Functions of Nitric Oxide and Endothelium-derived Hyperpolarizing Factor are impaired in Poor Run-off Autogenous Rabbit Arterial Grafts
| Project/Area Number |
17H04290
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cardiovascular surgery
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
杉本 昌之 名古屋大学, 医学部附属病院, 病院講師 (00447814)
伊藤 猛雄 名古屋市立大学, 医薬学総合研究院(医学), 研究員 (70159888)
坂野 比呂志 名古屋大学, 医学部附属病院, 講師 (80584721)
室原 豊明 名古屋大学, 医学系研究科, 教授 (90299503)
児玉 章朗 名古屋大学, 医学部附属病院, 病院講師 (10528748)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2019: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2018: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
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| Keywords | 内膜肥厚 / EDHF / 異常血流モデル / 内皮機能 / 外科 / 生理学 / 薬理学 |
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| Outline of Final Research Achievements |
Background: Vascular endothelium induces smooth muscle cell (SMC) relaxation mainly mediated by endothelium-derived nitric oxide (EDNO) and endothelium-derived hyperpolarizing factor (EDHF). The present study was undertaken to determine whether the functions of EDNO and EDHF might be altered in poor run-off artery graft compared to “non-occluded graft”. Methods: The carotid artery was excised and implanted in its original position as an autogenous graft(“non-occluded graft”), and the most inferior branch of the external carotid artery served as the only outflow for the present conditions (“poor run-off graft”).
Conclusions: The functions of both EDNO and EDHF are impaired in poor run-off artery grafts.
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| Academic Significance and Societal Importance of the Research Achievements |
今回の結果より内皮由来過分極因子(EDHF)と血管内膜肥厚との関連が示唆され、EDHFをターゲットとした新しい治療戦略への発展が期待される。EDHFとグラフト内膜肥厚への関与、さらにはステント再狭窄との関連の研究は、閉塞性動脈硬化症だけではなく虚血性心血管病患者の晩期障害となる自家静脈、自家動脈グラフトの狭窄・閉塞、ステント再狭窄の病態解明を企図するもので、EDHFをターゲットとした新たな心血管病治療の可能性示唆し臨床的にも有用な結果であると思われた。
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Report
(4 results)
Research Products
(43 results)
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[Journal Article] Zilver PTX Post-market Surveillance Study of Paclitaxel-Eluting Stents for Treating Femoropopliteal Artery Disease in Japan: 2-Year Results.2019
Author(s)
Kichikawa K, Ichihashi S, Yokoi H, Ohki T, Nakamura M, Komori K, Nanto S, O'Leary EE, Lottes AE, Snyder SA, Dake MD
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Journal Title
Cardiovasc Intervent Radiol.
Volume: 42(3)
Issue: 3
Pages: 358-364
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Long-Term Effectiveness of the Zilver PTX Drug-Eluting Stent for Femoropopliteal Peripheral Artery Disease in Patients with No Patent Tibial Runoff Vessels-Results from the Zilver PTX Japan Post-Market Surveillance Study2018
Author(s)
Cipollari S, Yokoi H, Ohki T, Kichikawa K, Nakamura M, Komori K, Nanto S, O'Leary EE, Lottes AE, Saunders AT, Dake MD
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Journal Title
J Vasc Interv Radiol
Volume: 29(1)
Issue: 1
Pages: 9-17
DOI
Related Report
Peer Reviewed / Open Access
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