| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2021: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2020: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2019: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2018: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Outline of Final Research Achievements |
Five years ago, in a 2017 application, we wrote that the epilepsy modeled by Girdin knockout mice had explosive energy release events, suggesting that energy pooling at excitatory neuron axon terminals was the initial cause. However, a 5-year study did not provide evidence to strongly support this hypothesis, but rather a histology of temporal lobe epilepsy with hippocampal sclerosis and tonic-clonic seizures reproducibly occurred in one of conditional knockout mice in pure inhibitory neuron lineage. The final results indicated that a deficiency of one particular inhibitory neuron population in Girdin knockout mice was the initial cause.
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