| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2019: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2018: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Fiscal Year 2017: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
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| Outline of Final Research Achievements |
In a salt-sensitive hypertension rat model, feeding a low protein diet during pregnancy caused augmentation of hypertension in pups. We found that the mechanism underlying the phenomenon include changes in DNA methylation in the gene of Ptger1, which is known to be involved in blood pressure regulation. Even in such a situation, the adverse effect can be partially reversed by feeding high protein diets or low protein diets.
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