| Project/Area Number |
17H04221
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Infectious disease medicine
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| Research Institution | Kumamoto University |
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Principal Investigator |
Suzu Shinya 熊本大学, ヒトレトロウイルス学共同研究センター, 教授 (80363513)
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| Co-Investigator(Kenkyū-buntansha) |
野依 修 熊本大学, ヒトレトロウイルス学共同研究センター, 特定事業研究員 (30737151)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2019: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2017: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
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| Keywords | エイズ / 潜伏感染 / HIV-1 / fibrocytes / HIV / HIV潜伏感染 / Fibrocytes |
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| Outline of Final Research Achievements |
In this study, we identified fibrocytes as a candidate for HIV-1 latently infected cells. First, we revealed that fibrocytes are infected with HIV-1 through analyses of treatment-naïve patients, and mechanisms by which HIV-1 efficiently infects fibrocytes. We also found that the number of fibrocytes increases in HIV-1 infection, which persists even after long-term anti-retroviral therapy. Similar results were observed in monkeys infected with HIV-1-related monkey-tropic virus SIV. Finally, we revealed that not only resting CD4+ T cells but also fibrocytes are important HIV-1 latently infected cells through analyses of long-term treated patients whose viral load in plasma is undetectable.
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| Academic Significance and Societal Importance of the Research Achievements |
潜伏感染は薬剤耐性ウイルスと並んで、エイズ研究領域で解決すべき重要な課題でとなっている。これまで代表的な潜伏感染細胞として静止期CD4+ T細胞が良く知られているが、排除する治療法は未だなく、そもそもこれらが潜伏感染全体をカバーするかもまだ明らかではない。従って、全ての潜伏感染細胞を一つずつ同定して、そしてそれらの相対的な貢献度を明確にする必要があり、本研究では私達のオリジナルのfibrocytesについて実践したものである。
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