Study on the chemistry of water pollution by aryl halides originated from personal care products and their risk reduction

• Project/Area Number: 17H03094
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Green/Environmental chemistry
• Research Institution: Iwate University
• Principal Investigator: Terasaki Masanori 岩手大学, 人文社会科学部, 教授 (10363904)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000); Fiscal Year 2019: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2018: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2017: ¥13,520,000 (Direct Cost: ¥10,400,000、Indirect Cost: ¥3,120,000)
• Keywords: 防腐剤 / 水質汚染 / 生態毒性 / 受容体結合活性 / ハロゲン化副生成物 / AhR活性 / EROD活性 / 薬物代謝 / 活性寄与率 / リスク因子 / 臭素化パラベン / 生態リスク評価 / 固相抽出 / LC-MS / 環境分析 / 有害化学物質 / 芳香族化合物 / 生物蓄積 / 臭素化副生成物 / エストロジェン活性 / 急性遊泳阻害試験

Outline of Final Research Achievements

Parabens are used as preservatives in pharmaceuticals and personal care products. Parabens react with aqueous chlorine, which is used in disinfection processes, leading to the formation of halogenated parabens. This study investigated measuring brominated paraben concentrations in the river and whether brominated parabens have a hazard in the aquatic environment.
The concentration and toxicities (acute toxicities of an aquatic organism and AhR activity) of parabens increased with the length of the hydrocarbonated chain
and the number of bromine substituents. These compounds had the highest contributions to the observed toxicities in water samples.

Academic Significance and Societal Importance of the Research Achievements

日常的に使われている防腐剤が消毒工程で水に含まれる微量の臭素と反応して臭素化体となり、水環境を汚染していることを世界で初めて明らかにした。特に分子量の大きい防腐剤は臭素化されると、汚染濃度や毒性が相乗的に高くなり、水生生物に対して高リスクであることが判明した。これら高リスクの物質について重点的に環境モニタリングをする必要性を示した。

Research Products

• [Journal Article] Occurrence and AhR activity of brominated parabens in the Kitakami River, North Japan (2020)
  • Author(s): Gouukon Yoshikazu、Yasuda Michiko T.、Yasukawa Hiro、Terasaki Masanori
  • Journal Title: Chemosphere Volume: 249 Pages: 126152-126152
  • DOI: 10.1016/j.chemosphere.2020.126152
  • Peer Reviewed
• [Journal Article] Estrogen agonistic/antagonistic activity of brominated parabens (2018)
  • Author(s): Sasaki Kohei、Terasaki Masanori
  • Journal Title: Environmental Science and Pollution Research Volume: 25 Issue: 21 Pages: 21257-21266
  • DOI: 10.1007/s11356-018-2600-3
  • Peer Reviewed
• [Presentation] AhR activity of brominated disinfection by-products of parabens in the river water (2019)
  • Author(s): Gouukon Yoshikazu and Terasaki Masanori
  • Organizer: SETAC North America 40th Annual Meeting
  • Int'l Joint Research
• [Presentation] 河川水中の臭素化パラベンとAhR活性:北上川における事例 (2019)
  • Author(s): 郷右近 嘉一、寺崎 正紀
  • Organizer: 第28回環境化学討論会
• [Presentation] Effect of bromination on the estrogen agonistic/antagonistic activity of parabens (2017)
  • Author(s): Kohei Sasaki and Masanori Terasaki
  • Organizer: Society of Environmental Toxicology and Chemistry (SETAC) North America 38th Annual Meeting
  • Int'l Joint Research