Elucidation of the immune regulation by dendritic cell subsets

• Project/Area Number: 17H04088
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Immunology
• Research Institution: Wakayama Medical University
• Principal Investigator: Kaisho Tsuneyasu 和歌山県立医科大学, 先端医学研究所, 教授 (60224325)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000); Fiscal Year 2019: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2018: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000); Fiscal Year 2017: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
• Keywords: 樹状細胞 / がん免疫 / ケモカイン / 炎症性サイトカイン / 遺伝子改変マウス / 免疫アジュバント / マクロファージ / 腸管免疫 / サブセット / T細胞 / 発がん

Outline of Final Research Achievements

Antigen presenting cells such as dendritic cells or macrophages show their specific functions, depending on their subsets or tissue localization. It is crucial to understand those functions and regulate immune responses based on the understanding. We have generated a novel type of anti-cancer vaccine by which cancer peptide antigens can be delivered to a dendritic cell subset with high ability to support anti-cancer cytotoxic T cell immunity. The vaccine could induce potent anti-cancer immune responses and effects in mice models. We have also analyzed immune adjuvant effects of the cholera toxin (CT). CT was found to activate murine resident peritoneal macrophages to produce a proinflammatory cytokine, IL-1beta. We have further clarified the molecular mechanisms by which CT induces production of IL-1beta in the macrophage.

Academic Significance and Societal Importance of the Research Achievements

本研究で示した抗がんワクチン療法は、これまで十分機能していなかったがん抗原ペプチド療法を有効に使用できる方法論を示した点で有用であり、マウスモデルで標的となっている抗原提示細胞がヒトにも存在している点からも非常に意義深い成果であると言える。また、マウス組織に常在するマクロファージにおけるコレラ毒素による炎症性サイトカイン産生誘導作用およびその分子基盤を明らかにした点に関しても、その免疫アジュバント作用を有効に活用できる道が開けたことを示している点で非常に重要な成果であると言える。

Research Products

• [Int'l Joint Research] Yale Univ./Harvard Medical School/Emory Univ.(米国)
• [Int'l Joint Research] Univ.of Melbourne/Australian National Univ./Telethon Kids Institute(オーストラリア)
• [Int'l Joint Research] Mainz Univ./Univ. Hospital Wuerzburg/Univ. Hospital Cologne(ドイツ)
• [Int'l Joint Research] London Research Institute/Imperial College/Cardiff Univ.(英国)
• [Int'l Joint Research] San Raffaele Scientific Institute/ICGEB(イタリア)
• [Int'l Joint Research] Yale Univ./Harvard Medical School/Emory Univ.(米国)
• [Int'l Joint Research] Univ.of Melbourne/Australian National Univ./Telethon Kids Institute(オーストラリア)
• [Int'l Joint Research] Mainz Univ./Bonn Univ./Univ. Hospital Cologne(ドイツ)
• [Int'l Joint Research] London Research Institute/Imperial College/Cardiff Univ.(英国)
• [Int'l Joint Research] San Raffaele Scientific Institute/ICGEB(イタリア)
• [Int'l Joint Research]
• [Int'l Joint Research] Yale Univ./Harvard Medical School/Emory University(米国)
• [Int'l Joint Research] Univ. of Melbourne/Australian National University/Telethon Kids Institute(Australia)
• [Int'l Joint Research] Mainz Univ/Bonn Univ/University Hospital Cologne(Germany)
• [Int'l Joint Research] San Raffaele Scientific Institute(Italy)
• [Int'l Joint Research] London Research Institute(英国)
• [Int'l Joint Research]
• [Journal Article] Osteoprotegerin-dependent Mcell self-regulation balances gut infection and immunity. (2020)
  • Author(s): Kimura S, Nakamura Y, Kobayashi N, Shiroguchi K, KawakamiE, Mutoh M, Takahashi-Iwanaga H, Yamada T, Hisamoto M, Nakamura M, Udagawa N, Sato S, KaishoT, Iwanaga T, Hase K.
  • Journal Title: Nat Commun Volume: 11 Issue: 1 Pages: 234-234
  • DOI: 10.1038/s41467-019-13883-y
  • Peer Reviewed / Open Access
• [Journal Article] Microfold cell-dependent antigen transport alleviates infectious colitis by inducing antigen-specific cellular immunity (2020)
  • Author(s): Nakamura Yutaka、Mimuro Hitomi、Kunisawa Jun、Furusawa Yukihiro、Takahashi Daisuke、Fujimura Yumiko、Kaisho Tsuneyasu、Kiyono Hiroshi、Hase Koji
  • Journal Title: Mucosal Immunology Volume: in press Issue: 4 Pages: 679-690
  • DOI: 10.1038/s41385-020-0263-0
  • Peer Reviewed / Open Access
• [Journal Article] Anticancer effects of chemokine-directed antigen delivery to a cross-presenting dendritic cell subset with immune checkpoint blockade (2020)
  • Author(s): Mizumoto Y, Hemmi H, Katsuda M, Miyazawa M, Kitahata Y, Miyamoto A, Nakamori M, Ojima T, Matsuda K, Nakamura M, Hayata K, Fukuda-Ohta Y, Sugiyama M, Ohta T, Orimo T, Okura S, Sasaki I, Tamada K, Yamaue H, Kaisho T.
  • Journal Title: British Journal of Cancer Volume: 122 Issue: 8 Pages: 1185-1193
  • DOI: 10.1038/s41416-020-0757-2
  • Peer Reviewed / Open Access
• [Journal Article] The mechanism of action of Spi-B in the transcriptional activation of the interferon-α4 gene. (2020)
  • Author(s): R. Miyazaki, H. Saiga, T. Kato, T. Bakoshi, R. Senba, A. Shintani, M. Suzuki, K. Takao, I. Sasaki, A. Iizuka, M. Sugiyama, N. Iwami, Y. Fukuda-Ohta, H. Hemmi, T. Tanaka, M. Miyake, T. Kaisho, K. Hoshino.
  • Journal Title: Biochem Biophys Res Commun. Volume: 30;525 Issue: 2 Pages: 477-482
  • DOI: 10.1016/j.bbrc.2020.02.101
  • Peer Reviewed / Open Access
• [Journal Article] IL-12 From Endogenous cDC1, and Not Vaccine DC, Is Required for Th1 Induction. (2020)
  • Author(s): D. Ashour, P. Arampatzi, V. Pavlovic, K. U Forstner, T. Kaisho, A. Beilhack, F. Erhard, M. B Lutz.
  • Journal Title: JCI Insight Volume: 21;5 Issue: 10 Pages: 135143-135143
  • DOI: 10.1172/jci.insight.135143
  • Peer Reviewed / Open Access
• [Journal Article] A defined commensal consortium elicits CD8 T cells and anti-cancer immunity (2019)
  • Author(s): T.Tanoue, S.Morita, D.R.Plichta, A.N.Skelly, W.Suda, Y.Sugiura, S.Narushima, H.Vlamakis, I.Motoo, K.Sugita, A.Shiota, K.Takeshita, K.Yasuma, D.Riethmacher, T.Kaisho, J.M.Norman, D.Mucida, M.Suematsu, T.Yaguchi, V.Bucci, T.Inoue, Y.Kawakami, B.Olle, B.Roberts, M.Hattori, R.J.Xavier, K.Atarashi, K.Honda
  • Journal Title: Nature Volume: 565 Issue: 7741 Pages: 600-605
  • DOI: 10.1038/s41586-019-0878-z
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Cholera toxin B induces interleukin-1β production from resident peritoneal macrophages through the pyrin inflammasome as well as the NLRP3 inflammasome (2019)
  • Author(s): Orimo T, Sasaki I, Hemmi H, Ozasa T, Fukuda-Ohta Y, Ohta T, Morinaka M, Kitauchi M, Yamaguchi T, Sato Y, Tanaka T, Hoshino K, Katayama KI, Fukuda S, Miyake K, Yamamoto M, Satoh T, Furukawa K, Kuroda E, Ishii KJ, Takeda K, Kaisho T
  • Journal Title: International Immunology Volume: 印刷中 Issue: 10 Pages: 657-668
  • DOI: 10.1093/intimm/dxz004
  • Peer Reviewed / Open Access
• [Journal Article] Hyperglycemia is associated with psoriatic inflammation in both humans and mice (2019)
  • Author(s): Ikumi K, Odanaka M, Shime H, Imai M, Osaga S, Taguchi O, Nishida E, Hemmi H, Kaisho T, Morita A, Yamazaki S
  • Journal Title: Journal of Investigative Dermatology Volume: 印刷中 Issue: 6 Pages: 1329-1338
  • DOI: 10.1016/j.jid.2019.01.029
  • Peer Reviewed / Open Access
• [Journal Article] Sox8 is essential for M cell maturation to accelerate IgA response at the early stage after weaning in mice (2019)
  • Author(s): Kimura Shunsuke、Kobayashi Nobuhide、Nakamura Yutaka、Kanaya Takashi、Takahashi Daisuke、Fujiki Ryoji、Mutoh Mami、Obata Yuuki、Iwanaga Toshihiko、Nakagawa Tomoo、Kato Naoya、Sato Shintaro、Kaisho Tsuneyasu、Ohno Hiroshi、Hase Koji
  • Journal Title: The Journal of Experimental Medicine Volume: 216 Issue: 4 Pages: 831-846
  • DOI: 10.1084/jem.20181604
  • Peer Reviewed / Open Access
• [Journal Article] Identification of a novel CCDC22 mutation in a patient with severe Epstein?Barr virus-associated hemophagocytic lymphohistiocytosis and aggressive natural killer cell leukemia (2019)
  • Author(s): Yamashita Y, Nishikawa A, Iwahashi Y, Fujimoto M, Sasaki I, Mishima H, Kinoshita A, Hemmi H, Kanazawa N, Ohshima K, Imadome KI, Murata SI、Yoshiura KI, Kaisho T, Sonoki T, Tamura S
  • Journal Title: International Journal of Hematology Volume: 印刷中 Issue: 6 Pages: 744-750
  • DOI: 10.1007/s12185-019-02595-0
  • Peer Reviewed / Open Access
• [Journal Article] Programmed cell death ligand 1 disruption by clustered regularly interspaced short palindromic repeats/Cas9‐genome editing promotes antitumor immunity and suppresses ovarian cancer progression (2019)
  • Author(s): Yahata T, Mizoguchi M, Kimura A, Orimo T, Toujima S, Kuninaka Y, Nosaka M, Ishida Y, Sasaki I, Fukuda‐Ohta Y, Hemmi H, Iwahashi N, Noguchi T, Kaisho T, Kondo T, Ino K
  • Journal Title: Cancer Science Volume: 110 Issue: 4 Pages: 1279-1292
  • DOI: 10.1111/cas.13958
  • Peer Reviewed / Open Access
• [Journal Article] Systems analysis reveals complex biological processes during virus infection fate decisions. (2019)
  • Author(s): Argilaguet. J, Pedragosa. M, Esteve-Codina. A, Riera. G, Vidal. E, Peligero-Cruz. C, Casella. V, Andreu. D, Kaisho. T, Bocharov. G, Ludewig. B, Heath. S, Meyerhans. A.
  • Journal Title: Genome Res Volume: 29 Issue: 6 Pages: 907-919
  • DOI: 10.1101/gr.241372.118
  • Peer Reviewed / Open Access
• [Journal Article] Type I Interferon Delivery by iPSC-Derived Myeloid Cells Elicits Antitumor Immunity via XCR1+ Dendritic Cells. (2019)
  • Author(s): Tsuchiya N, Zhang R, Iwama T, Ueda N, Liu T, Tatsumi M, Sasaki Y, Shimoda R, Osako Y, Sawada Y, Kubo Y, Miyashita A, Fukushima S, Cheng Z, Nakaki R, Takubo K, Okada S, Kaneko S, Ihn H, Kaisho T, Nishimura Y, Senju S, Endo I, Nakatsura T, Uemura Y.
  • Journal Title: Cell Rep. Volume: 29 Issue: 1 Pages: 162-175
  • DOI: 10.1016/j.celrep.2019.08.086
  • Peer Reviewed / Open Access
• [Journal Article] antibiotics enhances host resistance to viral infections in a microbiota-independent manner (2018)
  • Author(s): Smita Gopinath, Myoungjoo Kim, Tasfia Rakib, Patrick Wong, Michael Van Zandt, Natasha Barry, Tsuneyasu Kaisho, Andrew Goodman, Akiko Iwasaki
  • Journal Title: Nature MicrobiologyTopical application of aminoglycoside Volume: 3 Issue: 5 Pages: 611-621
  • DOI: 10.1038/s41564-018-0138-2
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Heme ameliorates dextran sodium sulfate-induced colitis through providing intestinal macrophages with noninflammatory profiles. (2018)
  • Author(s): Kayama H, Kohyama M, Okuzaki D, Motooka D, Barman S, Okumura R, Muneta M, Hoshino K, Sasaki I, Ise W, Matsuno H, Nishimura J, Kurosaki T, Nakamura S, Arase H, Kaisho T, Takeda K.
  • Journal Title: Proc Natl Acad Sci U S A. Volume: 115 Issue: 33 Pages: 8418-8423
  • DOI: 10.1073/pnas.1808426115
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] XCR1+樹状細胞による腸管免疫制御機構 (2018)
  • Author(s): 小笹俊哉、改正恒康
  • Journal Title: 医学のあゆみ Volume: 265(13) Pages: 1241-1247
• [Journal Article] 生体内における樹状細胞への腫瘍抗原送達システムによる新規がんペプチドワクチン療法 (2018)
  • Author(s): 水本有紀、勝田将裕、宮澤基樹、北畑裕司、宮本篤、中森幹人、尾島敏康、松田健司、邊見弘明、玉田耕治、改正恒康、山上裕機
  • Journal Title: 癌と化学療法 Volume: 45 Pages: 1469-1471
• [Journal Article] CD8+ T cells orchestrate pDC-XCR1+ dendritic cell spatial and functional cooperativity to optimize priming. (2017)
  • Author(s): A. Brewitz, S. Eickhoff, S. Daehling, T. Quast, S. Bedoui, R. A. Kroczek, C. Kurts, N. Garbi, W. Barchet, M. Iannacone, F. Klauschen, W. Kolanus, T. Kaisho, M. Colonna, R. N. Germain, W. Kastenmueller.
  • Journal Title: Immunity Volume: 46 Issue: 2 Pages: 205-219
  • DOI: 10.1016/j.immuni.2017.01.003
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Mast Cells Are Crucial for Induction of Group 2 Innate Lymphoid Cells and Clearance of Helminth Infections. (2017)
  • Author(s): Shimokawa C, Kanaya T, Hachisuka M, Ishiwata K, Hisaeda H, Kurashima Y, Kiyono H, Yoshimoto T, Kaisho T, Ohno H.
  • Journal Title: Immunity Volume: 46 Issue: 5 Pages: 863-874
  • DOI: 10.1016/j.immuni.2017.04.017
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Development of a novel CD4+ TCR transgenic line that reveals a dominant role for CD8+ DC and CD40-Signaling in the generation of helper and CTL responses to blood stage malaria. (2017)
  • Author(s): 3.D. Fernandez-Ruiz, LS. Lau, N. Ghazanfari, ..names of 12 authors were removed,,, A. Cozijnsen, V. Mollard, AD. Uboldi, CJ. Tonkin, TF. de Koning-Ward, PR. Gilson, T. Kaisho, A. Haque, BS. Crabb, FR. Carbone, GI. McFadden, WR. Heath.
  • Journal Title: J. Immunol. Volume: 199 Issue: 12 Pages: 4165-4179
  • DOI: 10.4049/jimmunol.1700186
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Essential involvement of the CX3CL1-CX3CR1 axis in bleomycin-induced pulmonary fibrosis via regulation of fibrocyte and M2 macrophage migration. (2017)
  • Author(s): 4.Y. Ishida, A. Kimura, M. Nosaka, Y. Kuninaka, H. Hemmi, I. Sasaki, T. Kaisho, N. Mukaida, T. Kondo.
  • Journal Title: Sci Rep Volume: 7 Issue: 1 Pages: 16833-16833
  • DOI: 10.1038/s41598-017-17007-8
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Ultraviolet B?Induced Maturation of CD11b-Type Langerin?Dendritic Cells Controls the Expansion of Foxp3+Regulatory T Cells in the Skin (2017)
  • Author(s): Yamazaki Sayuri、Odanaka Mizuyu、Nishioka Akiko、Kasuya Saori、Shime Hiroaki、Hemmi Hiroaki、Imai Masaki、Riethmacher Dieter、Kaisho Tsuneyasu、Ohkura Naganari、Sakaguchi Shimon、Morita Akimichi
  • Journal Title: The Journal of Immunology Volume: 200 Issue: 1 Pages: 119-129
  • DOI: 10.4049/jimmunol.1701056
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 樹状細胞による腸管免疫恒常性維持機構 (2017)
  • Author(s): 大田友和、改正恒康
  • Journal Title: 実験医学 Volume: 35 Pages: 1103-1109
• [Journal Article] 樹状細胞 (2017)
  • Author(s): 改正恒康
  • Journal Title: 臨床免疫・アレルギー科 Volume: 67 Pages: 606-611
  • NAID: 40021232347
• [Presentation] Impaired development of myeloid cells in mice carrying a patient-derived proteasome subunit mutation. (2020)
  • Author(s): 邊見弘明、折茂貴是、佐々木泉、加藤喬、大田(福田)有里、金城紀子、濱田聡、木下晃、吉浦孝一郎、大西秀典、金澤伸雄、改正恒康
  • Organizer: 第3回日本免疫不全・自己炎症学会総会・学術集会
  • Invited
• [Presentation] Novel proteasome-related autoinflammation and immunodeficiency disease caused by a distinct heterozygous missense mutation in the PSMB9 gene. (2019)
  • Author(s): N. Kanazawa, Y. Nakatani, Y. Inaba, K. Kunimoto, N. Kinjo, S. Hamada, T. Mizushima, A. Kinoshita, K. Yoshiura, J. Hamazaki, S. Murata, H. Ohnishi, T. Orimo, H. Hemmi, T. Kaisho
  • Organizer: The 44th Annual Meeting of the Japanese Society for Investigative Dermatology
  • Invited
• [Presentation] 乳児期から発熱と凍瘡様皮疹を反復し、新規のインターフェロン調節遺伝子異常が疑われた親子例 (2019)
  • Author(s): 本田尭、土橋隆俊、番場正博、大方詩子、渡辺絵美子、宮川俊一、杉浦仁、稲葉豊、神人正寿、井澤和司、邊見弘明、改正恒康、三嶋博之、木下晃、吉浦孝一郎、金澤伸雄
  • Organizer: 第2回日本免疫不全・自己炎症学会総会・学術集会
  • Invited
• [Presentation] 複合免疫不全症を来す新規LIG4症候群モデルマウスは炎症性腸疾患を自然発症する (2019)
  • Author(s): 田村志宣、山下友佑、大田（福田）有里、小笹俊哉、金澤伸雄、安岡弘直, 邊見弘明, 大島孝一、改正恒康、園木孝志
  • Organizer: 第59回リンパ網内系学会
  • Invited
• [Presentation] コレラ毒素Bサブユニットは細胞内病原体センサーNLRP3とPyrinを介して炎症性サイトカインIL-1βの産生を誘導する (2019)
  • Author(s): 佐々木泉、折茂貴是、邊見弘明、古川鋼一、改正恒康
  • Organizer: 第29回日本樹状細胞研究会
  • Invited
• [Presentation] ヒト疾患由来プロテアソームサブユニット突然変異導入マウスにおける樹状細胞分化障害 (2019)
  • Author(s): 邊見弘明、小笹俊哉、加藤喬、折茂貴是、大田（福田）有里、金澤伸雄、改正恒康
  • Organizer: 第29回日本樹状細胞研究会
  • Invited
• [Presentation] Lig4遺伝子改変マウスを用いた腸管免疫寛容破綻の病態解明 (2019)
  • Author(s): 田村志宣、山下友佑、折茂貴是、大田（福田）有里、小笹俊哉、中嶋一貴、金澤伸雄、邊見弘明、大島孝一、改正恒康、園木孝志
  • Organizer: 第47回日本臨床免疫学会総会
  • Invited
• [Presentation] 実験的自己免疫性脳脊髄炎の病態形成における腸管免疫系の重要性の検証 (2019)
  • Author(s): 込山星河、江川愛子、高橋大輔、改正恒康、長谷耕二
  • Organizer: 日本薬学会関東支部会
  • Invited
• [Presentation] コレラ毒素Bサブユニットによる炎症性サイトカインIL-1β産生誘導機構 (2019)
  • Author(s): 佐々木泉、折茂貴是、邊見弘明、土屋慧馬、井上正一、熊谷直光、古川鋼一、改正恒康
  • Organizer: 第26回日本免疫毒性学会学術年会
  • Invited
• [Presentation] Akimichi Morita, Sayuri Yamazaki.Successful treatment of psoriatic inflammation improves hyperglycemia in humans and mice. (2019)
  • Author(s): M. Odanaka, K. Ikumi, H. Shime, M. Imai, E. Nishida, H. Hemmi, T. Kaisho
  • Organizer: 第48回日本免疫学会総会・学術集会記録
  • Invited
• [Presentation] Defective dendritic cell and monocyte development in proteasome subunit mutant miceDefective dendritic cell and monocyte development in proteasome subunit mutant mice. (2019)
  • Author(s): H. Hemmi, T. Orimo, I. Sasaki, T. Kato, Y. Fukuda-Ohta, N. Kinjo, S. Hamada, A. Kinoshita, K. Yoshiura, H. Ohnishi, N. Kanazawa, T. Kaisho.
  • Organizer: 第48回日本免疫学会総会・学術集会記録
  • Invited
• [Presentation] Roles of endoplasmic reticulum stress in cholera toxinB-induced interleukine-1β production from resident peritoneal macrophages. (2019)
  • Author(s): I. Sasaki, S. Morita, D. Okuzaki, T. Orimo, H. Hemmi, K. Furukawa, T. Kaisho.
  • Organizer: 第48回日本免疫学会総会・学術集会記録
  • Invited
• [Presentation] Novel proteasome-related autoinflammation and immunodeficiency disease caused by a distinct heterozygous missense mutation in the PSMB9 gene. (2019)
  • Author(s): N. Kanazawa, N. Kinjo, S. Hamada, T. Mizushima, A. Kinoshita, K. Yoshiura, J. Hamazaki, S. Murata, H. Ohnishi, T. Orimo, H. Hemmi, T. Kaisho.
  • Organizer: 第48回日本免疫学会総会・学術集会記録
  • Invited
• [Presentation] Generation and analysis of mice carrying a novel heterozygous missense mutation of a protease subunit, PSMB9, in patients with autoinflammation and immunodeficiency. (2019)
  • Author(s): H. Hemmi, N. Kanazawa, N. Kinjo, S. Hamada, H. Ohnishi, T. Mizushima, A. Kinoshita, K.-I. Yoshiura, T. Kaisho.
  • Organizer: The 10th Biannual Meeting of the International Society of Systemic Auto-Inflammatory Diseases (ISSAID).
  • Int'l Joint Research
• [Presentation] A case of neonatal-onset proteasome-associated autoinflammation and immunodeficiency disease resembling but distinct from Nakajo-Nishimura syndrome. (2019)
  • Author(s): Kinjo, S. Hamads, K. Nakanishi, H. Mishima, A. Kinoshita, K.-I. Yoshiura, T. Mizushima, J. Hamazaki, S. Murata, H. Hemmi, T. Kaisho, N. Kanazawa.
  • Organizer: The 10th Biannual Meeting of the International Society of Systemic Auto-Inflammatory Diseases (ISSAID).
  • Int'l Joint Research
• [Presentation] Regulatory T cells with a distinctive feature expand through dermal dendritic cells in the ultraviolet B exposed skin. (2019)
  • Author(s): S. Yamazaki, M. Odanaka, H. Shime, M. Imai, H. Hemmi, T. Kaisho, N. Ohkura, S. Sakaguchi, A. Morita.
  • Organizer: 16th International Workshop on Langerhans Cells
  • Int'l Joint Research
• [Presentation] Sox8 is essential for the maturation of M cells and accelerates IgA response at the early stage after weaning. (2019)
  • Author(s): N. Kobayashi, S. Kimura, Y. Nakamura, T. Kanaya, T. Kaisho, H. Ohno, T. Iwanaga, K. Hase
  • Organizer: The 18th Awaji International Forum on Infection and Immunity.
  • Int'l Joint Research
• [Presentation] Cholera toxin B can induce interleukine-1β production from resident peritoneal macrophages in synergy with lipopolysaccharides. (2019)
  • Author(s): I. Sasaki, T. Orimo, H. Hemmi, K. Furukawa, T. Kaisho.
  • Organizer: The 18th Awaji International Forum on Infection and Immunity.
  • Int'l Joint Research
• [Presentation] ケモカイン受容体XCR1を発現する樹状細胞サブセットによる免疫制御 (2019)
  • Author(s): 改正恒康
  • Organizer: 近畿大学薬学部
  • Invited
• [Presentation] Analysis of mice carrying a novel mutation in a proteasome subunit gene identifed in an autoinammatory disease patient (2019)
  • Author(s): 金澤伸雄、小笹俊哉、邊見弘明、加藤喬、折茂貴是、佐々木泉、福田(大田)有里、改正恒康、木下晃、吉浦孝一郎、金城紀子、水島恒裕
  • Organizer: 第2回日本免疫不全・自己炎症学会総会・学術集会
  • Invited
• [Presentation] 皮膚科医に知っていただきたい樹状細胞の機能的および病理的意義 (2018)
  • Author(s): 改正恒康、邊見弘明、小笹俊哉
  • Organizer: 第117回日本日本皮膚科学会総会
  • Invited
• [Presentation] プロテアソーム関連自己炎症性症候群のマウスモデル (2018)
  • Author(s): 改正恒康、邊見弘明、金澤伸雄、加藤喬、稲葉豊、小笹俊哉
  • Organizer: 第39回日本炎症・再生学会
  • Invited
• [Presentation] Current overview of functions and development of dendritic cells (2018)
  • Author(s): Tsuneyasu Kaisho
  • Organizer: 第47回日本免疫学会総会
  • Invited
• [Presentation] 中條－西村症候群からプロテアソーム関連自己炎症/免疫不全症候群へ (2018)
  • Author(s): 金澤伸雄、中谷友美、原知之、稲葉豊、国本佳代、古川福実、神人正寿、金城紀子、水島恒裕、三嶋博之、木下晃、吉浦孝一郎、加藤喬、福田有里、邊見弘明、改正恒康
  • Organizer: 第25回分子皮膚科学フォーラム
• [Presentation] 新規LIG4遺伝子変異を導入したLIG4症候群モデルマウス A mouse model of LIG4 syndrome with novel LIG4 mutation (2018)
  • Author(s): 山下友佑、田村志宣、福田有里、小笹俊哉、金澤伸雄、邊見弘明、吉浦孝一郎、改正恒康、園木孝志
  • Organizer: 第80回日本血液学会学術集会
• [Presentation] Impaired development of dendritic cells in proteasome subunit mutant mice (2018)
  • Author(s): Hiroaki Hemmi, Toshiya Ozasa, Akira Kinoshita, Takashi Kato, Takashi Orimo, Izumi Sasaki, Yuri Fukuda-Ohta, Noriko Kinjo, Koh-Ichiro Yoshiura, Tsunehiro Mizushima,Nobuo Kanazawa, Tsuneyasu Kaisho
  • Organizer: 第47回日本免疫学会総会・学術集会記録
• [Presentation] Cholera toxin B can induce interleukine-1β production in peritoneal macrophages through activation of pyrin inflammasome (2018)
  • Author(s): Izumi Sasaki, Takashi Orimo, Hiroaki Hemmi, Toshiya Ozasa, Yuri Fukuda-Ohta, Mio Morinaka, Shinji Fukuda, Koichi Furukawa, Etsushi Kuroda, Ken J. Ishii, Tsuneyasu Kaisho
  • Organizer: 第47回日本免疫学会総会・学術集会記録
• [Presentation] The mechanism of action of Spi-B in transcriptional activation of the interferon-α4 gene (2018)
  • Author(s): Ryo Miyazaki, Hiroyuki Saiga, Tsuneyasu Kaisho, Katsuaki Hoshino.
  • Organizer: 第47回日本免疫学会総会・学術集会記録
• [Presentation] Cancer Vaccine Composed of Whole Tumor Cells Genetically Modified to Secrete the XCL1 (2018)
  • Author(s): Atsushi Miyamoto, Hemmi Hiroaki, Yuki Mizumoto, Masahiro Katsuda, Yuri Ohta,Katsuaki Hoshino, Hiroki Yamaue, Tsuneyasu Kaisho.
  • Organizer: 第47回日本免疫学会総会・学術集会記録
• [Presentation] Dendritic cells expressing a unique set of genes associated with immunological tolerance are specialized to expand thymus-derived Foxp3+ regulatory T cells in the ultraviolet B-exposed skin (2018)
  • Author(s): Sayuri Yamazaki, Mizuyu Odanaka, Akiko Nishioka, Hiroaki Shime, Hiroaki Hemmi,Masaki Imai, Tsuneyasu Kaisho, Naganari Ohkura, Shimon Sakaguchi, Akimichi Morita
  • Organizer: 第47回日本免疫学会総会・学術集会記録
• [Presentation] Hyperglycemia is associated with psoriatic inflammation in both humans and mice (2018)
  • Author(s): Mizuyu Odanaka, Kyoko Ikumi, Hiroaki Shime, Masaki Imai, Hiroaki Hemmi, Tsuneyasu Kaisho, Akimichi Morita, Sayuri Yamazaki
  • Organizer: 第47回日本免疫学会総会・学術集会記録
• [Presentation] Sox8 is essential for the differentiation of M cells and antigen-specific IgA response (2018)
  • Author(s): Nobuhide Kobayashi, Shunsuke Kimura, Yutaka Nakamura, Takashi Kanaya, Tsuneyasu Kaisho, Hiroshi Ohno, Koji Hase
  • Organizer: 第47回日本免疫学会総会・学術集会記
• [Presentation] Osteoprotegerin-dependent M-cell self-regulation balances gut infection and immunity (2018)
  • Author(s): Shunsuke Kimura, Yutaka Nakamura, Nobuhide Kobayashi, Tsuneyasu Kaisho, Koji Hase
  • Organizer: 第47回日本免疫学会総会・学術集会記録
• [Presentation] M-cell-dependent antigen uptake mitigates infectious colitis by shaping mucosal barrier function (2018)
  • Author(s): Yutaka Nakamura, Hitomi Mimuro, Jun Kunisawa, Tsuneyasu Kaisho, Hiroshi Kiyono, Koji Hase
  • Organizer: 第47回日本免疫学会総会・学術集会記録
• [Presentation] A case of neonatal-onset proteasome-associated autoinflammatory syndrome resembling but distinct from Nakajo-Nishimura syndrome (2018)
  • Author(s): Noriko Kinjo, Hiroyuki Mishima, Akira Kinoshita, Koh-Ichiro Yoshiura,Tsunehiro Mizushima, Jun Hamazaki, Shigeo Murata, Hiroaki Hemmi, Tsuneyasu Kaisho,Nobuo Kanazawa
  • Organizer: 第47回日本免疫学会総会・学術集会記録
• [Presentation] Analysis of mice carrying a novel mutation in a proteasome subunit gene identified in anautoinflammatory disease patient (2018)
  • Author(s): Toshiya Ozasa, Hiroaki Hemmi, Akira Kinoshita, Takashi Kato, Takashi Orimo, Izumi Sasaki, Yuri Fukuda-Ohta, Noriko Kinjo, Koh-Ichiro Yoshiura, Tsunehiro Mizushima, Nobuo Kanazawa, Tsuneyasu Kaisho
  • Organizer: 第47回日本免疫学会総会・学術集会記録
• [Presentation] XCR1+DCへの選択的な送達を目的とした新規抗がんワクチンの開発 (2018)
  • Author(s): 宮本篤、勝田将裕、邊見弘明、宮澤基樹、北畑裕司、水本有紀、小林良平、改正恒康、山上裕機
  • Organizer: 第46回和歌山悪性腫瘍研究会
• [Presentation] CRISPR/Cas9による腫瘍上のPD-L1欠損はマウス卵巣癌モデルにおいて抗腫瘍免疫を促進し、腫瘍進展を抑制する (2018)
  • Author(s): 八幡環、岩橋尚幸、野口智子、溝口美佳、東嶋左緒里、改正恒康、近藤稔和、井篦一彦
  • Organizer: 第46回和歌山悪性腫瘍研究会
• [Presentation] Immune regulation by a dendritic cell subset expressing a chemokine receptor, XCR1 (2018)
  • Author(s): Tsuneyasu Kaisho
  • Organizer: 15th International Symposium on Dendritic Cells
  • Int'l Joint Research / Invited
• [Presentation] Foxp3+ regulatory T cells are expanded by ultraviolet B-exposed PD-L1+ skin dendritic cell expressing a unique set of genes in a CSF1-independent manner (2018)
  • Author(s): Sayuri Yamazaki, Mizuyu Odanaka, Hiroaki Shime, Masaki Imai, Akiko Nishioka, Saori Kasuya, Dieter Riethmacher, Hiroaki Hemmi, Tsuneyasu Kaisho, Naganari Ohkura, Shimon Sakaguchi, Akimichi Morita
  • Organizer: International Investigative Dermatology 2018
  • Int'l Joint Research
• [Presentation] Successful treatment of psoriatic inflammation restores hyperglycemia (2018)
  • Author(s): Kyoko Ikumi, Mizuyu Odanaka, Hiroaki Shime, Masaki Imai, Osamu Taguchi, Hiroaki Hemmi, Tsuneyasu Kaisho, Sayuri Yamazaki, Akimichi Morita
  • Organizer: International Investigative Dermatology 2018
  • Int'l Joint Research
• [Presentation] Time-resolved systems analysis of virus infection fate regulation: the XCL1-XCR1 communication axis links T cell exhaustion with effector maintenance (2018)
  • Author(s): J. Argilaguet, M. Pedragosa, A. Esteve-Codina, G. Riera, E. Vidal, C. Peligero-Cruz, D. Andreu, T. Kaisho, G. Bocharov, B. Ludewig, S. Heath, A. Meyerhans
  • Organizer: 15th International Symposium on Dendritic Cells
  • Int'l Joint Research
• [Presentation] Mast Cells Are Crucial for Induction of Group 2 Innate Lymphoid Cells and Clearance of Helminth Infections (2018)
  • Author(s): Chikako Shimokawa, Takashi Kanaya, Masami Hachisuka, Kenji Ishiwata, Hajime Hisaeda, Yosuke Kurashima, Hiroshi Kiyono, Tomohiro Yoshimoto, Tsuneyasu Kaisho, Hiroshi Ohno
  • Organizer: The 3rd International Conference on Innate Lymphoid Cells (ILC2018)
  • Int'l Joint Research
• [Presentation] Spi-Bは圧負荷による心不全の病態形成において炎症と線維化を抑制して保護的に機能する (2017)
  • Author(s): 1.木村章彦、福田有里、加藤喬、佐々木泉、改正恒康、近藤稔和
  • Organizer: 第38回日本炎症・再生医学会
• [Presentation] 樹状細胞サブセットに注目したがんペプチドワクチンの開発 (2017)
  • Author(s): 2.水本有紀、勝田将裕、宮澤基樹、北畑裕司、宮本篤、中森幹人、松田健司、尾島敏康 早田啓治、邊見弘明、改正恒康、山上裕機
  • Organizer: 第38回 癌免疫外科研究会
• [Presentation] 粘膜感染防御における腸管特殊上皮M細胞の役割の解明 (2017)
  • Author(s): 中村有孝、國澤純、改正恒康、清野宏、長谷耕二
  • Organizer: 第160回日本獣医学会学術集会
• [Presentation] がん抗原ペプチドの生体内樹状細胞サブセット送達によるワクチン療法の開発 (2017)
  • Author(s): 4.水本有紀、勝田将裕、宮澤基樹、北畑裕司、宮本篤、中森幹人、尾島敏康、松田健司、早田啓治、邊見弘明、改正恒康、山上裕機
  • Organizer: 第30回日本バイオセラピィ学会学術集会総会
• [Presentation] An Ets family member, Ets2 is required for Cholera toxin-induced arginase-1 gene expression. (2017)
  • Author(s): K. Negoro, M. Tane, M. Morinaka, Y. Fukuda, I. Sasaki, T. Kaisho
  • Organizer: 第46回日本免疫学会総会学術集会記録
• [Presentation] Roles of arginine and methionine metabolism in cholera toxin-induced adjuvant effects. (2017)
  • Author(s): I. Sasaki, T. Orimo, H. Hemmi, T. Ozasa, Y. Fukuda, S. Fukuda, T. Kaisho.
  • Organizer: 第46回日本免疫学会総会学術集会記録
• [Presentation] Spi-C inhibits expression of a subset of Toll-like receptor 4-inducible genes in intestinal CX3CR1high macrophages and prevents colonic inflammation. (2017)
  • Author(s): H. Kayama, M. Kohyama, H. Arase, T. Kaisho, K. Takeda.
  • Organizer: 第46回日本免疫学会総会学術集会記録
• [Presentation] Decline of lysyl oxidase protein causes acute aortic dissection in Spi-B knockout mice. (2017)
  • Author(s): A. Taruya, A. Kimura, Y. Ishida, M. Nosaka, K. Yumi, I. Sasaki, T. Kaisho, T. Kondo.
  • Organizer: 第46回日本免疫学会総会学術集会記録
• [Presentation] Spi-B plays a protective role in pressure overload-induced heart failure through attenuation of cardiac inflammation. (2017)
  • Author(s): 1.A. Kimura, Y. Ihida, M. Nosaka, I. Sasaki, H. Yamamoto, Y. Kuninaka, T. Kato, Y. Fukuda, T. Kaisho, T. Kondo.
  • Organizer: 22nd World Congress Heart Disease
  • Int'l Joint Research
• [Remarks] 新規抗がんワクチン開発 県立医大が成果を発表
  • URL: https://www.wakayamashimpo.co.jp/2020/03/20200317_92750.html
• [Remarks] 県立医科大研究チームが新がんワクチン開発
  • URL: https://www.hidakashimpo.co.jp/news1/2020/03
• [Remarks] 抗がん活性の強い樹状細胞へがん抗原ペプチドを選択的に送達させる新規抗がんワクチンの開発
  • URL: https://research-er.jp/articles/view/87282
• [Remarks] 和歌山県立医科大学 先端医学研究所 生体調節機構研究部
  • URL: http://www.wakayama-med.ac.jp/med/seitai/index.php