Development of indocyanine green-binding anti-cancer drug with specific accumulation in hepatocellular carcinoma
| Project/Area Number |
17H03595
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Tumor therapeutics
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
國土 典宏 国立研究開発法人国立国際医療研究センター, その他部局等, 理事長 (00205361)
浦野 泰照 東京大学, 大学院薬学系研究科(薬学部), 教授 (20292956)
稲垣 善則 東京大学, 医学部附属病院, 助教 (40733390)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2019: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2018: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2017: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
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| Keywords | 肝細胞癌 / 抗癌剤 / ドラッグデリバリーシステム / 物質代謝 |
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| Outline of Final Research Achievements |
The present study aimed to develop the new anti-cancer drug for hepatocellular carcinoma (HCC) by utilizing indocyanine green (ICG) that has the characteristics of accumulating in HCC. The newly synthesized ICG-Gemcitabine (ICG-Gem) accumulated in HCC tissue as well as ICG. The cytotoxicity of ICG-Gem to normal cells was weaker than that of gemcitabine (Gem) while the cytotoxicity to HCC cells was comparable. The direct injection of ICG-Gem to mouse tumor xenograft had the effect to inhibit the tumor growth compared with that of Gem. These results suggest that ICG-Gem may be available for the new anti-cancer drug of hepatic arterial infusion chemotherapy.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究では、肝細胞癌（HCC）組織におけるインドシアニングリーン（ICG）の特異的滞留性がHCCへの抗癌剤の送達に有用であることを示唆した。この成果は、非特異的な毒性の発生という課題を抱えており、開発が立ち遅れているHCCに対する新規抗癌剤の開発に貢献するものと期待される。また、ICGの特異的滞留性機構の解明は、HCC細胞における特有の代謝機構の存在を立証することにつながり、学術的に意義深い。
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Report
(4 results)
Research Products
(26 results)
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[Presentation] 肝癌蛍光イメージング：肝切除への臨床応用と光線力学的治療の可能性2019
Author(s)
石沢 武彰, 白田 力, 稲垣 善則, 國土 貴嗣, 廣吉 淳子, 市田 晃彦, 赤松 延久, 有田 淳一, 金子 順一, 神谷 真子, 浦野 泰照, 長谷川 潔
Organizer
第81回日本臨床外科学会総会
Related Report
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[Presentation] Assessment of preoperative liver function in patients with hepatocellular carcinoma - The ALICE Grade2017
Author(s)
Kokudo T, Shirata C, Miyazaki Y, Amikura K, Yamaguchi T, Arita J, Kaneko J, Akamatsu N, Sakamoto Y, Takahashi A, Sakamoto H, Kokudo N, Hasegawa K
Organizer
IASGO 2017 (27th World Congress of the International Association of Surgeons)
Related Report
Int'l Joint Research
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[Presentation] ICG-guided hepatectomy2017
Author(s)
Hasegawa K, Kawaguchi Y, Yamashita S, Kokudo T, Togashi J, Arita J, Kaneko J, Akamatsu N, Sakamoto Y, Kokudo N.
Organizer
11th International Minimal Invasive Surgery Symposium and 7th CME Course of IASGO
Related Report
Int'l Joint Research / Invited
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