Dynamic regulation of cortico-striatal transmission in non-human primates

• Project/Area Number: 17H03539
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurophysiology / General neuroscience
• Research Institution: Hokkaido University
• Principal Investigator: TANAKA MASAKI 北海道大学, 医学研究院, 教授 (90301887)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000); Fiscal Year 2019: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000); Fiscal Year 2018: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000); Fiscal Year 2017: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 線条体 / 大脳基底核 / LFP / 機能結合 / ベータ波 / 眼球運動 / 霊長類 / 大脳基底核ループ / 計時 / ゲイン調節 / 脳波律動 / 皮質線条体路 / 誘発応答 / 皮質線条体経路 / 状況依存性 / 誘発LFP / 時間生成 / 局所場電位 / 刺激誘発応答 / ドパミン / サル

Outline of Final Research Achievements

The basal ganglia are essential for adjusting the size and speed of movements along with selecting actions for given situations. During preparation of self-timed eye movements, we found that the time course of neuronal activity in the striatum differed from that in the cerebellar nucleus; the former was scaled by the length of time to be measured, while the latter correlated with trial-by-trial latency variation. We also found that the low-frequency components of local field potentials and visual evoked responses recorded from the striatum dynamically changed according to the length of time to be measured. On the other hand, the striatal evoked response to electrical stimulation of the cortex was too small to investigate the effects of behavioral conditions, so future studies should consider the use of optogenetic manipulation.

Academic Significance and Societal Importance of the Research Achievements

本研究により、計時における線条体と小脳の違いが明らかとなるとともに、線条体における状況依存的な情報生成メカニズムの一端が示された。パーキンソン病では運動の開始が困難になるだけでなく、状況に応じて行動選択をし、運動の速度や大きさを調節し、また、時間を計ることが難しくなる。同疾患では大脳基底核ループにおける低周波数律動が著明に亢進していることが知られており、本研究で示唆された低周波数律動のフレキシブルな変化によって大脳-線条体経路の機能結合が動的に調整される機構が障害されている可能性がある。このように、本研究は大脳基底核の情報処理を明らかにし、疾患時の病態生理の理解を進めることに寄与する。

Research Products

• [Int'l Joint Research] タフツ大学(米国)
• [Int'l Joint Research] タフツ大学/ベイラー医科大学/米国立衛生研究所（NIH）(米国)
• [Journal Article] Spatial and temporal adaptation of predictive saccades based on motion inference (2020)
  • Author(s): Itoh Takeshi D.、Takeya Ryuji、Tanaka Masaki
  • Journal Title: Scientific Reports Volume: 10 Issue: 1 Pages: 5280-5280
  • DOI: 10.1038/s41598-020-62211-8
  • Peer Reviewed / Open Access
• [Journal Article] Neural oscillations in the primate caudate nucleus correlate with different preparatory states for temporal production (2019)
  • Author(s): Suzuki Tomoki W.、Tanaka Masaki
  • Journal Title: Communications Biology Volume: 2 Issue: 1 Pages: 102-102
  • DOI: 10.1038/s42003-019-0345-2
  • Peer Reviewed / Open Access
• [Journal Article] Entrained neuronal activity to periodic visual stimuli in the primate striatum compared with the cerebellum (2019)
  • Author(s): Kameda Masashi、Ohmae Shogo、Tanaka Masaki
  • Journal Title: eLife Volume: 8 Pages: 48702-48702
  • DOI: 10.7554/elife.48702
  • Peer Reviewed / Open Access
• [Journal Article] Consensus Paper: Experimental neurostimulation of the cerebellum (2019)
  • Author(s): Miterko LN, Baker KB, Beckinghausen J, Bradnam LV, Cheng MY, Cooperrider J, DeLong MR, Gornati SV, Hallett M, Heck DH, Hoebeek FE, Kouzani AZ, Kuo SH, Louis ED, Machado A, Manto M, McCambridge AB, Nitsche MA, Taib NOB, Popa T, Tanaka M, Timmann D, Steinberg GK, Wang EH, Wichmann T, Xie T, Sillitoe RV
  • Journal Title: Cerebellum Volume: 18 Issue: 6 Pages: 1064-1097
  • DOI: 10.1007/s12311-019-01041-5
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Different contributions of preparatory activity in the basal ganglia and cerebellum for self-timing (2018)
  • Author(s): Kunimatsu Jun、Suzuki Tomoki W、Ohmae Shogo、Tanaka Masaki
  • Journal Title: eLife Volume: 7
  • DOI: 10.7554/elife.35676
  • NAID: 120006522668
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Temporal Generalization of Synchronized Saccades Beyond the Trained Range in Monkeys (2018)
  • Author(s): Takeya Ryuji、Patel Aniruddh D、Tanaka Masaki
  • Journal Title: Frontiers in Psychology Volume: 9 Pages: 2172-2172
  • DOI: 10.3389/fpsyg.2018.02172
  • NAID: 120006545956
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] BAY：自発的運動タイミングへの大脳基底核と小脳の異なる関与 (2018)
  • Author(s): 國松 淳、田中真樹
  • Journal Title: 北海道医学雑誌 Volume: 93 Pages: 94-94
• [Journal Article] Causal Role of Noradrenaline in the Timing of Internally Generated Saccades in Monkeys (2017)
  • Author(s): Suzuki Tomoki W.、Tanaka Masaki
  • Journal Title: Neuroscience Volume: 366 Pages: 15-22
  • DOI: 10.1016/j.neuroscience.2017.10.003
  • NAID: 120006543294
  • Peer Reviewed
• [Journal Article] Predictive and tempo-flexible synchronization to a visual metronome in monkeys (2017)
  • Author(s): Takeya Ryuji、Kameda Masashi、Patel Aniruddh D.、Tanaka Masaki
  • Journal Title: Sci. Rep Volume: 7 Issue: 1 Pages: 6127-6127
  • DOI: 10.1038/s41598-017-06417-3
  • NAID: 120006352212
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 注意の脳内ネットワーク (2017)
  • Author(s): 竹谷隆司、田中真樹
  • Journal Title: Clinical Neuroscience Volume: 35 Pages: 938-940
• [Journal Article] 計時と予測の神経機構 (2017)
  • Author(s): 田中真樹、鈴木智貴、亀田将史、竹谷隆司
  • Journal Title: Brain and Nerve Volume: 69 Pages: 1213-1222
• [Presentation] Two distinct subcortical signals for self-timing (2019)
  • Author(s): 田中真樹
  • Organizer: Pre-NCM meeting on Eye and Head Movement Control System in Kyoto
  • Invited
• [Presentation] 計時と予測の神経機構 (2019)
  • Author(s): 田中真樹
  • Organizer: 東大機能生物学セミナー
  • Invited
• [Presentation] Subcortical signals for temporal prediction of periodic events (2019)
  • Author(s): 田中真樹
  • Organizer: 2019 Gordon Research Conference of Cerebellum
  • Int'l Joint Research / Invited
• [Presentation] 時間のタスクにおける基底核と小脳の違い (2019)
  • Author(s): 田中真樹
  • Organizer: 第34回日本大脳基底核研究会（JBAGS2019）シンポジウム
  • Invited
• [Presentation] Subcortical signals for temporal prediction of rhythmic events (2019)
  • Author(s): 田中真樹
  • Organizer: Timing Research Forum 2019 Meeting (TRF2)
  • Int'l Joint Research / Invited
• [Presentation] 時間予測と小脳、基底核 (2019)
  • Author(s): 田中真樹
  • Organizer: 第49回日本臨床神経生理学会
  • Invited
• [Presentation] Neurons in the primate deep cerebellar nuclei carry both temporal prediction and error signals during synchronized saccades (2019)
  • Author(s): 竹谷隆司、田中真樹
  • Organizer: 第42回日本神経科学大会
• [Presentation] Ketamine-induced alterations in memory capacity and exploratory behavior during oculomotor foraging in monkeys (2019)
  • Author(s): 澤頭 亮、田中真樹
  • Organizer: 第42回日本神経科学大会
• [Presentation] 採餌行動のモデルとケタミンによる変化 (2019)
  • Author(s): 澤頭 亮、田中真樹
  • Organizer: 日本生理学会北海道地方会
• [Presentation] Spontaneous grouping of synchronized eye movements in monkeys and humans. (2019)
  • Author(s): Takeya R & Tanaka M
  • Organizer: The 2nd Timing Research Forum (TRF2)
  • Int'l Joint Research
• [Presentation] Neuronal correlates of temporal prediction of visual metronome in the primate striatum compared with the cerebellum (2019)
  • Author(s): Kameda M & Tanaka M
  • Organizer: The 2nd Timing Research Forum (TRF2)
  • Int'l Joint Research
• [Presentation] Neuronal signals regulating and monitoring of synchronized saccade timing in the primate deep cerebellar nuclei (2019)
  • Author(s): Takeya R & Tanaka M
  • Organizer: Soc Neurosci
  • Int'l Joint Research
• [Presentation] Dissociation of sensory from motor related signals for rhythm perception in the primate striatum and deep cerebellar nuclei (2019)
  • Author(s): Kameda M & Tanaka M
  • Organizer: Soc Neurosci
  • Int'l Joint Research
• [Presentation] Subcortical mechanism of self-timing and temporal prediction (2019)
  • Author(s): 田中真樹
  • Organizer: 2018年度東北大学電気通信研究所研究会
  • Invited
• [Presentation] 運動タイミングを決める皮質下機構 (2018)
  • Author(s): 田中真樹
  • Organizer: 日本生体医工学会大会オーガナイズドシンポジウム
  • Invited
• [Presentation] Roles of subcortical preparatory signals in self-timing (2018)
  • Author(s): 田中真樹
  • Organizer: The 75th FUJIHARA Seminar
  • Int'l Joint Research / Invited
• [Presentation] Comparison of neuronal activity between the striatum and cerebellum for beat-based timing.（周期的な時間予測における線条体と小脳核の神経活動の比較） (2018)
  • Author(s): 亀田将史、田中真樹
  • Organizer: 第41回日本神経科学大会
• [Presentation] 同期眼球運動の自発的な分節化 (2018)
  • Author(s): 竹谷隆司、田中真樹
  • Organizer: 第12回Motor Control研究会
• [Presentation] Contextual changes in cortico-striatal transmission during time production in monkeys (2018)
  • Author(s): Suzuki Tomoki W, Tanaka Masaki
  • Organizer: Society for Neuroscience
  • Int'l Joint Research
• [Presentation] Neuronal correlates of beat-based timing in the primate striatum (2018)
  • Author(s): Kameda Masashi, Ohmae Shogo, Tanaka Masaki
  • Organizer: Society for Neuroscience
  • Int'l Joint Research
• [Presentation] Sensory prediction signals in the primate cerebellar nuclei during synchronized saccades (2018)
  • Author(s): Takeya Ryuji, Tanaka Masaki
  • Organizer: The 75th FUJIHARA Seminar
  • Int'l Joint Research
• [Presentation] 眼球運動における視床大脳経路の役割 (2018)
  • Author(s): 田中真樹
  • Organizer: 日本視覚学会2018年冬季大会 特別講演 工学院大学新宿キャンパス 東京都
  • Invited
• [Presentation] 運動タイミングを制御する２つの信号 (2018)
  • Author(s): 田中真樹
  • Organizer: 平成30年度 京大霊長研共同利用研究会 京都大学霊長類研究所 犬山市
  • Invited
• [Presentation] Cerebellar contribution to higher-order motor control (2017)
  • Author(s): Tanaka, M.
  • Organizer: 台湾臨床神経生理学会 国立台湾病院国際会議センター 台北市
  • Int'l Joint Research / Invited
• [Presentation] Neuronal mechanism of temporal prediction in the primate brain (2017)
  • Author(s): Tanaka, M.
  • Organizer: Internal Workshop on Basal Ganglia Functions 2017 玉川学園大学 町田市
  • Int'l Joint Research / Invited
• [Presentation] Subcortical signals for beat-based timing (2017)
  • Author(s): Tanaka, M.
  • Organizer: The 2nd Internal Symposium on the Science of Mental Time 奈良春日野国際フォーラム 奈良市
  • Int'l Joint Research / Invited
• [Presentation] 大脳基底核と小脳の時間情報処理 (2017)
  • Author(s): 田中真樹
  • Organizer: 第32回日本大脳基底核研究会（JBAGS2017）シンポジウム 三河湾リゾートリンクス 西尾市
  • Invited
• [Presentation] 小脳の高次脳機能への関与をヒトとサルで評価する (2017)
  • Author(s): 田中真樹
  • Organizer: 日本神経科学大会 教育シンポジウム 幕張メッセ 千葉市
  • Invited
• [Presentation] Roles of the basal ganglia and cerebellum in self-timing (2017)
  • Author(s): 田中真樹
  • Organizer: 日本神経科学大会 企画シンポジウム 幕張メッセ 千葉市
  • Invited
• [Presentation] リズムに乗る脳のしくみ (2017)
  • Author(s): 田中真樹
  • Organizer: 第14回ナショナルバイオリソースプロジェクト公開シンポジウム 文部省NBRP 東京都
  • Invited
• [Presentation] LFP in the primate caudate nucleus reflect different preparatory states during the time production task. (2017)
  • Author(s): 鈴木智貴、田中真樹
  • Organizer: 第40回日本神経科学大会 幕張メッセ 千葉市
• [Presentation] タイミング予測に関連した線条体ニューロンの活動とその特性 (2017)
  • Author(s): 亀田将史、田中真樹
  • Organizer: 第11回Motor Control研究会 中京大学 名古屋市
• [Presentation] サルの予測性眼球運動にみられた自発的な体制化 (2017)
  • Author(s): 竹谷隆司、田中真樹
  • Organizer: 日本生理学会北海道地方会 北海道医療大学 石狩郡当別町
• [Presentation] 周期的な時間予測における線条体と小脳の役割 (2017)
  • Author(s): 亀田将史、田中真樹
  • Organizer: 日本生理学会北海道地方会 北海道医療大学 石狩郡当別町
• [Presentation] サッカード適応学習への運動性視床の不活化の影響 (2017)
  • Author(s): 上林菜月、田中真樹
  • Organizer: 日本生理学会北海道地方会 北海道医療大学 石狩郡当別町
• [Book] ガイトン生理学原著13版（Guyton and Hall Textbook of Medical Physiology, 13th ed） 第57章「小脳と大脳基底核の運動全般における役割」（邦訳） (2018)
  • Author(s): 田中真樹
  • Total Pages: 1100
  • Publisher: エルゼビア・ジャパン株式会社
  • ISBN: 9784860347741
• [Book] 新 感覚・知覚心理学ハンドブック 第5章6節「注意の神経メカニズム」、7節「注意の障害」 (2018)
  • Author(s): 竹谷隆司、田中真樹
  • Total Pages: 615
  • Publisher: 誠信書房
• [Book] ガイトン生理学原著13版 第57章「小脳と大脳基底核の運動全般における役割」（邦訳） (2018)
  • Author(s): 田中真樹
  • Publisher: エルゼビア・ジャパン
• [Remarks] 研究室HP
  • URL: http://niseiri.med.hokudai.ac.jp/
• [Remarks] http://niseiri.med.hokudai.ac.jp/
• [Remarks] 研究室ホームページ
  • URL: http://niseiri.med.hokudai.ac.jp/