Single cell analysis of autoimmune liver diseases
| Project/Area Number |
17H04058
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Human pathology
|
|---|
| Research Institution | Kanazawa University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
橋本 真一 和歌山県立医科大学, 和歌山県立医科大学 先端医学研究所, 教授 (00313099)
|
|---|
| Project Period (FY) |
2017-04-01 – 2020-03-31
|
| Project Status |
Completed (Fiscal Year 2019)
|
| Budget Amount *help |
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2019: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
|
|---|
| Keywords | 病理 / 原発性胆汁性胆管炎 / １細胞遺伝子解析 / 肝疾患 / 1細胞遺伝子解析 |
|---|
| Outline of Final Research Achievements |
The novel analysis of single cell analysis using human liver tissues revealed the identification and function of each cells composing normal and diseased livers and characterized the cell populations organizing various pathological conditions. Immune cells and mesenchymal cells as well as liver resident epithelial cells (hepatocytes and cholangiocytes) consist of varied cell populations and its heterogeneity could characterize each liver diseases. Moreover, the pathological significance of histological findings found in various hepatobiliary diseases could be clarified from the aspect of the comprehensive gene expression in each constituent cells.
|
| Academic Significance and Societal Importance of the Research Achievements |
病理診断学は細胞から組織、臓器さらには病態へと形態学的に認識・診断する学問であり、長年の組織学的および免疫組織化学的知見の蓄積を基盤とするが、疾患を構成する個々の細胞種の機能や動的評価は不可能である。今回の新規解析法による肝臓病の研究にて、肝組織に出現する組織学的所見と各所見を構成するクルーの細胞社会を解析することができ、さらには各肝疾患の病態形成における個々の細胞種の同定及びそれらの意義を明らかにすることができ、各肝疾患に対する新規の治療戦略への一端を担うことができた。
|
Report
(4 results)
Research Products
(59 results)
-
-
[Journal Article] Serum C16:1n7/C16:0 ratio as a diagnostic marker for non-alcoholic steatohepatitis.2019
Author(s)
K Yamada, E Mizukoshi, T Seike, R Horii, T Terashima, N Iida, M Kitahara, H Sunagozaka, K Arai, T Yamashita, M Honda, T Takamura, K Harada, S Kaneko.
-
Journal Title
J Gastroenterol Hepatol
Volume: 34
Issue: 10
Pages: 1829-1835
DOI
Related Report
Peer Reviewed / Open Access
-
[Journal Article] The challenges of primary biliary cholangitis: What is new and what needs to be done2019
Author(s)
Terziroli Beretta-Piccoli B, Mieli-Vergani G, Vergani D, Vierling JM, Adams D, Alpini G, Banales JM, Beuers U, Bowlus C, Carbone M, Chazouill O, et al.
-
Journal Title
Journal of Autoimmunity
Volume: 105
Pages: 102328-102328
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] Acute presentation of autoimmune hepatitis: a multicentre study with detailed histological evaluation in a large cohort of patients.2017
Author(s)
Hiep NC, Harada K, Ouchi H, Sato Y,Tsuneyama , Kage M, Nakano M, Yoshizawa K, Takahashi A, Abe , Kang JH, Koike K, Inui A, Fujisawa T, Takaki A, Arinaga-Hino T, Torimura T, Suzuki Y, Fujiwara K, Zeniya Ohira H, Tanaka A, Takikawa H;Intractable Liver and Biliary Diseases Study Group of Japan.
-
Journal Title
J Clin Pathol.
Volume: 70(11)
Issue: 11
Pages: 961-969
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
-
-
-
[Presentation] EFFICACY AND SAFETY OF E6011,ANTI-HUMAN FRACTALKINE MONOCLONAL ANTIBODY, INPATIENTS WITH PRIMARY BILIARY CHOLANGITIS WITH AN INCOMPLETE RESPONSE TO URSODEOXYCHOLIC ACID:A PLACEBO-CONTROLLED DOUBLE-BLIND COMPARISON PHESE 2 STUDY2019
Author(s)
Atsushi Tanaka, Masabiru Abe, Tadashi Namisaki, Shinji Shimoda, Mikiko Zeniya, Akio Ido, Hitoshi Yoshiji, Hiromasa Ohira, Kenichi Harada, Yuko Kakuda, Atsushi Umeda, Yuki Kamiya, Yukari Higasine, Seiichiro Hojo, Toshio Imai, Tetsu Kawano, Yasuni Nakanuma, Hirohito Tsubouchi.
Organizer
AASLD The Liver Meeting 2019
Related Report
Int'l Joint Research
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Increased expression and altered localization of cathepsis Z is associated with progression to jaundice-stage in primary biliary cholangitis.2017
Author(s)
Aiba Y, Ito M, Nakamura H, Komori A , Abiru S, Nagaoka S. Yatsuhashi H, Nakamura M, Harada K, Aishima S, Hitomi Y, Kokudo N, Tokunaga K, Nishida N, Kawashima M, Uemoto S, Takatsuki M, Eguchi S, Shimoda S, Ito M, Komori A, Yatsuhashi H, Nakamura M.
Organizer
AASLD The Liver Meeting 2017
Related Report
Int'l Joint Research
-
-
-
-
-
-
-
-
-
-
-
[Book] Pathology of the Bile Duct2017
Author(s)
Nakanuma Y, Harada K, Enomoto K, Nishikawa Y, Shimoda S, Komori A, Miyata N, Baba H, Sugitani A, Takahashi R, Kai K, Moritoki Y, Kikuchi K, Koichi T, Kozaka K, Matsui O, Kondo F, Fukusato T, Kokairin T, Saito K, Soejima Y, Aishima S, et al.
Total Pages
212
Publisher
Springer
ISBN
9789811034992
Related Report
