Analysis of chronic active EBV infection by comprehensive genome study
| Project/Area Number |
17H04081
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Virology
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| Research Institution | Nagoya University |
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Principal Investigator |
Kimura Hiroshi 名古屋大学, 医学系研究科, 教授 (30303621)
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| Co-Investigator(Kenkyū-buntansha) |
奥野 友介 名古屋大学, 医学部附属病院, 病院講師 (00725533)
伊藤 嘉規 名古屋大学, 医学系研究科, 准教授 (20373491)
村田 貴之 藤田医科大学, 医学部, 教授 (30470165)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2019: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2018: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2017: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
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| Keywords | Epstein-Barrウイルス / 慢性活動性EBV感染症 / 欠失ウイルス / 悪性リンパ腫 / ウイルス / 遺伝子 / EBV / CAEBV / 次世代シーケンサー |
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| Outline of Final Research Achievements |
Chronic active EBV infection (CAEBV) is an intractable disease which is characterized by EBV-infected T/natural killer cells and recurrent/persistent infectious mononucleosis-like symptoms. To clarify the neoplastic nature and pathogenesis of CAEBV, we performed comprehensive genetic analysis in patients with CAEBV. The study revealed that somatic driver mutations were found in EBV-infected cells, suggesting a unique role of these mutations in neoplastic proliferation of EBV-infected cells. Interestingly, the EBV genome harbored frequent intragenic deletions that were common in various EBV-associated lymphomas. Our findings highlight a pathogenic link between intragenic EBV deletions and EBV-associated lymphomagenesis.
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| Academic Significance and Societal Importance of the Research Achievements |
慢性活動性Epstein-Barr virus（EBV）感染症は、わが国をはじめとする東アジアに多いT/NK細胞性リンパ増殖性疾患である。本症は予後不良で治療法も確立されていない難治性疾患である上に、発症病理についても未だ不明な点が多い。本研究で得られた知見は、慢性活動性EBV感染症のみならずEBV関連リンパ腫や上咽頭がん・胃がんなどEBV関連上皮系腫瘍に共通する分子機構、さらには他の腫瘍ウイルスの発がんメカニズムを解明につながる可能性があると考えている。
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Report
(4 results)
Research Products
(12 results)
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[Journal Article] Defective Epstein-Barr virus in chronic active infection and haematological malignancy.2019
Author(s)
Okuno Y, Murata T, Sato Y,Yoshida K, Sawada A, Inoue M, Kawa K, Seto M, Ohshima K, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Nishida T, Kiyoi H, Kato S, Nakamura S, Morishima S, Yoshikawa T, Fujiwara S, Shimizu N, Isobe Y, Noguchi M, Kikuta A, Iwatsuki K, Takahashi Y, Kojima S, Ogawa S, Kimura H.
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Journal Title
Nat Microbiol.
Volume: 4
Issue: 3
Pages: 404-413
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Gene expression analysis of hypersensitivity to mosquito bite, chronic active EBV infection and NK/T-lymphoma/leukemia2017
Author(s)
Kana Washio, Takashi Oka, Lamia Abdalkader, Michiko Muraoka, Akira Shimada, Megumi Oda, Hiaki Sato, Katsuyoshi Takata, Yoshitoyo Kagami, Norio Shimizu, Seiichi Kato, Hiroshi Kimura, Kazunori Nishizaki, Tadashi Yoshino & Hirokazu Tsukahara
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Journal Title
Leukemia & Lymphoma
Volume: 58
Issue: 11
Pages: 1-12
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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