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Establishment and evaluation of the information environment for patients and donors to participate in pre- and post-liver transplant care

Research Project

Project/Area Number 17H04095
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Medical sociology
Research InstitutionKansai Medical University (2019)
Kyoto University (2017-2018)

Principal Investigator

YAMASHIKI Noriyo  関西医科大学, 医学部, 講師 (90420215)

Co-Investigator(Kenkyū-buntansha) 上本 伸二  京都大学, 医学研究科, 教授 (40252449)
野間 俊一  京都大学, 医学研究科, 客員研究員 (40314190)
海道 利実  京都大学, 医学研究科, 准教授 (80314194)
上田 佳秀  京都大学, 医学研究科, 講師 (90378662)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Fiscal Year 2019: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2018: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2017: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywordsチーム医療 / 移植医療学 / 受療行動 / スマートフォンアプリ / 肝移植ドナー / アルコール性肝硬変 / 移植医療額 / バイオエシックス / 消化器内科学
Outline of Final Research Achievements

We developed a mobile application to support medical care using smartphone for living liver donor candidates. The web-based mobile application was well accepted by the living liver donor candidates and potentially helped them understand the donor evaluation process and reduce anxiety. Based on the experience of this study, it was thought that the combination of tools utilizing mobile electronic devices with hands-on medical care would be useful in creating a better information environment for patients.
For patients with alcoholic liver disease, which is increasing indication for liver transplantation in recent years, participation in an abstinence program by psychiatrists and allied health care providers has been shown to reduce post-transplant relapse drinking. It was thought that further study would be desirable to develop a versatile treatment guideline that includes self-help program with improved accessibility.

Academic Significance and Societal Importance of the Research Achievements

診療ニーズに即したモバイルアプリケーションを開発・導入することで、実臨床において患者の支援につながることが示され、国内・国際学会で報告し、その成果を現在論文投稿中である。本研究で作成したiPhoneアプリケーションについては、現在Appストアで公開されている。アルコール性肝疾患に関する検討の成果についても学会報告・論文報告を行った。また本研究の成果の一部については「肝移植内科研究会・成果報告会」を主催し(令和1年7月25日キャンパスプラザ京都)、国内外11大学から16名の消化器肝臓内科医が参加し、近年の移植適応についての変更点や、肝移植診療における消化器肝臓内科医の役割について議論した。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (18 results)

All 2020 2019 2018 2017 Other

All Int'l Joint Research (1 results) Journal Article (5 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 5 results,  Open Access: 2 results) Presentation (12 results) (of which Int'l Joint Research: 3 results)

  • [Int'l Joint Research] Mahidol University(タイ)

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Use of Nakanuma staging and cytokeratin 7 staining for diagnosing recurrent primary biliary cholangitis after living‐donor liver transplantation2020

    • Author(s)
      Yamashiki Noriyo、Haga Hironori、Ueda Yoshihide、Ito Takashi、Yagi Shintaro、Kamo Naoko、Hata Koichiro、Mori Akira、Kaido Toshimi、Okajima Hideaki、Uemoto Shinji
    • Journal Title

      Hepatology Research

      Volume: 50 Issue: 4 Pages: 478-487

    • DOI

      10.1111/hepr.13476

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Alcohol relapse and its predictors after liver transplantation for alcoholic liver disease: a systematic review and meta-analysis2019

    • Author(s)
      Chuncharunee Lancharat、Yamashiki Noriyo、Thakkinstian Ammarin、Sobhonslidsuk Abhasnee
    • Journal Title

      BMC Gastroenterology

      Volume: 19 Issue: 1

    • DOI

      10.1186/s12876-019-1050-9

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 当院におけるアルコール性肝硬変に対する肝移植後の有害再飲酒予防への取組み.2019

    • Author(s)
      山敷宣代、野間俊一、梅谷由美、石橋朋子、糀谷康子、八木真太郎、岡島英明、海道利実、上本伸二.
    • Journal Title

      日本アルコール関連問題学会雑誌

      Volume: 1 Pages: 206-211

    • NAID

      40022194199

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical Outcomes after Liver Transplantation for Hepatorenal Syndrome: A Systematic Review and Meta-Analysis.2018

    • Author(s)
      Utako P, Emyoo T, Anothaisintawee T, Yamashiki N, Thakkinstian A, Sobhonslidsuk A.
    • Journal Title

      Biomed Res Int

      Volume: - Pages: 1-8

    • DOI

      10.1155/2018/5362810

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The use of hepatitis B immunoglobulin with or without hepatitis B vaccine to prevent de novo hepatitis B in pediatric recipients of anti-HBc-positive livers.2018

    • Author(s)
      Yamashiki N, Yoshizawa A, Ueda Y, Kaido T, Okajima H, Marusawa H, Seno H, Uemoto S.
    • Journal Title

      Pediatr Transplant

      Volume: 22 Issue: 5

    • DOI

      10.1111/petr.13227

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Presentation] アルコール性肝硬変に対する肝移植の適応評価の現状2019

    • Author(s)
      山敷宣代、海道利実、上本伸二
    • Organizer
      第55回日本肝臓学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] アルコール性肝硬変に対する肝移植の適応評価時における介入と内科的諸問題2019

    • Author(s)
      山敷宣代、野間俊一、上田佳秀、白井久也 、福光剣、伊藤孝司、八木真太郎、秦浩一、梅谷由美、石橋朋子、糀谷康子、岡島英明、海道利実、上本伸二
    • Organizer
      第37回日本肝移植学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] アルコール性肝硬変に対する肝移植患者における飲酒習慣とALDH2一塩基多型との関連2019

    • Author(s)
      山敷宣代、海道利実、上本伸二
    • Organizer
      JDDW2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] Relapse rate of habitual alcohol use may be affected by donor’s ALDH2 polymorphism after living donor liver transplantation for alcoholic cirrhosis.2019

    • Author(s)
      Yamashiki N, Ueda Y, Noma S, Kaido T, Uemoto S.
    • Organizer
      The Liver Meeting 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] アルコール性肝疾患に対する肝移植後長期予後と再飲酒予防への取り組み.2018

    • Author(s)
      山敷宣代、野間俊一、上田佳秀、白井久也、福光剣、伊藤孝司、八木真太郎、吉澤淳、秦浩一郎、梅谷由美、石橋朋子、糀谷康子、岡島英明、海道利実、上本伸二.
    • Organizer
      第36回日本肝移植研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 肝移植後の原発性胆汁性胆管炎再発診断におけるNakanumaらの組織学的病期分類およびCK7染色の有用性の検討2018

    • Author(s)
      山敷宣代, 羽賀博典, 上田佳秀, 吉澤淳, 八木真太郎, 秦浩一郎, 森章, 岡島英明, 海道利実, 上本伸二.
    • Organizer
      第54日本肝臓学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Development of a mobile application for living liver donors to assist their understandings of a series of preoperative tests.2018

    • Author(s)
      Yamashiki N, Ishibashi T, Umeya Y, Uehara M, Noma S, Okajima H, Kaido T, Uemoto S
    • Organizer
      The 27th Congress of The Transplantation Society
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Alcohol relapse and its predictors after liver transplantation for alcoholic liver disease a systematic review and meta-analysis.2018

    • Author(s)
      Chuncharunee L, Yamashiki N, Thakkinstian A, Sobhonslidsuk A
    • Organizer
      DDW 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 肝移植実施施設における消化器肝臓内科医の役割.2018

    • Author(s)
      山敷宣代, 上田佳秀, 上本伸二
    • Organizer
      第54回日本移植学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 当院におけるアルコール性肝疾患に対する肝移植後の有害再飲酒予防への取組み.2018

    • Author(s)
      山敷宣代, 野間俊一, 梅谷由美, 石橋朋子, 糀谷康子, 八木真太郎, 岡島英明, 海道利実, 上本伸二
    • Organizer
      第40回日本アルコール関連問題学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 当院における肝移植後B型肝炎再活性化対策と成績2017

    • Author(s)
      山敷宣代、上田佳秀、上本伸二
    • Organizer
      JDDW2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] 肝移植におけるチーム医療の実践と有用性2017

    • Author(s)
      海道利実
    • Organizer
      第53回日本移植学会
    • Related Report
      2017 Annual Research Report

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Published: 2017-04-28   Modified: 2021-02-19  

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