Comprehensive analysis of gut microbiome and epigenetic changes in esophageal cancer.
| Project/Area Number |
17H04273
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Kumamoto University |
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Principal Investigator |
Baba Yoshifumi 熊本大学, 病院, 非常勤診療医師 (20599708)
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| Co-Investigator(Kenkyū-buntansha) |
美馬 浩介 熊本大学, 病院, 非常勤診療医師 (00546559)
澤 智裕 熊本大学, 大学院生命科学研究部(医), 教授 (30284756)
吉田 直矢 熊本大学, 病院, 特任准教授 (60467983)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2019: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2018: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2017: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
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| Keywords | 腸内細菌叢 / LINE-1 / 食道癌 / 腫瘍免疫 / Fusobacterium / microbiome / 16S rRNA シークエンス / LNE-1 / Fusobacterium nucleatum / epigenetics / esophageal cancer |
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| Outline of Final Research Achievements |
Fusobacterium nucleatum (F. nucleatum), which primarily inhabits the oral cavity, causes periodontal disease. F. nucleatum influences the development and progression of esophageal cancer. First, we showed that F. nucleatum tumors had lower LINE-1 methylation level (global DNA methylation). Second, we could demonstrate that LINE-1 hypomethylation was associated with LINE-1 copy number in esophageal cancers. Third, we found that tumor LINE-1 hypomethylation level was associated with a diminished peritumoral lymphocytic reaction.
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| Academic Significance and Societal Importance of the Research Achievements |
腸内細菌叢microbiomeは薬剤などにより後天的に変化させうるものであり、疾患治療のターゲットとしてもきわめて有望である。よって、“Fusobacteriumという口腔内に存在する菌が、食道癌のメチル化や腫瘍免疫に関与する”という今回得られた結果は臨床応用に直結する可能性があり、創薬へ向けた橋渡し研究として極めて意義深いものである。
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Report
(4 results)
Research Products
(19 results)
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[Journal Article] IDO1 Expression Is Associated With Immune Tolerance and Poor Prognosis in Patients With Surgically Resected Esophageal Cancer.2018
Author(s)
Kiyozumi Y, Baba Y, Okadome K, Yagi T, Ishimoto T, Iwatsuki M, Miyamoto Y, Yoshida N, Watanabe M, Komohara Y, Baba H.
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Journal Title
Ann Surg
Volume: Mar 27
Issue: 6
Pages: 1-1
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] LINE-1 methylation level and local immune response in esophageal cancer2018
Author(s)
Yoshifumi Baba、Keisuke Kosumi, Daichi Nomoto, Kazuo Okadome, Taisuke Yagi, Yuki Kiyozumi, Kojiro Eto, Yukiharu Hiyoshi, Takatsugu Ishimoto, Masaaki Iwatsuki, Shiro Iwagami, Yuji Miyamoto, Naoya Yoshida, Hideo Baba
Organizer
The International Society for Disease of the Esophagus(ISDE)
Related Report
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