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Demonstration of integrated microfluidic system that realizes selection / placement / 3-dimensional complex of cells

Research Project

Project/Area Number 17H03463
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Biofunction/Bioprocess
Research InstitutionChiba University

Principal Investigator

Seki Minoru  千葉大学, 大学院工学研究院, 教授 (80206622)

Co-Investigator(Kenkyū-buntansha) 山田 真澄  千葉大学, 大学院工学研究院, 准教授 (30546784)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2019: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2018: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2017: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Keywordsマイクロ・ナノデバイス / 細胞選抜 / 3次元組織 / 細胞外マトリックス / 細胞アッセイ / マイクロナノデバイス
Outline of Final Research Achievements

In constructing a three-dimensional tissue model by assembling individual cells, the technology of selecting the required cells, accurately arranging multiple types of cells, and fixing them in a three-dimensional space is essential.
In this study, we developed a microfluidic device that automatically and efficiently achieves these individual operations, demonstrated its usefulness, and developed a connected system that integrates them. Then, we actually demonstrated the production of composite liver tissues and multi-layered blood vessel models.

Academic Significance and Societal Importance of the Research Achievements

通常の手作業の実験系では不可能な,精密な細胞操作を可能とする新規システムの開発を行うことができた。特に細胞の選抜においては,高効率な新規マイクロ流体デバイスを提案でき,また細胞の配置と組織化については,細胞親和性のあるハイドロゲル材料に細胞を生きたまま導入し,その機能を向上できることが確認された。これらの手法は,再生医療や創薬のみならず,診断医療や基礎生物学にも役立つ基盤技術になりえるものである。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (65 results)

All 2019 2018 2017

All Journal Article (17 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 17 results,  Open Access: 1 results) Presentation (47 results) (of which Int'l Joint Research: 15 results,  Invited: 1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Laborless, Automated Microfluidic Tandem Cell Processor for Visualizing Intracellular Molecules of Mammalian Cells2019

    • Author(s)
      Mu Tinglin、Toyoda Hajime、Kimura Yuki、Yamada Masumi、Utoh Rie、Umeno Daisuke、Seki Minoru
    • Journal Title

      Analytical Chemistry

      Volume: 92 Issue: 3 Pages: 2580-2588

    • DOI

      10.1021/acs.analchem.9b04288

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced Immunoadsorption on Imprinted Polymeric Microstructures with Nanoengineered Surface Topography for Lateral Flow Immunoassay Systems2019

    • Author(s)
      Aoyama Shuhei、Monden Kenji、Akiyama Yuto、Yamada Masumi、Seki Minoru
    • Journal Title

      Analytical Chemistry

      Volume: 91 Issue: 21 Pages: 13377-13382

    • DOI

      10.1021/acs.analchem.9b03454

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hydrodynamic Microparticle Separation Mechanism Using Three-Dimensional Flow Profiles in Dual-Depth and Asymmetric Lattice-Shaped Microchannel Networks2019

    • Author(s)
      Yanai Takuma、Ouchi Takatomo、Yamada Masumi、Seki Minoru
    • Journal Title

      Micromachines

      Volume: 10 Issue: 6 Pages: 425-425

    • DOI

      10.3390/mi10060425

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] One-step Formation of Microporous Hydrogel Sponges Encapsulating Living Cells by Utilizing Bicontinuous Dispersion of Aqueous Polymer Solutions2019

    • Author(s)
      Aruto Hori, Yuki Watabe, Masumi Yamada, Yuya Yajima, Rie Utoh, and Minoru Seki
    • Journal Title

      ACS Applied Bio Materials

      Volume: 2 Issue: 5 Pages: 2237-2245

    • DOI

      10.1021/acsabm.9b00194

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Composite PDMS-based in situ Patterning of Collagen Microgels for Perfusion Cell Culture Microsystems2019

    • Author(s)
      Misaki Kato, Mayu Fukushi, Masumi Yamada, Rie Utoh, and Minoru Seki
    • Journal Title

      Proceedings of the 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2019)

      Volume: 1 Pages: 282-283

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vertical Slit-fractionation: High-throughput Particle/cell Separation2019

    • Author(s)
      Naotaka Jin, Jumpei Yamamoto, Masumi Yamada, Kazuki Iijima, Koji Katayama, and Minoru Seki
    • Journal Title

      Proceedings of the 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2019)

      Volume: 1 Pages: 606-607

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Numbering-up Strategy of Hydrodynamic Microfluidic Filters for Continuous-flow High-throughput Cell Sorting2019

    • Author(s)
      Ryoken Ozawa, Hideki Iwadate, Hajime Toyoda, Masumi Yamada*, and Minoru Seki
    • Journal Title

      Lab on a Chip

      Volume: 19 Issue: 10 Pages: 1828-1837

    • DOI

      10.1039/c9lc00053d

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Formation of Pressurizable Hydrogel-based Vascular Tissue Models by Selective Gelation in Composite PDMS Channels2019

    • Author(s)
      Mayu Fukushi, Keita Kinoshita, Masumi Yamada, Yuya Yajima, Rie Utoh, and Minoru Seki
    • Journal Title

      RSC Advances

      Volume: 9 Issue: 16 Pages: 9136-9144

    • DOI

      10.1039/c9ra00257j

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] PDMS Microstencil Plate-supported Fabrication of Ultra-thin, Condensed ECM Membranes for Separated Cell Coculture on Both Surfaces2019

    • Author(s)
      Hideki Iwadate, Masumi Yamada, Naoki Kimura, Rina Hashimoto, Yuya Yajima, Rie Utoh, and Minoru Seki
    • Journal Title

      Sensors and Actuators B: Chemical

      Volume: 287 Pages: 486-495

    • DOI

      10.1016/j.snb.2019.02.067

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Thermally Imprinted Microcone Structure-assisted Lateral-flow Immunoassay Platforms for Detecting Disease Marker Proteins2019

    • Author(s)
      Shuhei Aoyama, Yuto Akiyama, Kenji Monden, Masumi Yamada, and Minoru Seki*
    • Journal Title

      Analyst

      Volume: 144(5) Issue: 5 Pages: 1519-1526

    • DOI

      10.1039/c8an01903g

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Wrapping of Linear Cell Assemblies with Tubular Collagen Membranes Using Multilayered Microfluidic Devices2018

    • Author(s)
      Kotone Saeki, Masumi Yamada, Sakiko Enomoto, Yuya Yajima, Rie Utoh, and Minoru Seki
    • Journal Title

      Proc. MicroTAS 2018

      Volume: 1 Pages: 1442-1444

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Planar Slit Channel System for Label-free, Deformability-based selective capture of Circulating Tumor Cells2018

    • Author(s)
      Makoto Furuhata, Masumi Yamada, and Minoru Seki
    • Journal Title

      Proc. MicroTAS 2018

      Volume: 1 Pages: 1254-1256

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Micropassage-embedding Composite Hydrogel Fibers Enable Quantitative Evaluation of Cancer Cell Invasion under 3D Coculture Conditions2018

    • Author(s)
      Sugimoto M, Kitagawa Y, Yamada M, Yajima Y, Utoh R, Seki M
    • Journal Title

      Lab Chip

      Volume: 印刷中 Issue: 9 Pages: 1378-1387

    • DOI

      10.1039/c7lc01280b

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of a Perfusable 3D Liver Cell Cultivation System via Bundling-up Assembly of Cell-laden Microfibers2018

    • Author(s)
      Yuya Yajima, Chu Ning Lee, Masumi Yamada, Rie Utoh, and Minoru Seki
    • Journal Title

      Journal of Bioscience and Bioengineering

      Volume: in press Issue: 1 Pages: 111-118

    • DOI

      10.1016/j.jbiosc.2018.01.022

    • NAID

      210000005735

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Multiphase Microfluidic Processes to Produce Alginate-Based Microparticles and Fibers2018

    • Author(s)
      Masumi Yamada and Minoru Seki
    • Journal Title

      JOURNAL OF CHEMICAL ENGINEERING OF JAPAN

      Volume: 51 Issue: 4 Pages: 318-330

    • DOI

      10.1252/jcej.17we328

    • NAID

      130006712134

    • ISSN
      0021-9592, 1881-1299
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Collagen Microparticle-Mediated 3D Cell Organization: A Facile Route to Bottom-up Engineering of Thick and Porous Tissues2017

    • Author(s)
      Yajima Y, Yamada M, Utoh R, and Seki M
    • Journal Title

      ACS Biomater Sci Eng

      Volume: 3(9) Issue: 9 Pages: 2144-2154

    • DOI

      10.1021/acsbiomaterials.7b00131

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Collagen gelation on phosphate particle-embedding PDMS (PP-PDMS) channel: An efficient approach to vascular tissue engineering2017

    • Author(s)
      Mayu Fukushi, Yuya Yajima, Rie Utoh, Masumi Yamada, Kazuya Furusawa, and Minoru Seki
    • Journal Title

      Proc. MicroTAS 2017

      Volume: 1 Pages: 1145-1146

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Presentation] Polyion-Induced Production of Fragmented Collagen Microfibers for 3D Cell Cultivation2019

    • Author(s)
      Keigo Yamanaka, Sakiko Enomoto, Akihiro Morita, Aruto Hori, Rie Utoh, Masumi Yamada, and Minoru Sek
    • Organizer
      2nd G'L'owing Polymer Symposium in KANTO (GPS-K 2019), Tokyo University of Science Katushika Campus, Tokyo, Japan
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effects of Collagen Microparticles on Formation of Three Dimensional Composite Tissue Models of Primary Hepatocytes2019

    • Author(s)
      Akihiro Morita, Rie Utoh, Masumi Yamada, and Minoru Seki
    • Organizer
      The 30th 2019 International Symposium on Micro-NanoMechatronics and Human Science (MHS 2019), Nagoya, Japan
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Vertical Slit-fractionation: High-throughput Particle/cell Separation2019

    • Author(s)
      Naotaka Jin, Jumpei Yamamoto, Masumi Yamada, Kazuki Iijima, Koji Katayama and Minoru Seki
    • Organizer
      The 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2019), Congress Center Basel, Basel, Switzerland
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Composite PDMS-based in situ Patterning of Collagen Microgels for Perfusion Cell Culture Microsystems2019

    • Author(s)
      Misaki Kato, Mayu Fukushi, Masumi Yamada, Rie Utoh, and Minoru Seki
    • Organizer
      The 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2019), Congress Center Basel, Basel, Switzerland
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Microengineering of Collagen Hydrogels Integrated into Microfluidic Devices for Perfusion Culture of Mammalian Cells2019

    • Author(s)
      Misaki Kato, Mayu Fukushi, Masumi Yamada, Rie Utoh, and Minoru Seki
    • Organizer
      18th Asian Pacific Confederation of Chemical Engineering congress(APCChE2019), Sapporo Convention Center, Sapporo, Japa
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of Highly Efficient Cell Staining System via Multistep Carrier-Medium Exchange2019

    • Author(s)
      Tinglin Mu, Hajime Toyoda, Masumi Yamada, Rie Utoh, Minoru Seki
    • Organizer
      The 14th Asian Congress on Biotechnology (ACB2019), Tamsui Township near Taipei city, Taiwan
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ゲル化剤含有マイクロピラー構造を用いた細胞包埋コラーゲンゲルの微細加工2019

    • Author(s)
      加藤美咲,堀 有音,山田真澄,鵜頭理恵,関 実
    • Organizer
      化学とマイクロ・ナノシステム学会第40回研究会,アクトシティ浜松
    • Related Report
      2019 Annual Research Report
  • [Presentation] マイクロノズル統合型流体デバイスを用いた細胞導入コラーゲンチューブの作製2019

    • Author(s)
      佐伯琴音,榎本紗希子,矢嶋祐也,鵜頭理恵,山田真澄,関 実
    • Organizer
      第36回「センサ・マイクロマシンと応用システム」シンポジウム,アクトシティ浜松
    • Related Report
      2019 Annual Research Report
  • [Presentation] コラーゲンチューブ培養法による肝細胞微小線形オルガノイドの作製2019

    • Author(s)
      佐伯琴音,榎本紗希子,矢嶋祐也,鵜頭理恵,山田真澄,関 実
    • Organizer
      第71回日本生物工学会大会,岡山大学津島キャンパス
    • Related Report
      2019 Annual Research Report
  • [Presentation] 断片化コラーゲンマイクロファイバーを用いる3次元細胞培養系の開発2019

    • Author(s)
      山中啓吾,森田明寛,山田真澄,鵜頭理恵,関 実
    • Organizer
      日本生物工学会 2019年度生物工学若手研究者の集い(若手会)夏のセミナー,琵琶湖白浜荘
    • Related Report
      2019 Annual Research Report
  • [Presentation] 簡便なスケールアップを可能にするマイクロ流体スリット構造を用いた粒子分離2019

    • Author(s)
      神 尚孝,山本純平,山田真澄,飯島和樹,片山晃治,関 実
    • Organizer
      化学工学会横浜大会,横浜国立大学
    • Related Report
      2019 Annual Research Report
  • [Presentation] コラーゲン微粒子複合化による初代肝細胞のシート状3次元培養系2019

    • Author(s)
      森田明寛,鵜頭理恵,矢嶋祐也,山田真澄,関 実
    • Organizer
      第26回HAB研究機構学術年会,昭和大学 上條記念館
    • Related Report
      2019 Annual Research Report
  • [Presentation] 断片化コラーゲンマイクロファイバーの高効率作製法の開発とその応用2019

    • Author(s)
      山中 啓吾,森田 明寛,山田 真澄,鵜頭 理恵,関 実
    • Organizer
      化学とマイクロ・ナノシステム学会第39回研究会,金沢大学宝町・鶴間キャンパス
    • Related Report
      2019 Annual Research Report
  • [Presentation] 多段階溶液交換プロセッサーを利用した細胞内サイトカインの可視化2019

    • Author(s)
      穆 廷林,豊田 一,山田 真澄,鵜頭 理恵,関 実
    • Organizer
      化学工学会 第84年会,芝浦工業大学 豊洲キャンパス,2019年3月13~15日
    • Related Report
      2018 Annual Research Report
  • [Presentation] 断片化マイクロコラーゲンファイバーを導入した肝細胞スフェロイド培養の肝機能への効果2019

    • Author(s)
      鵜頭理恵,榎本紗希子,山中啓吾,山田真澄,関 実
    • Organizer
      化学工学会 第84年会,芝浦工業大学 豊洲キャンパス,2019年3月13~15日
    • Related Report
      2018 Annual Research Report
  • [Presentation] Microfabrication of Ultra-thin ECM Films for Controlled Cell Coculture Systems2019

    • Author(s)
      Hideki Iwadate, Masumi Yamada, Rie Utoh, and Minoru Seki
    • Organizer
      化学工学会 第84年会,芝浦工業大学 豊洲キャンパス,2019年3月13~15日
    • Related Report
      2018 Annual Research Report
  • [Presentation] 肝スフェロイド培養における断片化コラーゲンマイクロファイバー内包の効果2019

    • Author(s)
      鵜頭理恵,榎本紗希子,山中啓吾,山田真澄,関 実
    • Organizer
      シンポジウム:細胞アッセイ技術の現状と将来,産業技術総合研究所つくばセンター 共用講堂,2019年1月30日
    • Related Report
      2018 Annual Research Report
  • [Presentation] マイクロステンシルプレート内濃縮によるECM薄膜の作製と肝臓細胞培養への応用2019

    • Author(s)
      岩舘秀樹,木村尚貴,橋本里奈,矢嶋祐也,山田真澄,鵜頭理恵,関 実
    • Organizer
      シンポジウム:細胞アッセイ技術の現状と将来,産業技術総合研究所つくばセンター 共用講堂,2019年1月30日
    • Related Report
      2018 Annual Research Report
  • [Presentation] Separated Co-culture of Heterotypic Cells Using Microfabricated Thin ECM Membranes2018

    • Author(s)
      Hideki Iwadate, Naoki Kimura, Rina Hashimoto, Yuya Yajima, Rie Utoh, Masumi Yamada, and Minoru Seki
    • Organizer
      29th 2018 International Symposium on Micro-NanoMechatronics and Human Science (MHS 2018), Nagoya University, Japan, Dec. 9-12, 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Planar Slit Channel System for Label-free, Deformability-based selective capture of Circulating Tumor Cells2018

    • Author(s)
      Makoto Furuhata, Masumi Yamada, and Minoru Seki
    • Organizer
      The 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2018), Kaohsiung Exhibition Center, Kaohsiung, Taiwan, Nov. 11-15, 2018.
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Wrapping of Linear Cell Assemblies with Tubular Collagen Membranes Using Multilayered Microfluidic Devices2018

    • Author(s)
      Kotone Saeki, Masumi Yamada, Sakiko Enomoto, Yuya Yajima, Rie Utoh, and Minoru Seki
    • Organizer
      The 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2018), Kaohsiung Exhibition Center, Kaohsiung, Taiwan, Nov. 11-15, 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] タンデム型溶液交換プロセッサーを用いた希少細胞の高効率染色2018

    • Author(s)
      穆 廷林,豊田 一,山田真澄,鵜頭理恵,関 実
    • Organizer
      化学とマイクロ・ナノシステム学会 第38回研究会 札幌市民交流プラザ 2018年10月30日-11月1日
    • Related Report
      2018 Annual Research Report
  • [Presentation] 3次元微粒子培養系によるシート状肝組織のワンステップ作製2018

    • Author(s)
      森田明寛,矢嶋祐也,山田真澄,鵜頭理恵,関 実
    • Organizer
      化学とマイクロ・ナノシステム学会 第38回研究会 札幌市民交流プラザ 2018年10月30日-11月1日
    • Related Report
      2018 Annual Research Report
  • [Presentation] 血中がん細胞の捕捉と純化のためのマイクロ流体デバイスの開発2018

    • Author(s)
      古畑 誠,山田真澄,関 実
    • Organizer
      化学工学会 第50回秋季大会 鹿児島大学 郡元キャンパス 2018年9月18~20日
    • Related Report
      2018 Annual Research Report
  • [Presentation] 細胞を内腔に導入可能なコラーゲンチューブのワンステップ作製2018

    • Author(s)
      佐伯琴音, 榎本紗希子, 矢嶋祐也, 鵜頭理恵, 山田真澄, 関 実
    • Organizer
      化学工学会 第50回秋季大会 鹿児島大学 郡元キャンパス 2018年9月18~20日
    • Related Report
      2018 Annual Research Report
  • [Presentation] 希少細胞の連続的化学処理を可能とする多段階溶液交換プロセッサーの開発2018

    • Author(s)
      穆 廷林,豊田 一,山田 真澄,関 実
    • Organizer
      第70回日本生物工学会大会 関西大学 千里山キャンパス 2018年9月5~7日
    • Related Report
      2018 Annual Research Report
  • [Presentation] 流路内壁相転移法による血管模倣ハイドロゲルチューブの作製2018

    • Author(s)
      福士万由,矢嶋祐也,古澤和也,鵜頭理恵,山田真澄,関 実
    • Organizer
      日本混相流学会 混相流シンポジウム2018,東北大学青葉山東キャンパス,2018年8月8日~10日
    • Related Report
      2018 Annual Research Report
  • [Presentation] マイクロ流体デバイスを用いた細胞の配列化およびカプセル化技術の開発2018

    • Author(s)
      佐伯琴音,榎本紗希子,矢嶋祐也,鵜頭理恵,山田真澄,関 実
    • Organizer
      2018年度 生物工学若手研究者の集い(若手会)夏のセミナー,北見工業大学,2018年6月30日~7月1日
    • Related Report
      2018 Annual Research Report
  • [Presentation] ECM薄膜を組み込んだ細胞培養用マイクロ灌流デバイスの開発2018

    • Author(s)
      岩舘秀樹,木村尚貴,橋本里奈,矢嶋祐也,山田真澄,鵜頭理恵,関 実
    • Organizer
      2018年度 生物工学若手研究者の集い(若手会)夏のセミナー,北見工業大学,2018年6月30日~7月1日
    • Related Report
      2018 Annual Research Report
  • [Presentation] 多層マイクロ流体デバイスを用いた細胞導入コラーゲンチューブの作製2018

    • Author(s)
      佐伯琴音,榎本紗希子,矢嶋祐也,鵜頭理恵,山田真澄,関 実
    • Organizer
      化学とマイクロ・ナノシステム学会第37回研究会 産業技術総合研究所 つくばセンター 2018年5月21日-22日
    • Related Report
      2018 Annual Research Report
  • [Presentation] ECM薄膜を統合した細胞培養用マイクロ流体デバイス2018

    • Author(s)
      岩舘秀樹,木村尚貴,橋本里奈,矢嶋祐也,山田真澄,鵜頭理恵,関 実
    • Organizer
      第25回 HAB研究機構学術年会,産業総合技術研究所つくばセンター 共用講堂,2018年5月24~26日
    • Related Report
      2018 Annual Research Report
  • [Presentation] マトリックス内に生細胞を包埋可能なポンジ状ハイドロゲル培養系の開発2018

    • Author(s)
      堀 有音,渡部有紀,矢嶋祐也,山田真澄,鵜頭理恵,関 実
    • Organizer
      シンポジウム:細胞アッセイ技術の現状と将来 アステラス製薬株式会社つくば研究センター 2018年1月19日
    • Related Report
      2017 Annual Research Report
  • [Presentation] 共連続水性2相分散系を利用した細胞包埋スポンジ状ハイドロゲルの作製2018

    • Author(s)
      堀 有音 ,渡部有紀,矢嶋祐也,山田真澄,鵜頭理恵,関 実
    • Organizer
      化学工学会 第83年会 関西大学 千里山キャンパス 2018年3月13~15日
    • Related Report
      2017 Annual Research Report
  • [Presentation] 流路内コラーゲンゲル堆積法によるチューブ状生体組織の作製2018

    • Author(s)
      福士万由,矢嶋祐也,古澤和也,鵜頭理恵,山田真澄,関 実
    • Organizer
      化学工学会 第83年会 関西大学 千里山キャンパス 2018年3月13~15日
    • Related Report
      2017 Annual Research Report
  • [Presentation] Microfluidic device for multistep particle processing based on hydrodynamic carrier-fluid exchange2017

    • Author(s)
      Hajime Toyoda, Masumi Yamada, and Minoru Seki
    • Organizer
      Third International Symposium on Multiscale Multiphase Process Engineering (MMPE2017), Toyama International Conference Center, Japan, May. 8-11, 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Invasion Assay of Cancer Cells Using Hierarchically-patterned Hydrogel Sheets2017

    • Author(s)
      Manami Sugimoto, Yoichi Kitagawa, Yuya Yajima, Rie Utoh, Masumi Yamada, and Minoru Seki
    • Organizer
      RSC Tokyo International Conference 2017 - Analytical Technology Towards Future Society - (JASIS 2017), Makuhari Messe, Chiba, Japan, Sep. 7-8, 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Deformability-based Capturing of Circulating Tumor Cells in Planar Microfluidic Channels2017

    • Author(s)
      Yamada Masumi, Makoto Furuhata, and Minoru Seki
    • Organizer
      The 23st Symposium of Young Asian Biochemical Engineers’ Community (YABEC 2017), Jin Jiang International Hotel Xi’an, China, Oct. 18-20, 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Collagen Gelation on Phosphate Particle-embedding PDMS (PP-PDMS) Channel: An Efficient Approach to Vascular Tissue Engineering2017

    • Author(s)
      Mayu Fukushi, Yuya Yajima, Rie Utoh, Masumi Yamada, Kazuya Furusawa and Minoru Seki
    • Organizer
      The 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2017), Savannah International Trade & Convention Center, Savannah, GA, USA, Oct. 22-26, 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Control of Invasion Direction of Cancer Cells Using Hierarchically Patterned Hydrogel Sheets2017

    • Author(s)
      Manami Sugimoto, Yoichi Kitagawa, Yuya Yajima, Rie Utoh, Masumi Yamada, and Minoru Seki
    • Organizer
      28th 2017 International Symposium on Micro-NanoMechatronics and Human Science (MHS 2017), Nagoya University, Japan, Dec. 3-6, 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Highly Efficient Multistep Microfluidic Cell Processor for Rare Cell Analysis2017

    • Author(s)
      Hajime Toyoda, Masumi Yamada, and Minoru Seki
    • Organizer
      Lab-on-a-Chip & Microfluidics, Point-of-Care Diagnostics & Global Health Asia 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] リン酸塩‐PDMS流路を用いたコラーゲンチューブの形成とその応用2017

    • Author(s)
      福士万由,矢嶋祐也,古澤和也,鵜頭理恵,山田真澄,関 実
    • Organizer
      化学とマイクロ・ナノシステム学会第35回研究会 東京工業大学 大岡山キャンパス 2017年5月22~23日
    • Related Report
      2017 Annual Research Report
  • [Presentation] 流路内堆積法によるコラーゲンベース血管組織の作製2017

    • Author(s)
      福士万由,矢嶋祐也,古澤和也,鵜頭理恵,山田真澄,関 実
    • Organizer
      生物工学若手研究者の集い 夏のセミナー2017 ツネイシしまなみビレッジ 2017年7月22~23日
    • Related Report
      2017 Annual Research Report
  • [Presentation] 磁気泳動とマイクロ流路層流系を利用した細胞の分離・選抜2017

    • Author(s)
      山田真澄,関 実
    • Organizer
      日本磁気学会 第214回研究会/第42回強磁場応用専門研究会 中央大学駿河台記念館330号室 2017年8月3日
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] コラーゲンチューブの流路内形成による血管様組織の作製2017

    • Author(s)
      福士万由,矢嶋祐也,古澤和也,鵜頭理恵,山田真澄,関 実
    • Organizer
      化学工学会東京大会 早稲田大学西早稲田キャンパス 2017年8月9~10日
    • Related Report
      2017 Annual Research Report
  • [Presentation] 薄層平板型マイクロ流路における血中循環がん細胞の捕捉挙動の観察2017

    • Author(s)
      古畑誠,山田真澄,関 実
    • Organizer
      日本混相流学会 混相流シンポジウム2017 電気通信大学 2017年8月19日~21日
    • Related Report
      2017 Annual Research Report
  • [Presentation] 格子状微小流路を利用する微粒子・細胞の分離選抜システム2017

    • Author(s)
      山田真澄,関 実
    • Organizer
      日本分析化学会第66年会 東京理科大学葛飾キャンパス 2017年9月9~12日
    • Related Report
      2017 Annual Research Report
  • [Presentation] 平板型マイクロ流路を用いた血中循環がん細胞の捕捉挙動の解析2017

    • Author(s)
      古畑誠,山田真澄,関 実
    • Organizer
      化学とマイクロ・ナノシステム学会第36回研究会 桐生市市民文化会館 スカイホール 2017年10月4~5日
    • Related Report
      2017 Annual Research Report
  • [Patent(Industrial Property Rights)] コラーゲンチューブの作製方法2018

    • Inventor(s)
      山田,関,佐伯,鵜頭,榎本,矢嶋
    • Industrial Property Rights Holder
      千葉大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2018-093710
    • Filing Date
      2018
    • Related Report
      2018 Annual Research Report

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Published: 2017-04-28   Modified: 2021-02-19  

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