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Academic Systematization of Separation Analysis Based on Phase Separation Multiphase Flow and Its Practical Technical Improvements

Research Project

Project/Area Number 17H03083
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Analytical chemistry
Research InstitutionDoshisha University

Principal Investigator

Tsukagoshi Kazuhiko  同志社大学, 理工学部, 教授 (60227361)

Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2020: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2019: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2018: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2017: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
Keywords相分離混相流 / 学術的体系化 / 技術的体系化 / クロマトグラフィー / 微小空間 / 抽出 / 微小領域 / 相分離 / 液液界面 / 管径方向分配流 / 分離回収 / 分離 / 二相分離混相流 / PEG/デキストラン / 分離分析 / 動的液-液界面
Outline of Final Research Achievements

Capillary chromatography, which utilizes two liquid phase flows generated by "phase-separated multiphase flow" as a mobile phase and a pseudo-stationary phase, is based on an original idea and has not been reported elsewhere. Since it does not require special machining of the capillary or the application of voltage, it can realize drastic simplification and simplification of equipment and operation compared to conventional methods. Therefore, it is of great significance to improve capillary chromatography using "phase separation multiphase flow" from the academic research level to a general-purpose system with marketability by accumulating research. In this research, we will develop capillary chromatography based on "phase separation multi-phase flow", which has a great impact both academically and socially.

Academic Significance and Societal Importance of the Research Achievements

微小領域の流れとして,層流,電気浸透流,非混和混相流がある.二相分離混合溶液を用いて,それらとは異なる流れ,相分離混相流が見出された.相分離混相流には,さまざまな動的液-液界面が観察されるが,環状流は,相分離混相流によって初めて微小領域内に創出されており,興味深い流れである.その創出メカニズムを学術的視点から掘り下げた.さらにTRDFを利用して,クロマトグラフィー,抽出,混合,化学反応に関わる技術開発を行い,技術的体系化を試みた.今後,学術面および技術面において,幅広い研究・開発が行われることが期待される.

Report

(5 results)
  • 2022 Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (12 results)

All 2022 2019 2018 2017

All Journal Article (12 results) (of which Peer Reviewed: 11 results,  Open Access: 3 results)

  • [Journal Article] Discovery of Phase-separated Multiphase Flows and Attempts at Academic and Technical Systematization2022

    • Author(s)
      Kazuhiko Tsukagoshi
    • Journal Title

      BUNSEKI KAGAKU

      Volume: 71 Issue: 1.2 Pages: 25-39

    • DOI

      10.2116/bunsekikagaku.71.25

    • ISSN
      0525-1931
    • Year and Date
      2022-01-05
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Microfluidic Behavior of Ternary Mixed Solutions of Water/Acetonitrile/Ethyl Acetate through Experiments and Computer Simulations2022

    • Author(s)
      Keigo Yonekura, Kazushi Nishimura, Katsumi Tsuchiya, Kenichi Yamashita, Masaharu Murata, and Kazuhiko Tsukagoshi
    • Journal Title

      Analytical Sciences

      Volume: 38 Issue: 4 Pages: 731-736

    • DOI

      10.1007/s44211-022-00083-w

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of Tube Radial Distribution Chromatography Based on Phase-Separation Multiphase Flow Created via Pressure Loss2019

    • Author(s)
      Susumu Wada, Kazuhiko Tsukagoshi, Katsumi Tsuchiya, Ken Hirota, Kenichi Yamashita, and Masaharu Murata
    • Journal Title

      Analytical Sciences

      Volume: 35 Pages: 803-806

    • NAID

      130007676946

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mixing Process of Ternary Mixed Solvent Solutions in a Tapered-Microchannel and Application to Analysis method of Mixing Characteristics in Microfluidic Channel2019

    • Author(s)
      Ryuki Mori, Yuko Nakata, Kazuhiko Tsukagoshi, Katsumi Tsuchiya, Ken Hirota, Kenichi Yamashita, and Masaharu Murata
    • Journal Title

      Journal of Flow Injection Analysis

      Volume: 36 Pages: 19-25

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Confirmation of Separation Mechanism Through Visualization of Microfluidic Behavior of Fluorescent Analytes in Tube Radial Distribution Chromatography2019

    • Author(s)
      Yoshuke Takatsuki, Katsumi Tsuchiya, Kenichi Yamashita, and Masaharu Murata
    • Journal Title

      Chromatography

      Volume: 40 Pages: 163-168

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phase separation and collection of annular flow by phase transformation2019

    • Author(s)
      Aya Yoshioka, Kazuhiko Tsukagoshi, Katsumi Tsuchiya, Ken Hirota, Kenichi Yamashita, and Masaharu Murata
    • Journal Title

      Analytical Sciences

      Volume: 35 Pages: 1279-1282

    • NAID

      130007743080

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Microfluidic Inverted Flow of Ternary Water/Hydrophilic/Hydrophobic Organic Solvent Solution in a Y-Type Microchannel and a Proposal of the Response Microfluidic Analysis through the Experiment2019

    • Author(s)
      Bun Yamawaki, Ryuki Mori, Kazuhiko Tsukagoshi, Katsumi Tsuchiya, Kenichi Yamashita, and Masaharu Murata
    • Journal Title

      Analytical Sciences

      Volume: 35 Pages: 249-256

    • NAID

      130007609470

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phase Separation Multi-Phase Flow Using an Aqueous Two-Phase System of a Polyethylene Glycol/Dextran Mixed Solution2018

    • Author(s)
      Naoya Imanishi, Tetsuo Yamashita, Kazuhiko Tsukagoshi, and Masaharu Murata
    • Journal Title

      Analytical Sciences

      Volume: 34 Pages: 953-958

    • NAID

      130007432308

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tube Radial Distribution Chromatography System Developed by Combining Commercially Available HPLC System and Open-Tubular Capillary Tube as Separation Column2018

    • Author(s)
      Kento Yamada, Hyo Kan, and Kazuhiko Tsukagoshi
    • Journal Title

      Talanta

      Volume: 183 Pages: 89-93

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Implementation of Tube Radial Distribution Chromatography by Using a Commercially Available HPLC System2018

    • Author(s)
      Hyo Kan, Kento Yamada, Nobuyuki Sanada, Koyo Nakata, and Kazuhiko Tsukagoshi
    • Journal Title

      Analytical Sciences

      Volume: 34 Pages: 239-241

    • NAID

      130006342046

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Microfluidic Analytical System with On-Line Luminol Chemiluminescence Detection Based on Annular Flow of Phase Separation Multiphase Flow2017

    • Author(s)
      Manai Junki、Nishiyama Kei、Tsukagoshi Kazuhiko
    • Journal Title

      Journal of Analytical Sciences, Methods and Instrumentation

      Volume: 07 Issue: 02 Pages: 29-39

    • DOI

      10.4236/jasmi.2017.72003

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Denaturation of DNA in ternary mixed solution of water/hydrophilic/hydrophobic organic solvent.2017

    • Author(s)
      Ito Y. Tsukagoshi K, Kobayashi A.
    • Journal Title

      J Anal Sci, Method Instrum.

      Volume: 7 Issue: 02 Pages: 40-46

    • DOI

      10.4236/jasmi.2017.72004

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access

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Published: 2017-04-28   Modified: 2024-01-30  

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