / 7T-functionalMRI / 超高磁場MRI / rs-fMRI / 超高磁場磁気共鳴画像法 / 脳・神経 / ネットワーク / 統計数学 / 社会医学
Outline of Final Research Achievements

In this study, we showed that entropy analysis (Power Spectral Entropy (PSE)) can be used to analyze brain functions, and we used cortical entropy maps created based on PSE to evaluate disorganized (random) information processing in the entire cortex of the brain.
ASD is more random than TD, depending on the degree of stimulus receptivity of the brain, and the results indicate that ASD is a random situation with disorganized information processing even at resting state. Furthermore, this method can analyze the changes in ASD under favorite conditions (entropy reduction), suggesting that it can lead to further elucidation of brain functions in ASD.

Academic Significance and Societal Importance of the Research Achievements

我々が提唱するエントロピー解析はマクロな機能的連結に主眼を置く現象論的な記載を行う既存の解析方法では見出すことができなかった環境の変化や刺激に対して敏感に反応してしまうといったようなASDが内部に抱えている神経基盤に基づく情報処理システムの解明に迫る可能性を秘めている。この解析方法はASDの複雑な情報処理機構の解明につながるとともに、治療を含めた様々な介入に対する効果を客観的に判断することにつながることも期待され、社会的に大きな意義があると思われる。

Report

(6 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (23 results)

All 2021 2020 2019 2018 2017

All Journal Article (20 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 19 results,  Open Access: 15 results) Presentation (2 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Hyperopic anisometropia with a shorter axial length ipsilateral to the ptotic eye in children with congenital ptosis.2021

    • Author(s)
      Ueki S, Suzuki Y, Kiyokawa M, Hanyu T, Fukuchi T.
    • Journal Title

      BMC Ophthalmol.

      Volume: 21 Issue: 1 Pages: 358-358

    • DOI

      10.1186/s12886-021-02126-8

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Altered Functional Network Architecture of the Brain in Prader Willi Syndrome2021

    • Author(s)
      Yamada K, Suzuki K, Watanabe M
    • Journal Title

      Brain Connectivity

      Volume: 62 Pages: 174-179

    • DOI

      10.1089/brain.2020.0914

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Retinal Aquaporin-4 and Regulation of Water Inflow Into the Vitreous Body2021

    • Author(s)
      Ueki Satoshi、Suzuki Yuji、Igarashi Hironaka
    • Journal Title

      Investigative Opthalmology & Visual Science

      Volume: 62 Issue: 2 Pages: 24-24

    • DOI

      10.1167/iovs.62.2.24

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Participant-driven Simulation Protocol With a Mock Scanner for Pediatric Magnetic Resonance Neuroimaging Preparation Without Sedation2020

    • Author(s)
      Yamada Kenichi、Suzuki Yuji、Ueki Satoshi、Itoh Kosuke、Watanabe Masaki、Suzuki Kiyotaka、Igarashi Hironaka
    • Journal Title

      Clinical Simulation in Nursing

      Volume: 47 Pages: 40-47

    • DOI

      10.1016/j.ecns.2020.07.002

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cerebellar Volumes Associate with Behavioral Phenotypes in Prader-Willi Syndrome2020

    • Author(s)
      Yamada Kenichi、Watanabe Masaki、Suzuki Kiyotaka、Suzuki Yuji
    • Journal Title

      The Cerebellum

      Volume: 19 Issue: 6 Pages: 778-787

    • DOI

      10.1007/s12311-020-01163-1

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Skull diplo? is rich in aquaporin-42020

    • Author(s)
      Suzuki Yuji、Kitaura Hiroki、Nakamura Yukimi、Kakita Akiyoshi、Huber Vincent J.、Capozzoli Nicholas、Kwee Ingrid L.、Nakada Tsutomu
    • Journal Title

      Heliyon

      Volume: 6 Issue: 1 Pages: e03259-e03259

    • DOI

      10.1016/j.heliyon.2020.e03259

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Age-related increase in GABAA receptor distribution in the prefrontal cortex2019

    • Author(s)
      Tobinaga Masanobu、Suzuki Yuji、Fujinaka Hidehiko、Ozawa Tetsuo、Nakajima Takashi
    • Journal Title

      Journal of Clinical Neuroscience

      Volume: ー Pages: 106-110

    • DOI

      10.1016/j.jocn.2019.03.044

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Visualizing the Distribution of Matrix Metalloproteinases in Ischemic Brain Using In Vivo 19F-Magnetic Resonance Spectroscopic Imaging2019

    • Author(s)
      Huber Vincent J.、Igarashi Hironaka、Ueki Satoshi、Terumitsu-Tsujita Mika、Nito Chikako、Ohno Ken、Suzuki Yuji、Itoh Kosuke、Kwee Ingrid L.、Nakada Tsutomu
    • Journal Title

      Contrast Media & Molecular Imaging

      Volume: 2019 Pages: 1-8

    • DOI

      10.1155/2019/8908943

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Developmental abnormalities of the brain exposed to childhood maltreatment detected by diffusion tensor imaging.2019

    • Author(s)
      Yamada K, Suzuki Y, Okuyama M, Watanabe M, Nakada T
    • Journal Title

      Neurological Research

      Volume: 41 Issue: 1 Pages: 19-25

    • DOI

      10.1080/01616412.2018.1522413

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A case of atraumatic tetanus developed initially with worsening headache in a woman regularly cared for chronic headache at an outpatient clinic2019

    • Author(s)
      Tobinaga Masanobu、Suzuki Yuji、Nakajima Takashi
    • Journal Title

      Clinical Case Reports

      Volume: 7 Issue: 3 Pages: 486-490

    • DOI

      10.1002/ccr3.2024

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Glymphatic systemの機能画像2019

    • Author(s)
      鈴木雄治
    • Journal Title

      Clinical Neuroscience

      Volume: 37 Pages: 46-8

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Aquaporin PET differentiates between grade III and IV human astrocytoma.2018

    • Author(s)
      Suzuki Y, Nakamura Y, Yamada K, Kurabe S, Okamoto K, Aoki H, Kitaura H, Kakita A, Fujii Y, Huber VJ, Igarashi H, Kwee IL, Nakada T
    • Journal Title

      Neurosurgery

      Volume: 印刷中 Issue: 6 Pages: 842-846

    • DOI

      10.1093/neuros/nyx314

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 3DAC PROPELLER: An overly underused powerful MRI modality2018

    • Author(s)
      Nakada T, Suzuki K, Suzuki Y. Nakada K, Kwee IL
    • Journal Title

      Anatomy Physiol Biochem Int J

      Volume: 4 Pages: 555626-555626

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Advances and Challenges in Assessing 2-Hydroxyglutarate in Gliomas by Magnetic Resonance Spectroscopy: A Short Review.2018

    • Author(s)
      Natsumeda M, Igarashi H, Motohashi K, Suzuki Y, Ohkubo M, Okamoto K, Watanabe M, Nakada T, Fujii Y
    • Journal Title

      Neuropsychiatry

      Volume: 8 Pages: 1831-8

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Abnormal Distribution of GABAA Receptors in Brain of Duchenne Muscular Dystrophy Patients.2017

    • Author(s)
      Suzuki Y, Higuchi S, Aida I, Nakajima T, Nakada T
    • Journal Title

      Muscle Nerve

      Volume: Apr;55(4) Issue: 4 Pages: 591-595

    • DOI

      10.1002/mus.25383

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Maturational decrease of glutamate in the human cerebral cortex from childhood to young adulthood: a 1H-MR spectroscopy study.2017

    • Author(s)
      Shimizu M, Suzuki Y, Yamada K, Ueki S, Watanabe M, Igarashi H, Nakada T.
    • Journal Title

      Pediatr Res

      Volume: 82 Issue: 5 Pages: 749-752

    • DOI

      10.1038/pr.2017.101

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MRI characteristics of the glia limitans externa: A 7T study.2017

    • Author(s)
      Suzuki K, Yamada K, Nakada K, Suzuki Y, Watanabe M, Kwee IL, Nakada T
    • Journal Title

      Magn Reson Imaging

      Volume: 44 Pages: 140-145

    • DOI

      10.1016/j.mri.2017.08.012

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Slow accumulations of neural activities in multiple cortical regions precede self-initiation of movement: an event-related fMRI study2017

    • Author(s)
      Sakata H, Itoh K, Suzuki Y, Nakamura K, Watanabe M, Igarashi H, Nakada T
    • Journal Title

      eNEURO

      Volume: Oct 30;4(5)

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Aquaporin-4 Functionality and Virchow-Robin Space Water Dynamics: Physiological Model for Neurovascular Coupling and Glymphatic Flow2017

    • Author(s)
      Nakada Tsutomu、Kwee Ingrid、Igarashi Hironaka、Suzuki Yuji
    • Journal Title

      Int J Mol Sci.

      Volume: 18 Issue: 8 Pages: 1798-1798

    • DOI

      10.3390/ijms18081798

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Magnetic Resonance Imaging of Neurotransmitter-Related Molecules2017

    • Author(s)
      Igarashi Hironaka、Ueki Satoshi、Ohno Ken、Ohkubo Masaki、Suzuki Yuji
    • Journal Title

      Journal of Nippon Medical School

      Volume: 84 Issue: 4 Pages: 160-164

    • DOI

      10.1272/jnms.84.160

    • NAID

      130006140098

    • ISSN
      1345-4676, 1347-3409
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Relationship between reduction of water influx into CSF and senile plaque formation (β-amyloid)2017

    • Author(s)
      Yuji Suzuki
    • Organizer
      Society for Neuroscience
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] MRIを用いた発達へのアプローチ2017

    • Author(s)
      鈴木雄治
    • Organizer
      第21回酸素ダイナミクス研究会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Patent(Industrial Property Rights)] 発達障害および精神・神経系疾患の画像診断支援システム2019

    • Inventor(s)
      鈴木清隆、鈴木雄治
    • Industrial Property Rights Holder
      鈴木清隆、鈴木雄治
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Acquisition Date
      2021
    • Related Report
      2020 Annual Research Report

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Published: 2017-04-28   Modified: 2023-01-30  

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