Elucidation of the effects of anti-diabetes and anti-complications by activation of heat shock response pathway and translation for clinical application

• Project/Area Number: 17H04201
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Metabolomics
• Research Institution: Kumamoto University
• Principal Investigator: Araki Eiichi 熊本大学, 大学院生命科学研究部(医), 教授 (10253733)
• Co-Investigator(Kenkyū-buntansha): 近藤 龍也 熊本大学, 病院, 講師 (70398204)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000); Fiscal Year 2019: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2018: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000); Fiscal Year 2017: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
• Keywords: 糖尿病 / 慢性炎症 / インスリン抵抗性 / 脂肪肝 / 細胞内ストレス / 熱ストレス応答経路 / 熱応答性経路 / インスリン分泌不全

Outline of Final Research Achievements

The heat shock response (HSR) is a highly conserved biological defense and adaptation system from bacteria to human beings that responds not only to temperature changes but also to external stresses such as virus infection, ultraviolet or radiation exposure. As a result, it produces the heat shock protein (HSP) and contributes to cell and organ protection. HSR decreases its activity in chronic inflammation and chronic high glucose in diabetes, and causes a decline in the biological function of maintaining normal glucose tolerance. On the other hand, activation of HSP by various methods shows anti-diabetic effects such as enhancement of insulin sensitivity, improvement of glucose tolerance, reduction of visceral fat, and improvement of fatty liver. In our study, we showed that reduction of HSP in the whole body causes diabetes, and restoration of HSP72 expression in liver specifically can improve almost all systemic abnormal glucose metabolism.

Academic Significance and Societal Importance of the Research Achievements

HSR活性化をもたらす方法には薬物療法に加えて、我々独自の物理的HSR活性化療法がある。この方法は体外から温熱と特殊な微弱電流を併用施行することで、HSR活性化をもたらし糖代謝をヒト及びモデル動物で改善すること示されている。この作用機序における最も重要な臓器は肝臓であり肝臓特異的にHSP増強することで全身的耐糖能が改善する。

Research Products

• [Journal Article] Clinical Features of Patients with Acute Aortic Dissection After an Earthquake ～Experience from The Kumamoto Earthquake 2016～ (2020)
  • Author(s): Komorita Takashi、Fujisue Koichiro、Sueta Daisuke、Sakamoto Kenji、Yamamoto Eiichiro、Hashimoto Yoichiro、Sakamoto Tomohiro、Tsunoda Ryusuke、Uesugi Hideyuki、Suzuki Ryusuke、Naito Hisaki、Hanzawa Kazuhiko、Araki Eiichi、Nakayama Hideki、Kasaoka Shunji、Hokimoto Seiji、Fukui Toshihiro、Tsujita Kenichi
  • Journal Title: American Journal of Hypertension Volume: 33 (3) Issue: 3 Pages: 261-268
  • DOI: 10.1093/ajh/hpz183
  • Peer Reviewed / Open Access
• [Journal Article] Inhibition of inflammation-mediated DPP-4 expression by linagliptin increases M2 macrophages in atherosclerotic lesions (2020)
  • Author(s): Nishida Shuhei、Matsumura Takeshi、Senokuchi Takafumi、Murakami-Nishida Saiko、Ishii Norio、Morita Yutaro、Yagi Yoshitaka、Motoshima Hiroyuki、Kondo Tatsuya、Araki Eiichi
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 524 Issue: 1 Pages: 8-15
  • DOI: 10.1016/j.bbrc.2020.01.027
  • Peer Reviewed / Open Access
• [Journal Article] Pharmacokinetics and pharmacodynamics of dapagliflozin in combination with insulin in Japanese patients with type 1 diabetes (2019)
  • Author(s): Watada Hirotaka、Shiramoto Masanari、Ueda Shinya、Tang Weifeng、Asano Michiko、Thor?n Fredrik、Kim Hyosung、Yajima Toshitaka、Boulton David W.、Araki Eiichi
  • Journal Title: Diabetes, Obesity and Metabolism Volume: 21 Issue: 4 Pages: 876-882
  • DOI: 10.1111/dom.13593
  • Peer Reviewed / Open Access
• [Journal Article] Long-Term Efficacy and Safety of Pemafibrate, a Novel SelectivePeroxisome Proliferator-Activated Receptor-α Modulator (SPPARMα),in Dyslipidemic Patients with Renal Impairment (2019)
  • Author(s): Yokote K, Yamashita S, Arai H, Araki E, Suganami H, Ishibashi S, Of TheK-Study Group OB
  • Journal Title: Int J Mol Sci Volume: 20(3) Issue: 3 Pages: 706-706
  • DOI: 10.3390/ijms20030706
  • Peer Reviewed / Open Access
• [Journal Article] Hyperemesis gravidarum followed by refeeding syndrome causes electrolyte abnormalities induced rhabdomyolysis and diabetes insipidus (2019)
  • Author(s): Kondo Tatsuya、Nakamura Miwa、Kawashima Junji、Matsumura Takeshi、Ohba Takashi、Yamaguchi Munekage、Katabuchi Hidetaka、Araki Eiichi
  • Journal Title: Endocrine Journal Volume: 66 Issue: 3 Pages: 253-258
  • DOI: 10.1507/endocrj.EJ18-0496
  • NAID: 130007626248
  • ISSN: 0918-8959, 1348-4540
  • Peer Reviewed / Open Access
• [Journal Article] Impact of hepatic HSP72 on insulin signaling (2019)
  • Author(s): Kitano Sayaka、Kondo Tatsuya、Matsuyama Rina、Ono Kaoru、Goto Rieko、Takaki Yuki、Hanatani Satoko、Sakaguchi Masaji、Igata Motoyuki、Kawashima Junji、Motoshima Hiroyuki、Matsumura Takeshi、Kai Hirofumi、Araki Eiichi
  • Journal Title: American Journal of Physiology-Endocrinology and Metabolism Volume: 316 Issue: 2 Pages: E305-E318
  • DOI: 10.1152/ajpendo.00215.2018
  • Peer Reviewed / Open Access
• [Journal Article] Efficacy and safety of pemafibrate in people with type 2 diabetes and elevated triglyceride levels: 52‐week data from the PROVIDE study (2019)
  • Author(s): Araki Eiichi、Yamashita Shizuya、Arai Hidenori、Yokote Koutaro、Satoh Jo、Inoguchi Toyoshi、Nakamura Jiro、Maegawa Hiroshi、Yoshioka Narihito、Tanizawa Yukio、Watada Hirotaka、Suganami Hideki、Ishibashi Shun
  • Journal Title: Diabetes, Obesity and Metabolism Volume: 21 Issue: 7 Pages: 1737-1744
  • DOI: 10.1111/dom.13686
  • Peer Reviewed / Open Access
• [Journal Article] Mineralocorticoid Receptor May Regulate Glucose Homeostasis through the Induction of Interleukin-6 and Glucagon-Like peptide-1 in Pancreatic Islets (2019)
  • Author(s): Goto Rieko、Kondo Tatsuya、Ono Kaoru、Kitano Sayaka、Miyakawa Nobukazu、Watanabe Takuro、Sakaguchi Masaji、Sato Miki、Igata Motoyuki、Kawashima Junji、Motoshima Hiroyuki、Matsumura Takeshi、Shimoda Seiya、Araki Eiichi
  • Journal Title: Journal of Clinical Medicine Volume: 8 Issue: 5 Pages: 674-674
  • DOI: 10.3390/jcm8050674
  • Peer Reviewed / Open Access
• [Journal Article] Pioglitazone suppresses macrophage proliferation in apolipoprotein-E deficient mice by activating PPARγ (2019)
  • Author(s): Murakami-Nishida Saiko、Matsumura Takeshi、Senokuchi Takafumi、Ishii Norio、Kinoshita Hiroyuki、Yamada Sarie、Morita Yutaro、Nishida Shuhei、Motoshima Hiroyuki、Kondo Tatsuya、Komohara Yoshihiro、Araki Eiichi
  • Journal Title: Atherosclerosis Volume: 286 Pages: 30-39
  • DOI: 10.1016/j.atherosclerosis.2019.04.229
  • Peer Reviewed / Open Access
• [Journal Article] Comparison of the efficacy and safety of once-daily insulin degludec/insulin aspart (IDegAsp) and long-acting second-generation basal insulin (insulin degludec and insulin glargine 300 units/mL) in insulin-naïve Japanese adults with type 2 diabetes: a pilot, randomized, controlled study (2019)
  • Author(s): Shimoda Seiya、Sakamoto Wakana、Hokamura Ayaka、Matsuo Yasuto、Sekigami Taiji、Ichimori Shinji、Iwashita Shinsuke、Ishii Norio、Otsu Kae、Yoshimura Ryohei、Nishiyama Toshihiko、Sakaguchi Masaji、Nishida Kenro、Araki Eiichi
  • Journal Title: Endocrine Journal Volume: 66 Issue: 8 Pages: 745-752
  • DOI: 10.1507/endocrj.EJ19-0179
  • NAID: 130007696455
  • ISSN: 0918-8959, 1348-4540
  • Peer Reviewed / Open Access
• [Journal Article] Short-Term Cost-Effectiveness of Switching to Insulin Degludec in Japanese Patients With Type 2 Diabetes Receiving Basal-Bolus Therapy (2019)
  • Author(s): Jakob Langer 1, Michael L Wolden 2, Seiya Shimoda 3, Miki Sato 4, Eiichi Araki 4
  • Journal Title: Diabetes Therapy Volume: 10 (4) Issue: 4 Pages: 1347-1356
  • DOI: 10.1007/s13300-019-0635-1
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Superior efficacy with a fixed‐ratio combination of insulin degludec and liraglutide (IDegLira) compared with insulin degludec and liraglutide in insulin‐na?ve Japanese patients with type 2 diabetes in a phase 3, open‐label, randomized trial (2019)
  • Author(s): Kaku Kohei、Araki Eiichi、Tanizawa Yukio、Ross Agner Bue、Nishida Tomoyuki、Ranthe Mattis、Inagaki Nobuya
  • Journal Title: Diabetes, Obesity and Metabolism Volume: 21 Issue: 12 Pages: 2674-2683
  • DOI: 10.1111/dom.13856
  • Peer Reviewed / Open Access
• [Journal Article] Efficacy, Safety, and Tolerability of Oral Semaglutide Versus Placebo Added to Insulin With or Without Metformin in Patients With Type 2 Diabetes: The PIONEER 8 Trial (2019)
  • Author(s): Zinman Bernard、Aroda Vanita R.、Buse John B.、Cariou Bertrand、Harris Stewart B.、Hoff S?ren Tetens、Pedersen Karen Boje、Tarp-Johansen Mads Jeppe、Araki Eiichi
  • Journal Title: Diabetes Care Volume: 42 Issue: 12 Pages: 2262-2271
  • DOI: 10.2337/dc19-0898
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Differential predictive factors for cardiovascular events in patients with or without cancer history. (2019)
  • Author(s): Sueta D, Tabata N, Ikeda S, Saito Y, Ozaki K, Sakata K, Matsumura T, Yamamoto-Ibusuki M, Murakami Y, Jodai T, Fukushima S, Yoshida N, Kamba T, Araki E, Iwase H, Fujii K, Ihn H, Kobayashi Y, Minamino T, Yamagishi M, Maemura K, Baba H, Matsui K, Tsujita K.
  • Journal Title: Medicine (Baltimore). Volume: 98 Issue: 44 Pages: e17602-e17602
  • DOI: 10.1097/md.0000000000017602
  • Peer Reviewed / Open Access
• [Journal Article] Long-Term Efficacy and Safety of Linagliptin in a Japanese Population With Type 2 Diabetes Aged over 60 Years Treated With Basal Insulin: A Randomised Trial (2019)
  • Author(s): Eiichi Araki, Yuriko Unno, Yuko Tanaka, Wataru Sakamoto, Yuki Miyamoto
  • Journal Title: Advances in Therapy Volume: 36 (10) Issue: 10 Pages: 2697-2711
  • DOI: 10.1007/s12325-019-01065-7
  • Peer Reviewed / Open Access
• [Journal Article] Efficacy and Safety of Pemafibrate, a Novel Selective Peroxisome Proliferator-Activated Receptor α Modulator (SPPARMα): Pooled Analysis of Phase 2 and 3 Studies in Dyslipidemic Patients with or without Statin Combination (2019)
  • Author(s): Yamashita、Arai、Yokote、Araki、Matsushita、Nojima、Suganami、Ishibashi
  • Journal Title: International Journal of Molecular Sciences Volume: 20 Issue: 22 Pages: 5537-5537
  • DOI: 10.3390/ijms20225537
  • Peer Reviewed / Open Access
• [Journal Article] Efficacy and safety of dapagliflozin in Japanese patients with inadequately controlled type 1 diabetes (DEPICT‐5): 52‐week results from a randomized, open‐label, phase III clinical trial (2019)
  • Author(s): Araki Eiichi、Watada Hirotaka、Uchigata Yasuko、Tomonaga Osamu、Fujii Hitomi、Ohashi Hiroshi、Okabe Tadashi、Asano Michiko、Thoren Fredrik、Kim Hyosung、Yajima Toshitaka、Langkilde Anna Maria
  • Journal Title: Diabetes, Obesity and Metabolism Volume: 22 Issue: 4 Pages: 540-548
  • DOI: 10.1111/dom.13922
  • Peer Reviewed / Open Access
• [Journal Article] Efficacy and Safety of Pemafibrate Versus Fenofibrate in Patients with High Triglyceride and Low HDL Cholesterol Levels: A Multicenter, Placebo-Controlled, Double-Blind, Randomized Trial (2018)
  • Author(s): Arai Hidenori、Yamashita Shizuya、Yokote Koutaro、Araki Eiichi、Suganami Hideki、Ishibashi Shun、on behalf of the K-877 Study Group
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 25 Issue: 6 Pages: 521-538
  • DOI: 10.5551/jat.44412
  • NAID: 130007382568
  • ISSN: 1340-3478, 1880-3873
  • Year and Date: 2018-06-01
  • Peer Reviewed / Open Access
• [Journal Article] Impacts of the 2016 Kumamoto Earthquake on glycemic control in patients with diabetes (2018)
  • Author(s): Kondo Tatsuya、Miyakawa Nobukazu、Motoshima Hiroyuki、Hanatani Satoko、Ishii Norio、Igata Motoyuki、Yoshinaga Kayo、Kukidome Daisuke、Senokuchi Takafumi、Kawashima Junji、Furukawa Noboru、Matsumura Takeshi、Araki Eiichi
  • Journal Title: Journal of Diabetes Investigation Volume: 10 Issue: 2 Pages: 521-530
  • DOI: 10.1111/jdi.12891
  • Peer Reviewed / Open Access
• [Journal Article] The clinical course and pathophysiological investigation of adolescent gestational diabetes insipidus: a case report (2018)
  • Author(s): Kondo Tatsuya、Nakamura Miwa、Kitano Sayaka、Kawashima Junji、Matsumura Takeshi、Ohba Takashi、Yamaguchi Munekage、Katabuchi Hidetaka、Araki Eiichi
  • Journal Title: BMC Endocrine Disorders Volume: 18 Issue: 1 Pages: 4-4
  • DOI: 10.1186/s12902-018-0234-6
  • Peer Reviewed / Open Access
• [Journal Article] Effects of Pemafibrate, a Novel Selective PPARα Modulator, on Lipid and Glucose Metabolism in Patients With Type 2 Diabetes and Hypertriglyceridemia: A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Trial (2018)
  • Author(s): Araki Eiichi、Yamashita Shizuya、Arai Hidenori、Yokote Koutaro、Satoh Jo、Inoguchi Toyoshi、Nakamura Jiro、Maegawa Hiroshi、Yoshioka Narihito、Tanizawa Yukio、Watada Hirotaka、Suganami Hideki、Ishibashi Shun
  • Journal Title: Diabetes Care Volume: 41 Issue: 3 Pages: 538-546
  • DOI: 10.2337/dc17-1589
  • Peer Reviewed / Open Access
• [Journal Article] Efficacy and safety of pemafibrate (K-877), a selective peroxisome proliferator-activated receptor α modulator, in patients with dyslipidemia: Results from a 24-week, randomized, double blind, active-controlled, phase 3 trial (2018)
  • Author(s): Shun Ishibashi, Hidenori Arai, Koutaro Yokote, Eiichi Araki, Hideki Suganami, Shizuya Yamashita
  • Journal Title: J Clin Lipidol. Volume: 12 Issue: 1 Pages: 173-184
  • DOI: 10.1016/j.jacl.2017.10.006
  • Peer Reviewed / Open Access
• [Journal Article] Identification of microRNA that represses IRS-1 expression in liver. (2018)
  • Author(s): Ono K, Igata M, Kondo T, Kitano S, Takaki Y, Hanatani S, Sakaguchi M, Goto R, Senokuchi T, Kawashima J, Furukawa N, Motoshima H, Araki E
  • Journal Title: PLoS One Volume: 13 Issue: 1 Pages: 0191553-0191553
  • DOI: 10.1371/journal.pone.0191553
  • Peer Reviewed / Open Access
• [Journal Article] Inhibition of local macrophage growth ameliorates focal inflammation and suppresses atherosclerosis. (2018)
  • Author(s): Yamada S, Senokuchi T, Matsumura T, Morita Y, Ishii N, Fukuda K, Murakami S, Nishida S, Kawasaki S, Motoshima H, Furukawa N, Komohara Y, Fujiwara Y, Koga T, Yamagata K, Takeya M, Araki E
  • Journal Title: Arteriosclerosis, Thrombosis, and Vascular Biology Volume: 印刷中 Issue: 5 Pages: 994-1006
  • DOI: 10.1161/atvbaha.117.310320
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Study desirn of a phase II clinical trial to assess the efficacy and safety of eperisone in Japanese type 2 diabetes patients with risk and non-risk alleles of CDKAL1 (2018)
  • Author(s): Sakakida K1, Wei FY, Senokuchi T, Shimoda S, Kakuma T, Araki E, Tomizawa K; Eperisone for Diabetes with Impaired tRNA (EDIT) Study Group.
  • Journal Title: Acta Med Okayama. Volume: Aug;72(4) Pages: 423-426
  • Peer Reviewed
• [Journal Article] Japanese Clinical Practice Guideline for Diabetes 2016. (2018)
  • Author(s): Haneda M, Noda M, Origasa H, Noto H, Yabe D, Fujita Y, Goto A, Kondo T, Araki E
  • Journal Title: J Diabetes Investig. Volume: 9 Issue: 3 Pages: 657-697
  • DOI: 10.1111/jdi.12810
  • NAID: 120006469171
  • Peer Reviewed / Open Access
• [Journal Article] Effects of a novel selective peroxisome proliferator-activated receptor α modulator, pemafibrate (K-877), on hepatic and peripheral glucose uptake in patients with hypertriglyceridemia and insulin resistance (2018)
  • Author(s): Matsuba Ikuro、Matsuba Ren、Ishibashi Shun、Yamashita Shizuya、Arai Hidenori、Yokote Koutaro、Suganami Hideki、Araki Eiichi
  • Journal Title: Journal of Diabetes Investigation Volume: - Issue: 6 Pages: 0-0
  • DOI: 10.1111/jdi.12845
  • Peer Reviewed / Open Access
• [Journal Article] A Rare Case of Thyrotropin-Secreting Pituitary Adenoma Coexisting with Papillary Thyroid Carcinoma Presenting with Visual Disturbance without Hyperthyroidism (2018)
  • Author(s): Inoue Hirotaka、Shinojima Naoki、Ueda Ryuta、Yamamoto Keizo、Ishii Norio、Igata Motoyuki、Kawashima Junji、Araki Eiichi、Iwase Hirotaka、Mikami Yoshiki、Yano Shigetoshi、Mukasa Akitake
  • Journal Title: World Neurosurgery Volume: 119 Pages: 394-399
  • DOI: 10.1016/j.wneu.2018.07.274
  • Peer Reviewed / Open Access
• [Journal Article] Semaglutide Added to Basal Insulin in Type 2 Diabetes (SUSTAIN 5): A Randomized, Controlled Trial (2018)
  • Author(s): Rodbard Helena W、Lingvay Ildiko、Reed John、de la Rosa Raymond、Rose Ludger、Sugimoto Danny、Araki Eiichi、Chu Pei-Ling、Wijayasinghe Nelun、Norwood Paul
  • Journal Title: The Journal of Clinical Endocrinology & Metabolism Volume: 103 Issue: 6 Pages: 2291-2301
  • DOI: 10.1210/jc.2018-00070
  • Peer Reviewed / Open Access
• [Journal Article] Efficacy and Safety of Dapagliflozin in Patients With Inadequately Controlled Type 1 Diabetes (the DEPICT-2 Study): 24-Week Results From a Randomized Controlled Trial (2018)
  • Author(s): Mathieu Chantal、Dandona Paresh、Gillard Pieter、Senior Peter、Hasslacher Christoph、Araki Eiichi、Lind Marcus、Bain Stephen C.、Jabbour Serge、Arya Niki、Hansen Lars、Thor?n Fredrik、Langkilde Anna Maria
  • Journal Title: Diabetes Care Volume: 41 Issue: 9 Pages: 1938-1946
  • DOI: 10.2337/dc18-0623
  • Peer Reviewed
• [Journal Article] Impacts of tight multifactorial intervention in patients with type 2 diabetes: Implications from the Japan Diabetes Outcome Intervention Trial 3 (2018)
  • Author(s): Araki Eiichi、Senokuchi Takafumi、Furukawa Noboru
  • Journal Title: Journal of Diabetes Investigation Volume: 9 Issue: 5 Pages: 1022-1024
  • DOI: 10.1111/jdi.12872
  • Peer Reviewed / Open Access
• [Journal Article] Effects of pemafibrate (K-877) on cholesterol efflux capacity and postprandial hyperlipidemia in patients with atherogenic dyslipidemia (2018)
  • Author(s): Yamashita Shizuya、Arai Hidenori、Yokote Koutaro、Araki Eiichi、Suganami Hideki、Ishibashi Shun
  • Journal Title: Journal of Clinical Lipidology Volume: 12 Issue: 5 Pages: 747-750
  • DOI: 10.1016/j.jacl.2018.06.010
  • Peer Reviewed / Open Access
• [Journal Article] One-hour oral glucose tolerance test plasma glucose at gestational diabetes diagnosis is a common predictor of the need for insulin therapy in pregnancy and postpartum impaired glucose tolerance (2018)
  • Author(s): Nishikawa Takeshi、Ono Keiko、Hashimoto Shoko、Kinoshita Hiroyuki、Watanabe Takuro、Araki Hirotaka、Otsu Kae、Sakamoto Wakana、Harada Masahiro、Toyonaga Tetsushi、Kawakami Shoichi、Fukuda Jyunichiro、Haga Yoshio、Kukidome Daisuke、Takahashi Takeshi、Araki Eiich
  • Journal Title: Journal of Diabetes Investigation Volume: 9 Issue: 6 Pages: 1370-1377
  • DOI: 10.1111/jdi.12848
  • Peer Reviewed / Open Access
• [Journal Article] The eperisone for diabetes with inpaired tRNA(EDIT) study group: Study desirn of a phase II clinical trial to assess the efficacy and safety of eperisone in Japanese type 2 diabetes patients with risk and non-risk alleles of CDKAL1 (2018)
  • Author(s): Sakakida K, Wei FY, Senokuchi T, Shimoda S, Kakuma T, Araki E, Tomizawa K; Eperisone for Diabetes with Impaired tRNA (EDIT) Study Group.
  • Journal Title: Acta Med Okayama Volume: Aug;72(4) Pages: 423-426
  • Peer Reviewed
• [Presentation] Effects of linagliptin on macrophages and on progression of atherosclerosis in high fat-fed apoE-deficient mice (2019)
  • Author(s): Nishida S, Matsumura T, Senokuchi T, Ishii N, Murakami-Nishida S, Yamada S, Morita Y, Wada T, Motoshima H, Kondo T, Araki E.
  • Organizer: The 11th Scientific Meeting of the Asian Association for the Study of Diabetes.
  • Int'l Joint Research
• [Presentation] Unique role of the α4 component for S6-kinase activity in Metabolic Regulation and anti- Apoptotic effect in Brown Adipose Tissue (2019)
  • Author(s): Sakaguchi M, Okagawa S, Kitano S, Kondo T, Araki E
  • Organizer: The 79th ADA scientific meeting
  • Int'l Joint Research
• [Presentation] Oral semaglutide as add-on to insulin in T2D: PIONEER 8. (2019)
  • Author(s): Zinman B, Aroda VR, Buse JB, Cariou B, Harris SB, Hoff ST, Pedersen KB, Tarp-Johansen MJ, Araki E
  • Organizer: The 79th ADA scientific meeting
  • Int'l Joint Research
• [Presentation] The Hepatic Role of Heat Shock Protein 72 in the Pathogenesis of Type 2 Diabetes (2019)
  • Author(s): Kondo T, Kitano S, Miyakawa N, Watanabe T, Goto R, Ono K, Igata M, Kawashima J, Motoshima H, Matsumura T, Araki E
  • Organizer: The 79th ADA scientific meeting
  • Int'l Joint Research
• [Presentation] Pioglitazone Suppresses Macrophage Proliferation in Apolipoprotein-e Deficient Mice by Activating PPARγ (2019)
  • Author(s): Murakami-Nishida S, Matsumura T, Nishida S, Senokuchi T, Ishi N, Yamada S, Morita Y, Wada T, Motoshima H, Kondo T, Araki E
  • Organizer: The 79th ADA scientific meeting
  • Int'l Joint Research
• [Presentation] Linagliptin induces M2 macrophage polarization and suppresses progression of atherosclerosis in high fat-fed apoE-deficient mice (2019)
  • Author(s): Nishida S, Matsumura T, Senokuchi T, Ishii N, Murakami-Nishida S, Yamada S, Morita Y, Wada T, Motoshima H, Kondo T, Araki E
  • Organizer: The 79th ADA scientific meeting
  • Int'l Joint Research
• [Presentation] FoxK1 and FoxK2 are positive regulators for IR and IGF1R signalling in cell proliferation and metabolism. (2019)
  • Author(s): Sakaguchi M, Araki E, Mann M, Enerbra S, Kahn CR
  • Organizer: 55th Annual Meetng of the European Association of the Study of Diabetes.
  • Int'l Joint Research
• [Presentation] The organ cross talk in the regulation of glucose homeostasis through heat shock protein 72 expression. (2019)
  • Author(s): Kondo T, Kitano S, Miyakawa N, Watanabe T, Goto R, Igata M, Kawashima J, Motoshima H, Matsumura T, Araki E
  • Organizer: 55th Annual Meetng of the European Association of the Study of Diabetes.
  • Int'l Joint Research
• [Presentation] Pioglitazone suppresses macrophage proliferation in apolipoprotein-E deficient mice by activating PPARγ. (2019)
  • Author(s): Matsumura T, Nishida S.M, Nishida S, Senokuchi T, Ishii N, Morita Y, Wada T, Motoshima H, Kondo T, Arak E
  • Organizer: 55th Annual Meetng of the European Association of the Study of Diabetes.
  • Int'l Joint Research
• [Presentation] Role of Tissue Macrophages Proliferation in Insulin Resistance in the Liver and Adipose tissue. (2019)
  • Author(s): Wada T, Senokuchi T, Yamada S, Morita Y, Furusho T, Motoshima H, Ishi N, Matsumura T, Araki E
  • Organizer: International Diabetes Federation Congress 2019
  • Int'l Joint Research
• [Presentation] 糖尿病患者における肝細胞癌発生の実態調査. (2019)
  • Author(s): 松村剛，瀬ノ口隆文，建石良介，窪田直人，小池和彦，荒木栄一
  • Organizer: 第62回日本糖尿病学会年次学術集会
• [Presentation] 熊本発ブルーサークルメニューの開発とその効用． (2019)
  • Author(s): 近藤龍也
  • Organizer: 第7回アフリカ開発会議 ポストフォーラム in 熊本.
  • Invited
• [Presentation] 災害時の糖尿病患者支援~学会・協会の取り組みより (2019)
  • Author(s): 瀬ノ口隆文，本島 寛之，近藤龍也，荒木 栄一
  • Organizer: 第57回日本糖尿病学会 九州地方会
  • Invited
• [Presentation] 糖尿病治療薬の心/腎保護効果. (2019)
  • Author(s): 荒木栄一
  • Organizer: 日本内科学会学術集会第47回内科学の展望
  • Invited
• [Presentation] physical medicineによる2型糖尿病新規治療法の開発. (2019)
  • Author(s): 近藤龍也
  • Organizer: 第38回日本認知症学会学術集会.
  • Invited
• [Presentation] 糖尿病診療の Update;合併症の発症・進展阻止のために (2019)
  • Author(s): 荒木栄一
  • Organizer: 第66回九州支部生涯教育講演会
  • Invited
• [Presentation] ピオグリタゾンによるマクロファージ増殖抑制効果を介した糖尿病大血管合併症進展抑制効果. (2019)
  • Author(s): 松村剛，西田彩子，瀬ノ口隆文，石井規夫，山田沙梨恵，守田雄太郎，西田周平，和田敏明, 佐藤美希，本島寛之，近藤龍也，荒木栄一
  • Organizer: 第62回日本糖尿病学会年次学術集会
• [Presentation] 褐色脂肪組織におけるインスリンシグナル新規標的分子FoxK1/2の研究 (2019)
  • Author(s): 阪口雅司, C Ronald Kahn, 荒木栄一
  • Organizer: 第62回日本糖尿病学会年次学術集会
• [Presentation] SGLT2阻害薬によるマクロファージ活性制御の機序解明. (2019)
  • Author(s): 西田彩子，松村 剛，瀬ノ口隆文，石井規夫，山田沙梨恵，守田雄太郎，西田周平，和田敏明，佐藤美希，本島寛之，近藤龍也，荒木栄一
  • Organizer: 第62回日本糖尿病学会年次学術集会
• [Presentation] Heat Shock Protein 72 ノックアウトマウスにおける糖代謝異常発生機序の解明. (2019)
  • Author(s): 北野さやか，近藤龍也，渡邊拓郎，宮川展和，小野薫，花谷聡子，阪口雅司，後藤理英子，井形元維，河島淳司，本島寛之，荒木栄一
  • Organizer: 第62回日本糖尿病学会年次学術集会
• [Presentation] 膵α細胞の鉱質コルチコイドレセプタ―は膵島におけるIL-6とGLP-1分泌を制御する (2019)
  • Author(s): 後藤理英子, 近藤龍也, 荒木栄一
  • Organizer: 第62回日本糖尿病学会年次学術集会
• [Presentation] ピオグリタゾンの抗動脈硬化作用としてのマクロファージ増殖抑制効果の解析. (2019)
  • Author(s): 西田彩子，松村剛，西田周平，瀬ノ口隆文，石井規夫，山田沙梨恵，守田雄太郎，和田敏明，荒木栄一
  • Organizer: 第51回日本動脈硬化学会総会・学術集会
• [Presentation] DPP-4阻害薬リナグリプチンによるM2マクロファージ誘導効果の解析, (2019)
  • Author(s): 西田周平，松村剛，西田彩子，瀬ノ口隆文，石井規夫，山田沙梨恵，守田雄太郎，和田敏明，荒木栄一
  • Organizer: 第51回日本動脈硬化学会総会・学術集会
• [Presentation] DPP-4阻害薬によるマクロファージの極性変化を介した抗動脈硬化作用機序の解明 (2019)
  • Author(s): 西田周平，松村 剛，西田彩子，瀬ノ口隆文，荒木栄一
  • Organizer: 第69回日本体質医学会総会
• [Presentation] 全大腸切除後の高血糖にGLP-1製剤が有効であった症例の病態解明． (2019)
  • Author(s): 近藤龍也、井形元維, 河島淳司、瀬ノ口隆文、松村剛、本島寛之、荒木栄一
  • Organizer: 第57回日本糖尿病学会九州地方会
• [Presentation] Linagliptinによる糖尿病大血管症進展抑制効果とマクロファージへの影響. (2019)
  • Author(s): 西田周平，松村 剛，西田彩子，瀬ノ口隆文，石井規夫，山田沙梨恵，守田雄太郎，和田敏明，荒木栄一
  • Organizer: 第57回日本糖尿病学会九州地方会
• [Presentation] Impacts of the Kumamoto Earthquake 2016 on glycemic control in diabetic patients. (2018)
  • Author(s): Kondo T, Miyakawa N, Motoshima H, Ishii N, Igata M, Yoshinaga K, Kukidome D, Senokuchi T, Kawashima J, Matsumura T, Araki E
  • Organizer: The 78th ADA Scientific Meetng.
  • Int'l Joint Research
• [Presentation] Pharmacokinetics (PK) and Pharmacodynamics (PD) of Dapagliflozin (DAPA) in Combination with Insulin in Japanese Patients with T1D (2018)
  • Author(s): Watada H, Shiramoto M, Ueda S, Tang W, Asano M, Thoren F, Kim H, Yajima T, Boulton DW, Araki E
  • Organizer: The 78th ADA Scientific Meetng.
  • Int'l Joint Research
• [Presentation] 2型糖尿病の成因と病態Update (2018)
  • Author(s): 荒木栄一
  • Organizer: 第52回糖尿病学の進歩.
  • Invited
• [Presentation] 糖尿病診療の最前線. (2018)
  • Author(s): 荒木 栄一
  • Organizer: 第115回日本内科学会総会・講演会
  • Invited
• [Presentation] HSP72を標的としたインスリン抵抗性・肥満の治療. (2018)
  • Author(s): 荒木栄一
  • Organizer: 第39回日本肥満学会.
• [Presentation] 糖尿病治療の新たな展望. (2018)
  • Author(s): 荒木 栄一
  • Organizer: 第68回日本体質医学会総会
• [Presentation] 糖尿病治療Update;合併症の発症・進展阻止のために. (2018)
  • Author(s): 荒木 栄一
  • Organizer: 第39回日本肥満学会.
• [Presentation] ヒートパッドによる熱ストレス応答経路活性化. (2018)
  • Author(s): 近藤龍也
  • Organizer: 第56回日本糖尿病学会 九州地方会
• [Presentation] 日本人2型糖尿病患者における，ベースラインHbA1c 別のセマグルチドの有効性の検討. (2018)
  • Author(s): 荒木栄一
  • Organizer: 第61回日本糖尿病学会年次学術集会
• [Presentation] 「平成28年熊本地震」における糖尿病患者の血糖コントロールとその変動規定因子の検討. (2018)
  • Author(s): 近藤龍也, 宮川展和, 石井則夫, 吉永佳代, 井形元維, 久木留大介, 河島淳司, 瀬ノ口隆文, 松村剛, 本島寛之, 荒木栄一
  • Organizer: 第61回日本糖尿病学会年次学術総会
• [Presentation] 「平成28年熊本地震」における糖尿病患者の血糖管理状況とその規定因子. (2018)
  • Author(s): 近藤龍也, 宮川展和, 石井則夫, 吉永佳代, 井形元維, 久木留大介, 河島淳司, 瀬ノ口隆文, 松村剛, 本島寛之, 荒木栄一
  • Organizer: 第115回日本内科学会総会・講演会
• [Presentation] 妊娠悪阻による低K血症は横紋筋融解症と腎性尿崩症の原因となる. (2018)
  • Author(s): 近藤龍也,河島淳司,中村美和, 荒木栄一
  • Organizer: 第28回臨床内分泌代謝Update
• [Presentation] Impacts of th Kumamoto Earthquake 2016 on glycemic control in diabetic patients. (2018)
  • Author(s): Kondo T, Miyakawa N, Motoshima H, Ishii N, Igata M, Yoshinaga K, Kukidome D, Senokuchi T, Kawashima J, Matsumura T, Araki E
  • Organizer: The 78th ADA Scientific Meetng
  • Int'l Joint Research
• [Presentation] Pharmacokinetics (PK) and Pharmacodynamics (PD) of Dapagliflozin (DAPA) in Combination with Insulin in Japanese Patients with T1D (2018)
  • Author(s): Watada H, Shiramoto M, Ueda S, Tang W, Asano M, Thoren F, Kim H, Yajima T, Boulton DW, Araki E
  • Organizer: The 78th ADA Scientific Meetng
  • Int'l Joint Research
• [Presentation] 2型糖尿病の成因と病態Update (2018)
  • Author(s): 荒木栄一
  • Organizer: 第52回糖尿病学の進歩
  • Invited
• [Presentation] 糖尿病診療の最前線. (2018)
  • Author(s): 荒木栄一
  • Organizer: 第115回日本内科学会総会・講演会
  • Invited
• [Presentation] HSP72を標的としたインスリン抵抗性・肥満の治療. (2018)
  • Author(s): 荒木栄一
  • Organizer: 第39回日本肥満学会
• [Presentation] 糖尿病治療の新たな展望. (2018)
  • Author(s): 荒木栄一
  • Organizer: 第68回日本体質医学会総会
• [Presentation] 糖尿病治療Update;合併症の発症・進展阻止のために. (2018)
  • Author(s): 荒木栄一
  • Organizer: 第39回日本肥満学会.
• [Book] 阪口雅司, 荒木栄一 (2019)
  • Author(s): 日本臨牀 別冊「内分泌症候群（第3版）Ⅳ-その他の内分泌疾患を含めて-」Ⅷ．糖代謝９．インスリン受容体異常症(A型，B型)日本臨床 2019.
  • Total Pages: 376
  • Publisher: 日本臨床社
• [Book] 糖尿病最新の治療2019-2021 (2019)
  • Author(s): 門脇 孝、荒木 栄一、綿田 裕孝
  • Total Pages: 348
  • Publisher: 南江堂
  • ISBN: 9784524245567
• [Book] 万病のもと！糖尿病徹底対策 これが原因！NHKテキストきょうの健康(3)90-97, 2019. (2019)
  • Author(s): 荒木栄一
  • Total Pages: 126
  • Publisher: NHK出版
• [Book] 臨床研究から日常診療応用の実際と限界. 糖尿病UP DATE賢島セミナー2018 35 臨床研究から日常診療へのシームレスな活用 (2019)
  • Author(s): 荒木栄一
  • Total Pages: 101
  • Publisher: メディカルジャーナル社
  • ISBN: 4908437203
• [Book] インスリン受容体と共に核内に移行する新規標的経路 (2019)
  • Author(s): 阪口 雅司、大久保 侑馬、岡川 章太、荒木 栄一
  • Total Pages: 68
  • Publisher: ニュー・サイエンス社
• [Book] 特集／激増する糖尿病の診療最前線 糖尿病診断の進め方. 臨床と研究. (2018)
  • Author(s): 阪口雅司, 荒木栄一
  • Total Pages: 7
  • Publisher: 大道学館
• [Book] 脂肪細胞におけるインスリン受容体の役割. 糖尿病学. (2018)
  • Author(s): 阪口雅司, 荒木栄一
  • Total Pages: 7
  • Publisher: 診断と治療社
• [Book] TOPICS 誘導可能な脂肪特異的インスリン受容体欠損マウスの解析 Diabetes Journal (糖尿病と代謝) (2018)
  • Author(s): 阪口雅司, 荒木栄一
  • Total Pages: 2
  • Publisher: Diabetes Journal
• [Book] ADAガイドライン2018-米国での動き (2018)
  • Author(s): 荒木栄一, 阪口雅司, 瀬ノ口隆文
  • Total Pages: 4
  • Publisher: Diabetes Journal
• [Book] 新しい脂質異常症治療薬としての selective peroxisome proliferator-activated receptor α modulator (SPPARM α) とその可能性 (2018)
  • Author(s): 荒木栄一, 瀬ノ口隆文
  • Total Pages: 4
  • Publisher: 医歯薬出版
• [Book] 高中性脂肪血症治療の重要性;糖尿病合併症講師決勝の観点から (2018)
  • Author(s): 荒木栄一, 益崎裕章, 小田原雅人, 横手幸太郎
  • Total Pages: 2
  • Publisher: 日経メディカル
• [Book] 万病のもと！糖尿病徹底対策 (2018)
  • Author(s): 荒木栄一
  • Total Pages: 8
  • Publisher: NHKテキストきょうの健康
• [Book] 進化する糖尿病医療. (2018)
  • Author(s): 荒木栄一
  • Total Pages: 1
  • Publisher: BIO Clinica
• [Book] 糖尿病診療の最前線. (2018)
  • Author(s): 荒木栄一
  • Total Pages: 8
  • Publisher: 日本内科学会雑誌
• [Book] 糖尿病の治療とは. (2018)
  • Author(s): 荒木栄一
  • Total Pages: 4
  • Publisher: 別冊NHKテキストきょうの健康
• [Book] 今日から始める自己管理. (2018)
  • Author(s): 荒木栄一
  • Total Pages: 6
  • Publisher: 別冊NHKテキストきょうの健康
• [Book] 編集の言葉. (2018)
  • Author(s): 荒木栄一
  • Total Pages: 1
  • Publisher: Diabetes Care 日本語版
• [Book] 日本臨牀 別冊「内分泌症候群（第3版）Ⅳ-その他の内分泌疾患を含めて-」Ⅷ．糖代謝９．インスリン受容体異常症(A型，B型)日本臨床 (2018)
  • Author(s): 阪口雅司, 荒木栄一
  • Total Pages: 5
  • Publisher: 日本臨牀
• [Book] 平成28年熊本地震」における糖尿病患者の血糖コントロールに関わる因子の検討. (2018)
  • Author(s): 近藤龍也、宮川展和、本島寛之、花谷聡子、石井則夫、井形元維、吉永佳代、久木留大介、瀬ノ口隆文、河島淳司、松村剛、荒木栄一
  • Total Pages: 5
  • Publisher: 日本体質医学学会雑誌
• [Book] 特集／激増する糖尿病の診療最前線 糖尿病診断の進め方. 臨床と研究. (2018)
  • Author(s): 阪口雅司, 荒木栄一
  • Total Pages: 7
  • Publisher: 臨床と研究. 大道学館
• [Book] 阪口雅司, 荒木栄一 (2018)
  • Author(s): 阪口雅司, 荒木栄一
  • Total Pages: 7
  • Publisher: 診断と治療社
• [Book] 高中性脂肪血症治療の重要性:糖尿病合併症講師決勝の観点から (2018)
  • Author(s): 荒木栄一, 益崎裕章, 小田原雅人, 横手幸太郎
  • Total Pages: 2
  • Publisher: 日経メディカル
• [Book] 日本臨牀 別冊「内分泌症候群（第3版）Ⅳ-その他の内分泌疾患を含めて-」Ⅷ．糖代謝９．インスリン受 容体異常症(A型，B型)日本臨床 (2018)
  • Author(s): 阪口雅司, 荒木栄一
  • Total Pages: 5
  • Publisher: 日本臨牀
• [Remarks] 熊本大学大学院生命科学研究部 代謝内科学分野
  • URL: http://www2.kuh.kumamoto-u.ac.jp/met/