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Transplantation study of iPS cell-derived cardiomyocytes in non-human primates

Research Project

Project/Area Number 17H04173
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Cardiovascular medicine
Research InstitutionShinshu University

Principal Investigator

Shiba Yuji  信州大学, 学術研究院医学系, 教授 (70613503)

Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2020: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2019: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2018: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Keywords再生医療 / 多能性幹細胞 / 心不全 / iPS細胞 / 心筋再生 / 虚血性心疾患 / 心筋梗塞 / 循環器内科学 / 再生医学
Outline of Final Research Achievements

We performed three experiments itemized below to facilitate cardiac regeneration with iPS cell-derived cardiomyocytes (iPSC-CMs).
1) Autologous transplantation study of iPSC-CMs in chronic infarct model of non-human primates: We have generated iPS cell lines from six animals and generated cardiomyocytes. 2) Establishment of immunosuppression protocol following iPSC-CMs: We generated monkey iPS cell lines expressing AKaluc for bioluminescent imaging. 3) Transplantation study of iPSC-derived ventricular cardiomyocytes to control post-transplantation arrhythmia: We transplanted iPSC-ventricular CMs into 5 monkeys and found that the recipients tended to show less incidence of ventricular arrhythmia compared to those transplatned with iPSC-CMs

Academic Significance and Societal Importance of the Research Achievements

心不全は患者数、死亡率ともに高く、心臓移植以外の根本的治療の開発が必要である。多能性幹細胞(ES細胞またはiPS細胞)を用いた心筋再生治療が期待され、複数の研究機関で臨床試験が開始されている。しかし、この治療が標準的な治療として定着するためには多くの課題が残されている。本研究成果により、より有効で安全性の高い心筋再生治療の開発が期待される。

Report

(5 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (17 results)

All 2021 2020 2019

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 4 results) Presentation (13 results) (of which Int'l Joint Research: 4 results,  Invited: 13 results)

  • [Journal Article] Pluripotent Stem Cells for Cardiac Regeneration ― Current Status, Challenges, and Future Perspectives ―2020

    • Author(s)
      Shiba Yuji
    • Journal Title

      Circulation Journal

      Volume: 84 Issue: 12 Pages: 2129-2135

    • DOI

      10.1253/circj.CJ-20-0755

    • NAID

      130007942529

    • ISSN
      1346-9843, 1347-4820
    • Year and Date
      2020-11-25
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Increased predominance of the matured ventricular subtype in embryonic stem cell-derived cardiomyocytes in vivo2020

    • Author(s)
      Ichimura Hajime、Kadota Shin、Kashihara Toshihide、Yamada Mitsuhiko、Ito Kuniaki、Kobayashi Hideki、Tanaka Yuki、Shiba Naoko、Chuma Shinichiro、Tohyama Shugo、Seto Tatsuichiro、Okada Kenji、Kuwahara Koichiro、Shiba Yuji
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 11883-11883

    • DOI

      10.1038/s41598-020-68373-9

    • NAID

      120007006223

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Heart regeneration using pluripotent stem cells2020

    • Author(s)
      Kadota Shin、Tanaka Yuki、Shiba Yuji
    • Journal Title

      Journal of Cardiology

      Volume: 76 Issue: 5 Pages: 459-463

    • DOI

      10.1016/j.jjcc.2020.03.013

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pluripotent stem cell-derived cardiomyocyte transplantation for heart disease treatment.2019

    • Author(s)
      Kadota Shin, Shiba Yuji
    • Journal Title

      Curr Cardiol Rep.

      Volume: 21 Issue: 8 Pages: 73-73

    • DOI

      10.1007/s11886-019-1171-3

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Cardiac Regeneration via Pluripotent Stem Cells.2021

    • Author(s)
      Shiba Yuji
    • Organizer
      Myocardial Ischemia Symposium in Korea 2021
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 霊長類を用いた心筋再生治療の開発2021

    • Author(s)
      柴 祐司
    • Organizer
      第20回日本再生医療学会総会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Primate model for allogeneic transplantation study of iPS cell-derived cardiomyocytes.2021

    • Author(s)
      柴 祐司
    • Organizer
      第85回日本循環器学会学術集会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] iPS細胞を用いた心筋梗塞治療2020

    • Author(s)
      柴 祐司
    • Organizer
      第19回日本再生医療学会総会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Preclinical transplantation studies of pluripotent stem cell-derived cardiomyocytes for cardiac repair.2020

    • Author(s)
      Shiba Yuji
    • Organizer
      Myocardial Ischemia Symposium in Korea 2020
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Cardiac Regeneration with Pluripotent Stem Cells : A New Paradigm2020

    • Author(s)
      柴 祐司
    • Organizer
      第84回日本循環器学会学術集会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Monkey model-based development of cardiomyocyte regeneration therapy.2020

    • Author(s)
      柴 祐司
    • Organizer
      第84回日本循環器学会学術集会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Allogenic translation study of pluropotent stem cell-derived cardiomyocytes in non-human primate.2020

    • Author(s)
      柴 祐司
    • Organizer
      第24回日本心不全学会学術集会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] iPS細胞による心臓再生への挑戦2019

    • Author(s)
      柴 祐司
    • Organizer
      第30回日本医学会総会 2019 中部
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 多能性幹細胞を用いた心筋再生:霊長類を用いた前臨床試験2019

    • Author(s)
      柴 祐司
    • Organizer
      第67回日本心臓病学会学術集会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] ヒト以外の霊長類へのiPS細胞由来心筋細胞の移植に関する前臨床研究2019

    • Author(s)
      柴 祐司
    • Organizer
      Cell & Gene Therapy Asia 2019
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Stem cell and regenerative medicine.2019

    • Author(s)
      Shiba Yuji
    • Organizer
      The 12th APHRS Scientific Scession 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Preclinical transplantation study of iPS cell-derived cardiomyosytes in non-human primate.2019

    • Author(s)
      Shiba Yuji
    • Organizer
      The 1st Zhangjiang International Summit on Cell Therapy 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited

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Published: 2017-04-28   Modified: 2022-01-27  

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