• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

The role of a secreted protein Reelin in the brain and its therapeutic application.

Research Project

Project/Area Number 17H03985
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Biological pharmacy
Research InstitutionNagoya City University

Principal Investigator

Hattori Mitsuharu  名古屋市立大学, 医薬学総合研究院(薬学), 教授 (60272481)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2019: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2018: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2017: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Keywords脳 / 精神疾患 / 神経発達 / リーリン / プロテアーゼ / 神経細胞移動 / メタロプロテアーゼ / アルツハイマー病 / ノックアウトマウス / リン酸化 / 遺伝子改変マウス
Outline of Final Research Achievements

Reelin is important in the neuronal development and counteracting amyloid β toxicity. A specific proteolytic cleavage of Reelin abolishes its biological activity. We identified ADAMTS-3 as the major enzyme that inactivates Reelin in the brain. We also found that ADAMTS-2 is expressed in the adult brain at approximately the same level as ADAMTS-3. We generated ADAMTS-2 knockout (KO) mice and found that ADAMTS-2 significantly contributes to the N-t inactivation of Reelin in the postnatal cerebral cortex and hippocampus, but much less in the cerebellum. Therefore, it was suggested that ADAMTS-2 can be a therapeutic target for adult brain disorders such as schizophrenia and Alzheimer's disease.

Academic Significance and Societal Importance of the Research Achievements

WHOによると、精神神経疾患による損失年数(DALY)は非感染性疾患の1/4を占め、新規治療へのニーズが極めて高い疾患領域である。特に我が国を含む先進国においては、高齢化や高度なストレスを要因としてその患者数は増加しており、経済損失や治療コストも増加の一途を辿っている。しかし、精神神経疾患に関しては現状、病態の理解も不充分であり、その創薬の成功確度は他の疾患分野に比べて低く、停滞している。本研究の主要な部分は基礎研究であるが、既に製薬企業との共同研究を開始しており、応用研究も一部開始した。リーリンの研究では世界的でも最先端に位置し、新理論の確立も視野に入れる申請となっている。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (69 results)

All 2020 2019 2018 2017

All Journal Article (12 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 11 results,  Open Access: 5 results) Presentation (57 results) (of which Int'l Joint Research: 11 results)

  • [Journal Article] Physiological significance of proteolytic processing of Reelin revealed by cleavage-resistant Reelin knock-in mice.2020

    • Author(s)
      Okugawa et al.
    • Journal Title

      Sci. Rep.

      Volume: 10 Issue: 1 Pages: 4471-4471

    • DOI

      10.1038/s41598-020-61380-w

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reducing ADAMTS-3 Inhibits Amyloid β Deposition in <i>App</i> Knock-in Mouse2019

    • Author(s)
      Yamakage Y, Tsuiji H, Kohno T, Ogino H, Saito T, Saido TC, Hattori M.
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 42 Issue: 3 Pages: 354-356

    • DOI

      10.1248/bpb.b18-00899

    • NAID

      130007606923

    • ISSN
      0918-6158, 1347-5215
    • Year and Date
      2019-03-01
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential binding of anti-Reelin monoclonal antibodies reveals the characteristics of Reelin protein under various conditions2019

    • Author(s)
      Ishii Keisuke、Kohno Takao、Hattori Mitsuharu
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 514 Issue: 3 Pages: 815-820

    • DOI

      10.1016/j.bbrc.2019.05.005

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression and Preparation of Recombinant Reelin and ADAMTS-3 Proteins2019

    • Author(s)
      Kohno Takao、Ogino Himari、Yamakage Yuko、Hattori Mitsuharu
    • Journal Title

      Methods Mol. Biol.

      Volume: 2043 Pages: 93-104

    • DOI

      10.1007/978-1-4939-9698-8_8

    • ISBN
      9781493996971, 9781493996988
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Assay for Reelin-Cleaving Activity of ADAMTS and Detection of Reelin and Its Fragments in the Brain2019

    • Author(s)
      Ogino Himari、Yamakage Yuko、Yamashita Mihoshi B.、Kohno Takao、Hattori Mitsuharu
    • Journal Title

      Methods Mol. Biol.

      Volume: 2043 Pages: 105-111

    • DOI

      10.1007/978-1-4939-9698-8_9

    • ISBN
      9781493996971, 9781493996988
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A disintegrin and metalloproteinase with thrombospondin motifs 2 cleaves and inactivates Reelin in the postnatal cerebral cortex and hippocampus, but not in the cerebellum2019

    • Author(s)
      Yamakage Yuko、Kato Michinao、Hongo Aya、Ogino Himari、Ishii Keisuke、Ishizuka Takumi、Kamei Takana、Tsuiji Hitomi、Miyamoto Tomomi、Oishi Hisashi、Kohno Takao、Hattori Mitsuharu
    • Journal Title

      Molecular and Cellular Neuroscience

      Volume: 100 Pages: 103401-103401

    • DOI

      10.1016/j.mcn.2019.103401

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Semaphorin 6A?Plexin A2/A4 Interactions with Radial Glia Regulate Migration Termination of Superficial Layer Cortical Neurons2019

    • Author(s)
      Hatanaka Yumiko、Kawasaki Takahiko、Abe Takaya、Shioi Go、Kohno Takao、Hattori Mitsuharu、Sakakibara Akira、Kawaguchi Yasuo、Hirata Tatsumi
    • Journal Title

      iScience

      Volume: 21 Pages: 359-374

    • DOI

      10.1016/j.isci.2019.10.034

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Detachment of Chain-Forming Neuroblasts by Fyn-Mediated Control of cell-cell Adhesion in the Postnatal Brain.2018

    • Author(s)
      Fujikake K, Sawada M, Hikita T, Seto Y, Kaneko N, Herranz-Perez V, Dohi N, Homma N, Osaga S, Yanagawa Y, Akaike T, Garcia-Verdugo JM, Hattori M, Sobue K, Sawamoto K.
    • Journal Title

      Journal of Neuroscience

      Volume: 38 Issue: 19 Pages: 4598-4609

    • DOI

      10.1523/jneurosci.1960-17.2018

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Genetic and animal model analyses reveal the pathogenic role of a novel deletion of RELN in schizophrenia.2018

    • Author(s)
      Sobue A, Kushima I, Nagai T, Shan W, Kohno T, Aleksic B, Aoyama Y, Mori D, Arioka Y, Kawano N, Yamamoto M, Hattori M, Nabeshima T, Yamada K, Ozaki N.
    • Journal Title

      Sci Rep.

      Volume: 8 Issue: 1 Pages: 13046-13046

    • DOI

      10.1038/s41598-018-31390-w

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Reelin deficiency leads to aberrant lipid composition in mouse brain2018

    • Author(s)
      Mizukami T, Ikeda K, Shimanaka Y, Korogi K, Zhou C, Takase H, Tsuiji H, Kono N, Kohno T, Arai H, Arita M, Hattori M.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 505 Issue: 1 Pages: 81

    • DOI

      10.1016/j.bbrc.2018.09.089

    • URL

      https://pure.teikyo.jp/en/publications/20a0cf32-221e-433e-91b9-4f845cd345d4

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 分泌タンパク質リーリン分解酵素の同定と応用2018

    • Author(s)
      河野孝夫、服部光治
    • Journal Title

      Bioindustry

      Volume: 35 Pages: 11-17

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Secreted Metalloproteinase ADAMTS-3 Inactivates Reelin2017

    • Author(s)
      Ogino H, Hisanaga A, Kohno T, Kondo Y, Okumura K, Kamei T, Sato T, Asahara H, Tsuiji H, Fukata M, Hattori M
    • Journal Title

      J Neurosci

      Volume: 37 Issue: 12 Pages: 3181-3191

    • DOI

      10.1523/jneurosci.3632-16.2017

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 成熟マウスの前頭前皮質におけるReelin シグナルの活性化がMK801 誘発性行動障害に与える影響2020

    • Author(s)
      澤幡雅仁、浅野裕樹、永井拓、河野孝夫、鍋島俊隆、服部光治、山田清文
    • Organizer
      第136回 日本薬理学会近畿部会
    • Related Report
      2019 Annual Research Report
  • [Presentation] シナプス形成と可塑性におけるリーリン機能とその制御機構の解析2020

    • Author(s)
      石塚 拓巳、大石 久史、服部 光治
    • Organizer
      日本薬学会第140年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 分解抵抗型リーリンノックインマウスを用いた、海馬におけるリーリン分解の生理的意義の解明2020

    • Author(s)
      重信 奉文、奥川 英介、河野 孝夫、大石 久史、服部 光治
    • Organizer
      日本薬学会第140年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 生物発光イメージングを用いたリーリンの分泌機構の解明2020

    • Author(s)
      中尾洋介、横川慧、河野孝夫、鈴木崇弘、服部光治
    • Organizer
      日本薬学会第140年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Systematic analysis of brain pH and lactate levels in animal models: relationships and implications for behavioral outcomes2019

    • Author(s)
      Hideo Hagihara, et al.
    • Organizer
      21st Annual Meeting of the International Behavioural and Neural Genetics Society
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 分泌タンパク質リーリンによる海馬形成制御機構の解明2019

    • Author(s)
      石井圭介、河野孝夫、服部光治
    • Organizer
      第83回日本生化学会中部支部例会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 分泌タンパク質リーリンは脳でオリゴデンドロサイト前駆細胞の数と配置に影響を与える2019

    • Author(s)
      荻野ひまり、中島鼓美、鳥内皐暉、青山峰芳、服部光治
    • Organizer
      第42回日本神経科学大会・第62回日本神経化学大会(Neuro2019)
    • Related Report
      2019 Annual Research Report
  • [Presentation] 長鎖ノンコーディングRNAであるGomafuの核内繋留機構におけるSF3b2の寄与の解明2019

    • Author(s)
      上原理加、梅本銀河、中川真一、吉田稔、服部光治、築地仁美 Rika Uehara, Ginga Umemoto, Shinichi Nakagawa, Minoru Yoshida, Mitsuharu Hattori, Hitomi Tsuiji
    • Organizer
      第21回日本RNA学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 分解抵抗型リーリン発現マウスにおける海馬層構造異常の原因解明2019

    • Author(s)
      重信奉文、奥側英介、河野孝夫、大石久史、服部光治
    • Organizer
      第65回日本薬学会東海支部総会・大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] RNA干渉法を利用した脳内リーリンシグナルを増強させる手法の開発2019

    • Author(s)
      常浦祐未、北川佳奈子、高瀬冴子、澤幡雅仁、伊藤教道、河野孝夫、服部光治、永井拓、山田清文
    • Organizer
      第42回日本神経科学大会・第62回日本神経化学大会(Neuro2019)
    • Related Report
      2019 Annual Research Report
  • [Presentation] Reelinの前頭前皮質内投与がMK801誘発性行動障害およびc-Fos発現に与える影響2019

    • Author(s)
      澤幡雅仁、浅野裕樹、河野孝夫、服部光治、永井拓、山田清文
    • Organizer
      第42回日本神経科学大会・第62回日本神経化学大会(Neuro2019)
    • Related Report
      2019 Annual Research Report
  • [Presentation] 脳におけるリン脂質フリッパーゼの機能の解明2019

    • Author(s)
      大嶋智葉、中島鼓美、大石久史、服部光治 Tomoha Ohshima, Tsuzumi Nakajima, Hisashi Oishi, Mitsuharu Hattori
    • Organizer
      NCUライフサイエンスリトリート2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] 海馬形成における分泌タンパク質リーリンの機能解明2019

    • Author(s)
      石井圭介、河野孝夫、服部光治
    • Organizer
      第18回次世代を担う若手ファーマ・バイオフォーラム2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] 神経細胞における特定の脂肪酸の生理的意義2019

    • Author(s)
      興梠勝成、水上智晴、河野孝夫、服部光治 Katsunari Korogi, Tomoharu Mizukami, Takao Kohno, Mitsuharu Hattori
    • Organizer
      第18回次世代を担う若手ファーマ・バイオフォーラム2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] リーリンは発生後期における海馬形成を制御する2019

    • Author(s)
      石井圭介、河野孝夫、服部光治 Keisuke Ishii, Takao Kohno, Mitsuharu Hattori
    • Organizer
      第92回日本生化学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 脳におけるリン脂質フリッパーゼの機能の解明2019

    • Author(s)
      大嶋智葉、中島鼓美、大石久史、服部光治 Tomoha Ohshima, Tsuzumi Nakajima, Hisashi Oishi, Mitsuharu Hattori
    • Organizer
      第92回日本生化学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 神経細胞における特定の脂肪酸の生理的意義2019

    • Author(s)
      興梠勝成、水上智晴、河野孝夫、服部光治 Katsunari Korogi, Tomoharu Mizukami, Takao Kohno, Mitsuharu Hattori
    • Organizer
      第92回日本生化学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 長鎖ノンコーディングRNAであるGomafuの核内繋留機構におけるSF3b2の寄与の解明2019

    • Author(s)
      上原理加、梅本銀河、中川真一、吉田稔、服部光治、築地仁美 Rika Uehara, Ginga Umemoto, Shinichi Nakagawa, Minoru Yoshida, Mitsuharu Hattori, Hitomi Tsuiji
    • Organizer
      第92回日本生化学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 分泌タンパク質リーリンの切断を担う酵素ADAMTS-3の構造解析に向けた精製及び安定化の検討2019

    • Author(s)
      森由紀子、中尾洋介、河野孝夫、服部光治 Yukiko Mori, Yousuke Nakao, Takao Kohno, Mitsuharu Hattori
    • Organizer
      第92回日本生化学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] リーリンはオリゴデンドロサイト前駆細胞の数及び配置を制御する2019

    • Author(s)
      中島鼓美、荻野ひまり、鳥内皐暉、青山峰芳、服部光治
    • Organizer
      第92回日本生化学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 大脳皮質形成におけるリーリンの機能制御機構2019

    • Author(s)
      河野孝夫、服部光治
    • Organizer
      第92回日本生化学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Reelin regulates the positioning of late-born neurons during hippocampal development2019

    • Author(s)
      Keisuke Ishii, Takao Kohno, Mitsuharu Hattori
    • Organizer
      Society for Neuroscience (SFN) 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 成熟マウスにおけるReelinの前頭前皮質内微量投与がMK801誘発性行動障害及びcFos発現に与える影響2019

    • Author(s)
      澤幡雅仁、浅野裕樹、永井拓、河野孝夫、鍋島俊隆、服部光治、山田清文
    • Organizer
      日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] 神経細胞におけるリン脂質フリッパーゼの機能の解明2019

    • Author(s)
      大嶋智葉、中島鼓美、大石久史、服部光治 Tomoha Ohshima, Tsuzumi Nakajima, Hisashi Oishi, Mitsuharu Hattori
    • Organizer
      第42回日本分子生物学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 神経細胞における特定の脂肪酸の意義2019

    • Author(s)
      興梠 勝成 , 水上 智晴 , 河野 孝夫 , 関 仁望 , 仁子 陽輔 , 服部 光治
    • Organizer
      第42回日本分子生物学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 筋委縮性側索硬化症ALSの原因となるC9orf72遺伝子変異がもたらす細胞毒性の解析2019

    • Author(s)
      築地仁美、横川美丹衣、服部光治
    • Organizer
      日本薬学会第139年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Reelin C-terminal region regulates hippocampal layer formation2018

    • Author(s)
      Keisuke Ishii, Takao Kohno, and Mitsuharu Hattori
    • Organizer
      22nd Biennial Meeting of the International Society for Developmental Neuroscience
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Semaphorin 6A-Plexin A2/A4 signaling between neurons and radial glial cells is required for proper positioning of superficial layer neurons in the mouse cerebral cortex2018

    • Author(s)
      Yumiko Hatanaka, Takahiko Kawasaki, Takaya Abe, Go Shioi, Takao Kohno, Mitsuharu Hattori, Akira Sakakibara, Yasuo Kawaguchi, Tatsumi Hirata
    • Organizer
      22nd Biennial Meeting of the International Society for Developmental Neuroscience
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Microinjection of Reelin into the medial prefrontal cortex improves MK801-induced memory impairment2018

    • Author(s)
      Masahito Sawahata, Kanako Kitagawa, Yumi Tsuneura, Taku Nagai, Takao Kohno, Toshitaka Nabeshima, Mitsuharu Hattori, Kiyofumi Yamada
    • Organizer
      The 18th World Congress of Basic and Clinical Pharmacology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ADAMTS-2 mediates the specific cleavage of Reelin in the adult brain2018

    • Author(s)
      Yuko Yamakage, Michinao Kato, Aya Hongo, Himari Ogino, Takumi Ishizuka, Hitomi Tsuiji, Takao Kohno, Mitsuharu Hattori
    • Organizer
      第41回 日本神経科学大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] The interaction between Reelin and its novel binding protein is required for dendrite development of cortical upper-layer neurons.2018

    • Author(s)
      Takao Kohno, Makoto Makino, Keisuke Ishii, Yuki Hirota, Takao Honda, Kazunori Nakajima and Mitsuharu Hattori.
    • Organizer
      第41回 日本神経科学大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] SemaphorinA6 on radial glial cell and PlexinA2/A4 on neuron are required for proper positioning of superficial layer neurons in the cerebral cortex2018

    • Author(s)
      Yumiko Hatanaka, Takahiko Kawasaki, Takaya Abe, Go Shioi, Takao Kohno, Mitsuharu Hattori, Akira Sakakibara, Yasuo Kawaguchi, Tatsumi Hirata
    • Organizer
      第41回 日本神経科学大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Regulation of Reelin functions by proteolytic processing and its significance in brain development and functions2018

    • Author(s)
      MItsuharu Hattori
    • Organizer
      FENS Forum of Neuroscience 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] リーリンシグナルがアルツハイマー病発症に与える影響2018

    • Author(s)
      梅本銀河、中川真一、吉田稔、服部光治、築地仁美
    • Organizer
      第17回次世代を担う若手ファーマ・バイオフォーラム
    • Related Report
      2018 Annual Research Report
  • [Presentation] リーリンシグナルがアルツハイマー病発症に与える影響2018

    • Author(s)
      大嶋智葉、山影祐子、河野孝夫、斎藤貴志、西道隆臣、赤津裕康、松川則之、服部光治
    • Organizer
      第17回次世代を担う若手ファーマ・バイオフォーラム
    • Related Report
      2018 Annual Research Report
  • [Presentation] リーリンシグナルがアルツハイマー病発症に与える影響に関する解析2018

    • Author(s)
      大嶋智葉、山影祐子、河野孝夫、斎藤貴志、西道隆臣、服部光治
    • Organizer
      第91回日本生化学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 神経細胞における特定の脂肪酸の生理的意義についての解析2018

    • Author(s)
      興梠勝成、水上智晴、河野孝夫、服部光治
    • Organizer
      第91回日本生化学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] TDP-43 accelerates age-dependent degeneration of interneurons2018

    • Author(s)
      Hitomi Tsuiji, Ikuyo Inoue, Asako Furuya, Mari Takeuchi, Yuko Yamakage, Mitsuharu Hattori, Koji Yamanaka
    • Organizer
      12th Brain Research Conference
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 海馬層形成における分泌タンパク質リーリンの機能解明2018

    • Author(s)
      石井圭介、河野孝夫、服部光治
    • Organizer
      日本薬学会東海支部会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 脳の構造と機能に重要なタンパク質リーリンの機能増強マウスの作製と解析2018

    • Author(s)
      奥川英介、荻野ひまり、重信奉文、河野孝夫、大石久史、服部光治
    • Organizer
      日本薬学会東海支部会
    • Related Report
      2018 Annual Research Report
  • [Presentation] mRNA様long non-coding RNA であるGomafuの核内繋留機構の解明2018

    • Author(s)
      梅本銀河、上原理加、中川真一、吉田稔、服部光治、築地仁美
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 精神神経疾患の治療を志向した、分解抵抗型リーリンノックインマウスの作製と解析2018

    • Author(s)
      奥川英介、荻野ひまり、重信奉文、河野孝夫、大石久史、服部光治
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Activity of Reelin is regulated by ADMATS metalloproteinases2018

    • Author(s)
      Himari Ogino, Takao Kohno, Yuko Yamakage, Michinao Kato, Eisuke Okugawa, Takumi Ishizuka, Hitomi Tsuiji, Mitsuharu Hattori
    • Organizer
      Gordon Research Conference, Extracellular Proteolysis
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] リーリンと結合する新規分子の探索と生化学的解析2018

    • Author(s)
      牧野誠、河野孝夫、服部光治
    • Organizer
      日本薬学会第138年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 精神神経疾患の治療を志向した、分解抵抗型リーリンノックインマウスの作製と解析2017

    • Author(s)
      奥川英介、荻野ひまり、河野孝夫、服部光治
    • Organizer
      日本生化学会中部支部会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 脳機能に必須なタンパク質リーリンの新規結合分子に関する研究2017

    • Author(s)
      石井圭介、河野孝夫、服部光治
    • Organizer
      第63回 薬学会東海支部会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ADAMTS-3 Inactivates Reelin, an Important Regulator of Brain Development and Function2017

    • Author(s)
      Himari Ogino, Takao Kohno, Michinao Kato, Eisuke Okugawa, Mitsuharu Hattori
    • Organizer
      Gordon Research Conference, Matrix Metalloproteinase
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The functions of Reelin via a novel Reelin-binding protein.2017

    • Author(s)
      Takao Kohno, Hayata Yagyu, Mitsuharu Hattori
    • Organizer
      第40回 日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Secreted Metalloproteinase ADAMTS-3 Inactivates Reelin2017

    • Author(s)
      Himari Ogino, Arisa Hisanaga, Takao Kohno, Eisuke Okugawa, Tomoha Ohsima, Yuta Kondo, Kyoko Okumura, Takana Kamei, Tempei Sato, Hiroshi Asahara, Hitomi Tsuiji, Masaki Fukata, Mitsuharu Hattori
    • Organizer
      第40回 日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 分泌タンパク質リーリンによる、新たな脂質組成制御機構2017

    • Author(s)
      水上智晴、周春雨、池田和貴、高瀬広嗣、河野孝夫、築地仁美、嶋中雄太、新井洋由、有田誠、服部光治
    • Organizer
      第16回次世代を担う若手ファーマ・バイオフォーラム2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] 生後脳におけるリーリン特異的分解に寄与する酵素の解明2017

    • Author(s)
      山影祐子、加藤路尚、荻野ひまり、石塚拓巳、河野孝夫、服部光治
    • Organizer
      第16回次世代を担う若手ファーマ・バイオフォーラム2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] ADAMTS-3は大脳皮質と海馬におけるリーリン機能を負に制御する2017

    • Author(s)
      荻野ひまり、久永有紗、近藤佑多、河野孝夫、築地仁美、服部光治
    • Organizer
      第16回次世代を担う若手ファーマ・バイオフォーラム2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] 精神神経疾患の治療を志向した、分解抵抗型リーリンノックインマウスの作製と解析2017

    • Author(s)
      奥川英介、荻野ひまり、河野孝夫、服部光治
    • Organizer
      第16回次世代を担う若手ファーマ・バイオフォーラム2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] Regulation of Reelin function by specific proteolysis2017

    • Author(s)
      M. HATTORI, H. OGINO, E. OKUGAWA, Y. YAMAKAGE, T. KOHNO
    • Organizer
      Society for Neuroscience (SFN)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Contribution of ADMATS family members to Reelin inactivation in the postnatal brain2017

    • Author(s)
      M. KATO, T. KOHNO, M. HATTORI
    • Organizer
      Society for Neuroscience (SFN)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 脳機能改善を目指した、巨大分泌タンパク質リーリンの活性制御2017

    • Author(s)
      河野孝夫、服部光治
    • Organizer
      ConBio2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] To clarify how Reelin affects the lipid compositions of neurons2017

    • Author(s)
      Katsunari Korogi, Tomoharu Mizukami, Chunyu Zhou, Takao Kohno, Fumiyoshi Yamazaki, Katsuya Kabashima, Yuta Shimanaka, Kazutaka Ikeda, Hiroyuki Arai, Makoto Arita, Mitsutoshi Setou, Mitsuharu Hattori
    • Organizer
      ConBio2017
    • Related Report
      2017 Annual Research Report

URL: 

Published: 2017-04-28   Modified: 2021-02-19  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi