Optimal ultraviolet wavelength for immune regulation and development of ultraviolet-LED phototherapy
| Project/Area Number |
17H04242
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Nagoya City University |
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Principal Investigator |
Morita Akimichi 名古屋市立大学, 医薬学総合研究院(医学), 教授 (30264732)
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| Co-Investigator(Kenkyū-buntansha) |
山崎 小百合 名古屋市立大学, 医薬学総合研究院(医学), 教授 (70567255)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2019: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2018: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2017: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
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| Keywords | 紫外線 / 免疫制御 / 制御性Ｔ細胞 / 光線治療 / LED / 光線療法 / 制御性T細胞 |
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| Outline of Final Research Achievements |
Wavelength analysis to induce iTreg showed inhibition of delayed-type hypersensitivity and induction of Treg at 310 nm and induction of nTreg at 290-300 nm. Demethylation in Treg-related genes leads to Tregs with stable inhibitory functions. The decreased ability to suppress Treg in patients with psoriasis returned to almost normal after phototherapy, indicating that phototherapy restored Treg function. Regarding the induction of Treg in human skin lesions, we succeeded in FACS analysis from a small amount of whole blood collected as lesional blood and in the separation of CD4/CD8 by high-speed cell sorter. We also succeeded in the separation of regulatory T cells.
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| Academic Significance and Societal Importance of the Research Achievements |
今回の研究成果は、光線療法のメカニズムの一部を明らかにするとともに、乾癬の病態がより明確になることが期待される。またTh17細胞がその病態に関与していると考えられている自己免疫性脳脊髄炎（多発性硬化症）や様々な自己免疫疾患に対し光線療法が応用できる可能性があり、今回の研究がその足がかりとなる可能性がある。
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Report
(4 results)
Research Products
(29 results)
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[Journal Article] Hyperglycemia is associated with psoriatic inflammation in both humans and mice2019
Author(s)
Ikumi K, Odanaka M, Shime H, Imai M, Osaga S, Taguchi O, Nishida E, Hemmi H, Kaisho T, Morita A, Yamazaki S
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Journal Title
Journal of Investigative Dermatology
Volume: 印刷中
Issue: 6
Pages: 1329-1338
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Quantifying of serum IL-17A and TNFa to estimate the formation of psoriatic skin2017
Author(s)
Emi Nishida, Kan Torii, Saori Kasuya, Akiko Nishioka, Kyoko Ikumi, Shinnosuke Muramatsu, Akimichi Morita
Organizer
PASI formula, 2017 SID annual meeting, April 26-29, 2016, Portland
Related Report
Int'l Joint Research
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[Presentation] Photochemotherapy limits Treg plasticity and restores Treg function in psoriasis patients.2017
Author(s)
Kan Torii, Ryoji Kubo, Takuya Furuhashi, Shinnosuke Muramatsu, Yoko Sagawa, Chiyo Saito, Sayuri Yamazaki, Akimichi Morita
Organizer
47th Annual ESDR meeting, 27-30 September, 2017, Salzburg (Poster work)
Related Report
Int'l Joint Research
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[Presentation] The critical role of dendritic cell subset in expanding Foxp3+ regulatory T cells in the murine skin after ultraviolet B exposure.2017
Author(s)
Sayuri Yamazaki, Akiko Nishioka, Saori Kasuya, Mizuyu Odanaka, Hiroaki Hemmi, Masaki Imai, Dieter Riethmacher, Tsuneyasu Kaisho, Naganari Ohkura, Shimon Sakaguchi, Akimichi Morita
Organizer
5th International Workshop on Langerhans cell. 6-8 October, 2017, New York (Oral)
Related Report
Int'l Joint Research
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